Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.

PubWeight™: 1.70‹?› | Rank: Top 3%

🔗 View Article (PMID 7550342)

Published in Nat Genet on October 01, 1995

Authors

G T De Sanctis1, M Merchant, D R Beier, R D Dredge, J K Grobholz, T R Martin, E S Lander, J M Drazen

Author Affiliations

1: Combined Program in Pulmonary and Critical Care Medicine, Brigham Women's Hospital, Boston, Massachusetts 02115, USA.

Articles citing this

The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. J Clin Invest (2005) 2.91

A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol (2009) 2.53

Measuring the lung function in the mouse: the challenge of size. Respir Res (2003) 2.14

Sorting out the cytokines of asthma. J Exp Med (1996) 1.92

Hazardous air pollutants and asthma. Environ Health Perspect (2002) 1.67

Treatment of allergic airway inflammation and hyperresponsiveness by antisense-induced local blockade of GATA-3 expression. J Exp Med (2001) 1.52

Contribution of nitric oxide synthases 1, 2, and 3 to airway hyperresponsiveness and inflammation in a murine model of asthma. J Exp Med (1999) 1.38

Aquaporin 5-deficient mouse lungs are hyperresponsive to cholinergic stimulation. Proc Natl Acad Sci U S A (2001) 1.35

IgE in asthma and atopy: cellular and molecular connections. J Clin Invest (1999) 1.25

Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. J Clin Invest (2006) 1.22

The environment and asthma in U.S. inner cities. Environ Health Perspect (1999) 1.19

No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med (2005) 1.18

Rac2, a hematopoiesis-specific Rho GTPase, specifically regulates mast cell protease gene expression in bone marrow-derived mast cells. Mol Cell Biol (2002) 1.06

A survey of airway responsiveness in 36 inbred mouse strains facilitates gene mapping studies and identification of quantitative trait loci. Mol Genet Genomics (2010) 1.05

Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood. J Exp Med (1996) 1.04

Inhibition of T cell costimulation abrogates airway hyperresponsiveness in a murine model. J Clin Invest (1996) 1.03

Allergen-induced airway remodelling. Eur Respir J (2007) 0.98

Aligning mouse models of asthma to human endotypes of disease. Respirology (2014) 0.98

Apolipoprotein A-I attenuates ovalbumin-induced neutrophilic airway inflammation via a granulocyte colony-stimulating factor-dependent mechanism. Am J Respir Cell Mol Biol (2012) 0.96

Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice. Mamm Genome (2009) 0.94

Comparison of unrestrained plethysmography and forced oscillation for identifying genetic variability of airway responsiveness in inbred mice. Physiol Genomics (2010) 0.93

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene. PLoS One (2013) 0.91

Asthma from a pharmacogenomic point of view. Br J Pharmacol (2008) 0.89

Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation. J Clin Invest (1999) 0.89

Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma. Respir Res (2001) 0.89

The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated. Proc Natl Acad Sci U S A (2011) 0.88

Genetic regulation of Zfp30, CXCL1, and neutrophilic inflammation in murine lung. Genetics (2014) 0.87

Reciprocal backcross mice confirm major loci linked to hyperoxic acute lung injury survival time. Physiol Genomics (2009) 0.86

Using mouse genomics to understand idiopathic interstitial fibrosis. Proc Am Thorac Soc (2007) 0.85

Integrative genetic analysis of allergic inflammation in the murine lung. Am J Respir Cell Mol Biol (2014) 0.84

ATP-binding cassette transporter 1 attenuates ovalbumin-induced neutrophilic airway inflammation. Am J Respir Cell Mol Biol (2014) 0.84

A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense. Curr Respir Med Rev (2006) 0.83

The role of ADAM33 in the pathogenesis of asthma. Springer Semin Immunopathol (2003) 0.82

The structure of the human betaII-tryptase tetramer: fo(u)r better or worse. Proc Natl Acad Sci U S A (1999) 0.82

Identification of the Mhc region as an asthma susceptibility locus in recombinant congenic mice. Am J Respir Cell Mol Biol (2010) 0.80

Toward genetic dissection of high and low antibody responsiveness in Biozzi mice. Proc Natl Acad Sci U S A (1996) 0.80

Plethysmography Phenotype QTL in Mice Before and After Allergen Sensitization and Challenge. G3 (Bethesda) (2016) 0.78

In vivo function of an interleukin 2 receptor beta chain (IL-2Rbeta)/IL-4Ralpha cytokine receptor chimera potentiates allergic airway disease. J Exp Med (1998) 0.78

Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice. PLoS One (2012) 0.78

Parental genetic contributions in the AXB and BXA recombinant inbred mouse strains. Mamm Genome (2002) 0.77

Atopy, airway responsiveness, and genes. Thorax (1996) 0.77

Functional analysis of a novel ENU-induced PHD finger 11 (Phf11) mouse mutant. Mamm Genome (2014) 0.77

Detection of loci for allergic asthma using SMXA recombinant inbred strains of mice. Immunogenetics (2012) 0.77

Mapping of a chromosome 12 region associated with airway hyperresponsiveness in a recombinant congenic mouse strain and selection of potential candidate genes by expression and sequence variation analyses. PLoS One (2014) 0.76

Genetic analysis of lung function in inbred mice suggests vitamin D receptor as a candidate gene. Mol Genet Genomics (2011) 0.76

Age and Sex of Mice Markedly Affect Survival Times Associated with Hyperoxic Acute Lung Injury. PLoS One (2015) 0.76

The orl rat is more responsive to methacholine challenge than wild type. Pulm Pharmacol Ther (2014) 0.76

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life. JCI Insight (2016) 0.75

Role of m2 muscarinic receptor in the airway response to methacholine of mice selected for minimal or maximal acute inflammatory response. Biomed Res Int (2013) 0.75

Genetics of the guppy as a model for experiment in aquaculture. Genetica (2001) 0.75

Articles by these authors

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science (1999) 83.27

A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature (2001) 42.18

Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80

Interpreting patterns of gene expression with self-organizing maps: methods and application to hematopoietic differentiation. Proc Natl Acad Sci U S A (1999) 39.79

Construction of multilocus genetic linkage maps in humans. Proc Natl Acad Sci U S A (1987) 35.83

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature (2002) 28.79

Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A (2001) 24.34

Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet (1999) 24.24

Dissecting the regulatory circuitry of a eukaryotic genome. Cell (1998) 23.62

Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms. Nature (1988) 23.48

High-resolution haplotype structure in the human genome. Nat Genet (2001) 20.51

Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci U S A (2001) 19.30

An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature (2000) 19.19

Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science (1998) 18.23

An STS-based map of the human genome. Science (1995) 17.72

Mendelian factors underlying quantitative traits in tomato: comparison across species, generations, and environments. Genetics (1991) 17.40

Linkage disequilibrium in the human genome. Nature (2001) 17.24

On the allelic spectrum of human disease. Trends Genet (2001) 16.26

The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet (2000) 15.19

A gene map of the human genome. Science (1996) 14.32

Restriction fragment length polymorphism linkage map for Arabidopsis thaliana. Proc Natl Acad Sci U S A (1988) 13.85

Identification of genetic factors contributing to heterosis in a hybrid from two elite maize inbred lines using molecular markers. Genetics (1992) 13.63

A genetic linkage map of the human genome. Cell (1987) 13.37

Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet (1995) 12.78

Positive natural selection in the human lineage. Science (2006) 12.55

A physical map of 30,000 human genes. Science (1998) 12.43

Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children. Science (1987) 12.20

Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet (2001) 11.12

Genomic analysis of metastasis reveals an essential role for RhoC. Nature (2000) 10.11

Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J (2008) 10.08

Systematic detection of errors in genetic linkage data. Genomics (1992) 10.06

Genetic mapping of a gene causing hypertension in the stroke-prone spontaneously hypertensive rat. Cell (1991) 9.99

Ploidy regulation of gene expression. Science (1999) 9.98

Recognition of related proteins by iterative template refinement (ITR). Protein Sci (1994) 9.67

Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell (2001) 9.63

Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1986) 9.51

A genetic map of the mouse suitable for typing intraspecific crosses. Genetics (1992) 8.53

Human and mouse gene structure: comparative analysis and application to exon prediction. Genome Res (2000) 8.28

Mapping complex genetic traits in humans: new methods using a complete RFLP linkage map. Cold Spring Harb Symp Quant Biol (1986) 8.22

Chemosensitivity prediction by transcriptional profiling. Proc Natl Acad Sci U S A (2001) 7.51

Sponsorship, authorship, and accountability. Lancet (2001) 7.10

Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA (2001) 6.55

Rapid multipoint linkage analysis of recessive traits in nuclear families, including homozygosity mapping. Am J Hum Genet (1995) 6.51

Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Proc Natl Acad Sci U S A (2000) 6.30

Sponsorship, authorship, and accountability. N Engl J Med (2001) 6.20

Sponsorship, authorship and accountability. CMAJ (2001) 5.86

The plasticity of dendritic cell responses to pathogens and their components. Science (2001) 5.58

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet (1997) 5.34

Research on DNA typing catching up with courtroom application. Am J Hum Genet (1991) 5.28

Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell (1999) 4.97

The hematopoietic growth factor KL is encoded by the Sl locus and is the ligand of the c-kit receptor, the gene product of the W locus. Cell (1990) 4.91

Determination of ancestral alleles for human single-nucleotide polymorphisms using high-density oligonucleotide arrays. Nat Genet (1999) 4.79

Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast. Nature (1999) 4.71

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell (1993) 4.66

Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nat Genet (2000) 4.66

An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation: I. The roles of minor H antigens and endotoxin. Blood (1996) 4.65

A nonparametric approach for mapping quantitative trait loci. Genetics (1995) 4.49

Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (2009) 4.41

A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nat Genet (1994) 4.20

Loss-of-heterozygosity analysis of small-cell lung carcinomas using single-nucleotide polymorphism arrays. Nat Biotechnol (2000) 4.10

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell (1993) 4.06

Analysing complex genetic traits with chromosome substitution strains. Nat Genet (2000) 3.92

Genetic analysis of the fungus, Bremia lactucae, using restriction fragment length polymorphisms. Genetics (1988) 3.92

Faster multipoint linkage analysis using Fourier transforms. J Comput Biol (1998) 3.87

Epicutaneous sensitization with protein antigen induces localized allergic dermatitis and hyperresponsiveness to methacholine after single exposure to aerosolized antigen in mice. J Clin Invest (1998) 3.85

Churg-Strauss syndrome in patients receiving montelukast as treatment for asthma. Chest (2000) 3.84

Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am J Respir Crit Care Med (1998) 3.83

Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry (2002) 3.78

Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature (2007) 3.69

A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis. Cell (1995) 3.59

Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast. JAMA (1998) 3.57

Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet (2000) 3.52

The cloche and spadetail genes differentially affect hematopoiesis and vasculogenesis. Dev Biol (1998) 3.31

Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol (1999) 3.21

Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA (2001) 3.21

Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources. Proc Natl Acad Sci U S A (1980) 3.18

ARSACS, a spastic ataxia common in northeastern Québec, is caused by mutations in a new gene encoding an 11.5-kb ORF. Nat Genet (2000) 3.17

The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med (2000) 3.08

Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci U S A (1980) 2.94

Secretory phospholipase Pla2g2a confers resistance to intestinal tumorigenesis. Nat Genet (1997) 2.91

The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med (1994) 2.90

High-resolution genetic mapping of complex traits. Am J Hum Genet (1995) 2.89

Parental-specific methylation of an imprinted transgene is established during gametogenesis and progressively changes during embryogenesis. Cell (1991) 2.85

Inflammatory cytokines in patients with persistence of the acute respiratory distress syndrome. Am J Respir Crit Care Med (1996) 2.81

Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia. J Clin Invest (1999) 2.67

Sponsorship, authorship, and accountability. Ann Intern Med (2001) 2.66

Pulmonary responses to bronchoconstrictor agonists in the mouse. J Appl Physiol (1985) (1988) 2.64

Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci U S A (1993) 2.64

Cytokine balance in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2001) 2.60

Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature (1996) 2.58

The murine IL-13 receptor alpha 2: molecular cloning, characterization, and comparison with murine IL-13 receptor alpha 1. J Immunol (1998) 2.57

Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. Hum Mol Genet (1998) 2.57

Characterization of a regulatory region upstream of the ADR2 locus of S. cerevisiae. Nature (1982) 2.54

Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height. Am J Hum Genet (2001) 2.50

Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity. Biochem Biophys Res Commun (1980) 2.49

Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet (1996) 2.48

Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc Natl Acad Sci U S A (1994) 2.41

Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome. Am J Respir Crit Care Med (2001) 2.33

Active anaphylaxis in IgE-deficient mice. Nature (1994) 2.32