Published in BMC Bioinformatics on June 04, 2008
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Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. Br J Pharmacol (2010) 1.02
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CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. Biochem Pharmacol (2005) 1.17
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Defining the nucleotide binding sites of P2Y receptors using rhodopsin-based homology modeling. J Comput Aided Mol Des (2006) 1.01
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P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia. Int J Immunopathol Pharmacol (2005) 0.98
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Evidence for the Recognition of Non-Nucleotide Antagonists Within the Transmembrane Domains of the Human P2Y(1) Receptor. Drug Dev Res (2002) 0.95
Understanding the structural and functional differences between mouse thyrotropin-releasing hormone receptors 1 and 2. Proteins (2008) 0.88
Molecular modeling as a tool to investigate molecular recognition in P2Y receptors. Curr Pharm Des (2002) 0.82
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J (2006) 2.17
Purinergic signalling: from normal behaviour to pathological brain function. Prog Neurobiol (2011) 1.76
Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors. Glia (2003) 1.54
The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One (2008) 1.44
To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? Trends Pharmacol Sci (2005) 1.39
Purinergic signalling in inflammation of the central nervous system. Trends Neurosci (2009) 1.32
Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor. Biochem Pharmacol (2004) 1.26
Key concepts and critical issues on epoetin and filgrastim biosimilars. A position paper from the Italian Society of Hematology, Italian Society of Experimental Hematology, and Italian Group for Bone Marrow Transplantation. Haematologica (2011) 1.25
Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia. Brain Res Brain Res Rev (2005) 1.24
CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. Biochem Pharmacol (2005) 1.17
CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. J Cell Sci (2005) 1.13
The structural basis of cephalosporin formation in a mononuclear ferrous enzyme. Nat Struct Mol Biol (2003) 1.12
Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharmacol Exp Ther (2003) 1.12
A role for P2X7 in microglial proliferation. J Neurochem (2006) 1.10
The P2Y-like receptor GPR17 as a sensor of damage and a new potential target in spinal cord injury. Brain (2009) 1.07
Purinoceptor-mediated calcium signaling in primary neuron-glia trigeminal cultures. Cell Calcium (2007) 1.05
Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation. J Biol Chem (2011) 1.05
Blockade of A2A adenosine receptors prevents basic fibroblast growth factor-induced reactive astrogliosis in rat striatal primary astrocytes. Glia (2003) 1.03
Development of an immobilized GPR17 receptor stationary phase for binding determination using frontal affinity chromatography coupled to mass spectrometry. Anal Biochem (2008) 1.02
Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. Mol Pain (2010) 1.01
Free-energy landscape, principal component analysis, and structural clustering to identify representative conformations from molecular dynamics simulations: the myoglobin case. J Mol Graph Model (2009) 1.01
Influence of the [2Fe]H subcluster environment on the properties of key intermediates in the catalytic cycle of [FeFe] hydrogenases: hints for the rational design of synthetic catalysts. Angew Chem Int Ed Engl (2009) 0.99
2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem (2005) 0.98
The yeast cyclin-dependent kinase inhibitor Sic1 and mammalian p27Kip1 are functional homologues with a structurally conserved inhibitory domain. Biochem J (2005) 0.98
The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells. J Biol Chem (2013) 0.97
Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells. Am J Physiol Cell Physiol (2009) 0.97
The GPR17 receptor in NG2 expressing cells: focus on in vivo cell maturation and participation in acute trauma and chronic damage. Glia (2011) 0.96
Extrinsic purinergic regulation of neural stem/progenitor cells: implications for CNS development and repair. Stem Cell Rev (2012) 0.96
Peripheral benzodiazepine receptor ligands: mitochondrial transmembrane potential depolarization and apoptosis induction in rat C6 glioma cells. Biochem Pharmacol (2004) 0.95
Changes of peripheral A2A adenosine receptors in chronic heart failure and cardiac transplantation. FASEB J (2002) 0.94
Flexibility and enzymatic cold-adaptation: a comparative molecular dynamics investigation of the elastase family. Biochim Biophys Acta (2006) 0.94
Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease. Prog Neurobiol (2007) 0.94
NGF and heart: Is there a role in heart disease? Pharmacol Res (2010) 0.94
The recently deorphanized GPR80 (GPR99) proposed to be the P2Y15 receptor is not a genuine P2Y receptor. Trends Pharmacol Sci (2005) 0.93
Regulation of A2B adenosine receptor functioning by tumour necrosis factor a in human astroglial cells. J Neurochem (2004) 0.93
Expression and contribution of satellite glial cells purinoceptors to pain transmission in sensory ganglia: an update. Neuron Glia Biol (2010) 0.93
Validation of protein models by a neural network approach. BMC Bioinformatics (2008) 0.92
Pseudomonas aeruginosa cytochrome C(551): probing the role of the hydrophobic patch in electron transfer. J Inorg Biochem (2002) 0.91
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Regulation of PC12 cell survival and differentiation by the new P2Y-like receptor GPR17. Cell Signal (2010) 0.91
Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. BMC Struct Biol (2010) 0.91
Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor. J Med Chem (2010) 0.90
Structural insights into the active-ready form of [FeFe]-hydrogenase and mechanistic details of its inhibition by carbon monoxide. Inorg Chem (2007) 0.90
Oxygen-glucose deprivation increases the enzymatic activity and the microvesicle-mediated release of ectonucleotidases in the cells composing the blood-brain barrier. Neurochem Int (2011) 0.90
Mutations in the "lid" region affect chain length specificity and thermostability of a Pseudomonas fragi lipase. FEBS Lett (2005) 0.89
Aberrant A2A receptor function in peripheral blood cells in Huntington's disease. FASEB J (2003) 0.89
P2 receptors in human heart: upregulation of P2X6 in patients undergoing heart transplantation, interaction with TNFalpha and potential role in myocardial cell death. J Mol Cell Cardiol (2005) 0.88
Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury. Purinergic Signal (2013) 0.88
An acidic loop and cognate phosphorylation sites define a molecular switch that modulates ubiquitin charging activity in Cdc34-like enzymes. PLoS Comput Biol (2011) 0.88
Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced death. Glia (2010) 0.87
A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2'-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. Mol Pharmacol (2003) 0.87
The cold-active lipase of Pseudomonas fragi. Heterologous expression, biochemical characterization and molecular modeling. Eur J Biochem (2002) 0.87
Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease. Neurobiol Dis (2006) 0.86
In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases. J Comput Aided Mol Des (2011) 0.86
DFT characterization of the reaction pathways for terminal- to μ-hydride isomerisation in synthetic models of the [FeFe]-hydrogenase active site. Chem Commun (Camb) (2010) 0.86
Reactivity of peroxo forms of the vanadium haloperoxidase cofactor. A DFT investigation. J Am Chem Soc (2005) 0.85
Induction of COX-2 and reactive gliosis by P2Y receptors in rat cortical astrocytes is dependent on ERK1/2 but independent of calcium signalling. J Neurochem (2002) 0.84
Proton reduction and dihydrogen oxidation on models of the [2Fe]H cluster of [Fe] hydrogenases. A density functional theory investigation. Inorg Chem (2006) 0.84
Insights into the mechanism of electrocatalytic hydrogen evolution mediated by Fe2(S2C3H6)(CO)6: the simplest functional model of the Fe-hydrogenase active site. Inorg Chem (2007) 0.84
Protein flexibility in psychrophilic and mesophilic trypsins. Evidence of evolutionary conservation of protein dynamics in trypsin-like serine-proteases. FEBS Lett (2008) 0.84
Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death. Purinergic Signal (2012) 0.83
Purines regulate adult brain subventricular zone cell functions: contribution of reactive astrocytes. Glia (2013) 0.83
Role of purinergic signalling in neuro-immune cells and adult neural progenitors. Front Biosci (Landmark Ed) (2011) 0.83
DFT Investigation of H2 activation by [M(NHPnPr3)('S3')] (M = Ni, Pd). Insight into key factors relevant to the design of hydrogenase functional models. J Am Chem Soc (2005) 0.83
DFT investigation of structural, electronic, and catalytic properties of diiron complexes related to the [2Fe](H) subcluster of Fe-only hydrogenases. Inorg Chem (2002) 0.83
The isolated catalytic hairpin of the Ras-specific guanine nucleotide exchange factor Cdc25Mm retains nucleotide dissociation activity but has impaired nucleotide exchange activity. FEBS Lett (2005) 0.83
P2Y2 receptor antagonists as anti-allodynic agents in acute and sub-chronic trigeminal sensitization: role of satellite glial cells. Glia (2015) 0.82
Near native-state conformational landscape of psychrophilic and mesophilic enzymes: probing the folding funnel model. J Phys Chem B (2010) 0.82
Functionally relevant interplay between the Fe(4)S(4) cluster and CN(-) ligands in the active site of [FeFe]-hydrogenases. J Am Chem Soc (2010) 0.82
Upregulation of A2A adenosine receptor expression by TNF-alpha in PBMC of patients with CHF: a regulatory mechanism of inflammation. J Card Fail (2005) 0.82
Structural and electronic properties of the [FeFe] hydrogenase H-cluster in different redox and protonation states. A DFT investigation. Inorg Chem (2008) 0.82
Cardiomyocyte death induced by ischaemic/hypoxic stress is differentially affected by distinct purinergic P2 receptors. J Cell Mol Med (2012) 0.82
Three-dimensional structure of the catalytic domain of the yeast beta-(1,3)-glucan transferase Gas1: a molecular modeling investigation. J Mol Model (2005) 0.82
A theoretical study of spin states in Ni-S4 complexes and models of the [NiFe] hydrogenase active site. J Biol Inorg Chem (2004) 0.80
Insight into the catalytic mechanism of vanadium haloperoxidases. DFT investigation of vanadium cofactor reactivity. Inorg Chem (2006) 0.80
Deorphanisation of G protein-coupled receptors: A tool to provide new insights in nervous system pathophysiology and new targets for psycho-active drugs. Neurochem Int (2007) 0.80
In silico functional characterization of a double histone fold domain from the Heliothis zea virus 1. BMC Bioinformatics (2005) 0.80
The computational-based structure of Dwarf14 provides evidence for its role as potential strigolactone receptor in plants. BMC Res Notes (2012) 0.80
Chronic inflammatory diseases: do immunological patterns drive the choice of biotechnology drugs? A critical review. Autoimmunity (2014) 0.79
Resistance of human astrocytoma cells to apoptosis induced by mitochondria-damaging agents: possible implications for anticancer therapy. J Pharmacol Exp Ther (2005) 0.79
Isocyanide in biochemistry? A theoretical investigation of the electronic effects and energetics of cyanide ligand protonation in [FeFe]-hydrogenases. Chemistry (2011) 0.78
Opposite effects of uracil and adenine nucleotides on the survival of murine cardiomyocytes. J Cell Mol Med (2008) 0.78
Dynamic properties of a psychrophilic alpha-amylase in comparison with a mesophilic homologue. J Phys Chem B (2009) 0.78
Early phenotypic asymmetry of sister oligodendrocyte progenitor cells after mitosis and its modulation by aging and extrinsic factors. Glia (2014) 0.78
Quantum mechanical models of the resting state of the vanadium-dependent haloperoxidase. Inorg Chem (2004) 0.77
Unveiling how stereoelectronic factors affect kinetics and thermodynamics of protonation regiochemistry in [FeFe] hydrogenase synthetic models: a DFT investigation. J Am Chem Soc (2009) 0.77
Electrocatalytic dihydrogen evolution mechanism of [Fe2(CO)4(kappa(2)-Ph2PCH2CH2PPh2)(mu-S(CH2)3S)] and related models of the [FeFe]-hydrogenases active site: a DFT investigation. Dalton Trans (2010) 0.77
DFT/TDDFT exploration of the potential energy surfaces of the ground state and excited states of Fe2(S2C3H6)(CO)6: a simple functional model of the [FeFe] hydrogenase active site. J Phys Chem A (2009) 0.77
Computational and experimental approaches for assessing the interactions between the model calycin beta-lactoglobulin and two antibacterial fluoroquinolones. Proteins (2006) 0.76
A DFT study of EPR parameters in Cu(II) complexes of the octarepeat region of the prion protein. Phys Chem Chem Phys (2008) 0.76
Using peripheral blood mononuclear cells to determine proteome profiles in human cardiac failure. Eur J Heart Fail (2008) 0.76