The recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair.

PubWeight™: 1.44‹?› | Rank: Top 5%

🔗 View Article (PMC 2570486)

Published in PLoS One on October 31, 2008

Authors

Davide Lecca1, Maria Letizia Trincavelli, Paolo Gelosa, Luigi Sironi, Paolo Ciana, Marta Fumagalli, Giovanni Villa, Claudia Verderio, Carlotta Grumelli, Uliano Guerrini, Elena Tremoli, Patrizia Rosa, Serena Cuboni, Claudia Martini, Annalisa Buffo, Mauro Cimino, Maria P Abbracchio

Author Affiliations

1: Department of Pharmacological Sciences, University of Milan, Milan, Italy.

Articles citing this

FoxO1 target Gpr17 activates AgRP neurons to regulate food intake. Cell (2012) 2.03

Signals to promote myelin formation and repair. Nat Rev Neurol (2010) 1.95

Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist. Sci Signal (2013) 1.71

The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination. Nat Neurosci (2009) 1.60

Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS Neurol Disord Drug Targets (2011) 1.16

Candidate pathways for promoting differentiation or quiescence of oligodendrocyte progenitor-like cells in glioma. Cancer Res (2012) 1.15

GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A (2009) 1.14

Structural and functional rejuvenation of the aged brain by an approved anti-asthmatic drug. Nat Commun (2015) 1.10

Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation. J Biol Chem (2011) 1.05

Tumor necrosis factor-α synthesis inhibitor, 3,6'-dithiothalidomide, reverses behavioral impairments induced by minimal traumatic brain injury in mice. J Neurochem (2011) 1.04

Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants. Br J Pharmacol (2010) 1.02

The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells. J Biol Chem (2013) 0.97

Myelin regeneration in multiple sclerosis: targeting endogenous stem cells. Neurotherapeutics (2011) 0.93

Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. BMC Struct Biol (2010) 0.91

Is GPR17 a P2Y/leukotriene receptor? examination of uracil nucleotides, nucleotide sugars, and cysteinyl leukotrienes as agonists of GPR17. J Pharmacol Exp Ther (2013) 0.91

GPR17 regulates immune pulmonary inflammation induced by house dust mites. J Immunol (2010) 0.89

Changes of the GPR17 receptor, a new target for neurorepair, in neurons and glial cells in patients with traumatic brain injury. Purinergic Signal (2013) 0.88

A global transcriptome analysis reveals molecular hallmarks of neural stem cell death, survival, and differentiation in response to partial FGF-2 and EGF deprivation. PLoS One (2013) 0.86

Inhibition of 5-lipoxygenase activity in mice during cuprizone-induced demyelination attenuates neuroinflammation, motor dysfunction and axonal damage. Prostaglandins Leukot Essent Fatty Acids (2011) 0.84

Purinergic trophic signalling in glial cells: functional effects and modulation of cell proliferation, differentiation, and death. Purinergic Signal (2012) 0.83

Restoration of oligodendrocyte pools in a mouse model of chronic cerebral hypoperfusion. PLoS One (2014) 0.83

Purinergic signaling: a common pathway for neural and mesenchymal stem cell maintenance and differentiation. Front Cell Neurosci (2015) 0.82

Leukotrienes inhibit early stages of HIV-1 infection in monocyte-derived microglia-like cells. J Neuroinflammation (2012) 0.82

siRNA Treatment: "A Sword-in-the-Stone" for Acute Brain Injuries. Genes (Basel) (2013) 0.81

Microglia is a key player in the reduction of stroke damage promoted by the new antithrombotic agent ticagrelor. J Cereb Blood Flow Metab (2014) 0.81

The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases. Oxid Med Cell Longev (2016) 0.80

Role of adenosine in oligodendrocyte precursor maturation. Front Cell Neurosci (2015) 0.79

A rapid and efficient immunoenzymatic assay to detect receptor protein interactions: G protein-coupled receptors. Int J Mol Sci (2014) 0.79

Intertwining extracellular nucleotides and their receptors with Ca2+ in determining adult neural stem cell survival, proliferation and final fate. Philos Trans R Soc Lond B Biol Sci (2016) 0.79

Regulation of the timing of oligodendrocyte differentiation: mechanisms and perspectives. Neurosci Bull (2013) 0.78

Development of [(3)H]2-Carboxy-4,6-dichloro-1H-indole-3-propionic Acid ([(3)H]PSB-12150): A Useful Tool for Studying GPR17. ACS Med Chem Lett (2014) 0.78

A model of ischemia-induced neuroblast activation in the adult subventricular zone. PLoS One (2009) 0.77

Disruption of the alox5ap gene ameliorates focal ischemic stroke: possible consequence of impaired leukotriene biosynthesis. BMC Neurosci (2012) 0.77

Interactions between prostaglandins, leukotrienes and HIV-1: possible implications for the central nervous system. Retrovirology (2012) 0.77

Intracellular Protein Shuttling: A Mechanism Relevant for Myelin Repair in Multiple Sclerosis? Int J Mol Sci (2015) 0.77

Extracellular cues influencing oligodendrocyte differentiation and (re)myelination. Exp Neurol (2016) 0.76

Expression of dual nucleotides/cysteinyl-leukotrienes receptor GPR17 in early trafficking of cardiac stromal cells after myocardial infarction. J Cell Mol Med (2014) 0.76

Cellular and molecular characterization of multipolar Map5-expressing cells: a subset of newly generated, stage-specific parenchymal cells in the mammalian central nervous system. PLoS One (2013) 0.76

Synthesis and Ability of New Ligands for G Protein-Coupled Receptors 17 (GPR17). Med Sci Monit (2017) 0.75

Expression of GPR17, a regulator of oligodendrocyte differentiation and maturation, in Nasu-Hakola disease brains. Intractable Rare Dis Res (2017) 0.75

A new role for the P2Y-like GPR17 receptor in the modulation of multipotency of oligodendrocyte precursor cells in vitro. Purinergic Signal (2016) 0.75

Gpr17 in AgRP Neurons Regulates Feeding and Sensitivity to Insulin and Leptin. Diabetes (2015) 0.75

Emerging role of extracellular nucleotides and adenosine in multiple sclerosis. Purinergic Signal (2011) 0.75

Neuro-psychopharmacological perspective of Orphan receptors of Rhodopsin (class A) family of G protein-coupled receptors. Psychopharmacology (Berl) (2017) 0.75

Articles cited by this

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell (1999) 15.87

GFAP-expressing progenitors are the principal source of constitutive neurogenesis in adult mouse forebrain. Nat Neurosci (2004) 5.92

Astrocytes give rise to new neurons in the adult mammalian hippocampus. J Neurosci (2001) 5.66

Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci (2004) 4.44

A unified hypothesis on the lineage of neural stem cells. Nat Rev Neurosci (2001) 3.86

Cellular distribution and functions of P2 receptor subtypes in different systems. Int Rev Cytol (2004) 3.43

bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science (2004) 3.20

Adult ependymal cells are postmitotic and are derived from radial glial cells during embryogenesis. J Neurosci (2005) 3.19

Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol (1998) 2.84

Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci (2003) 2.37

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J (2006) 2.17

Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc Natl Acad Sci U S A (2005) 2.09

Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler Thromb Vasc Biol (2003) 2.08

NG2-expressing cells in the central nervous system: are they oligodendroglial progenitors? J Neurosci Res (2000) 1.82

International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors. Pharmacol Rev (2003) 1.66

ATP extracellular concentrations are increased in the rat striatum during in vivo ischemia. Neurochem Int (2005) 1.53

Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol (2003) 1.40

Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms. J Neurochem (1999) 1.30

Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor. Biochem Pharmacol (2004) 1.26

Focal cerebral ischemia induces increased myelin basic protein and growth-associated protein-43 gene transcription in peri-infarct areas in the rat brain. Exp Brain Res (2001) 1.22

New insights into brain damage in stroke-prone rats: a nuclear magnetic imaging study. Stroke (2002) 1.18

The experimental use of antisense oligonucleotides: a guide for the perplexed. J Clin Invest (2001) 1.17

Regeneration of the central nervous system using endogenous repair mechanisms. J Neurochem (2007) 1.17

CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. J Cell Sci (2005) 1.13

The molecular orchestra of the migration of oligodendrocyte precursors during development. Brain Res Brain Res Rev (2005) 1.10

Production of leukotrienes in a model of focal cerebral ischaemia in the rat. Br J Pharmacol (2001) 1.03

Functional characterization of a human receptor for neuropeptide FF and related peptides. Br J Pharmacol (2001) 1.01

P2Y1 and cysteinyl leukotriene receptors mediate purine and cysteinyl leukotriene co-release in primary cultures of rat microglia. Int J Immunopathol Pharmacol (2005) 0.98

Transcription profiling of adult and fetal human neuroprogenitors identifies divergent paths to maintain the neuroprogenitor cell state. Stem Cells (2007) 0.97

Functional roles of dopamine D2 and D3 autoreceptors on nigrostriatal neurons analyzed by antisense knockdown in vivo. J Neurosci (1997) 0.96

The discovery of the leukotrienes. Am J Respir Crit Care Med (2000) 0.94

A novel orphan G protein-coupled receptor primarily expressed in the brain is localized on human chromosomal band 2q21. J Neurochem (1998) 0.92

Spatial and temporal regulation of Ca2+/calmodulin-dependent protein kinase II activity in developing neurons. J Neurosci (2002) 0.89

Glutamate-mediated overexpression of CD38 in astrocytes cultured with neurones. J Neurochem (2004) 0.88

Leukotrienes in asthma. Adv Exp Med Biol (2003) 0.88

The inducible 70,000 molecular/weight heat shock protein is expressed in the degenerating dentate hilus and piriform cortex after systemic administration of kainic acid in the rat. Neuroscience (1996) 0.88

Ten years of antisense inhibition of brain G-protein-coupled receptor function. Brain Res Brain Res Rev (2003) 0.86

Articles by these authors

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy. Pharmacol Rev (2006) 5.28

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25

Common variants associated with plasma triglycerides and risk for coronary artery disease. Nat Genet (2013) 2.92

Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83

Insight into the nature of the CRP-coronary event association using Mendelian randomization. Int J Epidemiol (2006) 2.70

Storage and release of ATP from astrocytes in culture. J Biol Chem (2002) 2.50

Meta-analysis of randomized trials comparing off-pump with on-pump coronary artery bypass graft patency. Ann Thorac Surg (2005) 2.37

Purinergic control of T cell activation by ATP released through pannexin-1 hemichannels. Sci Signal (2008) 2.27

Inducible gene deletion in astroglia and radial glia--a valuable tool for functional and lineage analysis. Glia (2006) 2.19

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol (2013) 2.18

The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J (2006) 2.17

Astrocyte-derived ATP induces vesicle shedding and IL-1 beta release from microglia. J Immunol (2005) 2.09

Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler Thromb Vasc Biol (2003) 2.08

Measurements of carotid intima-media thickness and of interadventitia common carotid diameter improve prediction of cardiovascular events: results of the IMPROVE (Carotid Intima Media Thickness [IMT] and IMT-Progression as Predictors of Vascular Events in a High Risk European Population) study. J Am Coll Cardiol (2012) 1.96

[Off-pump coronary bypass surgery: pros and cons]. G Ital Cardiol (Rome) (2006) 1.94

Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol. Proc Natl Acad Sci U S A (2003) 1.87

Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J (2009) 1.78

Purinergic signalling: from normal behaviour to pathological brain function. Prog Neurobiol (2011) 1.76

Vesicular transmitter release from astrocytes. Glia (2006) 1.71

Oxytocin receptor polymorphisms and adult attachment style in patients with depression. Psychoneuroendocrinology (2009) 1.70

Cytokines present in smokers' serum interact with smoke components to enhance endothelial dysfunction. Cardiovasc Res (2011) 1.64

Requirement of estrogen receptor-alpha in insulin-like growth factor-1 (IGF-1)-induced uterine responses and in vivo evidence for IGF-1/estrogen receptor cross-talk. J Biol Chem (2001) 1.60

Tissue factor expression on platelets is a dynamic event. Blood (2010) 1.54

Surgery of left ventricular aneurysm: a meta-analysis of early outcomes following different reconstruction techniques. Ann Thorac Surg (2007) 1.54

Nucleotide-mediated calcium signaling in rat cortical astrocytes: Role of P2X and P2Y receptors. Glia (2003) 1.54

The novel roles of glial cells revisited: the contribution of radial glia and astrocytes to neurogenesis. Curr Top Dev Biol (2005) 1.47

Prevention of excessive endothelin-1 release in sclerotherapy: in vitro and in vivo studies. Dermatol Surg (2014) 1.44

Regulation of postnatal lung development and homeostasis by estrogen receptor beta. Mol Cell Biol (2003) 1.44

Human megakaryocytes confer tissue factor to a subset of shed platelets to stimulate thrombin generation. Thromb Haemost (2015) 1.40

To be or not to be (inflamed)--is that the question in anti-inflammatory drug therapy of neurodegenerative disorders? Trends Pharmacol Sci (2005) 1.39

Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients during 1 year of antidepressant treatments. J Affect Disord (2007) 1.38

Purinergic signalling in inflammation of the central nervous system. Trends Neurosci (2009) 1.32

Estrogens in the nervous system: mechanisms and nonreproductive functions. Annu Rev Physiol (2004) 1.32

Block of glutamate-glutamine cycle between astrocytes and neurons inhibits epileptiform activity in hippocampus. J Neurophysiol (2002) 1.28

Mechanisms underlying the neuronal calcium sensor-1-evoked enhancement of exocytosis in PC12 cells. J Biol Chem (2002) 1.28

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. Endocrinology (2009) 1.27

Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress. Eur J Cardiothorac Surg (2003) 1.27

Role of lipid microdomains in P/Q-type calcium channel (Cav2.1) clustering and function in presynaptic membranes. J Biol Chem (2003) 1.27

Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor. Biochem Pharmacol (2004) 1.26

Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: synthesis, biological evaluation and 3D-QSAR investigation. Bioorg Med Chem (2005) 1.26

Key concepts and critical issues on epoetin and filgrastim biosimilars. A position paper from the Italian Society of Hematology, Italian Society of Experimental Hematology, and Italian Group for Bone Marrow Transplantation. Haematologica (2011) 1.25

Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes. J Cell Biol (2008) 1.24

Pathophysiological roles of extracellular nucleotides in glial cells: differential expression of purinergic receptors in resting and activated microglia. Brain Res Brain Res Rev (2005) 1.24

Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue. Diabetes (2012) 1.22

Carotid intima-media thickness by B-mode ultrasound as surrogate of coronary atherosclerosis: correlation with quantitative coronary angiography and coronary intravascular ultrasound findings. Eur Heart J (2007) 1.20

The androgen derivative 5alpha-androstane-3beta,17beta-diol inhibits prostate cancer cell migration through activation of the estrogen receptor beta subtype. Cancer Res (2005) 1.19

Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage. J Hypertens (2009) 1.18

Serum 25-hydroxyvitamin D concentration in subclinical carotid atherosclerosis. Arterioscler Thromb Vasc Biol (2013) 1.18

Cholesterol reduction impairs exocytosis of synaptic vesicles. J Cell Sci (2010) 1.18

New insights into brain damage in stroke-prone rats: a nuclear magnetic imaging study. Stroke (2002) 1.18

Cross-sectional analysis of baseline data to identify the major determinants of carotid intima-media thickness in a European population: the IMPROVE study. Eur Heart J (2009) 1.17

Haploinsufficiency of the corepressor of estrogen receptor activity (REA) enhances estrogen receptor function in the mammary gland. Proc Natl Acad Sci U S A (2006) 1.17

Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels. Proc Natl Acad Sci U S A (2007) 1.17

CysLT1 leukotriene receptor antagonists inhibit the effects of nucleotides acting at P2Y receptors. Biochem Pharmacol (2005) 1.17

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism. EMBO J (2012) 1.16

Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism. J Am Coll Cardiol (2012) 1.14

CysLT1 receptor is a target for extracellular nucleotide-induced heterologous desensitization: a possible feedback mechanism in inflammation. J Cell Sci (2005) 1.13

Ala147Thr substitution in translocator protein is associated with adult separation anxiety in patients with depression. Psychiatr Genet (2009) 1.13

Microglial microvesicle secretion and intercellular signaling. Front Physiol (2012) 1.12

Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines. J Pharmacol Exp Ther (2003) 1.12

Platelet activation induces cell-surface immunoreactive tissue factor expression, which is modulated differently by antiplatelet drugs. Arterioscler Thromb Vasc Biol (2003) 1.12

The interleukin-8 (IL-8/CXCL8) receptor inhibitor reparixin improves neurological deficits and reduces long-term inflammation in permanent and transient cerebral ischemia in rats. Mol Med (2007) 1.11

EuroSCORE performance in valve surgery: a meta-analysis. Ann Thorac Surg (2010) 1.10

Apocynin prevents cyclooxygenase 2 expression in human monocytes through NADPH oxidase and glutathione redox-dependent mechanisms. Free Radic Biol Med (2004) 1.10

A role for P2X7 in microglial proliferation. J Neurochem (2006) 1.10

Amino acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF-1. Cell Metab (2011) 1.10

Carotid intima-media thickness and markers of inflammation, endothelial damage and hemostasis. Ann Med (2008) 1.10

Measurement of carotid artery intima-media thickness in dyslipidemic patients increases the power of traditional risk factors to predict cardiovascular events. Atherosclerosis (2006) 1.09