Published in Nat Rev Genet on June 10, 2008
Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature (2009) 8.12
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90
Autoimmune diseases: insights from genome-wide association studies. Hum Mol Genet (2008) 2.94
A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet (2010) 2.68
B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells. J Exp Med (2012) 2.36
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A (2009) 2.31
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis. Ann Neurol (2012) 2.15
Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann Neurol (2011) 1.86
Methylation patterns of cell-free plasma DNA in relapsing-remitting multiple sclerosis. J Neurol Sci (2010) 1.59
The epigenetics of autoimmunity. Cell Mol Immunol (2011) 1.47
Modifier effects between regulatory and protein-coding variation. PLoS Genet (2008) 1.42
The genetics and epigenetics of autoimmune diseases. J Autoimmun (2009) 1.40
Multiple sclerosis susceptibility alleles in African Americans. Genes Immun (2009) 1.32
Genome-wide CTCF distribution in vertebrates defines equivalent sites that aid the identification of disease-associated genes. Nat Struct Mol Biol (2011) 1.31
Micro-RNA dysregulation in multiple sclerosis favours pro-inflammatory T-cell-mediated autoimmunity. Brain (2011) 1.27
The role of genetics in the etiology of schizophrenia. Psychiatr Clin North Am (2010) 1.22
Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies. Annu Rev Med (2012) 1.21
Multiple sclerosis genetics--is the glass half full, or half empty? Nat Rev Neurol (2010) 1.15
Alterations of the human gut microbiome in multiple sclerosis. Nat Commun (2016) 1.15
Genetic association and altered gene expression of mir-155 in multiple sclerosis patients. Int J Mol Sci (2011) 1.11
Chronic progressive multiple sclerosis - pathogenesis of neurodegeneration and therapeutic strategies. Curr Neuropharmacol (2010) 1.10
Genome-wide approaches to schizophrenia. Brain Res Bull (2010) 1.09
Genetics and pathogenesis of multiple sclerosis. Semin Immunol (2009) 1.06
Intestinal microbiota as modulators of the immune system and neuroimmune system: impact on the host health and homeostasis. J Immunol Res (2015) 1.06
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med (2011) 1.06
Review part 2: Human herpesvirus-6 in central nervous system diseases. J Med Virol (2010) 1.05
Convergent functional genomics of oligodendrocyte differentiation identifies multiple autoinhibitory signaling circuits. Mol Cell Biol (2009) 1.05
Virus expanded regulatory T cells control disease severity in the Theiler's virus mouse model of MS. J Autoimmun (2011) 1.03
Targeting dendritic cells to treat multiple sclerosis. Nat Rev Neurol (2010) 1.02
From genes to function: the next challenge to understanding multiple sclerosis. Nat Rev Immunol (2009) 1.01
Sex and gender issues in multiple sclerosis. Ther Adv Neurol Disord (2013) 1.01
Transcriptome study of differential expression in schizophrenia. Hum Mol Genet (2013) 0.97
Genetic burden in multiple sclerosis families. Genes Immun (2013) 0.97
Refining the association of MHC with multiple sclerosis in African Americans. Hum Mol Genet (2010) 0.96
Rituximab efficiently depletes increased CD20-expressing T cells in multiple sclerosis patients. J Immunol (2014) 0.95
Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster. PLoS Genet (2016) 0.94
Myelin regeneration in multiple sclerosis: targeting endogenous stem cells. Neurotherapeutics (2011) 0.93
Revealing the genetic basis of multiple sclerosis: are we there yet? Curr Opin Genet Dev (2011) 0.93
Restoring the balance between disease and repair in multiple sclerosis: insights from mouse models. Dis Model Mech (2010) 0.92
New approaches in the management of multiple sclerosis. Drug Des Devel Ther (2010) 0.92
Blood B Cell and Regulatory Subset Content in Multiple Sclerosis Patients. J Mult Scler (Foster City) (2015) 0.92
Custom CGH array profiling of copy number variations (CNVs) on chromosome 6p21.32 (HLA locus) in patients with venous malformations associated with multiple sclerosis. BMC Med Genet (2010) 0.92
DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP). J Neuroinflammation (2012) 0.91
Modeling the effector - regulatory T cell cross-regulation reveals the intrinsic character of relapses in Multiple Sclerosis. BMC Syst Biol (2011) 0.91
Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1. PLoS One (2012) 0.90
An extension to a statistical approach for family based association studies provides insights into genetic risk factors for multiple sclerosis in the HLA-DRB1 gene. BMC Med Genet (2009) 0.90
Monitoring of multiple sclerosis immunotherapy: from single candidates to biomarker networks. J Neurol (2008) 0.88
Multiple sclerosis in children. Iran J Child Neurol (2013) 0.88
TRAIL/TRAIL receptor system and susceptibility to multiple sclerosis. PLoS One (2011) 0.86
Mechanisms of adaptation and progression in idiosyncratic drug induced liver injury, clinical implications. Liver Int (2015) 0.86
B-cell delivered gene therapy for tolerance induction: role of autoantigen-specific B cells. J Autoimmun (2010) 0.84
Perspectives on the use of multiple sclerosis risk genes for prediction. PLoS One (2011) 0.84
The double-edged sword of autoimmunity: lessons from multiple sclerosis. Toxins (Basel) (2010) 0.83
Chronic cerebrospinal vascular insufficiency is not associated with HLA DRB1*1501 status in multiple sclerosis patients. PLoS One (2011) 0.83
A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches. Hum Genet (2015) 0.82
Substrain differences reveal novel disease-modifying gene candidates that alter the clinical course of a rodent model of multiple sclerosis. J Immunol (2010) 0.81
Structural and dynamical insights on HLA-DR2 complexes that confer susceptibility to multiple sclerosis in Sardinia: a molecular dynamics simulation study. PLoS One (2013) 0.81
Vitamin D and multiple sclerosis. Iran J Neurol (2014) 0.79
Gene expression profiling in multiple sclerosis brain. Neurobiol Dis (2010) 0.79
CB1 receptor affects cortical plasticity and response to physiotherapy in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm (2014) 0.78
Multiple sclerosis. TNFRSF1A, TRAPS and multiple sclerosis. Nat Rev Neurol (2009) 0.78
H(1)R expression by CD11B(+) cells is not required for susceptibility to experimental allergic encephalomyelitis. Cell Immunol (2012) 0.77
HLA-DRα1-mMOG-35-55 treatment of experimental autoimmune encephalomyelitis reduces CNS inflammation, enhances M2 macrophage frequency, and promotes neuroprotection. J Neuroinflammation (2015) 0.76
Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair. Proc Natl Acad Sci U S A (2009) 0.76
MicroRNAs targeting TGFβ signalling underlie the regulatory T cell defect in multiple sclerosis. Brain (2016) 0.76
Autoimmune disease prevalence in a multiple sclerosis cohort in Argentina. Mult Scler Int (2014) 0.75
DQB1*06:02-Associated Pathogenic Anti-Myelin Autoimmunity in Multiple Sclerosis-Like Disease: Potential Function of DQB1*06:02 as a Disease-Predisposing Allele. Front Oncol (2014) 0.75
Bypassing hazard of housekeeping genes: their evaluation in rat granule neurons treated with cerebrospinal fluid of multiple sclerosis subjects. Front Cell Neurosci (2015) 0.75
Advances in systems biology approaches for autoimmune diseases. Immune Netw (2014) 0.75
Genome-wide homozygosity and multiple sclerosis in Orkney and Shetland Islanders. Eur J Hum Genet (2011) 0.75
Does the Gut Microbiota Influence Immunity and Inflammation in Multiple Sclerosis Pathophysiology? J Immunol Res (2017) 0.75
Role of tumour necrosis factor (TNF)-α and TNFRSF1A R92Q mutation in the pathogenesis of TNF receptor-associated periodic syndrome and multiple sclerosis. Clin Exp Immunol (2011) 0.75
CSF Proteomics Identifies Specific and Shared Pathways for Multiple Sclerosis Clinical Subtypes. PLoS One (2015) 0.75
Transcriptome sequencing study implicates immune-related genes differentially expressed in schizophrenia: new data and a meta-analysis. Transl Psychiatry (2017) 0.75
Multiple Sclerosis: Pathogenesis, Symptoms, Diagnoses and Cell-Based Therapy. Cell J (2016) 0.75
Genetic association of rs1520333 G/A polymorphism in the IL7 gene with multiple sclerosis susceptibility in Isfahan population. Adv Biomed Res (2014) 0.75
Oral Administration of the Probiotic Strain Escherichia coli Nissle 1917 Reduces Susceptibility to Neuroinflammation and Repairs Experimental Autoimmune Encephalomyelitis-Induced Intestinal Barrier Dysfunction. Front Immunol (2017) 0.75
Positive family history of idiopathic sudden sensorineural hearing loss. Eur Arch Otorhinolaryngol (2010) 0.75
Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med (2007) 17.06
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature (2011) 13.23
Complete MHC haplotype sequencing for common disease gene mapping. Genome Res (2004) 12.09
Methods for high-density admixture mapping of disease genes. Am J Hum Genet (2004) 12.02
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet (2009) 7.16
Genome-wide patterns of population structure and admixture in West Africans and African Americans. Proc Natl Acad Sci U S A (2009) 5.39
Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet (2007) 5.09
A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. Nat Genet (2005) 5.02
The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. Am J Hum Genet (2008) 4.79
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. Nat Genet (2013) 4.62
Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project. Immunogenetics (2008) 4.25
The beautiful and ethereal neurological exam: an appeal for research. Ann Neurol (2011) 4.10
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. Hum Mol Genet (2008) 3.93
Pathway and network-based analysis of genome-wide association studies in multiple sclerosis. Hum Mol Genet (2009) 3.92
Genome, epigenome and RNA sequences of monozygotic twins discordant for multiple sclerosis. Nature (2010) 3.90
Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial. Lancet (2011) 3.76
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. Ann Neurol (2011) 3.52
Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature (2008) 3.48
Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet (2006) 3.13
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS. Genes Dev (2009) 2.96
Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. PLoS Genet (2006) 2.80
Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. Lancet Neurol (2006) 2.77
Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet (2003) 2.71
Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration. Brain (2010) 2.61
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination. Nat Neurosci (2011) 2.61
A high-density screen for linkage in multiple sclerosis. Am J Hum Genet (2005) 2.50
The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A (2009) 2.38
Mapping of multiple susceptibility variants within the MHC region for 7 immune-mediated diseases. Proc Natl Acad Sci U S A (2009) 2.31
IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production. PLoS Genet (2009) 2.30
Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability. Mult Scler (2011) 2.07
Getting youth in the game: can we accelerate training for clinician-scientists? Ann Neurol (2010) 2.04
Frontline: Epitope recognition on the myelin/oligodendrocyte glycoprotein differentially influences disease phenotype and antibody effector functions in autoimmune demyelination. Eur J Immunol (2004) 2.01
A second major histocompatibility complex susceptibility locus for multiple sclerosis. Ann Neurol (2007) 1.99
Beaten into action: a perspective on blood sports. Ann Neurol (2012) 1.99
Differential micro RNA expression in PBMC from multiple sclerosis patients. PLoS One (2009) 1.98
Replication analysis identifies TYK2 as a multiple sclerosis susceptibility factor. Eur J Hum Genet (2009) 1.97
Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS? Ann Neurol (2010) 1.97
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene. Am J Hum Genet (2010) 1.89
Aggregation of multiple sclerosis genetic risk variants in multiple and single case families. Ann Neurol (2011) 1.86
The genetics of multiple sclerosis: an up-to-date review. Immunol Rev (2012) 1.74
Naive antibody gene-segment frequencies are heritable and unaltered by chronic lymphocyte ablation. Proc Natl Acad Sci U S A (2011) 1.74
Translational research for a new administration: what sort of change to believe in? Ann Neurol (2008) 1.71
Myelin regeneration: a recapitulation of development? Annu Rev Neurosci (2011) 1.70
Confounding underlies the apparent month of birth effect in multiple sclerosis. Ann Neurol (2013) 1.62
Genome-wide pharmacogenomic analysis of the response to interferon beta therapy in multiple sclerosis. Arch Neurol (2008) 1.59
Neurological disease on the global agenda. Ann Neurol (2008) 1.56
Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. PLoS Genet (2013) 1.55
Spinal cord gray matter atrophy correlates with multiple sclerosis disability. Ann Neurol (2014) 1.50
Neuromyelitis optica. Semin Neurol (2002) 1.48
The dangers of clinical conviction: an "M&M" of endovascular therapies for stroke. Ann Neurol (2013) 1.48
Peroxisome proliferator-activated receptor (PPAR)alpha expression in T cells mediates gender differences in development of T cell-mediated autoimmunity. J Exp Med (2007) 1.47
4-aminopyridine: new life for an old drug. Ann Neurol (2010) 1.43
A genome wide linkage disequilibrium screen in Parkinson's disease. J Neurol (2005) 1.41
Journeys in complex genetics: music and mental illness. Ann Neurol (2009) 1.39
Electronic medical records: does it take a village or a thousand points of light? Ann Neurol (2008) 1.39
That vexing problem of compensation. Ann Neurol (2008) 1.39
Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. Lancet Neurol (2007) 1.36
B cell exchange across the blood-brain barrier in multiple sclerosis. J Clin Invest (2012) 1.35
Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry. Nat Genet (2011) 1.30
Enhancing linkage analysis of complex disorders: an evaluation of high-density genotyping. Hum Mol Genet (2004) 1.29
Abrogation of T cell quiescence characterizes patients at high risk for multiple sclerosis after the initial neurological event. Proc Natl Acad Sci U S A (2008) 1.27
The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. Am J Hum Genet (2005) 1.26
A status report on neuroscience research, without grade inflation. Ann Neurol (2006) 1.24
Early editorial manuscript screening versus obligate peer review: a randomized trial. Ann Neurol (2007) 1.23
Vitamin D status predicts new brain magnetic resonance imaging activity in multiple sclerosis. Ann Neurol (2012) 1.18
Basic and clinical research: what is the most appropriate weighting in a public investment portfolio? Ann Neurol (2006) 1.18
Lack of support for association between the KIF1B rs10492972[C] variant and multiple sclerosis. Nat Genet (2010) 1.16
Multiple sclerosis genetics--is the glass half full, or half empty? Nat Rev Neurol (2010) 1.15
Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. J Immunol (2008) 1.13
Molecular characterization of antibody specificities against myelin/oligodendrocyte glycoprotein in autoimmune demyelination. Proc Natl Acad Sci U S A (2002) 1.11
Hippocampal demyelination and memory dysfunction are associated with increased levels of the neuronal microRNA miR-124 and reduced AMPA receptors. Ann Neurol (2013) 1.11
Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1. J Med Genet (2011) 1.11
Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15. Hum Mol Genet (2005) 1.10
Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. Arch Neurol (2009) 1.10
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain (2010) 1.06
Systems biology and its application to the understanding of neurological diseases. Ann Neurol (2009) 1.06
Modeling the cumulative genetic risk for multiple sclerosis from genome-wide association data. Genome Med (2011) 1.06
Transformative research. Ann Neurol (2008) 1.05
Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice. J Exp Med (2012) 1.04
Confounding in association studies: month of birth and multiple sclerosis. J Neurol (2014) 1.03
Multiple lessons for multiple sclerosis. N Engl J Med (2008) 1.03
Color vision is strongly associated with retinal thinning in multiple sclerosis. Mult Scler (2012) 1.03
Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. Am J Hum Genet (2012) 1.02