Published in Ann Oncol on June 09, 2008
Study of High Dose Intravenous (IV) Ascorbic Acid in Measurable Solid Tumor Disease | NCT01125449
IV Ascorbic Acid in Advanced Colorectal Cancer | NCT02969681
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (2015) 2.89
Oxalic acid excretion after intravenous ascorbic acid administration. Metabolism (2009) 2.14
Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One (2010) 1.92
Ascorbic acid: chemistry, biology and the treatment of cancer. Biochim Biophys Acta (2012) 1.89
Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clin Cancer Res (2010) 1.57
Vitamin C: a concentration-function approach yields pharmacology and therapeutic discoveries. Adv Nutr (2011) 1.45
Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. PLoS One (2012) 1.35
Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial. Cancer Chemother Pharmacol (2013) 1.33
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal (2013) 1.29
Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic Biol Med (2011) 1.27
Vitamin C and cancer revisited. Proc Natl Acad Sci U S A (2008) 1.24
Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis. J Transl Med (2014) 1.17
Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med (2012) 1.09
Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer. Cancer Chemother Pharmacol (2013) 1.07
Losing and finding a way at C: new promise for pharmacologic ascorbate in cancer treatment. Free Radic Biol Med (2009) 1.05
Mechanism of action of vitamin C in sepsis: ascorbate modulates redox signaling in endothelium. Biofactors (2009) 1.02
Intravenous vitamin C in the treatment of shingles: results of a multicenter prospective cohort study. Med Sci Monit (2012) 1.02
The effect of intravenous vitamin C on cancer- and chemotherapy-related fatigue and quality of life. Front Oncol (2014) 1.01
Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression. PLoS One (2009) 1.00
Manganoporphyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation. Cancer Res (2013) 0.99
Parenteral ascorbate as a cancer therapeutic: a reassessment based on pharmacokinetics. Antioxid Redox Signal (2013) 0.97
Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine. Proc Natl Acad Sci U S A (2016) 0.95
Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs. Cancer Chemother Pharmacol (2010) 0.94
Inhibitors of hydroperoxide metabolism enhance ascorbate-induced cytotoxicity. Free Radic Res (2013) 0.90
Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients. J Transl Med (2013) 0.90
Is there a role for oral or intravenous ascorbate (vitamin C) in treating patients with cancer? A systematic review. Oncologist (2015) 0.90
Effect of high-dose Ascorbic acid on vasopressor's requirement in septic shock. J Res Pharm Pract (2016) 0.89
Extracellular iron diminishes anticancer effects of vitamin C: an in vitro study. Sci Rep (2014) 0.88
Epigenetic impacts of ascorbate on human metastatic melanoma cells. Front Oncol (2014) 0.88
Simple biological systems for assessing the activity of superoxide dismutase mimics. Antioxid Redox Signal (2013) 0.86
Nutritional countermeasures targeting reactive oxygen species in cancer: from mechanisms to biomarkers and clinical evidence. Antioxid Redox Signal (2013) 0.86
Molecular mechanisms of pharmacological doses of ascorbate on cancer cells. Wien Med Wochenschr (2015) 0.84
Treatment of irradiated mice with high-dose ascorbic acid reduced lethality. PLoS One (2015) 0.83
The ROS-induced cytotoxicity of ascorbate is attenuated by hypoxia and HIF-1alpha in the NCI60 cancer cell lines. J Cell Mol Med (2013) 0.83
High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription. PLoS One (2013) 0.83
Multiple Myeloma Tumor Cells are Selectively Killed by Pharmacologically-dosed Ascorbic Acid. EBioMedicine (2017) 0.82
Vitamin C: the known and the unknown and Goldilocks. Oral Dis (2016) 0.82
Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression. Front Oncol (2014) 0.81
Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy. PLoS Negl Trop Dis (2012) 0.81
Manganoporphyrins and ascorbate enhance gemcitabine cytotoxicity in pancreatic cancer. Free Radic Biol Med (2015) 0.80
Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance. Free Radic Biol Med (2011) 0.80
A convenient method for measuring blood ascorbate concentrations in patients receiving high-dose intravenous ascorbate. J Am Coll Nutr (2013) 0.79
Mitochondrial Superoxide Dismutase Has a Protumorigenic Role in Ovarian Clear Cell Carcinoma. Cancer Res (2015) 0.79
Treatment of Pancreatic Cancer with Pharmacological Ascorbate. Curr Pharm Biotechnol (2015) 0.78
Direct spectrophotometric measurement of supra-physiological levels of ascorbate in plasma. Redox Biol (2016) 0.77
Production of ascorbic acid releasing biomaterials for pelvic floor repair. Acta Biomater (2015) 0.77
Vitamin C acts indirectly to modulate isotype switching in mouse B cells. Anat Cell Biol (2010) 0.77
Commonly used methods of complementary medicine in the treatment of breast cancer. Breast Care (Basel) (2013) 0.77
High-dose intravenous vitamin C combined with cytotoxic chemotherapy in patients with advanced cancer: a phase I-II clinical trial. PLoS One (2015) 0.77
Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy. Med Sci Monit (2016) 0.77
High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma. Yonsei Med J (2015) 0.77
Drug-induced reactive oxygen species (ROS) rely on cell membrane properties to exert anticancer effects. Sci Rep (2016) 0.77
A reactive oxygen species activation mechanism contributes to JS-K-induced apoptosis in human bladder cancer cells. Sci Rep (2015) 0.76
High-dose ascorbate with low-dose amphotericin B attenuates severity of disease in a model of the reappearance of candidemia during sepsis in the mouse. Am J Physiol Regul Integr Comp Physiol (2015) 0.76
Synergistic potentiation of D-fraction with vitamin C as possible alternative approach for cancer therapy. Int J Gen Med (2009) 0.76
In vitro and in vivo assessment of high-dose vitamin C against murine tumors. Exp Ther Med (2016) 0.76
Pharmacogenomic Characterization and Isobologram Analysis of the Combination of Ascorbic Acid and Curcumin-Two Main Metabolites of Curcuma longa-in Cancer Cells. Front Pharmacol (2017) 0.75
RelB expression determines the differential effects of ascorbic acid in normal and cancer cells. Cancer Res (2017) 0.75
Schedule Dependence in Cancer Therapy: Intravenous Vitamin C and the Systemic Saturation Hypothesis. J Orthomol Med (2012) 0.75
Potassium increases the antitumor effects of ascorbic acid in breast cancer cell lines in vitro. Oncol Lett (2016) 0.75
Pharmacological doses of daily ascorbate protect tumors from radiation damage after a single dose of radiation in an intracranial mouse glioma model. Front Oncol (2014) 0.75
Ascorbic acid does not reduce the anticancer effect of radiotherapy. Biomed Rep (2016) 0.75
Impact of high dose vitamin C on platelet function. World J Crit Care Med (2017) 0.75
Mega-dose vitamin C as therapy for human cancer? Proc Natl Acad Sci U S A (2008) 0.75
Increasing Superoxide Production and the Labile Iron Pool in Tumor Cells may Sensitize Them to Extracellular Ascorbate. Front Oncol (2014) 0.75
Pseudohypoglycemia or hyperglycemia caused by interference with self-monitoring blood glucose measurements in anticancer ascorbic acid therapy. J Diabetes Investig (2013) 0.75
Proteomic analysis of the vitamin C effect on the doxorubicin cytotoxicity in the MCF-7 breast cancer cell line. J Cancer Res Clin Oncol (2016) 0.75
p-Benzoquinone initiates non-invasive urothelial cancer through aberrant tyrosine phosphorylation of EGFR, MAP kinase activation and cell cycle deregulation: Prevention by vitamin C. Toxicol Rep (2017) 0.75
Upregulation of TET activity with ascorbic acid induces epigenetic modulation of lymphoma cells. Blood Cancer J (2017) 0.75
Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biol (2017) 0.75
2-O-α-D-Glucopyranosyl-l-ascorbic acid as an antitumor agent for infusion therapy. Biochem Biophys Rep (2017) 0.75
Influence of ascorbic acid on the activity of the investigational anticancer drug KP1019. J Biol Inorg Chem (2011) 0.75
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature (2000) 19.15
Differentiation of the "Intermediate" Coli-Like Bacteria. J Bacteriol (1942) 14.28
Differential Reactions in the Colon Group of Bacteria. Am J Public Health Nations Health (1934) 13.94
NOTES ON BACT. COLI AND BACT. AEROGENES. Am J Public Health (N Y) (1921) 9.89
The Effect of Metabolites of Escherichia coli on the Growth of Coli-Aerogenes Bacteria. J Bacteriol (1947) 9.43
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell (1991) 9.40
Characteristics of Coli-like Microorganisms from the Soil. J Bacteriol (1917) 8.18
A phage P22 gene controlling integration of prophage. Virology (1967) 7.98
Antibiotic Interrelationships among the Enteric Group of Bacteria. J Bacteriol (1947) 7.44
Immunological method for mapping genes on Drosophila polytene chromosomes. Proc Natl Acad Sci U S A (1982) 7.08
A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein. Cell (1994) 6.52
A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell (2001) 5.77
Cloning of herpes simplex virus type 1 sequences representing the whole genome. J Virol (1981) 5.66
Role of the histone deacetylase complex in acute promyelocytic leukaemia. Nature (1998) 5.63
Factors Affecting Germicidal Efficiency of Chlorine and Chloramine. Am J Public Health Nations Health (1944) 5.43
Regulation of even-skipped stripe 2 in the Drosophila embryo. EMBO J (1992) 4.63
Divergent homeo box proteins recognize similar DNA sequences in Drosophila. Nature (1988) 4.63
Nitrogen Availability as an Aid in the Differentiation of Bacteria in the Coli-Aerogenes Group. J Bacteriol (1938) 4.59
Some Factors Influencing the Germicidal Efficiency of Alkalies. Am J Public Health Nations Health (1928) 4.23
Some Observations on the Germicidal Efficiency of Chloramine-T and Calcium Hypochlorite. J Bacteriol (1935) 4.14
Transcriptional and genetic analyses of the herpes simplex virus type 1 genome: coordinates 0.29 to 0.45. J Virol (1984) 4.09
Antigenic variants of herpes simplex virus selected with glycoprotein-specific monoclonal antibodies. J Virol (1983) 4.04
The Facultative Sporulating Bacteria Producing Gas from Lactose. J Bacteriol (1937) 3.93
Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 A. J Mol Biol (1979) 3.88
SOME DIFFERENTIAL REACTIONS OF COLI-LIKE BACTERIA. Am J Public Health (N Y) (1917) 3.77
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila. Cell (1989) 3.77
Diagnosis of iron-deficiency anemia in the elderly. Am J Med (1990) 3.77
Neutralizing monoclonal antibodies specific for herpes simplex virus glycoprotein D inhibit virus penetration. J Virol (1987) 3.74
Dif, a dorsal-related gene that mediates an immune response in Drosophila. Cell (1993) 3.68
Modulation of enhancer-promoter interactions by insulators in the Drosophila embryo. Nature (1995) 3.61
Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). N Engl J Med (1991) 3.52
Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen. Cell (1993) 3.46
The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos. Genes Dev (1991) 3.45
The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo. Genes Dev (1992) 3.38
Characterization and localization of the even-skipped protein of Drosophila. EMBO J (1987) 3.29
Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila. Cell (1986) 3.03
Sequence-specific DNA-binding activities of the gap proteins encoded by hunchback and Krüppel in Drosophila. Nature (1989) 2.97
High-frequency transfer of cloned herpes simplex virus type 1 sequences to mammalian cells by protoplast fusion. Mol Cell Biol (1981) 2.97
Physical mapping of the mutation in an antigenic variant of herpes simplex virus type 1 by use of an immunoreactive plaque assay. J Virol (1983) 2.96
in vitro MORPHOGENESIS OF PHAGE P22 FROM HEADS AND BASE-PLATE PARTS. Proc Natl Acad Sci U S A (1967) 2.93
Regulation of a segmentation stripe by overlapping activators and repressors in the Drosophila embryo. Science (1991) 2.90
Ipsilateral breast tumor recurrence postlumpectomy is predictive of subsequent mortality: results from a randomized trial. Investigators of the Ontario Clinical Oncology Group. Int J Radiat Oncol Biol Phys (1994) 2.86
The dorsal morphogen is a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila. Cell (1991) 2.85
Herpes simplex virus type 1 glycoprotein C-negative mutants exhibit multiple phenotypes, including secretion of truncated glycoproteins. J Virol (1984) 2.84
GATA-dependent recruitment of MEF2 proteins to target promoters. EMBO J (2000) 2.79
dorsal-twist interactions establish snail expression in the presumptive mesoderm of the Drosophila embryo. Genes Dev (1992) 2.76
Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. J Natl Cancer Inst (1998) 2.75
The eve stripe 2 enhancer employs multiple modes of transcriptional synergy. Development (1996) 2.74
Homeo box genes of the Antennapedia and bithorax complexes of Drosophila. Cell (1985) 2.68
Transcriptional control signals of a herpes simplex virus type 1 late (gamma 2) gene lie within bases -34 to +124 relative to the 5' terminus of the mRNA. Mol Cell Biol (1986) 2.65
Transcriptional regulation of a pair-rule stripe in Drosophila. Genes Dev (1991) 2.63
Interaction of short-range repressors with Drosophila CtBP in the embryo. Science (1998) 2.61
3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase. Antimicrob Agents Chemother (1987) 2.60
RNA synthesis by vesicular stomatitis virus and a small plaque mutant: effects of cycloheximide. J Virol (1973) 2.58
The pseudorabies virus gII gene is closely related to the gB glycoprotein gene of herpes simplex virus. J Virol (1987) 2.58
Rapid identification of nonessential genes of herpes simplex virus type 1 by Tn5 mutagenesis. Science (1987) 2.57
Local inhibition and long-range enhancement of Dpp signal transduction by Sog. Nature (1999) 2.56
Establishment of the mesoderm-neuroectoderm boundary in the Drosophila embryo. Science (1991) 2.56
Spatial distribution of Antennapedia transcripts during Drosophila development. EMBO J (1983) 2.50
A randomized trial to assess the efficacy of surgery in addition to radiotherapy in patients with a single cerebral metastasis. Cancer (1996) 2.49
Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo. Dev Biol (1996) 2.42
EXCHANGE REACTIONS OF DIIODOTYROSINE. Science (1944) 2.41
Different core promoters possess distinct regulatory activities in the Drosophila embryo. Genes Dev (1998) 2.38
Phosphorylation of acyclovir (acycloguanosine) monophosphate by GMP kinase. J Biol Chem (1980) 2.38
Characterization of a notochord-specific enhancer from the Brachyury promoter region of the ascidian, Ciona intestinalis. Development (1997) 2.38
Autoregulatory and gap gene response elements of the even-skipped promoter of Drosophila. EMBO J (1989) 2.36
Short-range transcriptional repressors mediate both quenching and direct repression within complex loci in Drosophila. Genes Dev (1996) 2.36
1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity. Antimicrob Agents Chemother (1997) 2.31
Primary prevention of heart disease and stroke: a simplified approach to estimating risk of events and making drug treatment decisions. CMAJ (1997) 2.30
Spatially regulated expression of homeotic genes in Drosophila. Science (1985) 2.25
DIFFERENTIATION OF HUMAN AND SOIL STRAINS OF THE AEROGENES SECTION OF THE COLON GROUP. Am J Public Health (N Y) (1924) 2.25
Hormone replacement therapy use and variations in the risk of breast cancer. BJOG (2008) 2.24
Short-range repression permits multiple enhancers to function autonomously within a complex promoter. Genes Dev (1994) 2.24
Baseline staging tests in primary breast cancer: a practice guideline. CMAJ (2001) 2.22
Complementary patterns of even-skipped and fushi tarazu expression involve their differential regulation by a common set of segmentation genes in Drosophila. Genes Dev (1987) 2.22
dCtBP mediates transcriptional repression by Knirps, Krüppel and Snail in the Drosophila embryo. EMBO J (1998) 2.22
Hydrogen Sulfide Production as a Differential Test in the Colon Group. J Bacteriol (1936) 2.22
Supplemental social services improve outcomes in public addiction treatment. Addiction (1998) 2.21
The Fab-7 element of the bithorax complex attenuates enhancer-promoter interactions in the Drosophila embryo. Genes Dev (1996) 2.16
Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila. Nature (1984) 2.16
Expression of herpes simplex virus beta and gamma genes integrated in mammalian cells and their induction by an alpha gene product. Mol Cell Biol (1983) 2.15
A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol Cell Biol (1994) 2.15
A new recommended dietary allowance of vitamin C for healthy young women. Proc Natl Acad Sci U S A (2001) 2.12
A snapshot of waiting times for cancer surgery provided by surgeons affiliated with regional cancer centres in Ontario. CMAJ (2001) 2.11
A specific 15-bp TATA box promoter element is required for expression of a herpes simplex virus type 1 late gene. Genes Dev (1988) 2.11
Serologic differentiation between antitoxin responses to infection with Vibrio cholerae and enterotoxin-producing Escherichia coli. J Infect Dis (1983) 2.08
The substrate-facilitated transport of the glucose carrier across the human erythrocyte membrane. Biochim Biophys Acta (1965) 2.05
New concepts in the biology and biochemistry of ascorbic acid. N Engl J Med (1986) 2.05
Gap genes define the limits of antennapedia and bithorax gene expression during early development in Drosophila. EMBO J (1988) 2.02
Cross-regulatory interactions among pair-rule genes in Drosophila. Science (1986) 1.98
Human DNA sequences homologous to a protein coding region conserved between homeotic genes of Drosophila. Cell (1984) 1.98
Prospective randomized trial of docetaxel versus mitomycin plus vinblastine in patients with metastatic breast cancer progressing despite previous anthracycline-containing chemotherapy. 304 Study Group. J Clin Oncol (1999) 1.98
Theory of the electrokinetic behavior of human erythrocytes. Biophys J (1983) 1.97
Transcriptional repression in development. Curr Opin Cell Biol (1996) 1.96
Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev (2001) 1.94
Monoclonal antibodies define a domain on herpes simplex virus glycoprotein B involved in virus penetration. J Virol (1988) 1.94
Possible role of Fc receptors on cells infected and transformed by herpesvirus: escape from immune cytolysis. Infect Immun (1978) 1.93
CONCENTRATION OF GLUCOSE AND LACTOSE AND VIABILITY OF COLI-LIKE BATERIA. Am J Public Health (N Y) (1918) 1.91