Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients.

PubWeight™: 0.90‹?›

🔗 View Article (PMC 3751545)

Published in J Transl Med on August 15, 2013

Authors

Nina Mikirova, Joseph Casciari, Neil Riordan, Ronald Hunninghake

Articles cited by this

Inflammation and cancer. Nature (2002) 53.78

Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol (2002) 14.75

Paradoxical roles of the immune system during cancer development. Nat Rev Cancer (2006) 10.57

Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell (2005) 9.06

Production of large amounts of hydrogen peroxide by human tumor cells. Cancer Res (1991) 6.99

Radical causes of cancer. Nat Rev Cancer (2003) 5.45

Inflammation, a key event in cancer development. Mol Cancer Res (2006) 5.03

Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A (1976) 4.89

Role of systemic inflammatory response in predicting survival in patients with primary operable cancer. Future Oncol (2010) 4.83

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci U S A (1996) 4.45

Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med (2004) 4.30

Inflammation and cancer: an ancient link with novel potentials. Int J Cancer (2007) 4.19

Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med (1995) 3.75

Systemic inflammation, nutritional status and survival in patients with cancer. Curr Opin Clin Nutr Metab Care (2009) 3.57

High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. A randomized double-blind comparison. N Engl J Med (1985) 3.36

Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A (2005) 3.30

Failure of high-dose vitamin C (ascorbic acid) therapy to benefit patients with advanced cancer. A controlled trial. N Engl J Med (1979) 2.63

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A (2008) 2.50

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival. Biochem J (1998) 2.50

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J (1996) 2.31

Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ Res (1997) 2.27

Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol (2008) 2.27

Tumors and inflammatory infiltrates: friends or foes? Clin Exp Metastasis (2002) 2.08

Hypoxia and oxidative stress in breast cancer. Oxidative stress: its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast Cancer Res (2001) 1.97

Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy. Am J Physiol Gastrointest Liver Physiol (2004) 1.96

Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch Surg (2006) 1.93

Associations between C-reactive protein and benign prostatic hyperplasia/lower urinary tract symptom outcomes in a population-based cohort. Am J Epidemiol (2009) 1.92

Vitamin C: intravenous use by complementary and alternative medicine practitioners and adverse effects. PLoS One (2010) 1.92

Regulation of collagen synthesis by ascorbic acid. Proc Natl Acad Sci U S A (1981) 1.89

Ascorbic acid and cancer: a review. Cancer Res (1979) 1.88

C-reactive protein and all-cause mortality in a large hospital-based cohort. Clin Chem (2007) 1.79

Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer. Clin Cancer Res (2010) 1.57

Intravenously administered vitamin C as cancer therapy: three cases. CMAJ (2006) 1.43

Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell (2007) 1.41

Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Med Hypotheses (1995) 1.36

Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Int J Cancer (2008) 1.36

Pharmacologic concentrations of ascorbate are achieved by parenteral administration and exhibit antitumoral effects. Free Radic Biol Med (2009) 1.31

Ascorbic acid (vitamin C) improves the antineoplastic activity of doxorubicin, cisplatin, and paclitaxel in human breast carcinoma cells in vitro. Cancer Lett (1996) 1.28

Inflammation and cancer: causes and consequences. Clin Pharmacol Ther (2010) 1.27

Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer. Free Radic Biol Med (2011) 1.27

Vitamin C and cancer revisited. Proc Natl Acad Sci U S A (2008) 1.24

Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte-related host resistance. Br J Cancer (1982) 1.19

Potential role of sugar transporters in cancer and their relationship with anticancer therapy. Int J Endocrinol (2010) 1.13

Stromal cell oxidation: a mechanism by which tumors obtain vitamin C. Cancer Res (1999) 1.13

Effect of high-dose intravenous vitamin C on inflammation in cancer patients. J Transl Med (2012) 1.09

The use of antioxidants with first-line chemotherapy in two cases of ovarian cancer. J Am Coll Nutr (2003) 1.09

A pilot clinical study of continuous intravenous ascorbate in terminal cancer patients. P R Health Sci J (2005) 1.08

Vitamin C deficiency in cancer patients. Palliat Med (2005) 1.05

Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1. Altern Ther Health Med (2007) 1.02

Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours. Br J Cancer (2001) 1.02

High dose concentration administration of ascorbic acid inhibits tumor growth in BALB/C mice implanted with sarcoma 180 cancer cells via the restriction of angiogenesis. J Transl Med (2009) 1.00

Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression. PLoS One (2009) 1.00

Intravenous ascorbic acid: protocol for its application and use. P R Health Sci J (2003) 0.96

Scurvy in patients with cancer. BMJ (1998) 0.96

Ascorbate exerts anti-proliferative effects through cell cycle inhibition and sensitizes tumor cells towards cytostatic drugs. Cancer Chemother Pharmacol (2010) 0.94

Ascorbic acid: biologic functions and relation to cancer. J Natl Cancer Inst (1991) 0.93

Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany. In Vivo (2011) 0.93

Anti-angiogenic effect of high doses of ascorbic acid. J Transl Med (2008) 0.92

Novel function of ascorbic acid as an angiostatic factor. Angiogenesis (2003) 0.90

Concentrations of ascorbic acid in plasma and white blood cells of patients with cancer and noncancerous chronic disease. Cancer (1952) 0.90

Pharmacological ascorbic acid suppresses syngeneic tumor growth and metastases in hormone-refractory prostate cancer. In Vivo (2010) 0.90

Ascorbic acid enhances radiation-induced apoptosis in an HL60 human leukemia cell line. J Radiat Res (2011) 0.88

Ascorbate inhibition of angiogenesis in aortic rings ex vivo and subcutaneous Matrigel plugs in vivo. J Angiogenes Res (2010) 0.88

Cancer: a collagen disease, secondary to a nutritional deficiency. Arch Pediatr (1959) 0.87

Massive doses of vitamin C and the virus diseases. South Med Surg (1951) 0.87

The treatment of poliomyelitis and other virus diseases with vitamin C. South Med Surg (1949) 0.85

Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs. Cancer Res (1982) 0.85

Lipid peroxidation and antioxidant status in head and neck squamous cell carcinoma patients. Oxid Med Cell Longev (2010) 0.84

Potentiation of radiotherapy by nontoxic pretreatment with combined vitamins C and K3 in mice bearing solid transplantable tumor. Anticancer Res (1996) 0.83

Acute hepatitis treated with high doses of vitamin C. Report of a case. Ohio Med (1960) 0.82

Effects of high dose ascorbate administration on L-10 tumor growth in guinea pigs. P R Health Sci J (2005) 0.82

Toxicity, radiation sensitivity modification, and combined drug effects of ascorbic acid with misonidazole in vivo on FSaII murine fibrosarcomas. J Natl Cancer Inst (1987) 0.81

Ascorbic acid in cancer chemoprevention: translational perspectives and efficacy. Curr Drug Targets (2012) 0.77

Investigation of ascorbic acid levels in blood of cancer patients compared to normal subjects. Mo Med (1967) 0.76

Oxidation of L-ascorbic acid by cells of carcinoma of the human cervix. Nature (1965) 0.76