Published in J Theor Biol on May 04, 2008
A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit Care Med (2012) 1.69
Mechanistic simulations of inflammation: current state and future prospects. Math Biosci (2008) 1.40
Sepsis: Something old, something new, and a systems view. J Crit Care (2011) 1.29
Translational systems approaches to the biology of inflammation and healing. Immunopharmacol Immunotoxicol (2010) 1.18
Qualitatively distinct phenotypes in the design space of biochemical systems. FEBS Lett (2009) 1.06
Linking Inflammation, Cardiorespiratory Variability, and Neural Control in Acute Inflammation via Computational Modeling. Front Physiol (2012) 0.93
Translational applications of evaluating physiologic variability in human endotoxemia. J Clin Monit Comput (2012) 0.90
Sepsis: from pattern to mechanism and back. Crit Rev Biomed Eng (2012) 0.87
Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation. Antioxid Redox Signal (2015) 0.87
A practical approach to parameter estimation applied to model predicting heart rate regulation. J Math Biol (2012) 0.86
Global sensitivity analysis of a mathematical model of acute inflammation identifies nonlinear dependence of cumulative tissue damage on host interleukin-6 responses. J Theor Biol (2014) 0.83
Experimental validation of a theoretical model of cytokine capture using a hemoadsorption device. Ann Biomed Eng (2009) 0.83
Biomedical engineering strategies in system design space. Ann Biomed Eng (2011) 0.82
A mathematical model of pulmonary gas exchange under inflammatory stress. J Theor Biol (2010) 0.81
Systems engineering medicine: engineering the inflammation response to infectious and traumatic challenges. J R Soc Interface (2010) 0.80
Combined in silico, in vivo, and in vitro studies shed insights into the acute inflammatory response in middle-aged mice. PLoS One (2013) 0.79
Inflammation Following Traumatic Brain Injury in Humans: Insights from Data-Driven and Mechanistic Models into Survival and Death. Front Pharmacol (2016) 0.77
Competition Between Transients in the Rate of Approach to a Fixed Point. SIAM J Appl Dyn Syst (2009) 0.76
Computational modelling of the inflammatory response in trauma, sepsis and wound healing: implications for modelling resilience. Interface Focus (2014) 0.75
RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care (2006) 9.29
The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med (2002) 4.72
Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis. Crit Care Med (2003) 4.04
A comparison of three methods to estimate baseline creatinine for RIFLE classification. Nephrol Dial Transplant (2010) 3.45
Pneumonia: still the old man's friend? Arch Intern Med (2003) 3.12
Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States. Am J Respir Crit Care Med (2002) 3.02
Conditional outlier detection for clinical alerting. AMIA Annu Symp Proc (2010) 2.99
The effect of insulin feedback on closed loop glucose control. J Clin Endocrinol Metab (2011) 2.74
Growth of intensive care unit resource use and its estimated cost in Medicare. Crit Care Med (2008) 2.31
Healthcare costs and long-term outcomes after acute respiratory distress syndrome: A phase III trial of inhaled nitric oxide. Crit Care Med (2006) 2.27
Perceptions of safety culture vary across the intensive care units of a single institution. Crit Care Med (2007) 2.24
Systemic inflammation and remote organ injury following trauma require HMGB1. Am J Physiol Regul Integr Comp Physiol (2007) 2.12
Haloperidol use is associated with lower hospital mortality in mechanically ventilated patients. Crit Care Med (2005) 2.11
Outlier detection for patient monitoring and alerting. J Biomed Inform (2012) 2.10
Hemorrhagic shock induces NAD(P)H oxidase activation in neutrophils: role of HMGB1-TLR4 signaling. J Immunol (2007) 2.02
Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism. Hepatology (2009) 1.98
Cost-effectiveness of inhaled nitric oxide in the treatment of neonatal respiratory failure in the United States. Pediatrics (2003) 1.92
Acute removal of common sepsis mediators does not explain the effects of extracorporeal blood purification in experimental sepsis. Kidney Int (2011) 1.87
Role of toll-like receptors in changes in gene expression and NF-kappa B activation in mouse hepatocytes stimulated with lipopolysaccharide. Infect Immun (2002) 1.85
The acute inflammatory response in diverse shock states. Shock (2005) 1.83
Severe community-acquired pneumonia: use of intensive care services and evaluation of American and British Thoracic Society Diagnostic criteria. Am J Respir Crit Care Med (2002) 1.78
In silico design of clinical trials: a method coming of age. Crit Care Med (2004) 1.78
Nitric oxide and wound repair: role of cytokines? Nitric Oxide (2002) 1.73
Hospital mortality and resource use in subgroups of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial. Crit Care Med (2004) 1.73
Comparison of Cox and Gray's survival models in severe sepsis. Crit Care Med (2004) 1.72
Agent-based models in translational systems biology. Wiley Interdiscip Rev Syst Biol Med (2010) 1.70
A two-compartment mathematical model of endotoxin-induced inflammatory and physiologic alterations in swine. Crit Care Med (2012) 1.69
Suicide in the Northern Territory, 1981-2002. Med J Aust (2006) 1.68
A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation. J Theor Biol (2006) 1.68
A dynamical model of human immune response to influenza A virus infection. J Theor Biol (2006) 1.67
A reduced mathematical model of the acute inflammatory response II. Capturing scenarios of repeated endotoxin administration. J Theor Biol (2006) 1.65
Effect of pramlintide on prandial glycemic excursions during closed-loop control in adolescents and young adults with type 1 diabetes. Diabetes Care (2012) 1.63
The dynamics of acute inflammation. J Theor Biol (2004) 1.60
Resetting the transcription factor network reverses terminal chronic hepatic failure. J Clin Invest (2015) 1.58
Prehospital Hypotension Is Associated With Altered Inflammation Dynamics and Worse Outcomes Following Blunt Trauma in Humans. Crit Care Med (2015) 1.58
Toll-like receptor-4 signaling mediates hepatic injury and systemic inflammation in hemorrhagic shock. J Am Coll Surg (2006) 1.57
Inducible protein-10, a potential driver of neurally controlled interleukin-10 and morbidity in human blunt trauma. Crit Care Med (2014) 1.57
Mathematical models of the acute inflammatory response. Curr Opin Crit Care (2004) 1.54
Physiologic responses to severe hemorrhagic shock and the genesis of cardiovascular collapse: can irreversibility be anticipated? J Surg Res (2012) 1.53
Intensive care unit safety culture and outcomes: a US multicenter study. Int J Qual Health Care (2010) 1.50
How to write a critically appraised topic (CAT). Acad Radiol (2012) 1.46
Intensive care unit renal support therapy volume is not associated with patient outcome. Crit Care Med (2011) 1.42
Urine cytokines suggest an inflammatory response in the overactive bladder: a pilot study. Int Urol Nephrol (2009) 1.41
Mechanistic simulations of inflammation: current state and future prospects. Math Biosci (2008) 1.40
Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. J Exp Med (2005) 1.40
Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4. Am J Physiol Regul Integr Comp Physiol (2006) 1.40
A One-Nearest-Neighbor Approach to Identify the Original Time of Infection Using Censored Baboon Sepsis Data. Crit Care Med (2016) 1.39
Agent-based model of inflammation and wound healing: insights into diabetic foot ulcer pathology and the role of transforming growth factor-beta1. Wound Repair Regen (2007) 1.39
A patient-specific in silico model of inflammation and healing tested in acute vocal fold injury. PLoS One (2008) 1.38
Robust model-based quantification of global ventricular torsion from spatially sparse three-dimensional time series data by orthogonal distance regression: evaluation in a canine animal model under different pacing regimes. Pacing Clin Electrophysiol (2012) 1.38
Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2. Am J Physiol Regul Integr Comp Physiol (2009) 1.36
Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol (2009) 1.35
Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury. Shock (2013) 1.35
The production of antibody by invading B cells is required for the clearance of rabies virus from the central nervous system. PLoS Negl Trop Dis (2009) 1.34
Reduced hypoglycemia and increased time in target using closed-loop insulin delivery during nights with or without antecedent afternoon exercise in type 1 diabetes. Diabetes Care (2013) 1.33
Effect of insulin feedback on closed-loop glucose control: a crossover study. J Diabetes Sci Technol (2012) 1.32
Systemic inflammation and end organ damage following trauma involves functional TLR4 signaling in both bone marrow-derived cells and parenchymal cells. J Leukoc Biol (2007) 1.31
Sepsis: Something old, something new, and a systems view. J Crit Care (2011) 1.29
Severe sepsis in community-acquired pneumonia: when does it happen, and do systemic inflammatory response syndrome criteria help predict course? Chest (2006) 1.29
The use of an automated, portable glucose control system for overnight glucose control in adolescents and young adults with type 1 diabetes. Diabetes Care (2012) 1.27
Loss of calbindin-D28k from aging human cholinergic basal forebrain: relation to neuronal loss. J Comp Neurol (2003) 1.25
In silico and in vivo approach to elucidate the inflammatory complexity of CD14-deficient mice. Mol Med (2006) 1.25
Identifying Deviations from Usual Medical Care using a Statistical Approach. AMIA Annu Symp Proc (2010) 1.24
A dynamic view of trauma/hemorrhage-induced inflammation in mice: principal drivers and networks. PLoS One (2011) 1.24
Interplay of coronary artery calcification and traditional risk factors for the prediction of all-cause mortality in asymptomatic individuals. Circ Cardiovasc Imaging (2012) 1.22
Translational systems approaches to the biology of inflammation and healing. Immunopharmacol Immunotoxicol (2010) 1.18
Translational systems biology: introduction of an engineering approach to the pathophysiology of the burn patient. J Burn Care Res (2008) 1.17
Risk and markers of severe acute pancreatitis. Gastroenterol Clin North Am (2007) 1.16
From inverse problems in mathematical physiology to quantitative differential diagnoses. PLoS Comput Biol (2007) 1.16
Patterns of cytokine release and evolution of remote organ dysfunction after bilateral femur fracture. Shock (2008) 1.15
Mammalian transforming growth factor beta1 activated after ingestion by Anopheles stephensi modulates mosquito immunity. Infect Immun (2003) 1.14
In silico models of acute inflammation in animals. Shock (2006) 1.14
Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury. Shock (2008) 1.12
Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. Am J Physiol Lung Cell Mol Physiol (2005) 1.12
Translational systems biology of inflammation: potential applications to personalized medicine. Per Med (2010) 1.11
A mathematical simulation of the inflammatory response to anthrax infection. Shock (2008) 1.11
The PILGRIM study: in silico modeling of a predictive low glucose management system and feasibility in youth with type 1 diabetes during exercise. Diabetes Technol Ther (2014) 1.08
Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology (2002) 1.08
Mathematical modeling of posthemorrhage inflammation in mice: studies using a novel, computer-controlled, closed-loop hemorrhage apparatus. Shock (2009) 1.07
Multiplex analysis of urinary cytokine levels in rat model of cyclophosphamide-induced cystitis. Urology (2008) 1.07
The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis. Hepatology (2012) 1.07
Interacting neuroendocrine and innate and acquired immune pathways regulate neutrophil mobilization from bone marrow following hemorrhagic shock. J Immunol (2009) 1.07
Angiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany. Am J Gastroenterol (2010) 1.06
Primary chemotherapy for intracranial germ cell tumors: results of the third international CNS germ cell tumor study. Pediatr Blood Cancer (2010) 1.05