Published in Cell Death Differ on June 13, 2008
The BCL-2 family reunion. Mol Cell (2010) 7.32
Mitochondria in apoptosis: Bcl-2 family members and mitochondrial dynamics. Dev Cell (2011) 4.91
A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell (2011) 3.72
Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J (2011) 3.06
Mechanisms of action of Bcl-2 family proteins. Cold Spring Harb Perspect Biol (2013) 1.73
Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. J Cell Sci (2009) 1.70
Structure-guided design of a selective BCL-X(L) inhibitor. Nat Chem Biol (2013) 1.68
Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis. Cell Death Differ (2013) 1.54
Multiple functions of BCL-2 family proteins. Cold Spring Harb Perspect Biol (2013) 1.51
Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers. J Biol Chem (2010) 1.36
High-resolution structural characterization of a helical alpha/beta-peptide foldamer bound to the anti-apoptotic protein Bcl-xL. Angew Chem Int Ed Engl (2009) 1.34
Bax forms an oligomer via separate, yet interdependent, surfaces. J Biol Chem (2010) 1.27
The Role of BH3-Only Proteins in Tumor Cell Development, Signaling, and Treatment. Genes Cancer (2011) 1.23
Vaccinia virus protein C6 is a virulence factor that binds TBK-1 adaptor proteins and inhibits activation of IRF3 and IRF7. PLoS Pathog (2011) 1.22
Poxviruses and the evolution of host range and virulence. Infect Genet Evol (2013) 1.16
Cell death and the mitochondria: therapeutic targeting of the BCL-2 family-driven pathway. Br J Pharmacol (2014) 1.13
How vaccinia virus has evolved to subvert the host immune response. J Struct Biol (2011) 1.11
Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif. J Biol Chem (2010) 1.10
Conformational changes in Bcl-2 pro-survival proteins determine their capacity to bind ligands. J Biol Chem (2009) 1.09
Evolution of Bcl-2 homology motifs: homology versus homoplasy. Trends Cell Biol (2012) 1.08
A poxvirus Bcl-2-like gene family involved in regulation of host immune response: sequence similarity and evolutionary history. Virol J (2010) 1.07
The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage. J Biol Chem (2013) 1.05
A survey of host range genes in poxvirus genomes. Infect Genet Evol (2012) 1.05
Multipolar functions of BCL-2 proteins link energetics to apoptosis. Trends Cell Biol (2012) 1.05
tBid undergoes multiple conformational changes at the membrane required for Bax activation. J Biol Chem (2013) 1.04
Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1. PLoS Pathog (2010) 1.02
Structural biology of the Bcl-2 family and its mimicry by viral proteins. Cell Death Dis (2013) 1.01
Identification of bZIP interaction partners of viral proteins HBZ, MEQ, BZLF1, and K-bZIP using coiled-coil arrays. Biochemistry (2010) 1.00
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. J Med Chem (2010) 1.00
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence. PLoS Pathog (2011) 1.00
Poxvirus proteomics and virus-host protein interactions. Microbiol Mol Biol Rev (2009) 0.98
Vaccinia-induced epidermal growth factor receptor-MEK signalling and the anti-apoptotic protein F1L synergize to suppress cell death during infection. Cell Microbiol (2009) 0.98
Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB. J Biol Chem (2011) 0.97
After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization. J Biol Chem (2014) 0.97
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. PLoS Pathog (2011) 0.96
Deletion of the viral anti-apoptotic gene F1L in the HIV/AIDS vaccine candidate MVA-C enhances immune responses against HIV-1 antigens. PLoS One (2012) 0.96
Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells. Cell Death Differ (2011) 0.94
Molecular genetic analysis of orf virus: a poxvirus that has adapted to skin. Viruses (2015) 0.91
Vaccinia virus protein N2 is a nuclear IRF3 inhibitor that promotes virulence. J Gen Virol (2013) 0.90
The fowlpox virus BCL-2 homologue, FPV039, interacts with activated Bax and a discrete subset of BH3-only proteins to inhibit apoptosis. J Virol (2009) 0.89
Vaccinia virus F1L interacts with Bak using highly divergent Bcl-2 homology domains and replaces the function of Mcl-1. J Biol Chem (2009) 0.89
The restricted binding repertoire of Bcl-B leaves Bim as the universal BH3-only prosurvival Bcl-2 protein antagonist. Cell Death Dis (2012) 0.88
Genes in the terminal regions of orthopoxvirus genomes experience adaptive molecular evolution. BMC Genomics (2011) 0.88
Vaccinia virus protein F1L is a caspase-9 inhibitor. J Biol Chem (2009) 0.87
Vaccinia virus protein K7 is a virulence factor that alters the acute immune response to infection. J Gen Virol (2013) 0.86
Deerpox virus encodes an inhibitor of apoptosis that regulates Bak and Bax. J Virol (2010) 0.86
The vaccinia virus-encoded Bcl-2 homologues do not act as direct Bax inhibitors. J Virol (2011) 0.84
Structural changes in the BH3 domain of SOUL protein upon interaction with the anti-apoptotic protein Bcl-xL. Biochem J (2011) 0.84
The functional differences between pro-survival and pro-apoptotic B cell lymphoma 2 (Bcl-2) proteins depend on structural differences in their Bcl-2 homology 3 (BH3) domains. J Biol Chem (2014) 0.84
Vaccinia virus protein A49 is an unexpected member of the B-cell Lymphoma (Bcl)-2 protein family. J Biol Chem (2015) 0.83
Structural determinants of caspase-9 inhibition by the vaccinia virus protein, F1L. J Biol Chem (2011) 0.83
Locating Herpesvirus Bcl-2 Homologs in the Specificity Landscape of Anti-Apoptotic Bcl-2 Proteins. J Mol Biol (2015) 0.82
Sheeppox virus SPPV14 encodes a Bcl-2-like cell death inhibitor that counters a distinct set of mammalian proapoptotic proteins. J Virol (2012) 0.82
Bcl-2 proteins and calcium signaling: complexity beneath the surface. Oncogene (2016) 0.81
Structural insight into BH3 domain binding of vaccinia virus antiapoptotic F1L. J Virol (2014) 0.81
Pore formation by dimeric Bak and Bax: an unusual pore? Philos Trans R Soc Lond B Biol Sci (2017) 0.80
A motive for killing: effector functions of regulated lytic cell death. Immunol Cell Biol (2016) 0.79
Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 in complex with a benzoylurea peptidomimetic. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.79
Variola virus F1L is a Bcl-2-like protein that unlike its vaccinia virus counterpart inhibits apoptosis independent of Bim. Cell Death Dis (2015) 0.78
BH4 domain of Bcl-2 as a novel target for cancer therapy. Drug Discov Today (2015) 0.78
Celecoxib and Bcl-2: emerging possibilities for anticancer drug design. Future Med Chem (2012) 0.77
Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection. J Gen Virol (2014) 0.77
The N Terminus of the Vaccinia Virus Protein F1L Is an Intrinsically Unstructured Region That Is Not Involved in Apoptosis Regulation. J Biol Chem (2016) 0.76
Vaccinia Virus Immunomodulator A46: A Lipid and Protein-Binding Scaffold for Sequestering Host TIR-Domain Proteins. PLoS Pathog (2016) 0.75
The importance of evolutionarily conserved C-terminal basic residues for the stability of proapoptotic Bax protein. FEBS Open Bio (2016) 0.75
Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2. PLoS Pathog (2016) 0.75
Cloning and characterization of Bax1 and Bax2 genes of Ctenopharyngodon idellus and evaluation of transcript expression in response to grass carp reovirus infection. Fish Physiol Biochem (2016) 0.75
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science (2001) 22.06
HMG-1 as a late mediator of endotoxin lethality in mice. Science (1999) 17.72
Health information on the Internet: accessibility, quality, and readability in English and Spanish. JAMA (2001) 15.23
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature (2000) 11.49
Shape complementarity at protein/protein interfaces. J Mol Biol (1993) 10.40
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med (2000) 7.38
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association. Cell (1999) 6.59
Structure of the influenza virus glycoprotein antigen neuraminidase at 2.9 A resolution. Nature (1983) 5.56
Structure of the catalytic and antigenic sites in influenza virus neuraminidase. Nature (1983) 5.11
Regulation of flowering time by Arabidopsis photoreceptors. Science (1998) 5.11
VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J Cell Biol (1995) 5.04
Neuraxial block, death and serious cardiovascular morbidity in the POISE trial. Br J Anaesth (2013) 4.60
MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci U S A (1997) 4.20
Activation of EGFP expression by Cre-mediated excision in a new ROSA26 reporter mouse strain. Blood (2001) 3.93
Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell (1998) 3.86
Structure-activity analysis of synthetic autoinducing thiolactone peptides from Staphylococcus aureus responsible for virulence. Proc Natl Acad Sci U S A (1999) 3.79
Rhabdomyolysis. Intern Emerg Med (2007) 3.56
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor. Proteins (1992) 3.44
Enhancement of blue-light sensitivity of Arabidopsis seedlings by a blue light receptor cryptochrome 2. Proc Natl Acad Sci U S A (1998) 3.34
Three-dimensional structure of a complex of antibody with influenza virus neuraminidase. Nature (1987) 3.26
Perinuclear antineutrophil cytoplasmic antibodies in patients with Crohn's disease define a clinical subgroup. Gastroenterology (1996) 3.08
A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc Natl Acad Sci U S A (1996) 3.07
Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem (1993) 3.02
Crystallographic structure studies of an IgG molecule and an Fc fragment. Nature (1976) 3.00
Extracellular role of HMGB1 in inflammation and sepsis. J Intern Med (2004) 2.94
Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A (2001) 2.91
Fungi isolated from tobacco leaves and brown-spot lesions before and after flue-curing. Appl Microbiol (1968) 2.87
HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med (2001) 2.80
von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF. Hum Mol Genet (2001) 2.79
Antagonistic actions of Arabidopsis cryptochromes and phytochrome B in the regulation of floral induction. Development (1999) 2.76
Familial expression of anti-Saccharomyces cerevisiae mannan antibodies in affected and unaffected relatives of patients with Crohn's disease. Gut (2000) 2.71
Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J Biol Chem (2001) 2.57
Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2.2 A resolution. J Mol Biol (1991) 2.57
Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation (2000) 2.56
A "knockdown" mutation created by cis-element gene targeting reveals the dependence of erythroid cell maturation on the level of transcription factor GATA-1. Proc Natl Acad Sci U S A (1997) 2.55
Marker antibody expression stratifies Crohn's disease into immunologically homogeneous subgroups with distinct clinical characteristics. Gut (2000) 2.47
High mobility group box chromosomal protein 1: a novel proinflammatory mediator in synovitis. Arthritis Rheum (2002) 2.45
Randomized phase III study 306: adjunctive perampanel for refractory partial-onset seizures. Neurology (2012) 2.45
The structure of the fusion glycoprotein of Newcastle disease virus suggests a novel paradigm for the molecular mechanism of membrane fusion. Structure (2001) 2.41
The product of the pleiotropic Escherichia coli gene csrA modulates glycogen biosynthesis via effects on mRNA stability. J Bacteriol (1995) 2.40
Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors. J Virol (1998) 2.40
Establishing human prostate cancer cell xenografts in bone: induction of osteoblastic reaction by prostate-specific antigen-producing tumors in athymic and SCID/bg mice using LNCaP and lineage-derived metastatic sublines. Int J Cancer (1998) 2.36
Superior ex vivo cord blood expansion following co-culture with bone marrow-derived mesenchymal stem cells. Bone Marrow Transplant (2006) 2.29
Myc requires distinct E2F activities to induce S phase and apoptosis. Mol Cell (2001) 2.29
Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity. Arthritis Rheum (2003) 2.26
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma. J Hepatol (2000) 2.22
Lamivudine in late pregnancy to prevent perinatal transmission of hepatitis B virus infection: a multicentre, randomized, double-blind, placebo-controlled study. J Viral Hepat (2008) 2.19
CD8(+) T-cell selection, function, and death in the primary immune response in vivo. J Clin Invest (2000) 2.19
An open-label pilot study of low-dose thalidomide in chronically active, steroid-dependent Crohn's disease. Gastroenterology (1999) 2.16
Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC). J Virol (2001) 2.14
Crystal structure of ABT-737 complexed with Bcl-xL: implications for selectivity of antagonists of the Bcl-2 family. Cell Death Differ (2007) 2.12
Mutations in hepatitis B DNA polymerase associated with resistance to lamivudine do not confer resistance to adefovir in vitro. Hepatology (1998) 2.12
Analysis of optical spectra from single crystals of Rhodopseudomonas viridis reaction centers. Proc Natl Acad Sci U S A (1985) 2.11
Inhibition of nuclear hormone receptor activity by calreticulin. Nature (1994) 2.11
Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry (1999) 2.10
Pleiotropic regulation of central carbohydrate metabolism in Escherichia coli via the gene csrA. J Biol Chem (1995) 2.10
Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton Neurosci (2000) 2.06
Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res (2000) 2.02
High mobility group 1 B-box mediates activation of human endothelium. J Intern Med (2003) 2.00
Drug design against a shifting target: a structural basis for resistance to inhibitors in a variant of influenza virus neuraminidase. Structure (1998) 1.95
Glypican-3-deficient mice exhibit developmental overgrowth and some of the abnormalities typical of Simpson-Golabi-Behmel syndrome. J Cell Biol (1999) 1.93
E2F1 and E2F2 determine thresholds for antigen-induced T-cell proliferation and suppress tumorigenesis. Mol Cell Biol (2001) 1.91
Electrical properties and conduction in reperfused papillary muscle. Circ Res (2001) 1.91
Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion. J Biol Chem (1999) 1.86
Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9. Cell Death Differ (2002) 1.85
Induction of alloreactive cytotoxic T cells by acute virus infection of mice. J Immunol (1986) 1.84
Modifications and intracellular trafficking of FADD/MORT1 and caspase-8 after stimulation of T lymphocytes. Cell Death Differ (2004) 1.81
Molecular mechanisms of BK channel activation. Cell Mol Life Sci (2009) 1.81
Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma. Mol Cell Biol (1999) 1.80
Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2en. Virology (1995) 1.77
The structure of thermolysin: an electron density map at 2-3 A resolution. J Mol Biol (1972) 1.77
A common variant in methionine synthase reductase combined with low cobalamin (vitamin B12) increases risk for spina bifida. Mol Genet Metab (1999) 1.75
Communicating about risk of infectious diseases. JAMA (1996) 1.74
Production of immunoglobulin G and G1 antibodies to cytoskeletal protein by lamina propria cells in ulcerative colitis. Gastroenterology (1995) 1.74
A genome-wide search identifies potential new susceptibility loci for Crohn's disease. Inflamm Bowel Dis (1999) 1.74
Mutations affecting the development of the embryonic zebrafish brain. Development (1996) 1.73
Influenza virus neuraminidase with hemagglutinin activity. Virology (1984) 1.73
Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis. Am J Physiol Heart Circ Physiol (2001) 1.71
Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemost (2005) 1.70
Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets. Cell Death Differ (2006) 1.70
Three-dimensional structure of neuraminidase of subtype N9 from an avian influenza virus. Proteins (1987) 1.69
BH3-only proteins and their roles in programmed cell death. Oncogene (2008) 1.68
Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology (1992) 1.67
Electrostatic complementarity at protein/protein interfaces. J Mol Biol (1997) 1.67
Genetic dissection of ethanol tolerance in the budding yeast Saccharomyces cerevisiae. Genetics (2006) 1.67
Molecular genetic analysis of Rts1p, a B' regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A. Mol Cell Biol (1997) 1.66
The A alpha mating locus of Schizophyllum commune encodes two dissimilar multiallelic homeodomain proteins. Proc Natl Acad Sci U S A (1992) 1.66
The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia. Leukemia (2009) 1.63
Functional expression of hMYH, a human homolog of the Escherichia coli MutY protein. J Bacteriol (1999) 1.62
Genome-wide identification of aberrantly methylated promoter associated CpG islands in acute lymphocytic leukemia. Leukemia (2008) 1.61
Three-dimensional structure of the complex of 4-guanidino-Neu5Ac2en and influenza virus neuraminidase. Protein Sci (1995) 1.61
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
ACE-Asia intercomparison of a thermal-optical method for the determination of particle-phase organic and elemental carbon. Environ Sci Technol (2003) 1.59
Vascularization of the human fetal retina: roles of vasculogenesis and angiogenesis. Invest Ophthalmol Vis Sci (2000) 1.58
Bootstrap confidence intervals for the sensitivity of a quantitative diagnostic test. Stat Med (2000) 1.57