Published in J Org Chem on June 17, 2008
Rhodium-catalyzed transannulation of 1,2,3-triazoles with nitriles. J Am Chem Soc (2008) 1.86
Ynamides: a modern functional group for the new millennium. Chem Rev (2010) 1.77
Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide, and oligonucleotide chemistry. Chem Rev (2009) 1.53
Synthesis of amidines using N-allyl ynamides. A palladium-catalyzed allyl transfer through an ynamido-pi-allyl complex. Org Lett (2009) 1.04
N-allyl-N-sulfonyl ynamides as synthetic precursors to amidines and vinylogous amidines. An unexpected N-to-C 1,3-sulfonyl shift in nitrile synthesis. J Org Chem (2011) 0.97
An Efficient Synthesis of de novo Imidates via Aza-Claisen Rearrangements of N-Allyl Ynamides. Synlett (2010) 0.83
Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives. Eur J Med Chem (2016) 0.75
Microwave-assisted three-component domino reaction: Synthesis of indolodiazepinotriazoles. Beilstein J Org Chem (2013) 0.75
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Angew Chem Int Ed Engl (2002) 24.12
The growing impact of click chemistry on drug discovery. Drug Discov Today (2003) 6.79
Polytriazoles as copper(I)-stabilizing ligands in catalysis. Org Lett (2004) 5.49
Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition. J Am Chem Soc (2003) 5.34
Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. Angew Chem Int Ed Engl (2002) 3.06
Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates. J Am Chem Soc (2005) 2.75
Copper-catalyzed azide-alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(I) acetylides. Chem Soc Rev (2010) 2.68
Mechanism of the ligand-free CuI-catalyzed azide-alkyne cycloaddition reaction. Angew Chem Int Ed Engl (2005) 2.62
Ruthenium-catalyzed cycloaddition of alkynes and organic azides. J Am Chem Soc (2005) 2.35
"On water": unique reactivity of organic compounds in aqueous suspension. Angew Chem Int Ed Engl (2005) 2.21
Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes. Angew Chem Int Ed Engl (2004) 2.11
Copper(I)-catalyzed cycloaddition of organic azides and 1-iodoalkynes. Angew Chem Int Ed Engl (2009) 2.10
Discovery and characterization of catalysts for azide-alkyne cycloaddition by fluorescence quenching. J Am Chem Soc (2004) 1.89
Rhodium-catalyzed transannulation of 1,2,3-triazoles with nitriles. J Am Chem Soc (2008) 1.86
Rhodium-catalyzed enantioselective cyclopropanation of olefins with N-sulfonyl 1,2,3-triazoles. J Am Chem Soc (2009) 1.85
Ruthenium-catalyzed azide-alkyne cycloaddition: scope and mechanism. J Am Chem Soc (2008) 1.76
Ligand-accelerated Cu-catalyzed azide-alkyne cycloaddition: a mechanistic report. J Am Chem Soc (2007) 1.72
A sulfilimine bond identified in collagen IV. Science (2009) 1.69
Iterative in situ click chemistry creates antibody-like protein-capture agents. Angew Chem Int Ed Engl (2009) 1.64
Inhibitors of HIV-1 protease by using in situ click chemistry. Angew Chem Int Ed Engl (2006) 1.63
In situ click chemistry: enzyme inhibitors made to their own specifications. J Am Chem Soc (2004) 1.61
A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry. J Am Chem Soc (2003) 1.53
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation. Proc Natl Acad Sci U S A (2004) 1.52
A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-sulfonyl tetrazoles from azides and sulfonyl cyanides. Angew Chem Int Ed Engl (2002) 1.48
Recent advances in the transition metal-catalyzed twofold oxidative C-H bond activation strategy for C-C and C-N bond formation. Chem Soc Rev (2011) 1.48
In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. J Am Chem Soc (2005) 1.47
Palladium-catalyzed C-H functionalization of pyridine N-oxides: highly selective alkenylation and direct arylation with unactivated arenes. J Am Chem Soc (2008) 1.46
Synthesis and reactivity of rhodium(II) N-triflyl azavinyl carbenes. J Am Chem Soc (2010) 1.45
Organic synthesis "on water". Chem Rev (2009) 1.37
In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II. Angew Chem Int Ed Engl (2004) 1.35
Multivalent, bifunctional dendrimers prepared by click chemistry. Chem Commun (Camb) (2005) 1.32
The allylic azide rearrangement: achieving selectivity. J Am Chem Soc (2005) 1.30
Practical synthesis of amides from in situ generated copper(I) acetylides and sulfonyl azides. Angew Chem Int Ed Engl (2006) 1.29
Click chemistry: function follows form. Chem Soc Rev (2010) 1.23
Catalytic asymmetric C-H insertions of rhodium(II) azavinyl carbenes. J Am Chem Soc (2011) 1.22
Copper-catalyzed hydrative amide synthesis with terminal alkyne, sulfonyl azide, and water. J Am Chem Soc (2005) 1.22
Trimanganese complexes bearing bidentate nitrogen ligands as a highly efficient catalyst precursor in the epoxidation of alkenes. J Org Chem (2006) 1.21
Highly efficient one-pot synthesis of N-sulfonylamidines by Cu-catalyzed three-component coupling of sulfonyl azide, alkyne, and amine. J Am Chem Soc (2005) 1.20
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. J Med Chem (2005) 1.19
Efficient synthesis of 1-sulfonyl-1,2,3-triazoles. Org Lett (2010) 1.19
Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. J Biol Chem (2012) 1.18
Ruthenium-catalyzed cycloaddition of aryl azides and alkynes. Org Lett (2007) 1.16
Efficient synthesis of 2-substituted-1,2,3-triazoles. Org Lett (2008) 1.15
One-pot synthesis of 1,4-disubstituted 1,2,3-triazoles from in situ generated azides. Org Lett (2004) 1.14
Copper-catalyzed synthesis of N-sulfonyl-1,2,3-triazoles: controlling selectivity. Angew Chem Int Ed Engl (2007) 1.14
New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases. J Biol Chem (2011) 1.14
Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors. Chembiochem (2003) 1.13
Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited. Org Lett (2004) 1.13
One-pot copper(I)-catalyzed synthesis of 3,5-disubstituted isoxazoles. J Org Chem (2005) 1.13
A microwave-assisted click chemistry synthesis of 1,4-disubstituted 1,2,3-triazoles via a copper(I)-catalyzed three-component reaction. Org Lett (2004) 1.13
Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1. J Am Chem Soc (2011) 1.08
Copper-catalyzed reaction cascade: direct conversion of alkynes into N-sulfonylazetidin-2-imines. Angew Chem Int Ed Engl (2006) 1.08
Intermolecular oxidative C-N bond formation under metal-free conditions: control of chemoselectivity between aryl sp2 and benzylic sp3 C-H bond imidation. J Am Chem Soc (2011) 1.07
Cooperative multi-catalyst systems for one-pot organic transformations. Chem Soc Rev (2004) 1.06
Rhodium-catalyzed selective olefination of arene esters via C-H bond activation. Org Lett (2011) 1.04
Why is tetrazole formation by addition of azide to organic nitriles catalyzed by zinc(II) salts? J Am Chem Soc (2003) 1.02
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries. Bioorg Med Chem (2009) 1.02
Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. J Biol Chem (2011) 1.01
Arylation of rhodium(II) azavinyl carbenes with boronic acids. J Am Chem Soc (2012) 0.99
Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template. J Am Chem Soc (2012) 0.99
Regioselective introduction of heteroatoms at the C-8 position of quinoline N-oxides: remote C-H activation using N-oxide as a stepping stone. J Am Chem Soc (2014) 0.97
Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. J Med Chem (2009) 0.97
Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles. Org Lett (2010) 0.96
Identification of a new endogenous metabolite and the characterization of its protein interactions through an immobilization approach. J Am Chem Soc (2009) 0.96
Sulfur(VI) fluoride exchange (SuFEx): another good reaction for click chemistry. Angew Chem Int Ed Engl (2014) 0.95
Design, synthesis and bioactions of novel stable mimetics of lipoxins and aspirin-triggered lipoxins. Prostaglandins Leukot Essent Fatty Acids (2005) 0.95
Cu-facilitated C-O bond formation using N-hydroxyphthalimide: efficient and selective functionalization of benzyl and allylic C-H bonds. J Am Chem Soc (2008) 0.94
Iridium-catalyzed intermolecular amidation of sp³ C-H bonds: late-stage functionalization of an unactivated methyl group. J Am Chem Soc (2014) 0.93
A facile access to N-sulfonylimidates and their synthetic utility for the transformation to amidines and amides. Org Lett (2006) 0.93