Published in PLoS One on July 02, 2008
Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev (2009) 1.76
Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer. J Clin Oncol (2010) 1.68
IGF-I and IGFBP-3 polymorphisms in relation to circulating levels among African American and Caucasian women. Cancer Epidemiol Biomarkers Prev (2009) 1.58
Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocr Rev (2008) 1.38
Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor-Binding Protein-3 in Critical Illness. Crit Care Med (2015) 1.38
Genetic variation and circulating levels of IGF-I and IGFBP-3 in relation to risk of proliferative benign breast disease. Int J Cancer (2010) 1.18
A comprehensive analysis of common IGF1, IGFBP1 and IGFBP3 genetic variation with prospective IGF-I and IGFBP-3 blood levels and prostate cancer risk among Caucasians. Hum Mol Genet (2010) 1.18
Eighteen insulin-like growth factor pathway genes, circulating levels of IGF-I and its binding protein, and risk of prostate and breast cancer. Cancer Epidemiol Biomarkers Prev (2010) 1.17
Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Hum Mol Genet (2010) 1.16
Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer. Gastroenterology (2010) 1.11
Genetic variation in insulin-like growth factor signaling genes and breast cancer risk among BRCA1 and BRCA2 carriers. Breast Cancer Res (2009) 1.04
Identification of genetic determinants of IGF-1 levels and longevity among mouse inbred strains. Aging Cell (2010) 1.04
Dietary cadmium exposure and prostate cancer incidence: a population-based prospective cohort study. Br J Cancer (2012) 1.03
Germline polymorphisms in genes involved in the IGF1 pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients. Clin Cancer Res (2010) 0.97
Genotypes and haplotypes in the insulin-like growth factors, their receptors and binding proteins in relation to plasma metabolic levels and mammographic density. BMC Med Genomics (2010) 0.95
An analysis of growth, differentiation and apoptosis genes with risk of renal cancer. PLoS One (2009) 0.93
Genetic variants, prediagnostic circulating levels of insulin-like growth factors, insulin, and glucose and the risk of colorectal cancer: the Multiethnic Cohort study. Cancer Epidemiol Biomarkers Prev (2012) 0.92
Common genetic variation within IGFI, IGFII, IGFBP-1, and IGFBP-3 and endometrial cancer risk. Gynecol Oncol (2011) 0.92
Association of a common genetic variant of the IGF-1 gene with event-free survival in patients with HER2-positive breast cancer. J Cancer Res Clin Oncol (2012) 0.90
Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer risk. Carcinogenesis (2009) 0.89
Physical confirmation and mapping of overlapping rat mammary carcinoma susceptibility QTLs, Mcs2 and Mcs6. PLoS One (2011) 0.88
IGF gene polymorphisms and breast cancer in African-American and Hispanic women. Int J Oncol (2011) 0.86
Associations between genetic polymorphisms of insulin-like growth factor axis genes and risk for age-related macular degeneration. Invest Ophthalmol Vis Sci (2011) 0.85
IGF1 htSNPs in relation to IGF-1 levels in young women from high-risk breast cancer families: implications for early-onset breast cancer. Fam Cancer (2011) 0.81
IGF1, IGFBP1, and IGFBP3 genes and mammographic density: the Multiethnic Cohort. Int J Cancer (2010) 0.81
Circulating concentrations of insulin-like growth factor-I, insulin-like growth factor-binding protein-3, genetic polymorphisms and mammographic density in premenopausal Mexican women: results from the ESMaestras cohort. Int J Cancer (2013) 0.81
A multi-cohort study of polymorphisms in the GH/IGF axis and physical capability: the HALCyon programme. PLoS One (2012) 0.80
Genetic variability in IGF-1 and IGFBP-3 and body size in early life. BMC Public Health (2012) 0.78
Genetic and dietary determinants of insulin-like growth factor (IGF)-1 and IGF binding protein (BP)-3 levels among Chinese women. PLoS One (2014) 0.78
mRNA profiling reveals determinants of trastuzumab efficiency in HER2-positive breast cancer. PLoS One (2015) 0.78
No Association of Insulin-like Growth Factor Gene Polymorphisms with Survival in Patients with Colorectal Cancer. Cancer Res Treat (2011) 0.77
Clinical significance of insulin-like growth factor gene polymorphisms with survival in patients with gastrointestinal stromal tumors. J Korean Surg Soc (2012) 0.77
Insulin-like growth factor-1 genotypes and haplotypes influence the survival of prostate cancer patients with bone metastasis at initial diagnosis. BMC Cancer (2013) 0.77
Circulating IGF1 and IGF2 and SNP genotypes in men and pregnant and non-pregnant women. Endocr Connect (2014) 0.77
Insulin-like growth factor 1 gene polymorphism and breast cancer risk among arab omani women: a case-control study. Breast Cancer (Auckl) (2012) 0.76
Assessment of age-related changes in heritability and IGF-1 gene effect on circulating IGF-1 levels. Age (Dordr) (2014) 0.76
Effects of High-Order Interactions among IGFBP-3 Genetic Polymorphisms, Body Mass Index and Soy Isoflavone Intake on Breast Cancer Susceptibility. PLoS One (2016) 0.75
Genetic variation in the insulin, insulin-like growth factor, growth hormone, and leptin pathways in relation to breast cancer in African-American women: the AMBER consortium. NPJ Breast Cancer (2016) 0.75
Prospective study of insulin-like growth factor-I, insulin-like growth factor-binding protein 3, genetic variants in the IGF1 and IGFBP3 genes and risk of coronary artery disease. Int J Mol Epidemiol Genet (2011) 0.75
Polymorphisms of Insulin-Like Growth Factor 1 Pathway Genes and Breast Cancer Risk. Front Oncol (2016) 0.75
IGFBP3 polymorphisms and risk of esophageal cancer in a Chinese population. Int J Clin Exp Med (2015) 0.75
Genetic polymorphisms of insulin-like growth factor 1 and insulin-like growth factor binding protein 3, xenoestrogen, phytoestrogen, and premenopausal breast cancer. Curr Oncol (2016) 0.75
The mechanism of transactivation regulation due to polymorphic short tandem repeats (STRs) using IGF1 promoter as a model. Sci Rep (2016) 0.75
Insulin-like growth factor 1 receptor expression and IGF1R 3129G > T polymorphism are associated with response to neoadjuvant chemotherapy in breast cancer patients: results from the NEOZOTAC trial (BOOG 2010-01). Breast Cancer Res (2016) 0.75
Cadmium exposure and risk of prostate cancer: a meta-analysis of cohort and case-control studies among the general and occupational populations. Sci Rep (2016) 0.75
The structure of haplotype blocks in the human genome. Science (2002) 50.88
A multiethnic cohort in Hawaii and Los Angeles: baseline characteristics. Am J Epidemiol (2000) 13.17
European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr (2002) 8.77
Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals. Hum Hered (2002) 8.64
The Nurses' Health Study: lifestyle and health among women. Nat Rev Cancer (2005) 8.19
Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study. Hum Hered (2003) 5.78
Etiologic and early marker studies in the prostate, lung, colorectal and ovarian (PLCO) cancer screening trial. Control Clin Trials (2000) 5.37
Baseline characteristics of participants in the Women's Health Study. J Womens Health Gend Based Med (2000) 4.84
SNP500Cancer: a public resource for sequence validation and assay development for genetic variation in candidate genes. Nucleic Acids Res (2004) 3.47
A candidate gene approach to searching for low-penetrance breast and prostate cancer genes. Nat Rev Cancer (2005) 2.62
The IGF system and breast cancer. Endocr Relat Cancer (2001) 2.21
The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics. Cancer (2002) 1.55
Essential roles of IGFBP-3 and IGFBP-rP1 in breast cancer. Eur J Cancer (2005) 1.51
Circulating levels of insulin-like growth factors, their binding proteins, and breast cancer risk. Cancer Epidemiol Biomarkers Prev (2005) 1.50
Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review. Cancer Epidemiol Biomarkers Prev (2005) 1.47
Common genetic variation in IGF1 and prostate cancer risk in the Multiethnic Cohort. J Natl Cancer Inst (2006) 1.41
A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk. Br J Cancer (2005) 1.40
IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). Endocr Relat Cancer (2006) 1.39
Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study. Br J Cancer (2006) 1.34
IGF1 genotype, mean plasma level and breast cancer risk in the Hawaii/Los Angeles multiethnic cohort. Br J Cancer (2003) 1.27
Insulin-like growth factor binding proteins in the human circulation: a review. Horm Res (1994) 1.23
Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies. Cancer Res (2006) 1.16
Common genetic variation in the IGF-1 gene, serum IGF-I levels and breast density. Breast Cancer Res Treat (2007) 1.16
Haplotype-based association studies of IGFBP1 and IGFBP3 with prostate and breast cancer risk: the multiethnic cohort. Cancer Epidemiol Biomarkers Prev (2006) 1.14
Polymorphic variation at the -202 locus in IGFBP3: Influence on serum levels of insulin-like growth factors, interaction with plasma retinol and vitamin D and breast cancer risk. Int J Cancer (2003) 1.10
Genetic variation in IGF1, IGFBP3, IRS1, IRS2 and risk of breast cancer in women living in Southwestern United States. Breast Cancer Res Treat (2006) 1.07
Implications for prostate cancer of insulin-like growth factor-I (IGF-I) genetic variation and circulating IGF-I levels. J Clin Endocrinol Metab (2007) 1.06
IGF and insulin action in the mammary gland: lessons from transgenic and knockout models. J Mammary Gland Biol Neoplasia (2000) 1.03
Igf-I genetic variation and breast cancer: the multiethnic cohort. Cancer Epidemiol Biomarkers Prev (2006) 0.97
Introduction: IGFs and IGFBPs in the normal mammary gland and in breast cancer. J Mammary Gland Biol Neoplasia (2000) 0.91
Polymorphisms in the IGF-1 and IGFBP 3 promoter and the risk of breast cancer. Breast Cancer Res Treat (2005) 0.86
Cancer statistics, 2008. CA Cancer J Clin (2008) 86.74
Cancer statistics, 2009. CA Cancer J Clin (2009) 83.57
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Cancer statistics, 2007. CA Cancer J Clin (2007) 53.49
Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med (2011) 38.61
Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med (2003) 35.39
Cancer statistics, 2006. CA Cancer J Clin (2006) 30.71
Mortality results from a randomized prostate-cancer screening trial. N Engl J Med (2009) 30.05
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. JAMA (2002) 28.72
Cancer statistics, 2005. CA Cancer J Clin (2005) 25.65
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst (2004) 19.00
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer (2004) 16.69
Assessing the impact of population stratification on genetic association studies. Nat Genet (2004) 16.28
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Replicating genotype-phenotype associations. Nature (2007) 16.11
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Cancer statistics, 2004. CA Cancer J Clin (2004) 15.72
Multiple regions within 8q24 independently affect risk for prostate cancer. Nat Genet (2007) 14.37
Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet (2009) 13.64
Cancer statistics, 2003. CA Cancer J Clin (2003) 13.46
Body-mass index and mortality among 1.46 million white adults. N Engl J Med (2010) 13.34
Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation (2003) 12.78
Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med (2007) 12.55
The decrease in breast-cancer incidence in 2003 in the United States. N Engl J Med (2007) 12.23
Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med (2003) 11.58
Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med (2012) 11.48
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet (2007) 10.81
Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc Natl Acad Sci U S A (2006) 10.32
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA (2011) 9.13
Spatial analysis of air pollution and mortality in Los Angeles. Epidemiology (2005) 8.64
Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med (2008) 8.40
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24