Published in EMBO Rep on July 04, 2008
VE-cadherin: at the front, center, and sides of endothelial cell organization and function. Curr Opin Cell Biol (2010) 1.49
Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos. PLoS One (2009) 1.28
Organization and signaling of endothelial cell-to-cell junctions in various regions of the blood and lymphatic vascular trees. Cell Tissue Res (2008) 1.26
Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats. BMC Neurol (2010) 0.97
Role of TGF-β and the tumor microenvironment during mammary tumorigenesis. Gene Expr (2011) 0.97
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock. Nat Commun (2015) 0.94
Reverse genetics screen in zebrafish identifies a role of miR-142a-3p in vascular development and integrity. PLoS One (2012) 0.91
Microbial induction of vascular pathology in the CNS. J Neuroimmune Pharmacol (2010) 0.86
Endothelial cell-to-cell junctions: adhesion and signaling in physiology and pathology. Cold Spring Harb Perspect Med (2012) 0.85
Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1. J Cell Mol Med (2015) 0.80
Resolvin D1 via prevention of ROS-mediated SHP2 inactivation protects endothelial adherens junction integrity and barrier function. Redox Biol (2017) 0.75
Convergence of Wnt, beta-catenin, and cadherin pathways. Science (2004) 13.13
Deconstructing the cadherin-catenin-actin complex. Cell (2005) 8.39
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell (1999) 7.33
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol (2003) 5.74
Endothelial cell-cell junctions: happy together. Nat Rev Mol Cell Biol (2004) 5.37
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Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta (2007) 4.74
Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell (2000) 4.69
Endothelial-pericyte interactions in angiogenesis. Cell Tissue Res (2003) 4.39
Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev (2004) 4.12
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol (2006) 3.95
A novel endothelial-specific membrane protein is a marker of cell-cell contacts. J Cell Biol (1992) 3.85
Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev (2005) 3.79
Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol (1999) 3.78
Developmental defects in mouse embryos lacking N-cadherin. Dev Biol (1997) 3.39
Inhibition of RhoA by p120 catenin. Nat Cell Biol (2000) 3.33
Occludin as a possible determinant of tight junction permeability in endothelial cells. J Cell Sci (1997) 2.97
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol (2003) 2.92
VE-cadherin: the major endothelial adhesion molecule controlling cellular junctions and blood vessel formation. Arterioscler Thromb Vasc Biol (2007) 2.91
The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol (2003) 2.77
Claudins in occluding junctions of humans and flies. Trends Cell Biol (2006) 2.73
The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol (2007) 2.69
Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol (2004) 2.57
Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction. J Clin Invest (2004) 2.48
p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin. Mol Biol Cell (2005) 2.37
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart. J Cell Biol (1996) 2.27
Re-solving the cadherin-catenin-actin conundrum. J Biol Chem (2006) 2.19
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development (2001) 2.19
Differential localization of VE- and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J Cell Biol (1998) 2.08
Role of vascular endothelial-cadherin in vascular morphogenesis. Development (1999) 2.06
Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol (2001) 2.06
VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J (2002) 2.05
Embryonic heart and skin defects in mice lacking plakoglobin. Dev Biol (1996) 2.01
p120-catenin: Past and present. Biochim Biophys Acta (2006) 1.98
Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature (2004) 1.88
Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis. Biochim Biophys Acta (2007) 1.87
Targeted null-mutation in the vascular endothelial-cadherin gene impairs the organization of vascular-like structures in embryoid bodies. Proc Natl Acad Sci U S A (1997) 1.84
VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly. Blood (2004) 1.81
ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med (2006) 1.75
Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts. J Exp Med (2006) 1.67
Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell (2008) 1.63
Rescuing desmoplakin function in extra-embryonic ectoderm reveals the importance of this protein in embryonic heart, neuroepithelium, skin and vasculature. Development (2001) 1.60
Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. Oncogene (1999) 1.54
Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Mol Cell Biol (2008) 1.52
Vascular endothelial cell-specific phosphotyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood (2006) 1.50
N-cadherin acts upstream of VE-cadherin in controlling vascular morphogenesis. J Cell Biol (2005) 1.49
N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken. Dev Dyn (2000) 1.48
Extrajunctional distribution of N-cadherin in cultured human endothelial cells. J Cell Sci (1992) 1.48
Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice. J Clin Invest (2004) 1.47
Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A (2007) 1.45
Frodo links Dishevelled to the p120-catenin/Kaiso pathway: distinct catenin subfamilies promote Wnt signals. Dev Cell (2006) 1.30
A mutant receptor tyrosine phosphatase, CD148, causes defects in vascular development. Mol Cell Biol (2003) 1.27
Rescuing the N-cadherin knockout by cardiac-specific expression of N- or E-cadherin. Development (2001) 1.27
Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth. Cancer Res (2005) 1.23
Identification and cloning of two species of cadherins in bovine endothelial cells. EMBO J (1990) 1.23
The head domain of plakophilin-1 binds to desmoplakin and enhances its recruitment to desmosomes. Implications for cutaneous disease. J Biol Chem (1999) 1.21
Fibroblast growth factor-2 failed to induce angiogenesis in junctional adhesion molecule-A-deficient mice. Arterioscler Thromb Vasc Biol (2006) 1.19
Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem (2003) 1.11
Receptor protein tyrosine phosphatase micro regulates the paracellular pathway in human lung microvascular endothelia. Am J Pathol (2005) 1.10
N-cadherin deficiency impairs pericyte recruitment, and not endothelial differentiation or sprouting, in embryonic stem cell-derived angiogenesis. Exp Cell Res (2005) 1.02
A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis. Blood (2006) 1.01
Desmoplakin expression and organization at human umbilical vein endothelial cell-to-cell junctions. J Cell Sci (1996) 1.00
Receptor protein tyrosine phosphatase mu expression as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Int J Dev Biol (2003) 0.97
Receptor-type protein-tyrosine phosphatase mu is expressed in specific vascular endothelial beds in vivo. Exp Cell Res (1999) 0.95
The complexus adhaerens of mammalian lymphatic endothelia revisited: a junction even more complex than hitherto thought. Cell Tissue Res (2005) 0.88
Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-mu-deficient mice. Am J Physiol Heart Circ Physiol (2005) 0.87
Intramolecular interactions between the juxtamembrane domain and phosphatase domains of receptor protein-tyrosine phosphatase RPTPmu. Regulation of catalytic activity. J Biol Chem (2000) 0.85
Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell (2008) 4.17
Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev (2004) 4.12
Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med (2007) 4.10
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol (2006) 3.95
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev (2003) 3.48
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol (2008) 3.15
The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell (2009) 3.08
Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. J Cell Biol (2003) 2.92
Sox18 induces development of the lymphatic vasculature in mice. Nature (2008) 2.91
The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility. J Cell Biol (2003) 2.77
EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature (2013) 2.70
The role of junctional adhesion molecules in vascular inflammation. Nat Rev Immunol (2007) 2.69
Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol (2004) 2.57
Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. FEBS Lett (2005) 2.45
p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin. Mol Biol Cell (2005) 2.37
Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood (2009) 2.10
VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells. Proc Natl Acad Sci U S A (2002) 2.08
The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling. Dev Cell (2010) 2.01
Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin. Blood (2008) 2.00
VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell (2002) 1.97
VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly. Blood (2004) 1.81
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun (2012) 1.78
Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration. J Cell Sci (2008) 1.74
VE-cadherin and endothelial adherens junctions: active guardians of vascular integrity. Dev Cell (2013) 1.73
CCM1 regulates vascular-lumen organization by inducing endothelial polarity. J Cell Sci (2010) 1.68
Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol (2007) 1.64
Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease. Gastroenterology (2008) 1.62
Sox18 and Sox7 play redundant roles in vascular development. Blood (2007) 1.60
Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells. J Exp Med (2005) 1.56
Adhesion molecule signalling: not always a sticky business. Nat Rev Mol Cell Biol (2011) 1.55
Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway. J Biol Chem (2005) 1.47
JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood (2007) 1.47
Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice. J Clin Invest (2004) 1.47
Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability. Cancer Res (2002) 1.45
A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability. Blood (2002) 1.45
The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues. J Leukoc Biol (2006) 1.42
Endothelial cell migration directs testis cord formation. Dev Biol (2008) 1.35
The multiple languages of endothelial cell-to-cell communication. Arterioscler Thromb Vasc Biol (2006) 1.33
Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2005) 1.33
VE-Cadherin-mediated cell-cell interaction suppresses sprouting via signaling to MLC2 phosphorylation. Curr Biol (2009) 1.29
cAMP response element-binding protein regulates differentiation and survival of newborn neurons in the olfactory bulb. J Neurosci (2005) 1.29
Stable vascular connections and remodeling require full expression of VE-cadherin in zebrafish embryos. PLoS One (2009) 1.28
Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice. J Exp Med (2011) 1.25
Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis. Blood (2003) 1.23
Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke. Dis Model Mech (2008) 1.23
VE-cadherin is a critical endothelial regulator of TGF-beta signalling. EMBO J (2008) 1.22
Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy. Circulation (2006) 1.20
Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization. J Clin Invest (2014) 1.20
Endothelial cadherins and tumor angiogenesis. Exp Cell Res (2005) 1.18
Vascular endothelial-cadherin and vascular stability. Curr Opin Hematol (2012) 1.15
Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling. Arterioscler Thromb Vasc Biol (2002) 1.14
Sox7 and Sox17 are strain-specific modifiers of the lymphangiogenic defects caused by Sox18 dysfunction in mice. Development (2009) 1.13
VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation. Nat Commun (2013) 1.13
Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun (2013) 1.12
JAM-A promotes neutrophil chemotaxis by controlling integrin internalization and recycling. J Cell Sci (2009) 1.12
Mesoangioblasts, vessel-associated multipotent stem cells, repair the infarcted heart by multiple cellular mechanisms: a comparison with bone marrow progenitors, fibroblasts, and endothelial cells. Arterioscler Thromb Vasc Biol (2005) 1.10
Adherens junctions in endothelial cells regulate vessel maintenance and angiogenesis. Thromb Res (2007) 1.09
Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function. J Cell Biol (2014) 1.07
Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. J Neurosci (2007) 1.07
Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration. Blood (2005) 1.04
VE-cadherin expression and clustering maintain low levels of survivin in endothelial cells. Am J Pathol (2004) 1.03
Expression of junctional adhesion molecule-A prevents spontaneous and random motility. J Cell Sci (2005) 1.02
Generation and characterization of a mouse lymphatic endothelial cell line. Cell Tissue Res (2006) 1.02
The transcellular railway: insights into leukocyte diapedesis. Nat Cell Biol (2006) 1.01
Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo. J Cell Sci (2004) 1.01
Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications. Thromb Haemost (2005) 0.99
Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS One (2013) 0.98
Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis. Circulation (2013) 0.94
Overlapping and divergent signaling pathways of N-cadherin and VE-cadherin in endothelial cells. Blood (2012) 0.94
Importance of junctional adhesion molecule-A for neointimal lesion formation and infiltration in atherosclerosis-prone mice. Arterioscler Thromb Vasc Biol (2005) 0.93
Adherens junctions. Curr Biol (2008) 0.91
The molecular basis of the blood brain barrier differentiation and maintenance. Is it still a mystery? Pharmacol Res (2010) 0.91
Hepatocyte-conditioned medium sustains endothelial differentiation of human hematopoietic-endothelial progenitors. Hepatology (2007) 0.89
ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migration. J Biol Chem (2004) 0.88
Role of synectin in lymphatic development in zebrafish and frogs. Blood (2010) 0.88
Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure. J Card Fail (2007) 0.88
Abrogation of junctional adhesion molecule-A expression induces cell apoptosis and reduces breast cancer progression. PLoS One (2011) 0.86
Accelerated endothelial wound healing on microstructured substrates under flow. Biomaterials (2012) 0.86
VE-cadherin at a glance. Cell Tissue Res (2014) 0.84
The control of endothelial cell functions by adherens junctions. Novartis Found Symp (2007) 0.84
Inactivation of junctional adhesion molecule-A enhances antitumoral immune response by promoting dendritic cell and T lymphocyte infiltration. Cancer Res (2010) 0.84
Skeletal myogenic progenitors in the endothelium of lung and yolk sac. Exp Cell Res (2003) 0.83
Transcriptional regulation of arterial differentiation via Wnt, Sox and Notch. Curr Opin Hematol (2014) 0.82
Targeting endothelial junctional adhesion molecule-A/ EPAC/ Rap-1 axis as a novel strategy to increase stem cell engraftment in dystrophic muscles. EMBO Mol Med (2013) 0.81
Ve-ptp modulates vascular integrity by promoting adherens junction maturation. PLoS One (2012) 0.80
Opposite effects of tumor necrosis factor and soluble fibronectin on junctional adhesion molecule-A in endothelial cells. Am J Physiol Lung Cell Mol Physiol (2005) 0.80
Vascular endothelial cadherin modulates renal interstitial fibrosis. Nephron Exp Nephrol (2011) 0.79
New insights in the control of vascular permeability: vascular endothelial-cadherin and other players. Curr Opin Hematol (2015) 0.78
Levels of circulating pro-angiogenic cells predict cardiovascular outcomes in patients with chronic heart failure. J Card Fail (2009) 0.77
Keratinocyte junctions and the epidermal barrier: how to make a skin-tight dress. J Cell Biol (2002) 0.76
Corrigendum: Vascular Endothelial (VE)-Cadherin, Endothelial Adherens Junctions, and Vascular Disease. Cold Spring Harb Perspect Biol (2017) 0.75