Published in Proc Natl Acad Sci U S A on April 12, 2010
Regulators of G-protein signaling and their Gα substrates: promises and challenges in their use as drug discovery targets. Pharmacol Rev (2011) 1.98
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes. Cell Metab (2016) 1.96
Design and functional characterization of a novel, arrestin-biased designer G protein-coupled receptor. Mol Pharmacol (2012) 1.16
Chronic activation of a designer G(q)-coupled receptor improves β cell function. J Clin Invest (2013) 1.13
Amino-terminal cysteine residues differentially influence RGS4 protein plasma membrane targeting, intracellular trafficking, and function. J Biol Chem (2012) 0.93
RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents. J Physiol (2014) 0.91
Accelerated molecular dynamics simulations of ligand binding to a muscarinic G-protein-coupled receptor. Q Rev Biophys (2015) 0.89
RGS4 overexpression in the rat dorsal striatum modulates mGluR5- and amphetamine-mediated behavior and signaling. Psychopharmacology (Berl) (2011) 0.87
Muscarinic receptors as model targets and antitargets for structure-based ligand discovery. Mol Pharmacol (2013) 0.87
Allosteric effects of sodium ion binding on activation of the m3 muscarinic g-protein-coupled receptor. Biophys J (2015) 0.87
Spinophilin as a novel regulator of M3 muscarinic receptor-mediated insulin release in vitro and in vivo. FASEB J (2012) 0.85
Novel insights into the function of β-cell M3 muscarinic acetylcholine receptors: therapeutic implications. Trends Endocrinol Metab (2010) 0.84
G protein-coupled receptor signaling and sphingosine-1-phosphate play a phylogenetically conserved role in endocrine pancreas morphogenesis. Mol Cell Biol (2011) 0.83
Role of regulators of g-protein signaling 4 in ca signaling in mouse pancreatic acinar cells. Korean J Physiol Pharmacol (2011) 0.83
Rab family proteins regulate the endosomal trafficking and function of RGS4. J Biol Chem (2013) 0.82
Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node. Front Physiol (2012) 0.80
Employing novel animal models in the design of clinically efficacious GPCR ligands. Curr Opin Cell Biol (2013) 0.79
Minireview: Novel aspects of M3 muscarinic receptor signaling in pancreatic β-cells. Mol Endocrinol (2013) 0.78
CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo. Proc Natl Acad Sci U S A (2015) 0.78
Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors. Life Sci (2012) 0.78
The regulator of G-protein signaling RGS16 promotes insulin secretion and β-cell proliferation in rodent and human islets. Mol Metab (2016) 0.78
The role of M(3)-muscarinic receptor signaling in insulin secretion. Commun Integr Biol (2011) 0.77
Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol (2015) 0.77
Muscarinic control of MIN6 pancreatic β cells is enhanced by impaired amino acid signaling. J Biol Chem (2014) 0.76
Transcriptome analysis of pancreatic cells across distant species highlights novel important regulator genes. BMC Biol (2017) 0.75
β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions. Nat Commun (2017) 0.75
Unique Aspects of Cryptochrome in Chronobiology and Metabolism, Pancreatic β-Cell Dysfunction, and Regeneration: Research into Cysteine414-Alanine Mutant CRY1. J Diabetes Res (2016) 0.75
Regulator of G protein signaling Gβ5-R7 is a crucial activator of muscarinic M3 receptor-stimulated insulin secretion. FASEB J (2017) 0.75
Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50
Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem (1999) 10.14
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes. Diabetologia (2003) 7.88
Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40. Nature (2003) 6.87
GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins. Annu Rev Biochem (2000) 5.84
Cellular regulation of RGS proteins: modulators and integrators of G protein signaling. Pharmacol Rev (2002) 3.82
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov (2009) 3.26
Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function. Endocr Rev (2001) 2.92
New drug targets for type 2 diabetes and the metabolic syndrome. Nature (2001) 2.92
A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab (2006) 2.82
Molecular biology of muscarinic acetylcholine receptors. Crit Rev Neurobiol (1996) 2.71
Regulators of G-protein signalling as new central nervous system drug targets. Nat Rev Drug Discov (2002) 2.47
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets. Diabetologia (1993) 2.11
Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. Trends Pharmacol Sci (2008) 2.03
The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol (2009) 1.74
RGS proteins have a signalling complex: interactions between RGS proteins and GPCRs, effectors, and auxiliary proteins. Cell Signal (2005) 1.69
Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation. J Biol Chem (2007) 1.65
Quantitative real-time polymerase chain reaction measurement of regulators of G-protein signaling mRNA levels in mouse tissues. Methods Enzymol (2004) 1.63
R4 RGS proteins: regulation of G-protein signaling and beyond. Pharmacol Ther (2007) 1.63
RGS4 regulates parasympathetic signaling and heart rate control in the sinoatrial node. Circ Res (2008) 1.61
M3 muscarinic acetylcholine receptor-mediated signaling is regulated by distinct mechanisms. Mol Pharmacol (2008) 1.58
RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nat Neurosci (2006) 1.58
RGS proteins determine signaling specificity of Gq-coupled receptors. J Biol Chem (1999) 1.45
Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes (2004) 1.44
Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. Cancer Res (2009) 1.39
Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4). Biol Psychiatry (2006) 1.34
Differentially regulated expression of endogenous RGS4 and RGS7. J Biol Chem (2003) 1.25
A role of RGS proteins in drug addiction. Biochem Pharmacol (2007) 1.16
Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling. Semin Cell Dev Biol (2006) 1.10
The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7. Biochemistry (2009) 1.09
Regional expression of RGS4 mRNA in human brain. Eur J Neurosci (2004) 1.01
Effects of muscarinic receptor type 3 knockout on mouse islet secretory responses. Biochem Biophys Res Commun (2004) 0.99
Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. I. Cerebral cortex. Neuroscience (2006) 0.89
RGS4 controls renal blood flow and inhibits cyclosporine-mediated nephrotoxicity. Am J Transplant (2009) 0.88
Muscarinic stimulation and antagonism and glucoregulation in nondiabetic and obese hyperglycemic mice. Diabetes (1989) 0.87
Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis. Endocrinology (2008) 0.86
Bacterial artificial chromosome transgenic analysis of dynamic expression patterns of regulator of G-protein signaling 4 during development. II. Subcortical regions. Neuroscience (2006) 0.80
p53 regulates mitochondrial respiration. Science (2006) 9.06
Autism spectrum disorders: developmental disconnection syndromes. Curr Opin Neurobiol (2007) 6.96
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Nat Rev Drug Discov (2007) 4.83
Schizophrenia as a disorder of neurodevelopment. Annu Rev Neurosci (2002) 4.36
Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature (2012) 3.83
A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci U S A (2006) 3.55
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes. J Clin Invest (2003) 3.09
Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nat Med (2011) 3.06
Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol Dis (2008) 2.88
A critical role for beta cell M3 muscarinic acetylcholine receptors in regulating insulin release and blood glucose homeostasis in vivo. Cell Metab (2006) 2.82
Hypertrophy and/or Hyperplasia: Dynamics of Adipose Tissue Growth. PLoS Comput Biol (2009) 2.81
Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab (2011) 2.73
A transient placental source of serotonin for the fetal forebrain. Nature (2011) 2.71
Serotonin modulates the response of embryonic thalamocortical axons to netrin-1. Nat Neurosci (2007) 2.70
The conundrums of understanding genetic risks for autism spectrum disorders. Nat Neurosci (2011) 2.61
Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A (2004) 2.54
Activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature (2013) 2.49
Evaluation, diagnosis, and treatment of gastrointestinal disorders in individuals with ASDs: a consensus report. Pediatrics (2010) 2.45
Prenatal exposure to drugs: effects on brain development and implications for policy and education. Nat Rev Neurosci (2009) 2.33
Engineering GPCR signaling pathways with RASSLs. Nat Methods (2008) 2.29
Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology (2004) 2.22
Genetic disruption of cortical interneuron development causes region- and GABA cell type-specific deficits, epilepsy, and behavioral dysfunction. J Neurosci (2003) 2.18
Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry (2007) 2.12
Disruption of cerebral cortex MET signaling in autism spectrum disorder. Ann Neurol (2007) 2.02
Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One (2009) 1.98
Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. Cell Metab (2009) 1.98
Quantitative photo activated localization microscopy: unraveling the effects of photoblinking. PLoS One (2011) 1.95
A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci U S A (2009) 1.90
How the timing and quality of early experiences influence the development of brain architecture. Child Dev (2010) 1.87
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice. J Biol Chem (2010) 1.86
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol (2007) 1.83
Identification of clustering artifacts in photoactivated localization microscopy. Nat Methods (2011) 1.80
Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest (2011) 1.80
Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis. Cell Metab (2009) 1.80
Gene expression profiling reveals alterations of specific metabolic pathways in schizophrenia. J Neurosci (2002) 1.79
Conditional disruption of IkappaB kinase 2 fails to prevent obesity-induced insulin resistance. J Clin Invest (2004) 1.79
Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration. Hepatology (2007) 1.77
Early experience modifies the postnatal assembly of autonomic emotional motor circuits in rats. J Neurosci (2005) 1.76
Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochem Res (2003) 1.75
The organization of the transcriptional network in specific neuronal classes. Mol Syst Biol (2009) 1.74
Recombinant human insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus. Endocrinology (2006) 1.71
Muscarinic induction of hippocampal gamma oscillations requires coupling of the M1 receptor to two mixed cation currents. Neuron (2002) 1.71
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency. J Clin Invest (2005) 1.70
Association and linkage analyses of RGS4 polymorphisms in schizophrenia. Hum Mol Genet (2002) 1.68
Critical appraisal of DNA microarrays in psychiatric genomics. Biol Psychiatry (2006) 1.66
Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation. J Biol Chem (2007) 1.65
Xanthine oxidoreductase is a regulator of adipogenesis and PPARgamma activity. Cell Metab (2007) 1.63
A novel experimental strategy to assess the metabolic effects of selective activation of a G(q)-coupled receptor in hepatocytes in vivo. Endocrinology (2013) 1.62
Small-molecule agonists for the thyrotropin receptor stimulate thyroid function in human thyrocytes and mice. Proc Natl Acad Sci U S A (2009) 1.61
Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder. Autism Res (2008) 1.61
Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling. Nature (2009) 1.59
Alternative Gnas gene products have opposite effects on glucose and lipid metabolism. Proc Natl Acad Sci U S A (2005) 1.59
RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion. Nat Neurosci (2006) 1.58
Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression. Cell Rep (2013) 1.56
Disruption of hypoxia-inducible factor 1 in adipocytes improves insulin sensitivity and decreases adiposity in high-fat diet-fed mice. Diabetes (2011) 1.56
Gastrointestinal dysfunction in autism: parental report, clinical evaluation, and associated factors. Autism Res (2012) 1.55
M2 muscarinic acetylcholine receptor knock-out mice show deficits in behavioral flexibility, working memory, and hippocampal plasticity. J Neurosci (2004) 1.53
Characterization of central inhibitory muscarinic autoreceptors by the use of muscarinic acetylcholine receptor knock-out mice. J Neurosci (2002) 1.53
Reduced cocaine self-administration in muscarinic M5 acetylcholine receptor-deficient mice. J Neurosci (2005) 1.52
Persistent diet-induced obesity in male C57BL/6 mice resulting from temporary obesigenic diets. PLoS One (2009) 1.48
Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum. J Neurosci (2010) 1.47
Suitability of muscarinic acetylcholine receptor antibodies for immunohistochemistry evaluated on tissue sections of receptor gene-deficient mice. Naunyn Schmiedebergs Arch Pharmacol (2008) 1.47
Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice. J Neurosci (2002) 1.47
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B-null mice. J Clin Invest (2006) 1.44
Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism. Neuron (2005) 1.44
Muscarinic stimulation of pancreatic insulin and glucagon release is abolished in m3 muscarinic acetylcholine receptor-deficient mice. Diabetes (2004) 1.44
Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur J Neurosci (2003) 1.41
Role of muscarinic receptor subtypes in the constriction of peripheral airways: studies on receptor-deficient mice. Mol Pharmacol (2003) 1.40
Wnt signaling regulates hepatic metabolism. Sci Signal (2011) 1.38
Distinct genetic risk based on association of MET in families with co-occurring autism and gastrointestinal conditions. Pediatrics (2009) 1.37
Amygdala gene expression correlates of social behavior in monkeys experiencing maternal separation. J Neurosci (2007) 1.35
Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle. Proc Natl Acad Sci U S A (2009) 1.33
Single-neuron RNA-Seq: technical feasibility and reproducibility. Front Genet (2012) 1.32
Autism-associated promoter variant in MET impacts functional and structural brain networks. Neuron (2012) 1.29
Leptin improves insulin resistance and hyperglycemia in a mouse model of type 2 diabetes. Endocrinology (2005) 1.29
Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res (2008) 1.29
Expression of muscarinic and nicotinic acetylcholine receptors in the mouse urothelium. Life Sci (2007) 1.29
The alternative stimulatory G protein alpha-subunit XLalphas is a critical regulator of energy and glucose metabolism and sympathetic nerve activity in adult mice. J Biol Chem (2006) 1.27
Structural basis of G protein-coupled receptor-G protein interactions. Nat Chem Biol (2010) 1.27