Epigenetic mechanisms in drug addiction.

Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci (2011) 3.69

Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron (2009) 2.97

Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry (2010) 2.54

Reward processing by the opioid system in the brain. Physiol Rev (2009) 2.46

Epigenetic mechanisms in cognition. Neuron (2011) 2.31

Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Drug Alcohol Depend (2010) 2.10

A longitudinal study of epigenetic variation in twins. Epigenetics (2010) 2.06

Modulation of chromatin modification facilitates extinction of cocaine-induced conditioned place preference. Biol Psychiatry (2010) 1.98

Regulation of hippocampal H3 histone methylation by acute and chronic stress. Proc Natl Acad Sci U S A (2009) 1.72

Epigenetics in the nervous system. J Neurosci (2008) 1.65

Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. Ann N Y Acad Sci (2010) 1.64

Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdala. PLoS One (2011) 1.58

Neuroscience of behavioral and pharmacological treatments for addictions. Neuron (2011) 1.57

The epigenetic landscape of addiction. Ann N Y Acad Sci (2011) 1.51

Chronic cocaine-induced H3 acetylation and transcriptional activation of CaMKIIalpha in the nucleus accumbens is critical for motivation for drug reinforcement. Neuropsychopharmacology (2009) 1.46

Epigenetic regulation of the neural transcriptome: the meaning of the marks. Nat Neurosci (2010) 1.44

Neuroscience of alcoholism: molecular and cellular mechanisms. Cell Mol Life Sci (2009) 1.32

The genetics of addiction-a translational perspective. Transl Psychiatry (2012) 1.30

The emerging field of neuroepigenetics. Neuron (2013) 1.28

Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: unraveling the genome to understand the mind. Neurobiol Dis (2010) 1.26

BK Channels: mediators and models for alcohol tolerance. Trends Neurosci (2009) 1.26

DNA methylation regulates cocaine-induced behavioral sensitization in mice. Neuropsychopharmacology (2010) 1.19

Epigenetic alterations in the lateral amygdala are required for reconsolidation of a Pavlovian fear memory. Learn Mem (2011) 1.19

Histone deacetylases (HDAC)-induced histone modifications in the amygdala: a role in rapid tolerance to the anxiolytic effects of ethanol. Alcohol Clin Exp Res (2011) 1.18

Escalating ethanol intake is associated with altered corticostriatal BDNF expression. J Neurochem (2009) 1.13

Aberrant histone deacetylase2-mediated histone modifications and synaptic plasticity in the amygdala predisposes to anxiety and alcoholism. Biol Psychiatry (2013) 1.12

Epigenetic modulation of Homer1a transcription regulation in amygdala and hippocampus with pavlovian fear conditioning. J Neurosci (2012) 1.12

CBP in the nucleus accumbens regulates cocaine-induced histone acetylation and is critical for cocaine-associated behaviors. J Neurosci (2011) 1.12

Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem (2011) 1.07

Breaking barriers in the genomics and pharmacogenetics of drug addiction. Clin Pharmacol Ther (2010) 1.05

Epigenetic treatments for cognitive impairments. Neuropsychopharmacology (2011) 1.05

The Effects of Maternal Separation on Adult Methamphetamine Self-Administration, Extinction, Reinstatement, and MeCP2 Immunoreactivity in the Nucleus Accumbens. Front Psychiatry (2013) 1.03

Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters. J Neurochem (2011) 1.02

Chromatin regulation in drug addiction and depression. Dialogues Clin Neurosci (2009) 1.01

Stress and addiction: a dynamic interplay of genes, environment, and drug intake. Biol Psychiatry (2009) 1.00

The genetics of behavioral alcohol responses in Drosophila. Int Rev Neurobiol (2010) 0.99

Effects of the kappa opioid receptor antagonist, norbinaltorphimine, on stress and drug-induced reinstatement of nicotine-conditioned place preference in mice. Psychopharmacology (Berl) (2012) 0.99

CRACKing the histone code: cocaine's effects on chromatin structure and function. Horm Behav (2010) 0.96

Long-lasting dysregulation of gene expression in corticostriatal circuits after repeated cocaine treatment in adult rats: effects on zif 268 and homer 1a. Eur J Neurosci (2009) 0.96

Essential role of SIRT1 signaling in the nucleus accumbens in cocaine and morphine action. J Neurosci (2013) 0.95

Alcohol-induced plasticity in the dynorphin/kappa-opioid receptor system. Front Mol Neurosci (2012) 0.95

Epigenetics across the human lifespan. Front Cell Dev Biol (2014) 0.93

Susceptibility of the adolescent brain to cannabinoids: long-term hippocampal effects and relevance to schizophrenia. Transl Psychiatry (2012) 0.92

How the epigenome contributes to the development of psychiatric disorders. Dev Psychobiol (2010) 0.92

Hormonal programming across the lifespan. Horm Metab Res (2012) 0.91

Epigenetic mechanisms in neurological and neurodegenerative diseases. Front Cell Neurosci (2015) 0.90

Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior. Mamm Genome (2009) 0.89

Positive and negative effects of alcohol and nicotine and their interactions: a mechanistic review. Neurotox Res (2011) 0.88

Neuroplasticity in addiction: cellular and transcriptional perspectives. Front Mol Neurosci (2012) 0.88

Development of novel pharmacotherapeutics for tobacco dependence: progress and future directions. Nicotine Tob Res (2012) 0.88

Mechanisms of transgenerational inheritance of addictive-like behaviors. Neuroscience (2013) 0.88

Effects of histone deacetylase inhibitors on amygdaloid histone acetylation and neuropeptide Y expression: a role in anxiety-like and alcohol-drinking behaviours. Int J Neuropsychopharmacol (2014) 0.87

Sodium butyrate-induced histone acetylation strengthens the expression of cocaine-associated contextual memory. Neurobiol Learn Mem (2013) 0.87

Circadian rhythms and addiction: mechanistic insights and future directions. Behav Neurosci (2014) 0.87

Epigenetics and psychostimulant addiction. Cold Spring Harb Perspect Med (2013) 0.86

Hyposensitivity to gamma-aminobutyric acid in the ventral tegmental area during alcohol withdrawal: reversal by histone deacetylase inhibitors. Neuropsychopharmacology (2013) 0.85

How Preclinical Models Evolved to Resemble the Diagnostic Criteria of Drug Addiction. Biol Psychiatry (2015) 0.84

Inhibition of GSK3 attenuates amphetamine-induced hyperactivity and sensitization in the mouse. Behav Brain Res (2012) 0.83

Addiction-related gene regulation: risks of exposure to cognitive enhancers vs. other psychostimulants. Prog Neurobiol (2012) 0.83

Reversible histone methylation regulates brain gene expression and behavior. Horm Behav (2010) 0.83

The inhibition of histone deacetylases reduces the reinstatement of cocaine-seeking behavior in rats. Curr Neuropharmacol (2011) 0.82

Stress, epigenetics, and alcoholism. Alcohol Res (2012) 0.82

Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry. J Genet Syndr Gene Ther (2012) 0.81

Redox-based epigenetic status in drug addiction: a potential contributor to gene priming and a mechanistic rationale for metabolic intervention. Front Neurosci (2015) 0.80

Chronic co-administration of nicotine and methamphetamine causes differential expression of immediate early genes in the dorsal striatum and nucleus accumbens of rats. Neuroscience (2013) 0.79

Selective serotonin re-uptake inhibitors potentiate gene blunting induced by repeated methylphenidate treatment: Zif268 versus Homer1a. Addict Biol (2013) 0.79

DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders. Sci Rep (2016) 0.79

Life-long consequences of juvenile exposure to psychotropic drugs on brain and behavior. Prog Brain Res (2014) 0.78

Molecular basis of alcoholism. Handb Clin Neurol (2014) 0.78

Emerging roles of epigenetic mechanisms in Parkinson's disease. Funct Integr Genomics (2011) 0.78

Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior. Pharmacol Rev (2016) 0.78

Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner? Mol Neurobiol (2015) 0.78

The effects of cocaine on HIV transcription. J Neurovirol (2015) 0.78

Ongoing Response in BRAF V600E-Mutant Melanoma After Cessation of Intermittent Vemurafenib Therapy: A Case Report. Target Oncol (2016) 0.77

CNS genes implicated in relapse. Subst Abuse (2008) 0.77

Cannabis controversies: how genetics can inform the study of comorbidity. Addiction (2014) 0.77

Prolonged Induction of miR-212/132 and REST Expression in Rat Striatum Following Cocaine Self-Administration. Mol Neurobiol (2016) 0.77

Early-life stress interactions with the epigenome: potential mechanisms driving vulnerability toward psychiatric illness. Behav Pharmacol (2014) 0.77

BRG1 in the Nucleus Accumbens Regulates Cocaine-Seeking Behavior. Biol Psychiatry (2016) 0.77

Cocaine triggers epigenetic alterations in the corticostriatal circuit. Brain Res (2014) 0.77

New approaches to manipulating the epigenome. Dialogues Clin Neurosci (2014) 0.77

The emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neurons. Int J Mol Sci (2014) 0.77

Glucocorticoids regulation of FosB/ΔFosB expression induced by chronic opiate exposure in the brain stress system. PLoS One (2012) 0.77

Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction. Int Rev Neurobiol (2015) 0.77

A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood. Brain Struct Funct (2016) 0.76

Current perspectives on the neurobiology of drug addiction: a focus on genetics and factors regulating gene expression. ISRN Neurol (2012) 0.76

Epigenetic mechanisms and therapeutic perspectives for neurodevelopmental disorders. Pharmaceuticals (Basel) (2012) 0.76

Synergistic interactions between histone deacetylase inhibitors and drugs of abuse. Neuropsychopharmacology (2009) 0.76

Histone acetylation in the nucleus accumbens shell modulates ethanol-induced locomotor activity in DBA/2J mice. Alcohol Clin Exp Res (2014) 0.76

Neurogenetic and epigenetic correlates of adolescent predisposition to and risk for addictive behaviors as a function of prefrontal cortex dysregulation. J Child Adolesc Psychopharmacol (2015) 0.76

HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling. Sci Rep (2016) 0.75

The transgenerational inheritance of autism-like phenotypes in mice exposed to valproic acid during pregnancy. Sci Rep (2016) 0.75

Making Sense of Epigenetics. Int J Neuropsychopharmacol (2016) 0.75

Cytogenetic risks and possible adverse health effects by narcotic substances dependent. Int J Prev Med (2012) 0.75

The Epigenetic Mechanisms of Amphetamine. J Addict Prev (2015) 0.75

Detection of epigenetic changes using ANOVA with spatially varying coefficients. Stat Appl Genet Mol Biol (2013) 0.75

Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes. Psychoneuroendocrinology (2011) 0.75

Histone acetylation of the htr3a gene in the prefrontal cortex of Wistar rats regulates ethanol-seeking behavior. Neural Regen Res (2012) 0.75

Transcranial direct current stimulation produces long-lasting attenuation of cocaine-induced behavioral responses and gene regulation in corticostriatal circuits. Addict Biol (2016) 0.75

Potentiated gene regulation by methylphenidate plus fluoxetine treatment: Long-term gene blunting (Zif268, Homer1a) and behavioral correlates. Basal Ganglia (2014) 0.75

Chromatin modifications and their function. Cell (2007) 55.98

The language of covalent histone modifications. Nature (2000) 44.92

The role of chromatin during transcription. Cell (2007) 26.48

Epigenetic programming by maternal behavior. Nat Neurosci (2004) 20.92

Genome-wide map of nucleosome acetylation and methylation in yeast. Cell (2005) 15.08

Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci (2006) 12.37

Genome regulation by polycomb and trithorax proteins. Cell (2007) 11.96

Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol (2001) 10.69

Phenotypic plasticity and the epigenetics of human disease. Nature (2007) 10.37

Controlling the double helix. Nature (2003) 8.61

Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev (2006) 8.48

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci (2006) 8.24

Heterochromatin and epigenetic control of gene expression. Science (2003) 7.12

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell (2002) 7.10

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90

Recovery of learning and memory is associated with chromatin remodelling. Nature (2007) 6.72

Covalent modification of DNA regulates memory formation. Neuron (2007) 6.20

Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci (2007) 6.00

Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem (2004) 5.99

Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell (2005) 5.96

Mapping global histone acetylation patterns to gene expression. Cell (2004) 5.57

Circadian regulator CLOCK is a histone acetyltransferase. Cell (2006) 5.24

Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19

Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron (2005) 5.09

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96

Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci (2003) 4.60

Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry (2007) 4.37

Expression of the transcription factor deltaFosB in the brain controls sensitivity to cocaine. Nature (1999) 4.29

Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol (2004) 4.24

Regulation of cocaine reward by CREB. Science (1998) 4.07

Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission. Neuron (2005) 3.75

Dynamic BDNF activity in nucleus accumbens with cocaine use increases self-administration and relapse. Nat Neurosci (2007) 3.44

Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving. J Neurosci (2003) 3.30

DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PLoS One (2007) 3.30

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol (2006) 3.15

Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature (2001) 3.09

Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biol Psychiatry (2006) 3.00

The histone tails of the nucleosome. Curr Opin Genet Dev (1998) 2.94

Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. Neuron (2004) 2.76

DeltaFosB: a molecular switch for long-term adaptation in the brain. Brain Res Mol Brain Res (2004) 2.67

Induction of a long-lasting AP-1 complex composed of altered Fos-like proteins in brain by chronic cocaine and other chronic treatments. Neuron (1994) 2.61

Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking. Neuron (2004) 2.57

Maternal care as a model for experience-dependent chromatin plasticity? Trends Neurosci (2005) 2.53

A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal. J Neurosci (2004) 2.47

Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci (2008) 2.34

Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci (2004) 2.30

CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum. Proc Natl Acad Sci U S A (2005) 2.28

Brain chromatin remodeling: a novel mechanism of alcoholism. J Neurosci (2008) 2.27

Neuronal activity-dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5. J Neurochem (2003) 2.20

A phosphatase cascade by which rewarding stimuli control nucleosomal response. Nature (2008) 2.10

Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice. J Neurosci (2005) 2.01

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. Nature (2000) 1.89

DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci (2007) 1.74

c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes. J Neurosci (2006) 1.55

Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes. Nucleic Acids Res (2006) 1.52

Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Synapse (2003) 1.50

Transgenic mice expressing an inhibitory truncated form of p300 exhibit long-term memory deficits. Learn Mem (2007) 1.48

Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. J Neurosci (2005) 1.43

Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. Neuropsychopharmacology (2007) 1.42

Drug-induced activation of dopamine D(1) receptor signaling and inhibition of class I/II histone deacetylase induce chromatin remodeling in reward circuitry and modulate cocaine-related behaviors. Neuropsychopharmacology (2008) 1.38

Dopamine D2-like antagonists induce chromatin remodeling in striatal neurons through cyclic AMP-protein kinase A and NMDA receptor signaling. J Neurochem (2004) 1.25

Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression. J Neurochem (2001) 1.24

Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci (2006) 1.22

Drug-induced epigenetic changes produce drug tolerance. PLoS Biol (2007) 1.18

Altered memory capacities and response to stress in p300/CBP-associated factor (PCAF) histone acetylase knockout mice. Neuropsychopharmacology (2007) 1.18

Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage. Eur J Neurosci (2006) 1.15

Histone deacetylase inhibitors modulates the induction and expression of amphetamine-induced behavioral sensitization partially through an associated learning of the environment in mice. Behav Brain Res (2007) 1.13

Heritable gene repression through the action of a directed DNA methyltransferase at a chromosomal locus. J Biol Chem (2008) 1.08

Glutamate induces histone H3 phosphorylation but not acetylation in striatal neurons: role of mitogen- and stress-activated kinase-1. J Neurochem (2007) 1.05

Neural mechanisms of addiction: the role of reward-related learning and memory. Annu Rev Neurosci (2006) 12.37

Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress. Science (2006) 9.31

Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. Cell (2007) 8.99

Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nat Neurosci (2006) 8.24

The molecular neurobiology of depression. Nature (2008) 6.51

Epigenetic regulation in psychiatric disorders. Nat Rev Neurosci (2007) 6.00

The many faces of CREB. Trends Neurosci (2005) 5.58

Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science (2010) 5.48

Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron (2005) 5.09

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96

New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci (2006) 4.62

Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci (2003) 4.60

Essential role of the histone methyltransferase G9a in cocaine-induced plasticity. Science (2010) 3.97

Mania-like behavior induced by disruption of CLOCK. Proc Natl Acad Sci U S A (2007) 3.92

Psychobiology and molecular genetics of resilience. Nat Rev Neurosci (2009) 3.71

Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci (2011) 3.69

DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. Nat Neurosci (2010) 3.47

Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens. Nat Neurosci (2010) 3.41

Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci U S A (2004) 3.37

CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli. Proc Natl Acad Sci U S A (2002) 3.32

Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23

Antidepressant actions of histone deacetylase inhibitors. J Neurosci (2009) 3.17

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15

The brain reward circuitry in mood disorders. Nat Rev Neurosci (2013) 3.08

The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens. Trends Neurosci (2010) 3.02

Cocaine regulates MEF2 to control synaptic and behavioral plasticity. Neuron (2008) 3.01

Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins. Neuron (2009) 2.97

CREB modulates excitability of nucleus accumbens neurons. Nat Neurosci (2006) 2.95

Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci U S A (2005) 2.95

Early life programming and neurodevelopmental disorders. Biol Psychiatry (2010) 2.93

Antidepressant effect of optogenetic stimulation of the medial prefrontal cortex. J Neurosci (2010) 2.84

IRS2-Akt pathway in midbrain dopamine neurons regulates behavioral and cellular responses to opiates. Nat Neurosci (2006) 2.71

DeltaFosB: a molecular switch for long-term adaptation in the brain. Brain Res Mol Brain Res (2004) 2.67

The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress. Nat Neurosci (2008) 2.64

RGS9 modulates dopamine signaling in the basal ganglia. Neuron (2003) 2.61

Linking molecules to mood: new insight into the biology of depression. Am J Psychiatry (2010) 2.54

Methylphenidate treatment during pre- and periadolescence alters behavioral responses to emotional stimuli at adulthood. Biol Psychiatry (2003) 2.37

Brain-derived neurotrophic factor conditional knockouts show gender differences in depression-related behaviors. Biol Psychiatry (2006) 2.36

Distinct subclasses of medium spiny neurons differentially regulate striatal motor behaviors. Proc Natl Acad Sci U S A (2010) 2.36

Delta FosB mediates epigenetic desensitization of the c-fos gene after chronic amphetamine exposure. J Neurosci (2008) 2.34

Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures. J Neurosci (2004) 2.30

DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation. J Neurosci (2006) 2.29

Induction of deltaFosB in reward-related brain structures after chronic stress. J Neurosci (2004) 2.27

Nuclear factor kappa B signaling regulates neuronal morphology and cocaine reward. J Neurosci (2009) 2.25

Regulation of neurogenesis in adult mouse hippocampus by cAMP and the cAMP response element-binding protein. J Neurosci (2002) 2.21

Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat Neurosci (2012) 2.20

Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models. J Neurosci (2009) 2.18

Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc Natl Acad Sci U S A (2010) 2.17

An essential role for DeltaFosB in the nucleus accumbens in morphine action. Nat Neurosci (2006) 2.17

Molecular neurobiology of drug addiction. Annu Rev Med (2004) 2.16

Striatal cell type-specific overexpression of DeltaFosB enhances incentive for cocaine. J Neurosci (2003) 2.16

The presynaptic active zone protein RIM1alpha is critical for normal learning and memory. Neuron (2004) 2.14

Neurobiology of resilience. Nat Neurosci (2012) 2.13

CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. Nat Neurosci (2009) 2.11

Essential role for RGS9 in opiate action. Proc Natl Acad Sci U S A (2003) 2.08

Paternal transmission of stress-induced pathologies. Biol Psychiatry (2011) 2.07

Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology (2007) 2.04

Neurotrophic factors and structural plasticity in addiction. Neuropharmacology (2008) 1.99

DeltaFosB accumulates in a GABAergic cell population in the posterior tail of the ventral tegmental area after psychostimulant treatment. Eur J Neurosci (2005) 1.95

Homeostatic and hedonic signals interact in the regulation of food intake. J Nutr (2009) 1.95

A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron (2011) 1.92

Involvement of the lateral hypothalamic peptide orexin in morphine dependence and withdrawal. J Neurosci (2003) 1.89

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect. J Neurosci (2002) 1.89

Chronic cocaine-regulated epigenomic changes in mouse nucleus accumbens. Genome Biol (2014) 1.88

The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons. Front Neuroanat (2011) 1.87

The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance. J Neurosci (2005) 1.86

Regulation of drug reward by cAMP response element-binding protein: evidence for two functionally distinct subregions of the ventral tegmental area. J Neurosci (2005) 1.84

Delta FosB regulates wheel running. J Neurosci (2002) 1.80

Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression. Biol Psychiatry (2003) 1.78

Elevated levels of GluR1 in the midbrain: a trigger for sensitization to drugs of abuse? Trends Neurosci (2002) 1.77

Orexin signaling mediates the antidepressant-like effect of calorie restriction. J Neurosci (2008) 1.76

Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. J Neurosci (2010) 1.75

DeltaFosB induction in orbitofrontal cortex mediates tolerance to cocaine-induced cognitive dysfunction. J Neurosci (2007) 1.74

Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens. Proc Natl Acad Sci U S A (2011) 1.69

A silent synapse-based mechanism for cocaine-induced locomotor sensitization. J Neurosci (2011) 1.68

Epigenetics in the nervous system. J Neurosci (2008) 1.65

Lateral hypothalamic neuropeptides in reward and drug addiction. Life Sci (2003) 1.65

Maturation of silent synapses in amygdala-accumbens projection contributes to incubation of cocaine craving. Nat Neurosci (2013) 1.65

Adult hippocampal neurogenesis is functionally important for stress-induced social avoidance. Proc Natl Acad Sci U S A (2010) 1.64

Epigenetics of the depressed brain: role of histone acetylation and methylation. Neuropsychopharmacology (2012) 1.64

A novel role of the WNT-dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression. J Neurosci (2011) 1.61

AKT signaling within the ventral tegmental area regulates cellular and behavioral responses to stressful stimuli. Biol Psychiatry (2008) 1.60

The influence of DeltaFosB in the nucleus accumbens on natural reward-related behavior. J Neurosci (2008) 1.58

diffReps: detecting differential chromatin modification sites from ChIP-seq data with biological replicates. PLoS One (2013) 1.58

Regional and cellular mapping of cAMP response element-mediated transcription during naltrexone-precipitated morphine withdrawal. J Neurosci (2002) 1.58

Topographical organization of GABAergic neurons within the ventral tegmental area of the rat. Synapse (2007) 1.57

Tropomyosin-related kinase B in the mesolimbic dopamine system: region-specific effects on cocaine reward. Biol Psychiatry (2008) 1.55

Neurotrophic mechanisms in drug addiction. Neuromolecular Med (2004) 1.54

HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity. Nat Neurosci (2012) 1.52

Role of cAMP response element-binding protein in the rat locus ceruleus: regulation of neuronal activity and opiate withdrawal behaviors. J Neurosci (2006) 1.51

The epigenetic landscape of addiction. Ann N Y Acad Sci (2011) 1.51

Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci (2012) 1.50

Fluoxetine exposure during adolescence alters responses to aversive stimuli in adulthood. J Neurosci (2014) 1.48

∆FosB differentially modulates nucleus accumbens direct and indirect pathway function. Proc Natl Acad Sci U S A (2013) 1.46

Epigenetic mechanisms of depression and antidepressant action. Annu Rev Pharmacol Toxicol (2012) 1.45

Use of herpes virus amplicon vectors to study brain disorders. Biotechniques (2005) 1.43

Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area. J Neurosci (2005) 1.43

Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons. J Neurosci (2003) 1.42

Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine. Proc Natl Acad Sci U S A (2007) 1.42

ΔFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli. J Neurosci (2013) 1.41