Michael L Dustin

Author PubWeight™ 246.64‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 ATP mediates rapid microglial response to local brain injury in vivo. Nat Neurosci 2005 11.55
2 Visualizing dendritic cell networks in vivo. Nat Immunol 2004 7.13
3 T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster. Immunity 2006 6.93
4 Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76. Nat Immunol 2005 6.48
5 Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling. J Exp Med 2005 5.55
6 Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 2010 5.49
7 The immunological synapse balances T cell receptor signaling and degradation. Science 2003 4.94
8 The growth factor progranulin binds to TNF receptors and is therapeutic against inflammatory arthritis in mice. Science 2011 4.76
9 T cell receptor signaling precedes immunological synapse formation. Science 2002 4.56
10 Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat Immunol 2004 4.21
11 Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol 2005 4.01
12 Altered TCR signaling from geometrically repatterned immunological synapses. Science 2005 3.94
13 Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse. Cell 2007 3.92
14 In vivo imaging of germinal centres reveals a dynamic open structure. Nature 2007 3.83
15 Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo. J Exp Med 2006 3.57
16 Protein kinase C-theta mediates negative feedback on regulatory T cell function. Science 2010 3.31
17 Dynamic imaging of the immune system: progress, pitfalls and promise. Nat Rev Immunol 2006 3.31
18 Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell 2008 3.29
19 Costimulation and endogenous MHC ligands contribute to T cell recognition. Nat Immunol 2001 3.24
20 Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. J Exp Med 2009 3.13
21 Mechanisms for segregating T cell receptor and adhesion molecules during immunological synapse formation in Jurkat T cells. Proc Natl Acad Sci U S A 2007 3.11
22 Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol 2010 3.01
23 Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med 2012 2.97
24 Stable T cell-dendritic cell interactions precede the development of both tolerance and immunity in vivo. Nat Immunol 2005 2.89
25 Myelomonocytic cell recruitment causes fatal CNS vascular injury during acute viral meningitis. Nature 2008 2.87
26 Radiation-induced CXCL16 release by breast cancer cells attracts effector T cells. J Immunol 2008 2.61
27 LFA-1/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation. Immunity 2004 2.47
28 Development and migration of plasma cells in the mouse lymph node. Immunity 2010 2.44
29 Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation. Immunity 2008 2.42
30 Force as a facilitator of integrin conformational changes during leukocyte arrest on blood vessels and antigen-presenting cells. Immunity 2007 2.19
31 T cell antigen receptor signaling and immunological synapse stability require myosin IIA. Nat Immunol 2009 2.17
32 What is the importance of the immunological synapse? Trends Immunol 2004 2.02
33 Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. Immunity 2009 1.98
34 A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J Exp Med 2011 1.97
35 Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol 2013 1.96
36 Supported planar bilayers in studies on immune cell adhesion and communication. J Immunol Methods 2003 1.95
37 CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia. Nature 2009 1.94
38 T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation. Biophys J 2008 1.92
39 Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes. Nat Immunol 2007 1.90
40 Integrin inside-out signaling and the immunological synapse. Curr Opin Cell Biol 2011 1.89
41 Lateral membrane waves constitute a universal dynamic pattern of motile cells. Phys Rev Lett 2006 1.85
42 Identification of transcriptional regulators in the mouse immune system. Nat Immunol 2013 1.79
43 Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses. Immunity 2009 1.74
44 Cytotoxic T lymphocytes form an antigen-independent ring junction. J Clin Invest 2004 1.72
45 The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2. Nat Cell Biol 2007 1.72
46 The transcriptional landscape of αβ T cell differentiation. Nat Immunol 2013 1.61
47 T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters. Proc Natl Acad Sci U S A 2011 1.61
48 Quantum dot/peptide-MHC biosensors reveal strong CD8-dependent cooperation between self and viral antigens that augment the T cell response. Proc Natl Acad Sci U S A 2006 1.58
49 Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity 2010 1.56
50 Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. J Clin Invest 2012 1.55
51 ICAM-1 co-stimulates target cells to facilitate antigen presentation. Curr Opin Immunol 2005 1.55
52 Micropatterning of costimulatory ligands enhances CD4+ T cell function. Proc Natl Acad Sci U S A 2008 1.55
53 The critical role of agrin in the hematopoietic stem cell niche. Blood 2011 1.54
54 Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes. Proc Natl Acad Sci U S A 2005 1.51
55 Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity 2002 1.50
56 PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med 2013 1.48
57 Requirements for T lymphocyte migration in explanted lymph nodes. J Immunol 2007 1.48
58 The immunological synapse: integrins take the stage. Immunol Rev 2002 1.47
59 Visualization of mucosal homeostasis via single- and multiphoton intravital fluorescence microscopy. J Leukoc Biol 2012 1.47
60 Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain. J Exp Med 2011 1.43
61 Small GTPases and LFA-1 reciprocally modulate adhesion and signaling. Immunol Rev 2007 1.42
62 WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity 2002 1.41
63 T cell-dendritic cell immunological synapses contain TCR-dependent CD28-CD80 clusters that recruit protein kinase C theta. J Immunol 2008 1.41
64 Cutting edge: activation by innate cytokines or microbial antigens can cause arrest of natural killer T cell patrolling of liver sinusoids. J Immunol 2008 1.38
65 Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med 2012 1.38
66 Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression. J Immunol 2010 1.38
67 Innate response to focal necrotic injury inside the blood-brain barrier. J Immunol 2006 1.31
68 Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites. J Immunol Methods 2009 1.29
69 Measuring diffusion and binding kinetics by contact area FRAP. Biophys J 2008 1.26
70 Analysis of two-dimensional dissociation constant of laterally mobile cell adhesion molecules. Biophys J 2006 1.25
71 Protein kinase C theta regulates stability of the peripheral adhesion ring junction and contributes to the sensitivity of target cell lysis by CTL. J Immunol 2008 1.24
72 Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation. Trends Immunol 2002 1.24
73 In silico models for cellular and molecular immunology: successes, promises and challenges. Nat Immunol 2003 1.21
74 Mechanosensing in T lymphocyte activation. Biophys J 2012 1.21
75 CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse. J Immunol 2005 1.20
76 The coreceptor CD2 uses plasma membrane microdomains to transduce signals in T cells. J Cell Biol 2009 1.20
77 Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J Immunol 2002 1.18
78 Dynamic imaging of the effector immune response to listeria infection in vivo. PLoS Pathog 2011 1.16
79 Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells. J Virol 2008 1.16
80 Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses. Proc Natl Acad Sci U S A 2012 1.16
81 Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse. Proc Natl Acad Sci U S A 2009 1.16
82 Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. J Virol 2009 1.14
83 Pillars article: The immunological synapse: a molecular machine controlling T cell activation. Science. 1999. 285: 221-227. J Immunol 2015 1.13
84 Nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse. J Biol Chem 2008 1.09
85 Th1 and Th2 cells form morphologically distinct immunological synapses. J Immunol 2008 1.08
86 Phospholipase D1 regulates lymphocyte adhesion via upregulation of Rap1 at the plasma membrane. Mol Cell Biol 2009 1.08
87 PKC-θ function at the immunological synapse: prospects for therapeutic targeting. Trends Immunol 2011 1.06
88 High plasma membrane lipid order imaged at the immunological synapse periphery in live T cells. Mol Membr Biol 2010 1.04
89 Migration of cytotoxic lymphocytes in cell cycle permits local MHC I-dependent control of division at sites of viral infection. J Exp Med 2011 1.03
90 The class II phosphatidylinositol 3 kinase C2beta is required for the activation of the K+ channel KCa3.1 and CD4 T-cells. Mol Biol Cell 2009 1.03
91 T-cell activation: a multidimensional signaling network. Curr Opin Cell Biol 2002 1.02
92 T cell receptor antagonism interferes with MHC clustering and integrin patterning during immunological synapse formation. J Cell Biol 2004 1.01
93 Stimulation of naïve T-cell adhesion and immunological synapse formation by chemokine-dependent and -independent mechanisms. Immunology 2002 1.00
94 A coupled diffusion-kinetics model for analysis of contact-area FRAP experiment. Biophys J 2008 0.97
95 Signaling microdomains in T cells. FEBS Lett 2010 0.97
96 T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse. Front Immunol 2012 0.96
97 A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling. Novartis Found Symp 2005 0.96
98 Scaffold protein Disc large homolog 1 is required for T-cell receptor-induced activation of regulatory T-cell function. Proc Natl Acad Sci U S A 2012 0.95
99 Cell:cell interactions in the immune system. Immunol Rev 2013 0.95
100 HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse. Viruses 2010 0.94
101 HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA). PLoS One 2011 0.92
102 Intravital two-photon microscopy of host-pathogen interactions in a mouse model of Staphylococcus aureus skin abscess formation. Cell Microbiol 2012 0.92
103 The large ectodomains of CD45 and CD148 regulate their segregation from and inhibition of ligated T-cell receptor. Blood 2013 0.92
104 Modulation of T cell activation by stomatin-like protein 2. J Immunol 2008 0.91
105 Mechanisms of Cellular Avidity Regulation in CD2-CD58-Mediated T Cell Adhesion. ACS Chem Biol 2006 0.91
106 Control of antigen presentation with a photoreleasable agonist peptide. J Am Chem Soc 2006 0.90
107 Exploiting the stress response to radiation to sensitize poorly immunogenic tumors to anti-CTLA-4 treatment. Oncoimmunology 2013 0.90
108 The synapse assembly model. Trends Immunol 2002 0.90
109 Polar redistribution of the sialoglycoprotein CD43: implications for T cell function. J Immunol 2002 0.89
110 Mitochondrial and plasma membrane pools of stomatin-like protein 2 coalesce at the immunological synapse during T cell activation. PLoS One 2012 0.89
111 Nanoscale ligand spacing influences receptor triggering in T cells and NK cells. Nano Lett 2013 0.88
112 CTLs respond with activation and granule secretion when serving as targets for T-cell recognition. Blood 2010 0.87
113 Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses. PLoS Comput Biol 2011 0.87
114 T cell activation is determined by the number of presented antigens. Nano Lett 2013 0.86
115 Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality. J Clin Invest 2016 0.83
116 Cross talk between CD3 and CD28 is spatially modulated by protein lateral mobility. Mol Cell Biol 2013 0.83
117 In vivo multiphoton microscopy technique to reveal the physiology of the mouse placenta. Am J Reprod Immunol 2012 0.83
118 Myeloid cells limit production of antibody-secreting cells after immunization in the lymph node. J Immunol 2013 0.82
119 Imaging of HIV-1 envelope-induced virological synapse and signaling on synthetic lipid bilayers. J Vis Exp 2012 0.82
120 Induction by IL 1 and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 1986. 137: 245-254. J Immunol 2011 0.81
121 Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells. Integr Biol (Camb) 2015 0.81
122 In vivo multiphoton microscopy technique to reveal the physiology of the mouse uterus. Am J Reprod Immunol 2012 0.81
123 A model for CD2/CD58-mediated adhesion strengthening. Ann Biomed Eng 2005 0.80
124 PKC-θ: hitting the bull's eye. Nat Immunol 2011 0.80
125 Agrin is required for survival and function of monocytic cells. Blood 2012 0.80
126 A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J. Immunol. 1986. 137: 1270-1274. J Immunol 2011 0.79
127 Nanoengineering of Immune Cell Function. Mater Res Soc Symp Proc 2009 0.79
128 Renal dendritic cells: an update. Nephron Exp Nephrol 2009 0.79
129 Interference with Ca(2+) release activated Ca(2+) (CRAC) channel function delays T-cell arrest in vivo. Eur J Immunol 2013 0.79
130 Dynamics of host defense: the view at the front lines. Nat Immunol 2007 0.77
131 Role of the crosstalk between CTLA-4 and NKG2D in the development of anti-CTLA-4 treatment strategies. Immunotherapy 2013 0.76
132 A polarizing situation. Nat Immunol 2004 0.76
133 T cell priming goes through a new phase. Nat Immunol 2013 0.75
134 Affinity measured by microcluster. J Exp Med 2010 0.75
135 "Cell biology meets physiology: functional organization of vertebrate plasma membranes"--the immunological synapse. Curr Top Membr 2013 0.75
136 A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies. PLoS One 2011 0.75