Increased OPRM1 DNA methylation in lymphocytes of methadone-maintained former heroin addicts.

PubWeight™: 1.23‹?› | Rank: Top 10%

🔗 View Article (PMC 2778040)

Published in Neuropsychopharmacology on July 23, 2008

Authors

David A Nielsen1, Vadim Yuferov, Sara Hamon, Colin Jackson, Ann Ho, Jurg Ott, Mary Jeanne Kreek

Author Affiliations

1: Laboratory of the Biology of the Addictive Diseases, The Rockefeller University, New York, NY 10065, USA. nielsen@rockefeller.edu

Associated clinical trials:

Comprehensive Study of Post-surgical Pain After Pectus or Spine Surgery | NCT04031716

Articles citing this

The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review. Alcohol Clin Exp Res (2011) 1.18

Epigenetic mechanisms of drug addiction. Neuropharmacology (2013) 1.17

Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann N Y Acad Sci (2010) 1.16

Behavioral epigenetics. Ann N Y Acad Sci (2011) 1.14

Breaking barriers in the genomics and pharmacogenetics of drug addiction. Clin Pharmacol Ther (2010) 1.05

Epigenetic signaling in psychiatric disorders. J Mol Biol (2014) 1.02

Epigenetic mechanisms of drug addiction. Curr Opin Neurobiol (2013) 1.01

Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts. Hum Genet (2010) 1.00

Transcriptional and epigenetic regulation of opioid receptor genes: present and future. Annu Rev Pharmacol Toxicol (2011) 0.97

Epigenetics and the transition from acute to chronic pain. Pain Med (2012) 0.93

Litter gender composition and sex affect maternal behavior and DNA methylation levels of the oprm1 gene in rat offspring. Front Psychiatry (2011) 0.92

Reversal of cocaine-conditioned place preference through methyl supplementation in mice: altering global DNA methylation in the prefrontal cortex. PLoS One (2012) 0.91

Increased methylation of the MOR gene proximal promoter in primary sensory neurons plays a crucial role in the decreased analgesic effect of opioids in neuropathic pain. Mol Pain (2014) 0.91

Epigenetics of drug abuse: predisposition or response. Pharmacogenomics (2012) 0.91

Epigenetic variation in the mu-opioid receptor gene in infants with neonatal abstinence syndrome. J Pediatr (2014) 0.88

Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine. Prog Biophys Mol Biol (2015) 0.87

Elevated levels of DNA methylation at the OPRM1 promoter in blood and sperm from male opioid addicts. J Opioid Manag (2011) 0.87

Determination of Methylated CpG Sites in the Promoter Region of Catechol-O-Methyltransferase (COMT) and their Involvement in the Etiology of Tobacco Smoking. Front Psychiatry (2010) 0.87

A cross-platform genome-wide comparison of the relationship of promoter DNA methylation to gene expression. Front Genet (2012) 0.87

Gene expression in the addicted brain. Int Rev Neurobiol (2014) 0.86

Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence. J Hum Genet (2012) 0.86

Methyl supplementation attenuates cocaine-seeking behaviors and cocaine-induced c-Fos activation in a DNA methylation-dependent manner. J Neurosci (2015) 0.83

Current and Future Prospects for Epigenetic Biomarkers of Substance Use Disorders. Genes (Basel) (2015) 0.83

Variation in regulator of G-protein signaling 17 gene (RGS17) is associated with multiple substance dependence diagnoses. Behav Brain Funct (2012) 0.82

Epigenetics of µ-opioid receptors: intersection with HIV-1 infection of the central nervous system. J Cell Physiol (2012) 0.82

Common and specific liability to addiction: approaches to association studies of opioid addiction. Drug Alcohol Depend (2012) 0.81

Forced Abstinence from Cocaine Self-Administration is Associated with DNA Methylation Changes in Myelin Genes in the Corpus Callosum: a Preliminary Study. Front Psychiatry (2012) 0.80

Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation. PLoS One (2014) 0.80

Epigenetics, drugs of abuse, and the retroviral promoter. J Neuroimmune Pharmacol (2013) 0.80

Litter and sex effects on maternal behavior and DNA methylation of the Nr3c1 exon 17 promoter gene in hippocampus and cerebellum. Int J Dev Neurosci (2014) 0.79

A Framework to Examine the Role of Epigenetics in Health Disparities among Native Americans. Nurs Res Pract (2013) 0.76

Two-hit exposure to polychlorinated biphenyls at gestational and juvenile life stages: 2. Sex-specific neuromolecular effects in the brain. Mol Cell Endocrinol (2015) 0.76

Novel pharmacotherapeutic strategies for treatment of opioid-induced neonatal abstinence syndrome. Semin Fetal Neonatal Med (2012) 0.76

The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. Front Psychiatry (2013) 0.75

Extreme marginalization: addiction and other mental health disorders, stigma, and imprisonment. Ann N Y Acad Sci (2011) 0.75

DNA methylation-based variation between human populations. Mol Genet Genomics (2016) 0.75

DNA methylation at the mu-1 opioid receptor gene (OPRM1) promoter predicts preoperative, acute, and chronic postsurgical pain after spine fusion. Pharmgenomics Pers Med (2017) 0.75

Articles cited by this

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet (2003) 25.57

CpG islands in vertebrate genomes. J Mol Biol (1987) 23.16

Epigenetic programming by maternal behavior. Nat Neurosci (2004) 20.92

An improved diagnostic evaluation instrument for substance abuse patients. The Addiction Severity Index. J Nerv Ment Dis (1980) 14.25

The story of Rett syndrome: from clinic to neurobiology. Neuron (2007) 8.08

Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem (2001) 6.85

Number of CpG islands and genes in human and mouse. Proc Natl Acad Sci U S A (1993) 6.79

Covalent modification of DNA regulates memory formation. Neuron (2007) 6.20

Chromatin remodeling is a key mechanism underlying cocaine-induced plasticity in striatum. Neuron (2005) 5.09

CpG methylation of the cAMP-responsive enhancer/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation. Genes Dev (1989) 5.00

Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96

Reelin promoter hypermethylation in schizophrenia. Proc Natl Acad Sci U S A (2005) 3.12

Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates. Bioinformatics (2004) 2.79

Hypermethylation of the reelin (RELN) promoter in the brain of schizophrenic patients: a preliminary report. Am J Med Genet B Neuropsychiatr Genet (2005) 2.34

Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Pharmacol Rev (2005) 2.23

MAOA methylation is associated with nicotine and alcohol dependence in women. Am J Med Genet B Neuropsychiatr Genet (2008) 1.97

Epigenetic regulation of 11 beta-hydroxysteroid dehydrogenase type 2 expression. J Clin Invest (2004) 1.87

Maternal cocaine administration causes an epigenetic modification of protein kinase Cepsilon gene expression in fetal rat heart. Mol Pharmacol (2007) 1.59

Substantial attributable risk related to a functional mu-opioid receptor gene polymorphism in association with heroin addiction in central Sweden. Mol Psychiatry (2004) 1.56

Epigenetic DNA hypermethylation of the HERP gene promoter induces down-regulation of its mRNA expression in patients with alcohol dependence. Alcohol Clin Exp Res (2006) 1.51

Imaging brain mu-opioid receptors in abstinent cocaine users: time course and relation to cocaine craving. Biol Psychiatry (2005) 1.48

DNA hypermethylation of the alpha synuclein promoter in patients with alcoholism. Neuroreport (2005) 1.46

Lowered DNA methyltransferase (DNMT-3b) mRNA expression is associated with genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm (Vienna) (2006) 1.43

Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. J Endocrinol (2006) 1.34

Homocysteine associated genomic DNA hypermethylation in patients with chronic alcoholism. J Neural Transm (Vienna) (2004) 1.33

Repeated cocaine administration upregulates kappa and mu, but not delta, opioid receptors. Neuroreport (1994) 1.28

DNA methylation and Sp1 binding determine the tissue-specific transcriptional activity of the mouse Abcc6 promoter. Biochem Biophys Res Commun (2006) 1.26

Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci (2006) 1.22

Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation. FASEB J (2007) 1.09

High methadone dose significantly reduces cocaine use in methadone maintenance treatment (MMT) patients. J Addict Dis (2006) 0.99

Azacitidine. Nat Rev Drug Discov (2005) 0.99

Effects of high-dose methadone maintenance on cocaine place conditioning, cocaine self-administration, and mu-opioid receptor mRNA expression in the rat brain. Neuropsychopharmacology (2005) 0.97

Role of CpG islands in the up-regulation of NMDA receptor NR2B gene expression following chronic ethanol treatment of cultured cortical neurons of mice. Neurochem Int (2005) 0.93

Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose "binge" cocaine-treated rats. Synapse (2005) 0.91

Expression of functional mu-opioid receptors during T cell development. J Neuroimmunol (2001) 0.91

Acute "binge" cocaine increases mu-opioid receptor mRNA levels in areas of the rat mesolimbic mesocortical dopamine system. Brain Res Bull (1999) 0.89

Transient upregulation of mu opioid receptor mRNA levels in nucleus accumbens during chronic cocaine administration. Can J Physiol Pharmacol (1998) 0.87

Localization of promoter elements in the human mu-opioid receptor gene and regulation by DNA methylation. Brain Res Mol Brain Res (1999) 0.83

Articles by these authors

Complement factor H polymorphism in age-related macular degeneration. Science (2005) 31.10

Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA (2009) 12.35

1-year retention and social function after buprenorphine-assisted relapse prevention treatment for heroin dependence in Sweden: a randomised, placebo-controlled trial. Lancet (2003) 4.41

Stress, dysregulation of drug reward pathways, and the transition to drug dependence. Am J Psychiatry (2007) 4.37

Mathematical multi-locus approaches to localizing complex human trait genes. Nat Rev Genet (2003) 4.18

The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia. Nat Genet (2005) 4.13

Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis. Psychopharmacology (Berl) (2002) 3.74

Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes. Arch Gen Psychiatry (2006) 3.55

A putative RUNX1 binding site variant between SLC9A3R1 and NAT9 is associated with susceptibility to psoriasis. Nat Genet (2003) 3.52

Distribution and characterization of regulatory elements in the human genome. Genome Res (2002) 3.34

Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration. Am J Hum Genet (2005) 3.19

Age-related macular degeneration--a genome scan in extended families. Am J Hum Genet (2003) 2.99

CFH and LOC387715/ARMS2 genotypes and treatment with antioxidants and zinc for age-related macular degeneration. Ophthalmology (2008) 2.90

Biochemistry of microbial degradation of hexachlorocyclohexane and prospects for bioremediation. Microbiol Mol Biol Rev (2010) 2.74

CpG island methylator phenotype associates with low-degree chromosomal abnormalities in colorectal cancer. Clin Cancer Res (2008) 2.65

Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states. Psychopharmacology (Berl) (2003) 2.27

Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Cell (2003) 2.06

Effects of extended access to high versus low cocaine doses on self-administration, cocaine-induced reinstatement and brain mRNA levels in rats. Psychopharmacology (Berl) (2004) 2.02

Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol (2006) 2.01

Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes. Arch Gen Psychiatry (2011) 2.01

Common liability to addiction and "gateway hypothesis": theoretical, empirical and evolutionary perspective. Drug Alcohol Depend (2012) 1.88

Association of genetic loci: replication or not, that is the question. Neurology (2004) 1.84

The single nucleotide polymorphism A118G alters functional properties of the human mu opioid receptor. J Neurochem (2007) 1.78

Sum statistics for the joint detection of multiple disease loci in case-control association studies with SNP markers. Genet Epidemiol (2003) 1.69

Nucleotide frequency variation across human genes. Genome Res (2003) 1.68

Increased attributable risk related to a functional mu-opioid receptor gene polymorphism in association with alcohol dependence in central Sweden. Neuropsychopharmacology (2005) 1.66

Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues. Psychoneuroendocrinology (2005) 1.66

Estimating rates of alternative splicing in mammals and invertebrates. Nat Genet (2004) 1.57

Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet (2007) 1.55

Something of value: the introduction of contingency management interventions into the New York City Health and Hospital Addiction Treatment Service. J Subst Abuse Treat (2005) 1.52

Cytochrome p450 complement (CYPome) of the avermectin-producer Streptomyces avermitilis and comparison to that of Streptomyces coelicolor A3(2). Biochem Biophys Res Commun (2003) 1.52

Joint identification of multiple genetic variants via elastic-net variable selection in a genome-wide association analysis. Ann Hum Genet (2010) 1.51

Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene. Am J Hum Genet (2006) 1.50

Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis. Synapse (2003) 1.50

Characterization of Autosomal Dominant Hypercholesterolemia Caused by PCSK9 Gain of Function Mutations and Its Specific Treatment With Alirocumab, a PCSK9 Monoclonal Antibody. Circ Cardiovasc Genet (2015) 1.50

Carbon dioxide-induced anesthesia results in a rapid increase in plasma levels of vasopressin. Endocrinology (2009) 1.49

The Kreek-McHugh-Schluger-Kellogg scale: a new, rapid method for quantifying substance abuse and its possible applications. Drug Alcohol Depend (2003) 1.48

Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors. Psychopharmacology (Berl) (2005) 1.43

Reactivity to laboratory stress provocation predicts relapse to cocaine. Drug Alcohol Depend (2009) 1.42

Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR. Hum Genet (2005) 1.37

Cigarette smoking, CFH, APOE, ELOVL4, and risk of neovascular age-related macular degeneration. Arch Ophthalmol (2007) 1.37

Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal. J Endocrinol (2006) 1.34

Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity? Neuropsychopharmacology (2005) 1.34

Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes (2010) 1.33

ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence. Hum Mol Genet (2008) 1.33

The LOC387715 gene, smoking, body mass index, environmental associations with advanced age-related macular degeneration. Hum Hered (2007) 1.30

Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration. Ophthalmology (2007) 1.30

κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addiction. Trends Neurosci (2012) 1.29

Efficiency of single-nucleotide polymorphism haplotype estimation from pooled DNA. Proc Natl Acad Sci U S A (2003) 1.27

KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer. Ann Surg Oncol (2009) 1.26

Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population. Spine (Phila Pa 1976) (2006) 1.24

Corrected-QT intervals as related to methadone dose and serum level in methadone maintenance treatment (MMT) patients: a cross-sectional study. Addiction (2007) 1.24

Effects of gender and cigarette smoking on reactivity to psychological and pharmacological stress provocation. Psychoneuroendocrinology (2008) 1.23

Microarray studies of psychostimulant-induced changes in gene expression. Addict Biol (2005) 1.22

Involvement of arginine vasopressin and V1b receptor in heroin withdrawal and heroin seeking precipitated by stress and by heroin. Neuropsychopharmacology (2007) 1.21

Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice. Psychopharmacology (Berl) (2004) 1.21

Critical issues in the treatment of hepatitis C virus infection in methadone maintenance patients. Addiction (2008) 1.20

Rhesus monkeys and humans share common susceptibility genes for age-related macular disease. Hum Mol Genet (2008) 1.20

A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. Nat Genet (2013) 1.19

Gender differences in cardiovascular and corticoadrenal response to stress and drug cues in cocaine dependent individuals. Psychopharmacology (Berl) (2006) 1.19

Progression of geographic atrophy and genotype in age-related macular degeneration. Ophthalmology (2010) 1.18

Angiotensinogen gene polymorphism at -217 affects basal promoter activity and is associated with hypertension in African-Americans. J Biol Chem (2002) 1.18

Collapsing SNP genotypes in case-control genome-wide association studies increases the type I error rate and power. Stat Appl Genet Mol Biol (2008) 1.17

The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys. Psychopharmacology (Berl) (2003) 1.17

Response to corticotropin-releasing hormone infusion in cocaine-dependent individuals. Arch Gen Psychiatry (2009) 1.17

Search for genetic markers and functional variants involved in the development of opiate and cocaine addiction and treatment. Ann N Y Acad Sci (2010) 1.16

Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. Neurobiol Aging (2010) 1.16

Redefinition of the human kappa opioid receptor gene (OPRK1) structure and association of haplotypes with opiate addiction. Pharmacogenetics (2004) 1.16

Pharmacokinetics of the plant-derived kappa-opioid hallucinogen salvinorin A in nonhuman primates. Synapse (2005) 1.13

Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission. Trends Pharmacol Sci (2010) 1.13

Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans. J Pharmacol Exp Ther (2006) 1.12

Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid. J Pharmacol Exp Ther (2008) 1.12

The signatures of autozygosity among patients with colorectal cancer. Cancer Res (2008) 1.10

Hypothalamic-pituitary-adrenocortical (HPA) axis response and biotransformation of oral naltrexone: preliminary examination of relationship to family history of alcoholism. Neuropsychopharmacology (2002) 1.08

Genome-wide autozygosity mapping in human populations. Genet Epidemiol (2009) 1.07

Conditioned place preference after single doses or "binge" cocaine in C57BL/6J and 129/J mice. Pharmacol Biochem Behav (2002) 1.07

A functional haplotype implicated in vulnerability to develop cocaine dependence is associated with reduced PDYN expression in human brain. Neuropsychopharmacology (2008) 1.07

Increased AMPA GluR1 receptor subunit labeling on the plasma membrane of dendrites in the basolateral amygdala of rats self-administering morphine. Synapse (2005) 1.07

Prodynorphin gene promoter repeat associated with cocaine/alcohol codependence. Addict Biol (2007) 1.06