Published in Am J Physiol Gastrointest Liver Physiol on July 24, 2008
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
The digestive neuronal-glial-epithelial unit: a new actor in gut health and disease. Nat Rev Gastroenterol Hepatol (2012) 1.22
Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol (2009) 1.19
Nerve-cancer interactions in the stromal biology of pancreatic cancer. Front Physiol (2012) 1.18
Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice. Carcinogenesis (2011) 1.16
Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion. Am J Physiol Gastrointest Liver Physiol (2011) 1.01
Muscarinic receptor agonists and antagonists: effects on cancer. Handb Exp Pharmacol (2012) 0.94
Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells. Biochem Biophys Res Commun (2011) 0.94
Generating human intestinal tissues from pluripotent stem cells to study development and disease. EMBO J (2015) 0.88
Muscarinic receptor signaling in colon cancer. Cancers (Basel) (2011) 0.86
mAChRs activation induces epithelial-mesenchymal transition on lung epithelial cells. BMC Pulm Med (2014) 0.85
Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem (2013) 0.84
Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Cancer Biol Ther (2015) 0.81
A novel muscarinic antagonist R2HBJJ inhibits non-small cell lung cancer cell growth and arrests the cell cycle in G0/G1. PLoS One (2012) 0.80
M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells. J Cell Mol Med (2013) 0.80
Novel information on the non-neuronal cholinergic system in orthopedics provides new possible treatment strategies for inflammatory and degenerative diseases. Orthop Rev (Pavia) (2009) 0.79
Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia. Mol Cancer (2014) 0.79
Targeting Phospholipid Metabolism in Cancer. Front Oncol (2016) 0.77
Extrinsic intestinal denervation modulates tumor development in the small intestine of Apc(Min/+) mice. J Exp Clin Cancer Res (2015) 0.75
Novel ligands of Choline Acetyltransferase designed by in silico molecular docking, hologram QSAR and lead optimization. Sci Rep (2016) 0.75
The molecular effects of a polymorphism in the 5'UTR of solute carrier family 44, member 5 that is associated with birth weight in Holsteins. PLoS One (2012) 0.75
Differential expression of M3 muscarinic receptors in progressive colon neoplasia and metastasis. Oncotarget (2017) 0.75
Bedside to bench: role of muscarinic receptor activation in ultrarapid growth of colorectal cancer in a patient with pheochromocytoma. Mayo Clin Proc (2013) 0.75
Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells. Biochem J (2017) 0.75
New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst (1990) 23.46
Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes. Proc Natl Acad Sci U S A (1991) 2.00
Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res (2003) 1.61
Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors. Biochem Pharmacol (2005) 1.44
Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line. Biochem Pharmacol (2006) 1.30
Human keratinocytes synthesize, secrete, and degrade acetylcholine. J Invest Dermatol (1993) 1.29
Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res (2008) 1.29
Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cancer Res (2003) 1.28
Biological functions of keratinocyte cholinergic receptors. J Investig Dermatol Symp Proc (1997) 1.27
Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells. Carcinogenesis (2000) 1.24
Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor. Clin Cancer Res (1999) 1.23
Cholinergic-adrenergic interactions on intestinal ion transport. Am J Physiol (1978) 1.23
M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res (2007) 1.23
Ultrastructural localisation of substance P and choline acetyltransferase in endothelial cells of rat coronary artery and release of substance P and acetylcholine during hypoxia. Experientia (1989) 1.19
"Phenotypic" pharmacology: the influence of cellular environment on G protein-coupled receptor antagonist and inverse agonist pharmacology. Biochem Pharmacol (2006) 1.08
Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line. Biochim Biophys Acta (2002) 1.07
Characterization of functional receptors for gastrointestinal hormones on human colon cancer cells. Cancer Res (1992) 1.06
Mechanism of cholinergic regulation of electrolyte transport in rat colon in vitro. Am J Physiol (1982) 1.04
Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat. Neuropsychopharmacology (2002) 1.01
Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and beta1-integrin on the cell surface. J Biol Chem (2007) 0.95
Acetylcholine-induced calcium signaling along the rat colonic crypt axis. Gastroenterology (1998) 0.92
Functional evidence for the presence of cholinergic nerve endings in the colonic mucosa of the rat. J Pharmacol Exp Ther (1982) 0.92
In vivo release of non-neuronal acetylcholine from the human skin as measured by dermal microdialysis: effect of botulinum toxin. Br J Pharmacol (2006) 0.84
Cholinesterase activity and enzyme components in healthy and cancerous human colorectal sections. Chem Biol Interact (2005) 0.83
Inhibition of human sperm motility by inhibitors of choline acetyltransferase. J Pharmacol Exp Ther (1981) 0.82
Human intestine epithelial cell acetyl- and butyrylcholinesterase. Mol Cell Biochem (1991) 0.80
A potent and selective tacrine analog--biomembrane permeation and physicochemical characterization. Pharm Dev Technol (2005) 0.78
Effect of parasympathetic denervation on acetylcholine levels in the rat parotid gland. Is there an extraneuronal pool of acetylcholine? Life Sci (1983) 0.78
Characterization of acetylcholinesterase in Caco-2 cells. Exp Biol Med (Maywood) (2002) 0.78
Acetylcholine in neurons and paraneurons: a histochemical study. Arch Histol Cytol (1989) 0.78
c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability. Mol Cell (2002) 5.47
Quality assessment of colonoscopic cecal intubation: an analysis of 6 years of continuous practice at a university hospital. Am J Gastroenterol (2006) 3.49
An FGF21-adiponectin-ceramide axis controls energy expenditure and insulin action in mice. Cell Metab (2013) 2.62
Effect of kidney transplantation on left ventricular systolic dysfunction and congestive heart failure in patients with end-stage renal disease. J Am Coll Cardiol (2005) 2.47
A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell (2010) 2.47
Increased radioresistance and accelerated B cell lymphomas in mice with Mdmx mutations that prevent modifications by DNA-damage-activated kinases. Cancer Cell (2009) 2.28
Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers. Int J Radiat Oncol Biol Phys (2004) 2.11
Carotid sinus hypersensitivity in asymptomatic older persons: implications for diagnosis of syncope and falls. Arch Intern Med (2006) 1.94
Maintenance immunosuppressive agents as risk factors for BK virus nephropathy: a case-control study. Transplantation (2009) 1.66
MRI features of cortical desmoid in acute knee trauma. AJR Am J Roentgenol (2011) 1.59
Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation. Proc Natl Acad Sci U S A (2007) 1.56
Bile acid-induced proliferation of a human colon cancer cell line is mediated by transactivation of epidermal growth factor receptors. Biochem Pharmacol (2005) 1.44
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
Post-transcriptional exon shuffling events in humans can be evolutionarily conserved and abundant. Genome Res (2011) 1.38
Human cecal bile acids: concentration and spectrum. Am J Physiol Gastrointest Liver Physiol (2007) 1.35
Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation. J Clin Oncol (2005) 1.35
The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions. Br J Pharmacol (2003) 1.33
Racial differences in liver inflammation and fibrosis related to chronic hepatitis C. Clin Gastroenterol Hepatol (2004) 1.32
Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line. Biochem Pharmacol (2006) 1.30
Genetic ablation of M3 muscarinic receptors attenuates murine colon epithelial cell proliferation and neoplasia. Cancer Res (2008) 1.29
Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cancer Res (2003) 1.28
Computational models for drug inhibition of the human apical sodium-dependent bile acid transporter. Mol Pharm (2009) 1.26
M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J (2004) 1.25
Long-term safety and efficacy of human-induced pluripotent stem cell (iPS) grafts in a preclinical model of retinitis pigmentosa. Mol Med (2012) 1.24
Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol (2009) 1.19
Muscarinic receptor subtype-3 gene ablation and scopolamine butylbromide treatment attenuate small intestinal neoplasia in Apcmin/+ mice. Carcinogenesis (2011) 1.16
The ceramide analog, B13, induces apoptosis in prostate cancer cell lines and inhibits tumor growth in prostate cancer xenografts. Prostate (2004) 1.15
3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation. Biochem Biophys Res Commun (2005) 1.07
Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line. Biochim Biophys Acta (2002) 1.07
Epstein-barr virus-induced resistance to drugs that activate the mitotic spindle assembly checkpoint in Burkitt's lymphoma cells. J Virol (2006) 1.07
Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice. Neuropsychopharmacology (2006) 1.06
The relationship of in vivo central CB1 receptor occupancy to changes in cortical monoamine release and feeding elicited by CB1 receptor antagonists in rats. Psychopharmacology (Berl) (2005) 1.04
shRNA knockdown of guanylate cyclase 2e or cyclic nucleotide gated channel alpha 1 increases photoreceptor survival in a cGMP phosphodiesterase mouse model of retinitis pigmentosa. J Cell Mol Med (2011) 1.02
Gene therapy provides long-term visual function in a pre-clinical model of retinitis pigmentosa. Hum Mol Genet (2012) 1.02
Mesolimbic dopamine super-sensitivity in melanin-concentrating hormone-1 receptor-deficient mice. J Neurosci (2005) 1.02
Lentivirus-mediated expression of cDNA and shRNA slows degeneration in retinitis pigmentosa. Exp Biol Med (Maywood) (2011) 1.02
Muscarinic receptor agonists stimulate human colon cancer cell migration and invasion. Am J Physiol Gastrointest Liver Physiol (2011) 1.01
Xanthogranulomatous pyelonephritis in a renal allograft associated with xanthogranulomatous diverticulitis: report of the first case and review of the literature. Nephrol Dial Transplant (2007) 1.00
Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis. Exp Cell Res (2008) 1.00
Biphasic effects of cannabinoids on acetylcholine release in the hippocampus: site and mechanism of action. J Neurosci (2003) 0.99
A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders. Trends Pharmacol Sci (2005) 0.97
Use of oral N-acetylcysteine for protection of melanocytic nevi against UV-induced oxidative stress: towards a novel paradigm for melanoma chemoprevention. Clin Cancer Res (2009) 0.96
KDM4B is a master regulator of the estrogen receptor signalling cascade. Nucleic Acids Res (2013) 0.96
Vasodilatory effects of cholinergic agonists are greatly diminished in aorta from M3R-/- mice. Eur J Pharmacol (2004) 0.96
Bile acids regulate cardiovascular function. Clin Transl Sci (2011) 0.95
Src-mediated aryl hydrocarbon and epidermal growth factor receptor cross talk stimulates colon cancer cell proliferation. Am J Physiol Gastrointest Liver Physiol (2012) 0.94
Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells. Biochem Biophys Res Commun (2011) 0.94
Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling. J Cell Physiol (2008) 0.93
Histologic findings in lung biopsies in patients with suspected graft-versus-host disease. Hum Pathol (2013) 0.93
Functional alterations of nicotinic neurotransmission in dopamine transporter knock-out mice. Neuropharmacology (2007) 0.91
Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors. Am J Physiol Gastrointest Liver Physiol (2005) 0.91
Deoxycholyltaurine-induced vasodilation of rodent aorta is nitric oxide- and muscarinic M(3) receptor-dependent. Eur J Pharmacol (2005) 0.89
Conditional expression of 15-lipoxygenase-1 inhibits the selenoenzyme thioredoxin reductase: modulation of selenoproteins by lipoxygenase enzymes. J Biol Chem (2004) 0.89
Dach1, a vertebrate homologue of Drosophila dachshund, is expressed in the developing eye and ear of both chick and mouse and is regulated independently of Pax and Eya genes. Mech Dev (2002) 0.89
Subretinal injection of gene therapy vectors and stem cells in the perinatal mouse eye. J Vis Exp (2012) 0.89
CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action. Mol Pharmacol (2006) 0.89
In vivo performance of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile acid transport. Mol Pharm (2014) 0.89
Hepatitis C knowledge among primary care residents: is our teaching adequate for the times? Am J Gastroenterol (2004) 0.88
A survey of credentialing practices of gastrointestinal endoscopy centers in the United States. J Clin Gastroenterol (2005) 0.88
BK virus-associated nephropathy in renal allograft recipients: rescue therapy by sirolimus-based immunosuppression. Transplantation (2004) 0.88
Cholinergic muscarinic receptor activation augments murine intestinal epithelial cell proliferation and tumorigenesis. BMC Cancer (2013) 0.87
Heterozygosity for factor V Leiden and G20210A prothrombin genotypes in a patient with mesenteric vein thrombosis. Dig Dis Sci (2002) 0.86
Lithocholylcholine, a bile acid/acetylcholine hybrid, is a muscarinic receptor antagonist. J Pharmacol Exp Ther (2002) 0.86
Muscarinic receptor signaling in colon cancer. Cancers (Basel) (2011) 0.86
Cholesterol embolization syndrome induced by thrombolytic therapy. Am J Cardiovasc Drugs (2008) 0.85
CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors. Eur Neuropsychopharmacol (2008) 0.85
SlimQuick™ - associated hepatotoxicity in a woman with alpha-1 antitrypsin heterozygosity. World J Hepatol (2012) 0.85
Design and characterization of a novel fluorinated magnetic resonance imaging agent for functional analysis of bile Acid transporter activity. Pharm Res (2013) 0.84
Scopolamine treatment and muscarinic receptor subtype-3 gene ablation augment azoxymethane-induced murine liver injury. J Pharmacol Exp Ther (2010) 0.84
Effects of deoxycholylglycine, a conjugated secondary bile acid, on myogenic tone and agonist-induced contraction in rat resistance arteries. PLoS One (2012) 0.84
Vigabatrin-induced retinal toxicity is partially mediated by signaling in rod and cone photoreceptors. PLoS One (2012) 0.83
Quantitation of T lymphocytes in posttransplant transbronchial biopsies. Hum Pathol (2009) 0.83
Thymoglobulin dose optimization for induction therapy in high risk kidney transplant recipients. Transplantation (2008) 0.83
Maternal abuse history, postpartum depression, and parenting: links with preschoolers' internalizing problems. Infant Ment Health J (2015) 0.82
Behavioral and biochemical responses to d-amphetamine in MCH1 receptor knockout mice. Synapse (2008) 0.82
Light-dependent phosphorylation of the gamma subunit of cGMP-phophodiesterase (PDE6gamma) at residue threonine 22 in intact photoreceptor neurons. Biochem Biophys Res Commun (2009) 0.82
Role of the W07-toxin on Vibrio cholerae-induced diarrhoea. Biochim Biophys Acta (2004) 0.82
RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer. Inflamm Bowel Dis (2013) 0.82
Generation of induced pluripotent stem cells from conjunctiva. Graefes Arch Clin Exp Ophthalmol (2014) 0.82
Retrieval yield of total and messenger RNA in mesenchymal tissue ex vivo. Clin Orthop Relat Res (2003) 0.81
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. Pain (2016) 0.81
Design and evaluation of a novel trifluorinated imaging agent for assessment of bile acid transport using fluorine magnetic resonance imaging. J Pharm Sci (2014) 0.81
Hyperbaric oxygen treatment for intractable diarrhea caused by pneumatosis coli. Gastrointest Endosc (2002) 0.81