Published in Cancer Res on January 01, 2003
Nicotine induces cell proliferation by beta-arrestin-mediated activation of Src and Rb-Raf-1 pathways. J Clin Invest (2006) 2.15
Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer Res (2008) 1.76
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
Acetylcholine-induced activation of M3 muscarinic receptors stimulates robust matrix metalloproteinase gene expression in human colon cancer cells. Am J Physiol Gastrointest Liver Physiol (2009) 1.19
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol (2008) 1.19
The epithelial cholinergic system of the airways. Histochem Cell Biol (2008) 1.17
The nicotinic receptor antagonists abolish pathobiologic effects of tobacco-derived nitrosamines on BEP2D cells. J Cancer Res Clin Oncol (2006) 1.16
The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer. Prog Neurobiol (2010) 1.09
Expression of the alpha7 nicotinic acetylcholine receptor in human lung cells. Respir Res (2005) 1.08
Small-cell lung cancer (human): potentiation of endocytic membrane activity by voltage-gated Na(+) channel expression in vitro. J Membr Biol (2005) 1.06
Neuronal characteristics of small-cell lung cancer. Br J Cancer (2005) 1.05
Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiation. Cell Commun Signal (2009) 1.05
Neurochemical pattern of the complex innervation of neuroepithelial bodies in mouse lungs. Histochem Cell Biol (2008) 0.99
Nicotine induces the up-regulation of the α7-nicotinic receptor (α7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway. J Biol Chem (2013) 0.98
Current research in perineural invasion of cholangiocarcinoma. J Exp Clin Cancer Res (2010) 0.98
Muscarinic receptor agonists and antagonists: effects on cancer. Handb Exp Pharmacol (2012) 0.94
Nicotine and lung cancer. J Carcinog (2013) 0.92
Nicotinic acetylcholine receptors mediate lung cancer growth. Front Physiol (2013) 0.91
FSH regulates acetycholine production by ovarian granulosa cells. Reprod Biol Endocrinol (2006) 0.90
ASCL1 regulates the expression of the CHRNA5/A3/B4 lung cancer susceptibility locus. Mol Cancer Res (2010) 0.88
From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene (2010) 0.87
M1 muscarinic receptor activation mediates cell death in M1-HEK293 cells. PLoS One (2013) 0.85
In vivo release of non-neuronal acetylcholine from the human skin as measured by dermal microdialysis: effect of botulinum toxin. Br J Pharmacol (2006) 0.84
Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem (2013) 0.84
From smoking to cancers: novel targets to neuronal nicotinic acetylcholine receptors. J Oncol (2011) 0.82
The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium. Am J Physiol Lung Cell Mol Physiol (2012) 0.81
Virtual screening against acetylcholine binding protein. J Biomol Screen (2011) 0.81
New associations of the genetic polymorphisms in nicotinic receptor genes with the risk of lung cancer. Life Sci (2012) 0.81
Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Cancer Biol Ther (2015) 0.81
Novel link between prostaglandin E2 (PGE2) and cholinergic signaling in lung cancer: The role of c-Jun in PGE2-induced α7 nicotinic acetylcholine receptor expression and tumor cell proliferation. Thorac Cancer (2015) 0.80
Airway-related vagal preganglionic neurons express multiple nicotinic acetylcholine receptor subunits. Auton Neurosci (2006) 0.80
M2 receptor activation inhibits cell cycle progression and survival in human glioblastoma cells. J Cell Mol Med (2013) 0.80
A novel muscarinic antagonist R2HBJJ inhibits non-small cell lung cancer cell growth and arrests the cell cycle in G0/G1. PLoS One (2012) 0.80
Cholinergic Targets in Lung Cancer. Curr Pharm Des (2016) 0.79
Divergent effects of muscarinic receptor subtype gene ablation on murine colon tumorigenesis reveals association of M3R and zinc finger protein 277 expression in colon neoplasia. Mol Cancer (2014) 0.79
Non-neuronal cholinergic system in airways and lung cancer susceptibility. Transl Lung Cancer Res (2013) 0.79
Dysregulated cholinergic network as a novel biomarker of poor prognostic in patients with head and neck squamous cell carcinoma. BMC Cancer (2015) 0.78
Targeting Phospholipid Metabolism in Cancer. Front Oncol (2016) 0.77
Nicotinic acetylcholine receptor expression in human airway correlates with lung function. Am J Physiol Lung Cell Mol Physiol (2015) 0.76
The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells. Sci Rep (2016) 0.76
Acetylcholine acts through M3 muscarinic receptor to activate the EGFR signaling and promotes gastric cancer cell proliferation. Sci Rep (2017) 0.75
Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium. Int Immunopharmacol (2015) 0.75
Measurement of Acetylcholine from Cell Lines. Bio Protoc (2013) 0.75
Cholinergic Machinery as Relevant Target in Acute Lymphoblastic T Leukemia. Front Pharmacol (2016) 0.75
Small cell lung cancer growth is inhibited by miR-342 through its effect of the target gene IA-2. J Transl Med (2016) 0.75
Use of ¹¹C-Choline positron emission tomography/computed tomography to investigate the mechanism of choline metabolism in lung cancer. Mol Med Rep (2015) 0.75
Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC). Oncotarget (2015) 0.75
Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location. J Neurosci (2006) 2.80
Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Association with alpha7 nicotinic acetylcholine receptors. Am J Respir Cell Mol Biol (2002) 2.22
Locomotor activity predicts acquisition of self-administration behavior but not cocaine intake. Behav Neurosci (2005) 1.88
Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta). BMC Genomics (2007) 1.87
Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer Res (2008) 1.76
Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer. J Thorac Oncol (2014) 1.55
Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology (2004) 1.42
Developmental periods of choline sensitivity provide an ontogenetic mechanism for regulating memory capacity and age-related dementia. Front Integr Neurosci (2008) 1.26
Site-specific mTOR phosphorylation promotes mTORC1-mediated signaling and cell growth. Mol Cell Biol (2009) 1.25
M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res (2007) 1.23
Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain. J Biol Chem (2008) 1.21
Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation. FASEB J (2004) 1.20
mTOR kinase domain phosphorylation promotes mTORC1 signaling, cell growth, and cell cycle progression. Mol Cell Biol (2011) 1.19
Decreased vesicular somatodendritic dopamine stores in leptin-deficient mice. J Neurosci (2007) 1.15
Allopregnanolone influences the consummatory processes that govern ethanol drinking in C57BL/6J mice. Behav Brain Res (2007) 1.15
Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis. Nat Neurosci (2005) 1.15
Choline transporter 1 maintains cholinergic function in choline acetyltransferase haploinsufficiency. J Neurosci (2004) 1.14
Leveraging human genomic information to identify nonhuman primate sequences for expression array development. BMC Genomics (2005) 1.13
Effects of prenatal nicotine exposure on primate brain development and attempted amelioration with supplemental choline or vitamin C: neurotransmitter receptors, cell signaling and cell development biomarkers in fetal brain regions of rhesus monkeys. Neuropsychopharmacology (2005) 1.12
Enhancement of cocaine-seeking behavior by repeated nicotine exposure in rats. Psychopharmacology (Berl) (2002) 1.09
Prenatal nicotine exposure increases GABA signaling and mucin expression in airway epithelium. Am J Respir Cell Mol Biol (2010) 1.07
Comment on "Multiple repressive mechanisms in the hippocampus during memory formation". Science (2016) 1.07
CRF enhancement of GIRK channel-mediated transmission in dopamine neurons. Neuropsychopharmacology (2009) 1.07
Vitamin C prevents the effects of prenatal nicotine on pulmonary function in newborn monkeys. Am J Respir Crit Care Med (2005) 1.06
The nicotinic acetylcholine receptor antagonist mecamylamine prevents escalation of cocaine self-administration in rats with extended daily access. Psychopharmacology (Berl) (2007) 1.03
Nicotine activates and up-regulates nicotinic acetylcholine receptors in bronchial epithelial cells. Am J Respir Cell Mol Biol (2008) 1.03
Intercenter reliability and validity of the rhesus macaque GeneChip. BMC Genomics (2007) 1.02
Injection of CART (cocaine- and amphetamine-regulated transcript) peptide into the nucleus accumbens reduces cocaine self-administration in rats. Behav Brain Res (2008) 1.01
Bone morphogenetic protein 9 induces the transcriptome of basal forebrain cholinergic neurons. Proc Natl Acad Sci U S A (2005) 0.99
Prenatal nicotine exposure alters lung function and airway geometry through α7 nicotinic receptors. Am J Respir Cell Mol Biol (2012) 0.98
Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex. Brain Res (2008) 0.97
A genetic animal model of differential sensitivity to methamphetamine reinforcement. Neuropharmacology (2012) 0.97
A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. Cancer Gene Ther (2003) 0.96
Reinforcing effects of the neurosteroid allopregnanolone in rats. Pharmacol Biochem Behav (2002) 0.96
Prenatal choline availability modulates hippocampal and cerebral cortical gene expression. FASEB J (2007) 0.94
Influence of reinforcement schedule on ethanol consumption patterns in non-food restricted male C57BL/6J mice. Alcohol (2007) 0.94
Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice. Psychopharmacology (Berl) (2008) 0.94
Purification and culture of nerve growth factor receptor (p75)-expressing basal forebrain cholinergic neurons. Nat Protoc (2008) 0.93
Molecular markers for rapidly identifying candidate genes in Chlamydomonas reinhardtii. Ery1 and ery2 encode chloroplast ribosomal proteins. Genetics (2003) 0.89
The influence of mecamylamine on ethanol and sucrose self-administration. Neuropharmacology (2009) 0.89
Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C. Neurotoxicol Teratol (2011) 0.89
Ocular metastasis of lung adenocarcinoma with ELM4-ALK translocation: A case report with a review of the literature. Saudi J Ophthalmol (2013) 0.88
Basic and clinical aspects of non-neuronal acetylcholine: expression of non-neuronal acetylcholine in lung cancer provides a new target for cancer therapy. J Pharmacol Sci (2008) 0.88
The neurosteroid environment in the hippocampus exerts bi-directional effects on seizure susceptibility in mice. Brain Res (2008) 0.88
Aerogenous metastases: a potential game changer in the diagnosis and management of primary lung adenocarcinoma. AJR Am J Roentgenol (2014) 0.87
Expression of lynx1 in developing lung and its modulation by prenatal nicotine exposure. Cell Tissue Res (2005) 0.87
BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons. J Neurosci (2010) 0.87
Prenatal choline supplementation protects against postnatal neurotoxicity. J Neurosci (2002) 0.86
BMP9 ameliorates amyloidosis and the cholinergic defect in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2013) 0.86
Acetylcholine from the mesopontine tegmental nuclei differentially affects methamphetamine induced locomotor activity and neurotransmitter levels in the mesolimbic pathway. Behav Brain Res (2011) 0.85
Choline transporter-like protein 4 (CTL4) links to non-neuronal acetylcholine synthesis. J Neurochem (2013) 0.84
Upregulation of acetylcholine synthesis by bone morphogenetic protein 9 in a murine septal cell line. J Physiol Paris (2001) 0.84
Is nicotine the estrogen of lung cancer? Am J Respir Crit Care Med (2009) 0.83
Dissociation of corticotropin-releasing factor receptor subtype involvement in sensitivity to locomotor effects of methamphetamine and cocaine. Psychopharmacology (Berl) (2011) 0.83
The influence of selection for ethanol withdrawal severity on traits associated with ethanol self-administration and reinforcement. Alcohol Clin Exp Res (2010) 0.83
Differential regulation of the high affinity choline transporter and the cholinergic locus by cAMP signaling pathways. Brain Res (2007) 0.83
Prenatal choline deficiency increases choline transporter expression in the septum and hippocampus during postnatal development and in adulthood in rats. Brain Res (2007) 0.83
Expression of high affinity choline transporter during mouse development in vivo and its upregulation by NGF and BMP-4 in vitro. Brain Res Dev Brain Res (2005) 0.83
RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis. Acta Biochim Biophys Sin (Shanghai) (2011) 0.82
The ly-6 protein, lynx1, is an endogenous inhibitor of nicotinic signaling in airway epithelium. Am J Physiol Lung Cell Mol Physiol (2012) 0.81
Resource utilization and costs during the initial years of lung cancer screening with computed tomography in Canada. J Thorac Oncol (2014) 0.81
Cocaine self-administration selectively decreases noradrenergic regulation of metabotropic glutamate receptor-mediated inhibition in dopamine neurons. J Neurosci (2004) 0.80
Nerve growth factor regulates the expression of the cholinergic locus and the high-affinity choline transporter via the Akt/PKB signaling pathway. J Neurochem (2008) 0.80
Raising gestational choline intake alters gene expression in DMBA-evoked mammary tumors and prolongs survival. FASEB J (2008) 0.80
Cocaine self-administration alters the locomotor response to microinjection of bicuculline into the ventral tegmental area of rats. Brain Res (2002) 0.80
Large scale analysis of positional effects of single-base mismatches on microarray gene expression data. BioData Min (2010) 0.80
Neuronal nicotinic acetylcholine receptors: not just in brain. Am J Physiol Lung Cell Mol Physiol (2003) 0.80
X-chromosome inactivation in monkey embryos and pluripotent stem cells. Dev Biol (2012) 0.79
Differential modulation of nerve growth factor receptor (p75) and cholinergic gene expression in purified p75-expressing and non-expressing basal forebrain neurons by BMP9. Brain Res (2008) 0.78
Local changes in neurosteroid levels in the substantia nigra reticulata and the ventral tegmental area alter chronic ethanol withdrawal severity in male withdrawal seizure-prone mice. Alcohol Clin Exp Res (2012) 0.78
Fetal pulmonary arterial vascular impedance reflects changes in fetal oxygenation at near-term gestation in a nonhuman primate model. Reprod Sci (2012) 0.77
Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression. Eur J Biochem (2002) 0.77
Conditioned taste aversion from neostigmine or methyl-naloxonium in the nucleus accumbens. Physiol Behav (2011) 0.77
A rare case of anaplastic variant of diffuse large B-cell lymphoma presenting as a lung primary. Int J Surg Pathol (2013) 0.76
Fetal ventricular diastolic filling characteristics in a primate model: the role of fetal heart rate and pulmonary vascular impedance. Reprod Sci (2010) 0.75