Published in PLoS One on December 28, 2012
Blocking M2 muscarinic receptor signaling inhibits tumor growth and reverses epithelial-mesenchymal transition (EMT) in non-small cell lung cancer (NSCLC). Cancer Biol Ther (2015) 0.81
The insect repellent N,N-diethyl-m-toluamide (DEET) induces angiogenesis via allosteric modulation of the M3 muscarinic receptor in endothelial cells. Sci Rep (2016) 0.76
Cholinergic Machinery as Relevant Target in Acute Lymphoblastic T Leukemia. Front Pharmacol (2016) 0.75
Inactivation of M2 AChR/NF-κB signaling axis reverses epithelial-mesenchymal transition (EMT) and suppresses migration and invasion in non-small cell lung cancer (NSCLC). Oncotarget (2015) 0.75
Cancer cell cycles. Science (1996) 21.29
Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age. Cell (1994) 9.25
Comparison of in vitro anticancer-drug-screening data generated with a tetrazolium assay versus a protein assay against a diverse panel of human tumor cell lines. J Natl Cancer Inst (1990) 4.08
Cyclin D-dependent kinases, INK4 inhibitors and cancer. Biochim Biophys Acta (2002) 3.77
Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol (2000) 2.84
Lung cancer: New biological insights and recent therapeutic advances. CA Cancer J Clin (2011) 2.42
Differential regulation of retinoblastoma protein function by specific Cdk phosphorylation sites. J Biol Chem (1996) 2.23
Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans. Pharmacol Ther (1998) 1.99
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis. Trends Pharmacol Sci (2008) 1.90
Activated cholinergic signaling provides a target in squamous cell lung carcinoma. Cancer Res (2008) 1.76
Acetylcholine is synthesized by and acts as an autocrine growth factor for small cell lung carcinoma. Cancer Res (2003) 1.61
Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man. Naunyn Schmiedebergs Arch Pharmacol (1997) 1.47
Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway bronchial epithelial cells. Endocrinology (2004) 1.42
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
Human keratinocytes synthesize, secrete, and degrade acetylcholine. J Invest Dermatol (1993) 1.29
M3 muscarinic receptor antagonists inhibit small cell lung carcinoma growth and mitogen-activated protein kinase phosphorylation induced by acetylcholine secretion. Cancer Res (2007) 1.23
Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine-synthesizing enzymes-mediated pathway in human colon adenocarcinoma HT-29 cells. Toxicol Appl Pharmacol (2007) 1.22
Immortalization of normal human bronchial epithelial cells by human papillomaviruses 16 or 18. Cancer Res (1991) 1.20
Acetylcholine release by human colon cancer cells mediates autocrine stimulation of cell proliferation. Am J Physiol Gastrointest Liver Physiol (2008) 1.19
Penehyclidine hydrochloride attenuates LPS-induced acute lung injury involvement of NF-kappaB pathway. Pharmacol Res (2009) 1.15
Role of alpha7-nicotinic acetylcholine receptor in human non-small cell lung cancer proliferation. Cell Prolif (2008) 1.07
Nicotine-induced human breast cancer cell proliferation attenuated by garcinol through down-regulation of the nicotinic receptor and cyclin D3 proteins. Breast Cancer Res Treat (2010) 1.04
G1 control gene status is frequently altered in resectable non-small cell lung cancer. Int J Cancer (1997) 1.04
Rapid activation of Stat3 and ERK1/2 by nicotine modulates cell proliferation in human bladder cancer cells. Toxicol Sci (2008) 1.03
Muscarinic cholinergic receptors promote growth of human prostate cancer cells. Prostate (1997) 0.99
Activation of mitogen-activated protein kinase by muscarinic receptors in astroglial cells: role in DNA synthesis and effect of ethanol. Glia (2001) 0.93
Cholinesterase activity of human lung tumours varies according to their histological classification. Carcinogenesis (2005) 0.92
Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: neurochemical mechanisms. Life Sci (2005) 0.90
Cholinergic signaling through nicotinic acetylcholine receptors stimulates the proliferation of cervical cancer cells: an explanation for the molecular role of tobacco smoking in cervical carcinogenesis? Int J Cancer (2009) 0.90
Mammalian glial cells in culture synthesize acetylcholine. Naunyn Schmiedebergs Arch Pharmacol (1997) 0.87
Malignant transformation of immortalized human bronchial epithelial cells by asbestos fibers. Environ Health Perspect (1997) 0.84
Targeting alpha7-nicotinic receptor for the treatment of pleural mesothelioma. Eur J Cancer (2008) 0.83
Pharmacological characteristics of liriodenine, isolated from Fissistigma glaucescens, a novel muscarinic receptor antagonist in guinea-pigs. Br J Pharmacol (1994) 0.83
Muscarinic receptors in cell lines from ovarian carcinoma: negative correlation with survival of patients. Gynecol Oncol (2002) 0.83
The effects of a new cholinolytic--8018--and its optical isomers on the central muscarinic and nicotinic receptors. Arch Int Pharmacodyn Ther (1990) 0.81
Cotargeting cyclin D1 starts a new chapter in lung cancer prevention and therapy. Cancer Prev Res (Phila) (2011) 0.80
Expression of the cholinergic gene locus in pulmonary arterial endothelial cells. Histochem Cell Biol (2000) 0.80
Association between genetic variation of CACNA1H and childhood absence epilepsy. Ann Neurol (2003) 2.79
SCN8A mutations in Chinese children with early onset epilepsy and intellectual disability. Epilepsia (2015) 2.17
NIPA2 located in 15q11.2 is mutated in patients with childhood absence epilepsy. Hum Genet (2012) 2.08
Mycorrhizal networks: des liaisons dangereuses? Trends Ecol Evol (2006) 1.82
A transcriptomic analysis of superhybrid rice LYP9 and its parents. Proc Natl Acad Sci U S A (2009) 1.67
Temporal dynamics of abiotic and biotic factors on leaf litter of three plant species in relation to decomposition rate along a subalpine elevation gradient. PLoS One (2013) 1.62
Extracellular matrix metalloproteinase inducer (EMMPRIN) is increased in human left ventricle after acute myocardial infarction. Arch Med Res (2009) 1.60
Immunolocalization of myostatin (GDF-8) following musculoskeletal injury and the effects of exogenous myostatin on muscle and bone healing. J Histochem Cytochem (2012) 1.51
Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: direct evidence for load-induced fluid flow. J Bone Miner Res (2011) 1.40
Chronic alcohol exposure stimulates adipose tissue lipolysis in mice: role of reverse triglyceride transport in the pathogenesis of alcoholic steatosis. Am J Pathol (2012) 1.37
Cargo binding induces dimerization of myosin VI. Proc Natl Acad Sci U S A (2009) 1.34
Mg-catalyzed autoclave synthesis of aligned silicon carbide nanostructures. J Phys Chem B (2006) 1.28
A method of finding optimal weight factors for compound identification in gas chromatography-mass spectrometry. Bioinformatics (2012) 1.27
Mitochondrial dysfunction in amyotrophic lateral sclerosis. Biochim Biophys Acta (2009) 1.27
In situ measurement of transport between subchondral bone and articular cartilage. J Orthop Res (2009) 1.25
Effect of low-magnitude, high-frequency vibration on osteocytes in the regulation of osteoclasts. Bone (2010) 1.22
Human umbilical cord Wharton's jelly-derived mesenchymal stem cells differentiate into a Schwann-cell phenotype and promote neurite outgrowth in vitro. Brain Res Bull (2010) 1.17
Mitochondria and chloroplasts as the original sites of melatonin synthesis: a hypothesis related to melatonin's primary function and evolution in eukaryotes. J Pineal Res (2012) 1.15
The prevalence of type 2 diabetes and hypertension in Uygur and Kazak populations. Cardiovasc Toxicol (2008) 1.11
Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints. Bone (2011) 1.10
Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome. Exp Mol Pathol (2011) 1.09
Remarkable performance of Ir1/FeO(x) single-atom catalyst in water gas shift reaction. J Am Chem Soc (2013) 1.09
Formation of tough interlocking microstructures in silicon nitride ceramics by dynamic ripening. Nature (2002) 1.08
Quality of life of outpatients in methadone maintenance treatment clinics. J Acquir Immune Defic Syndr (2010) 1.07
PlantMiRNAPred: efficient classification of real and pseudo plant pre-miRNAs. Bioinformatics (2011) 1.07
Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One (2010) 1.06
Metabolomic analysis of the effects of polychlorinated biphenyls in nonalcoholic fatty liver disease. J Proteome Res (2012) 1.06
Recellularized nerve allografts with differentiated mesenchymal stem cells promote peripheral nerve regeneration. Neurosci Lett (2012) 1.05
Measuring gene functional similarity based on group-wise comparison of GO terms. Bioinformatics (2013) 1.05
Emerging disparity in HIV/AIDS disease progression and mortality for men who have sex with men, Jiangsu Province, China. AIDS Behav (2014) 1.04
Amitriptyline-mediated cognitive enhancement in aged 3×Tg Alzheimer's disease mice is associated with neurogenesis and neurotrophic activity. PLoS One (2011) 1.04
Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. PLoS One (2011) 1.04
Modeling fluorescence recovery after photobleaching in loaded bone: potential applications in measuring fluid and solute transport in the osteocytic lacunar-canalicular system. Ann Biomed Eng (2008) 1.03
Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages. Cell Res (2010) 1.00
HIV risk-reduction counseling and testing on behavior change of MSM. PLoS One (2013) 1.00
Ultra-low-energy three-dimensional oxide-based electronic synapses for implementation of robust high-accuracy neuromorphic computation systems. ACS Nano (2014) 1.00
In situ intracellular calcium oscillations in osteocytes in intact mouse long bones under dynamic mechanical loading. FASEB J (2013) 1.00
SCN1A, SCN1B, and GABRG2 gene mutation analysis in Chinese families with generalized epilepsy with febrile seizures plus. J Hum Genet (2008) 1.00
The dependency of solute diffusion on molecular weight and shape in intact bone. Bone (2009) 0.99
An overview of SNP interactions in genome-wide association studies. Brief Funct Genomics (2014) 0.99
A novel insight into Gene Ontology semantic similarity. Genomics (2013) 0.98
The post-rigor structure of myosin VI and implications for the recovery stroke. EMBO J (2007) 0.98
Perlecan/Hspg2 deficiency alters the pericellular space of the lacunocanalicular system surrounding osteocytic processes in cortical bone. J Bone Miner Res (2011) 0.98
Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells. Neurosci Lett (2012) 0.98
Identification of frequent BRAF copy number gain and alterations of RAF genes in Chinese prostate cancer. Genes Chromosomes Cancer (2012) 0.98
Analogues and derivatives of oncrasin-1, a novel inhibitor of the C-terminal domain of RNA polymerase II and their antitumor activities. J Med Chem (2011) 0.97
In vitro effects of pirfenidone on cardiac fibroblasts: proliferation, myofibroblast differentiation, migration and cytokine secretion. PLoS One (2011) 0.96
Modulation of gene expression in human central nervous system tumors under methionine deprivation-induced stress. Cancer Res (2004) 0.96
Bioinformatic approaches to metabolic pathways analysis. Methods Mol Biol (2011) 0.96
Overexpression of EFEMP1 correlates with tumor progression and poor prognosis in human ovarian carcinoma. PLoS One (2013) 0.94
TWIST represses estrogen receptor-alpha expression by recruiting the NuRD protein complex in breast cancer cells. Int J Biol Sci (2012) 0.94
Molecular cloning and expression analysis of a monosaccharide transporter gene OsMST4 from rice (Oryza sativa L.). Plant Mol Biol (2007) 0.93
Spontaneous intracerebral hemorrhage in CADASIL. J Headache Pain (2013) 0.93
Inferring the soybean (Glycine max) microRNA functional network based on target gene network. Bioinformatics (2013) 0.93
Identification of a glyphosate-resistant mutant of rice 5-enolpyruvylshikimate 3-phosphate synthase using a directed evolution strategy. Plant Physiol (2005) 0.93
miR-221/222 suppression protects against endoplasmic reticulum stress-induced apoptosis via p27(Kip1)- and MEK/ERK-mediated cell cycle regulation. Biol Chem (2010) 0.93
Effect of low-magnitude, high-frequency vibration on osteogenic differentiation of rat mesenchymal stromal cells. J Orthop Res (2011) 0.93
Quantifying fluid shear stress in a rocking culture dish. J Biomech (2010) 0.92
Modulation of cell cycle and gene expression in pancreatic tumor cell lines by methionine deprivation (methionine stress): implications to the therapy of pancreatic adenocarcinoma. Mol Cancer Ther (2005) 0.92
Cyclic Hydraulic Pressure and Fluid Flow Differentially Modulate Cytoskeleton Re-Organization in MC3T3 Osteoblasts. Cell Mol Bioeng (2009) 0.92
Transcription-mediated chimeric RNAs in prostate cancer: time to revisit old hypothesis? OMICS (2014) 0.91
Experimental characterization of a 400 Gbit/s orbital angular momentum multiplexed free-space optical link over 120 m. Opt Lett (2016) 0.91
Signature miRNAs involved in the innate immunity of invertebrates. PLoS One (2012) 0.91
New variants in the CACNA1H gene identified in childhood absence epilepsy. Neurosci Lett (2006) 0.91
Ribosomal protein L29/HIP deficiency delays osteogenesis and increases fragility of adult bone in mice. J Orthop Res (2009) 0.91
Metabolic signatures of esophageal cancer: NMR-based metabolomics and UHPLC-based focused metabolomics of blood serum. Biochim Biophys Acta (2013) 0.90
Lauren classification combined with HER2 status is a better prognostic factor in Chinese gastric cancer patients. BMC Cancer (2014) 0.90
A role for Gcn5 in cardiomyocyte differentiation of rat mesenchymal stem cells. Mol Cell Biochem (2010) 0.90
Free-space optical communications using orbital-angular-momentum multiplexing combined with MIMO-based spatial multiplexing. Opt Lett (2015) 0.90
Multiple oxygen tension environments reveal diverse patterns of transcriptional regulation in primary astrocytes. PLoS One (2011) 0.90
An ultrahigh affinity d-peptide antagonist Of MDM2. J Med Chem (2012) 0.90
In situ permeability measurement of the mammalian lacunar-canalicular system. Bone (2010) 0.89
LyP-1-conjugated PEGylated liposomes: a carrier system for targeted therapy of lymphatic metastatic tumor. J Control Release (2011) 0.89
CRP promotes MMP-10 expression via c-Raf/MEK/ERK and JAK1/ERK pathways in cardiomyocytes. Cell Signal (2011) 0.89
Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system. J Bone Miner Res (2014) 0.89
A survey of HIV infection and related high-risk factors among men who have sex with men in Suzhou, Jiangsu, China. J Biomed Res (2011) 0.89
Mitotic arrest, apoptosis, and sensitization to chemotherapy of melanomas by methionine deprivation stress. Mol Cancer Res (2006) 0.89
DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis. Int J Biol Sci (2012) 0.89
Esophageal rupture caused by explosion of an automobile tire tube: a case report. J Med Case Rep (2013) 0.89
Interruption of RNA processing machinery by a small compound, 1-[(4-chlorophenyl)methyl]-1H-indole-3-carboxaldehyde (oncrasin-1). Mol Cancer Ther (2009) 0.88
Casein kinase 2 regulates in vivo bone formation through its interaction with bone morphogenetic protein receptor type Ia. Bone (2011) 0.88
Phase correction for a distorted orbital angular momentum beam using a Zernike polynomials-based stochastic-parallel-gradient-descent algorithm. Opt Lett (2015) 0.88
Novel AAO films and hollow nanostructures fabricated by ultra-high voltage hard anodization. Chem Commun (Camb) (2009) 0.88
A strategy for searching antigenic regions in the SARS-CoV spike protein. Genomics Proteomics Bioinformatics (2003) 0.88
An in-situ fluorescence-based optical extensometry system for imaging mechanically loaded bone. J Orthop Res (2010) 0.88
Characterizing molecular diffusion in the lens capsule. Matrix Biol (2009) 0.88
Nonlinear conversion efficiency in Kerr frequency comb generation. Opt Lett (2014) 0.88
Does blood pressure enhance solute transport in the bone lacunar-canalicular system? Bone (2010) 0.87
Role of insert-1 of myosin VI in modulating nucleotide affinity. J Biol Chem (2011) 0.87
Experimental demonstration of a 200-Gbit/s free-space optical link by multiplexing Laguerre-Gaussian beams with different radial indices. Opt Lett (2016) 0.87
Blocking the formation of radiation-induced breast cancer stem cells. Oncotarget (2014) 0.87
Rapid change of AM fungal community in a rain-fed wheat field with short-term plastic film mulching practice. Mycorrhiza (2011) 0.86
Comparison of GC-MS and GC×GC-MS in the analysis of human serum samples for biomarker discovery. J Proteome Res (2015) 0.86
Synergistic interactions between Glomus mosseae and Bradyrhizobium japonicum in enhancing proton release from nodules and hyphae. Mycorrhiza (2011) 0.86
The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility. PLoS One (2012) 0.86
Short laminin peptide for improved neural stem cell growth. Stem Cells Transl Med (2014) 0.86
LNETWORK: an efficient and effective method for constructing phylogenetic networks. Bioinformatics (2013) 0.86
Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J Pharmacol Exp Ther (2008) 0.86
Repetitive peroxide exposure reveals pleiotropic mitogen-activated protein kinase signaling mechanisms. J Signal Transduct (2010) 0.86
Retracted Targeting HMGB1 inhibits ovarian cancer growth and metastasis by lentivirus-mediated RNA interference. J Cell Physiol (2012) 0.86