Published in J Biol Chem on July 24, 2008
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. J Cell Mol Med (2011) 2.21
Diverse cell signaling events modulated by perlecan. Biochemistry (2008) 1.49
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism. J Biol Chem (2011) 1.04
RNA-seq profiles of immune related genes in the staghorn coral Acropora cervicornis infected with white band disease. PLoS One (2013) 1.01
Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity. Blood (2009) 1.01
Caspase activation regulates the extracellular export of autophagic vacuoles. Autophagy (2012) 0.97
Novel insights into the function and dynamics of extracellular matrix in liver fibrosis. Am J Physiol Gastrointest Liver Physiol (2015) 0.97
Perlecan Domain V induces VEGf secretion in brain endothelial cells through integrin α5β1 and ERK-dependent signaling pathways. PLoS One (2012) 0.95
Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Autophagy (2014) 0.95
Matrilysin/matrix metalloproteinase-7(MMP7) cleavage of perlecan/HSPG2 creates a molecular switch to alter prostate cancer cell behavior. Matrix Biol (2014) 0.94
Caspase-3-dependent export of TCTP: a novel pathway for antiapoptotic intercellular communication. Cell Death Differ (2010) 0.94
Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing. J Biol Chem (2012) 0.92
Oxygen-glucose deprivation and interleukin-1α trigger the release of perlecan LG3 by cells of neurovascular unit. J Neurochem (2011) 0.92
Decoding the Matrix: Instructive Roles of Proteoglycan Receptors. Biochemistry (2015) 0.90
MFG-E8 released by apoptotic endothelial cells triggers anti-inflammatory macrophage reprogramming. PLoS One (2012) 0.89
Regulation of endothelial cell functions by basement membrane- and arachidonic acid-derived products. Wiley Interdiscip Rev Syst Biol Med (2010) 0.88
Proteolytically Derived Endogenous Angioinhibitors Originating from the Extracellular Matrix. Pharmaceuticals (Basel) (2011) 0.84
Oxygen-glucose deprivation (OGD) and interleukin-1 (IL-1) differentially modulate cathepsin B/L mediated generation of neuroprotective perlecan LG3 by neurons. Brain Res (2011) 0.83
Endostatin and endorepellin: A common route of action for similar angiostatic cancer avengers. Adv Drug Deliv Rev (2015) 0.82
Blood vessel repair and regeneration in the ischaemic heart. Open Heart (2014) 0.79
A fragment of the LG3 peptide of endorepellin is present in the urine of physically active mining workers: a potential marker of physical activity. PLoS One (2012) 0.77
The role of perlecan and endorepellin in the control of tumor angiogenesis and endothelial cell autophagy. Connect Tissue Res (2015) 0.77
Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia. J Cereb Blood Flow Metab (2015) 0.75
Molecular Functions of Glycoconjugates in Autophagy. J Mol Biol (2016) 0.75
Impact of ischemia-reperfusion on extracellular matrix processing and structure of the basement membrane of the heart. PLoS One (2014) 0.75
Endothelial Cells in Antibody-Mediated Rejection of Kidney Transplantation: Pathogenesis Mechanisms and Therapeutic Implications. J Immunol Res (2017) 0.75
A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature (2007) 35.08
Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med (2007) 6.19
The Hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence. Science (2011) 3.52
Preferential recruitment of interferon-gamma-expressing TH17 cells in multiple sclerosis. Ann Neurol (2009) 2.87
Activated leukocyte cell adhesion molecule promotes leukocyte trafficking into the central nervous system. Nat Immunol (2007) 2.85
Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon development. J Cell Biochem (2006) 2.71
Biological functions of the small leucine-rich proteoglycans: from genetics to signal transduction. J Biol Chem (2008) 2.53
The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J (2003) 2.13
The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells. Blood (2011) 1.89
Extracellular matrix proteoglycans control the fate of bone marrow stromal cells. J Biol Chem (2005) 1.82
Genetic evidence for the coordinated regulation of collagen fibrillogenesis in the cornea by decorin and biglycan. J Biol Chem (2009) 1.79
Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system. Brain (2012) 1.78
Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis. Ann Neurol (2006) 1.76
Decorin is a novel antagonistic ligand of the Met receptor. J Cell Biol (2009) 1.76
Treatment optimization in MS: Canadian MS Working Group updated recommendations. Can J Neurol Sci (2013) 1.74
Angiotensin II controls occludin function and is required for blood brain barrier maintenance: relevance to multiple sclerosis. J Neurosci (2007) 1.71
FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney. Development (2013) 1.71
Influence of decorin and biglycan on mechanical properties of multiple tendons in knockout mice. J Biomech Eng (2005) 1.71
Decorin prevents metastatic spreading of breast cancer. Oncogene (2005) 1.69
Disruption of central nervous system barriers in multiple sclerosis. Biochim Biophys Acta (2010) 1.68
Endorepellin, a novel inhibitor of angiogenesis derived from the C terminus of perlecan. J Biol Chem (2002) 1.67
Maternal diabetes modulates renal morphogenesis in offspring. J Am Soc Nephrol (2008) 1.65
Endorepellin causes endothelial cell disassembly of actin cytoskeleton and focal adhesions through alpha2beta1 integrin. J Cell Biol (2004) 1.61
Decorin, a novel player in the insulin-like growth factor system. J Biol Chem (2005) 1.59
Functional consequences of neuromyelitis optica-IgG astrocyte interactions on blood-brain barrier permeability and granulocyte recruitment. J Immunol (2008) 1.58
Decorin suppresses tumor cell-mediated angiogenesis. Oncogene (2002) 1.57
Heparan sulfate: a complex polymer charged with biological activity. Chem Rev (2005) 1.57
Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activation. J Biol Chem (2006) 1.55
Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitope. J Biol Chem (2002) 1.53
Absence of decorin adversely influences tubulointerstitial fibrosis of the obstructed kidney by enhanced apoptosis and increased inflammatory reaction. Am J Pathol (2002) 1.52
Scleroderma-like properties of skin from caveolin-1-deficient mice: implications for new treatment strategies in patients with fibrosis and systemic sclerosis. Cell Cycle (2011) 1.52
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer (2008) 1.51
How do immune cells support and shape the brain in health, disease, and aging? J Neurosci (2013) 1.51
Usefulness of soluble fas levels for improving diagnostic accuracy and prognosis for acute coronary syndromes. Am J Cardiol (2010) 1.51
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21. Sci Signal (2011) 1.50
Decorin evokes protracted internalization and degradation of the epidermal growth factor receptor via caveolar endocytosis. J Biol Chem (2005) 1.50
Association of autoantibodies to nuclear lamin B1 with thromboprotection in systemic lupus erythematosus: lack of evidence for a direct role of lamin B1 in apoptotic blebs. Arthritis Rheum (2002) 1.49
Diverse cell signaling events modulated by perlecan. Biochemistry (2008) 1.49
Caveolin-1 and mitochondrial SOD2 (MnSOD) function as tumor suppressors in the stromal microenvironment: a new genetically tractable model for human cancer associated fibroblasts. Cancer Biol Ther (2011) 1.48
Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway. Cardiovasc Res (2013) 1.47
Proepithelin promotes migration and invasion of 5637 bladder cancer cells through the activation of ERK1/2 and the formation of a paxillin/FAK/ERK complex. Cancer Res (2006) 1.46
Decorin: a guardian from the matrix. Am J Pathol (2012) 1.46
Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin. Oncogene (2002) 1.42
Carboxylesterase 3 (EC 3.1.1.1) is a major adipocyte lipase. J Biol Chem (2004) 1.40
Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling. Cell Signal (2009) 1.40
Biologically active decorin is a monomer in solution. J Biol Chem (2003) 1.40
Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix Biol (2012) 1.39
Effect of altered matrix proteins on quasilinear viscoelastic properties in transgenic mouse tail tendons. Ann Biomed Eng (2003) 1.38
The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cells. Brain (2007) 1.36
Angiogenesis in collagen I requires alpha2beta1 ligation of a GFP*GER sequence and possibly p38 MAPK activation and focal adhesion disassembly. J Biol Chem (2003) 1.36
An antimetastatic role for decorin in breast cancer. Am J Pathol (2008) 1.34
A role for decorin in cutaneous wound healing and angiogenesis. Wound Repair Regen (2006) 1.33
Decorin antagonizes Met receptor activity and down-regulates {beta}-catenin and Myc levels. J Biol Chem (2010) 1.32
Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis. J Biol Chem (2003) 1.31
The glycosaminoglycan chain of decorin plays an important role in collagen fibril formation at the early stages of fibrillogenesis. FEBS J (2007) 1.31
BMP-1/Tolloid-like metalloproteases process endorepellin, the angiostatic C-terminal fragment of perlecan. J Biol Chem (2004) 1.31
A novel interaction between perlecan protein core and progranulin: potential effects on tumor growth. J Biol Chem (2003) 1.30
Immunologic privilege in the central nervous system and the blood-brain barrier. J Cereb Blood Flow Metab (2012) 1.30
Dependence of pathogen molecule-induced toll-like receptor activation and cell function on Neu1 sialidase. Glycoconj J (2009) 1.29
How do immune cells overcome the blood-brain barrier in multiple sclerosis? FEBS Lett (2011) 1.29
Decorin deficiency leads to impaired angiogenesis in injured mouse cornea. J Vasc Res (2004) 1.29
Protective niche for Borrelia burgdorferi to evade humoral immunity. Am J Pathol (2004) 1.29
Matrix revolutions: "tails" of basement-membrane components with angiostatic functions. Trends Cell Biol (2005) 1.28
Genetic deficiency of decorin causes intestinal tumor formation through disruption of intestinal cell maturation. Carcinogenesis (2008) 1.28
Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system. Nat Med (2009) 1.27
Diminished Th17 (not Th1) responses underlie multiple sclerosis disease abrogation after hematopoietic stem cell transplantation. Ann Neurol (2013) 1.27
The enigmatic nature of altruism in organ transplantation: a cross-cultural study of transplant physicians' views on altruism. BMC Res Notes (2010) 1.27
Peroxisome proliferator-activated receptor (PPAR)α and -γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way. Proc Natl Acad Sci U S A (2012) 1.26
Decorin causes autophagy in endothelial cells via Peg3. Proc Natl Acad Sci U S A (2013) 1.22
A central function for perlecan in skeletal muscle and cardiovascular development. J Cell Biol (2008) 1.22
Biological interplay between proteoglycans and their innate immune receptors in inflammation. FEBS J (2013) 1.22
Decorin deficiency enhances progressive nephropathy in diabetic mice. Am J Pathol (2007) 1.22
Strain-rate sensitive mechanical properties of tendon fascicles from mice with genetically engineered alterations in collagen and decorin. J Biomech Eng (2004) 1.22
In vivo selective and distant killing of cancer cells using adenovirus-mediated decorin gene transfer. FASEB J (2003) 1.22
Influence of decorin on the mechanical, compositional, and structural properties of the mouse patellar tendon. J Biomech Eng (2012) 1.20
Decorin-mediated regulation of fibrillin-1 in the kidney involves the insulin-like growth factor-I receptor and Mammalian target of rapamycin. Am J Pathol (2007) 1.20
Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3. J Biol Chem (2011) 1.20
Lysosomal sialidase (neuraminidase-1) is targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly. J Biol Chem (2005) 1.20
Determinants of human B cell migration across brain endothelial cells. J Immunol (2003) 1.19
Molecular pathology of NEU1 gene in sialidosis. Hum Mutat (2003) 1.19
Endorepellin in vivo: targeting the tumor vasculature and retarding cancer growth and metabolism. J Natl Cancer Inst (2006) 1.17
Retinoic acid induces blood-brain barrier development. J Neurosci (2013) 1.17
Therapeutic decisions in multiple sclerosis: moving beyond efficacy. JAMA Neurol (2013) 1.16
Effect of age and proteoglycan deficiency on collagen fiber re-alignment and mechanical properties in mouse supraspinatus tendon. J Biomech Eng (2013) 1.13
Monocyte differentiation up-regulates the expression of the lysosomal sialidase, Neu1, and triggers its targeting to the plasma membrane via major histocompatibility complex class II-positive compartments. J Biol Chem (2006) 1.13
Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions. Ann Neurol (2011) 1.13
The insulin-like growth factor receptor I promotes motility and invasion of bladder cancer cells through Akt- and mitogen-activated protein kinase-dependent activation of paxillin. Am J Pathol (2010) 1.13
Investigating tendon fascicle structure-function relationships in a transgenic-age mouse model using multiple regression models. Ann Biomed Eng (2004) 1.13
Glial influence on the blood brain barrier. Glia (2013) 1.12
Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. J Biol Chem (2006) 1.11
Endothelial cells provide feedback control for vascular remodeling through a mechanosensitive autocrine TGF-beta signaling pathway. Circ Res (2008) 1.11
Small leucine-rich proteoglycans, at the crossroad of cancer growth and inflammation. Curr Opin Genet Dev (2012) 1.11
Lipocalin 2 is a novel immune mediator of experimental autoimmune encephalomyelitis pathogenesis and is modulated in multiple sclerosis. Glia (2012) 1.11
Small leucine-rich proteoglycans orchestrate receptor crosstalk during inflammation. Cell Cycle (2012) 1.11
Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on α4 integrin. Brain (2011) 1.10
Enzymatic activity of lysosomal carboxypeptidase (cathepsin) A is required for proper elastic fiber formation and inactivation of endothelin-1. Circulation (2008) 1.10
Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice. Carcinogenesis (2011) 1.10
Protein misfolding as an underlying molecular defect in mucopolysaccharidosis III type C. PLoS One (2009) 1.09