Amino-terminal domains of c-myc and N-myc proteins mediate binding to the retinoblastoma gene product.

PubWeight™: 2.78‹?› | Rank: Top 1%

🔗 View Article (PMID 1865909)

Published in Nature on August 08, 1991

Authors

A K Rustgi1, N Dyson, R Bernards

Author Affiliations

1: Division of Molecular Genetics, Massachusetts General Hospital, Charlestown.

Articles citing this

Ethidium bromide provides a simple tool for identifying genuine DNA-independent protein associations. Proc Natl Acad Sci U S A (1992) 6.23

Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol (1994) 4.36

Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Dev (2000) 3.72

Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: identification of a gene with properties of the transcription factor E2F. Mol Cell Biol (1992) 3.58

The retinoblastoma protein is phosphorylated on multiple sites by human cdc2. EMBO J (1991) 3.15

Homologous sequences in adenovirus E1A and human papillomavirus E7 proteins mediate interaction with the same set of cellular proteins. J Virol (1992) 2.97

The activation domain of transcription factor PU.1 binds the retinoblastoma (RB) protein and the transcription factor TFIID in vitro: RB shows sequence similarity to TFIID and TFIIB. Proc Natl Acad Sci U S A (1993) 2.90

Transcriptional repression of the E2-containing promoters EIIaE, c-myc, and RB1 by the product of the RB1 gene. Mol Cell Biol (1992) 2.78

Interactions of the p107 and Rb proteins with E2F during the cell proliferation response. EMBO J (1993) 2.70

Extensive contribution of Rb-deficient cells to adult chimeric mice with limited histopathological consequences. EMBO J (1994) 2.57

Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A (1993) 2.31

Functional interaction between the HCMV IE2 transactivator and the retinoblastoma protein. EMBO J (1994) 2.25

The retinoblastoma gene product regulates Sp1-mediated transcription. Mol Cell Biol (1992) 2.21

The retinoblastoma protein binds E2F residues required for activation in vivo and TBP binding in vitro. Nucleic Acids Res (1993) 2.17

Direct transcriptional repression by pRB and its reversal by specific cyclins. Mol Cell Biol (1995) 2.13

The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein. Proc Natl Acad Sci U S A (1994) 2.06

TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein. Proc Natl Acad Sci U S A (1993) 2.00

EBNA-5, an Epstein-Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proc Natl Acad Sci U S A (1993) 1.99

The transcription factor E2F-1 is a downstream target of RB action. Mol Cell Biol (1995) 1.97

Identification of a Myc-dependent step during the formation of active G1 cyclin-cdk complexes. EMBO J (1995) 1.92

Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol Cell Biol (1996) 1.81

Myc-mediated apoptosis is blocked by ectopic expression of Bcl-2. Mol Cell Biol (1993) 1.79

Analysis of p107-associated proteins: p107 associates with a form of E2F that differs from pRB-associated E2F-1. J Virol (1993) 1.78

The transcription factor E2F-1 mediates the autoregulation of RB gene expression. Mol Cell Biol (1994) 1.73

Opposite regulation of gene transcription and cell proliferation by c-Myc and Max. Proc Natl Acad Sci U S A (1993) 1.70

Distinct sub-populations of the retinoblastoma protein show a distinct pattern of phosphorylation. EMBO J (1994) 1.67

Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles. Nat Cell Biol (2015) 1.61

Phosphorylation of the retinoblastoma protein by cdk2. Proc Natl Acad Sci U S A (1992) 1.61

Functional interactions between the retinoblastoma (Rb) protein and Sp-family members: superactivation by Rb requires amino acids necessary for growth suppression. Proc Natl Acad Sci U S A (1995) 1.61

Inhibition of apoptosis by the retinoblastoma gene product. EMBO J (1995) 1.58

Glycosylation of the c-Myc transactivation domain. Proc Natl Acad Sci U S A (1995) 1.58

Enhanced binding of a 95 kDa protein to p53 in cells undergoing p53-mediated growth arrest. EMBO J (1992) 1.49

The retinoblastoma protein physically associates with the human cdc2 kinase. Mol Cell Biol (1992) 1.40

Activation domains of L-Myc and c-Myc determine their transforming potencies in rat embryo cells. Mol Cell Biol (1992) 1.39

Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. EMBO J (1994) 1.37

Inhibitory effects of antisense oligodeoxynucleotides targeting c-myc mRNA on smooth muscle cell proliferation and migration. Proc Natl Acad Sci U S A (1993) 1.35

An essential domain of the c-myc protein interacts with a nuclear factor that is also required for E1A-mediated transformation. Mol Cell Biol (1995) 1.34

A bipartite nuclear localization signal in the retinoblastoma gene product and its importance for biological activity. Mol Cell Biol (1993) 1.27

Rb binds c-Jun and activates transcription. EMBO J (1998) 1.25

Nuclear protein phosphorylation and growth control. Biochem J (1992) 1.16

Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells. Mol Cell Biol (1993) 1.16

Lymphoma models for B cell activation and tolerance. X. Anti-mu-mediated growth arrest and apoptosis of murine B cell lymphomas is prevented by the stabilization of myc. J Exp Med (1994) 1.10

Negative regulation of transcription in eukaryotes. Biochem J (1993) 1.10

Human papillomavirus type 16 E7 protein inhibits DNA binding by the retinoblastoma gene product. Mol Cell Biol (1992) 1.03

Contrasting roles for c-Myc and L-Myc in the regulation of cellular growth and differentiation in vivo. EMBO J (1995) 1.02

Cell cycle regulation of the c-Myc transcriptional activation domain. Mol Cell Biol (1993) 1.01

The retinoblastoma-susceptibility gene product binds directly to the human TATA-binding protein-associated factor TAFII250. Proc Natl Acad Sci U S A (1995) 1.01

Myc transcription factors: key regulators behind establishment and maintenance of pluripotency. Regen Med (2010) 1.00

YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels. Proc Natl Acad Sci U S A (1996) 0.99

c-Myc cooperates with activated Ras to induce the cdc2 promoter. Mol Cell Biol (1994) 0.99

Differential expression of myc, max and RB1 genes in human gliomas and glioma cell lines. Br J Cancer (1994) 0.98

Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein. Mol Cell Biol (1994) 0.96

The adenovirus E1A 12S product displays functional redundancy in activating the human proliferating cell nuclear antigen promoter. J Virol (1993) 0.95

The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max. Mol Cell Biol (1995) 0.93

Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16. Br J Cancer (1995) 0.92

A dominant-negative mutant of Max that inhibits sequence-specific DNA binding by Myc proteins. Proc Natl Acad Sci U S A (1993) 0.91

Single amino acid substitutions in "low-risk" human papillomavirus (HPV) type 6 E7 protein enhance features characteristic of the "high-risk" HPV E7 oncoproteins. Proc Natl Acad Sci U S A (1992) 0.91

Overproduction of Rb protein after the G1/S boundary causes G2 arrest. Mol Cell Biol (1993) 0.91

Study of the role of retinoblastoma protein in terminal differentiation of murine erythroleukemia cells. Proc Natl Acad Sci U S A (1995) 0.88

Transgenic models of retinoblastoma: what they tell us about its cause and treatment. Trans Am Ophthalmol Soc (1994) 0.86

Expression of the woodchuck N-myc2 retroposon in brain and in liver tumors is driven by a cryptic N-myc promoter. Mol Cell Biol (1992) 0.85

Mab21l2 is essential for embryonic heart and liver development. PLoS One (2012) 0.83

The binding domain structure of retinoblastoma-binding proteins. Protein Sci (1993) 0.82

Functional Myc-Max heterodimer is required for activation-induced apoptosis in T cell hybridomas. J Exp Med (1994) 0.82

Changes in retinoblastoma gene expression during cervical cancer progression. Int J Exp Pathol (2002) 0.81

Detection of Heterozygous Mutation in the Retinoblastoma Gene in a Human Pituitary Adenoma Using PCR-SSCP Analysis and Direct Sequencing. Endocr Pathol (1995) 0.78

Apparent uncoupling of oncogenicity from fibroblast transformation and apoptosis in a mutant myc gene transduced by feline leukemia virus. J Virol (1996) 0.78

Image analysis quantitation of immunoreactive retinoblastoma protein in human thyroid neoplasms with a streptavidin-biotin-peroxidase staining technique. Am J Pathol (1991) 0.77

RB-loss puts focus on Myc. Nat Cell Biol (2015) 0.77

Cell cycle regulators p27 and pRb in lymphomas - correlation with histology and proliferative activity. Br J Cancer (2000) 0.77

Multiple Roles of MYC in Integrating Regulatory Networks of Pluripotent Stem Cells. Front Cell Dev Biol (2017) 0.75

Multiple changes in oncogenes and tumor suppressor genes in human retinoblastoma. Trans Am Ophthalmol Soc (1996) 0.75

Articles by these authors

(truncated to the top 100)

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature (1986) 13.96

Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J (1989) 7.69

A cDNA encoding a pRB-binding protein with properties of the transcription factor E2F. Cell (1992) 6.32

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev (1993) 5.54

Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells. Nature (1983) 5.40

rad-dependent response of the chk1-encoded protein kinase at the DNA damage checkpoint. Science (1996) 5.13

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes. Genes Dev (1997) 4.36

Independent binding of the retinoblastoma protein and p107 to the transcription factor E2F. Nature (1992) 4.21

The 2.2 kb E1b mRNA of human Ad12 and Ad5 codes for two tumor antigens starting at different AUG triplets. Cell (1981) 4.16

CDK-independent activation of estrogen receptor by cyclin D1. Cell (1997) 3.85

The retinoblastoma protein binds to a family of E2F transcription factors. Mol Cell Biol (1993) 3.75

Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev (1996) 3.61

Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity. Nature (1983) 2.96

Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage. Cell (2000) 2.95

RBF, a novel RB-related gene that regulates E2F activity and interacts with cyclin E in Drosophila. Genes Dev (1996) 2.92

E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo. Genes Dev (1994) 2.86

The regions of the retinoblastoma protein needed for binding to adenovirus E1A or SV40 large T antigen are common sites for mutations. EMBO J (1990) 2.80

Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev (1996) 2.71

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein. Nature (1997) 2.60

The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev (1995) 2.60

pRB plays an essential role in cell cycle arrest induced by DNA damage. Proc Natl Acad Sci U S A (1998) 2.49

Nuclear organization of DNA replication in primary mammalian cells. Genes Dev (2000) 2.48

Large T antigens of many polyomaviruses are able to form complexes with the retinoblastoma protein. J Virol (1990) 2.40

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes. Genes Dev (1995) 2.33

Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins. Genes Dev (1996) 2.26

E2F-5, a new E2F family member that interacts with p130 in vivo. Mol Cell Biol (1995) 2.26

Physical mapping of the globin gene deletion in hereditary persistence of foetal haemoglobin (HPFH). Nucleic Acids Res (1980) 2.20

Characterization of the retinoblastoma binding proteins RBP1 and RBP2. Oncogene (1993) 2.20

DNA-binding and trans-activation properties of Drosophila E2F and DP proteins. Proc Natl Acad Sci U S A (1994) 2.08

TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein. Proc Natl Acad Sci U S A (1993) 2.00

Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1. Genes Dev (1998) 1.97

Characterization of cells transformed by Ad5/Ad12 hybrid early region I plasmids. Virology (1982) 1.90

Retinoblastoma in transgenic mice. Nature (1990) 1.84

The role of RBF in the introduction of G1 regulation during Drosophila embryogenesis. EMBO J (1999) 1.83

N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma. Cell (1986) 1.78

p107 and p130: versatile proteins with interesting pockets. Exp Cell Res (2001) 1.73

Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. J Biol Chem (1997) 1.71

E2F-induced S phase requires cyclin E. Genes Dev (1996) 1.71

Physical mapping of the globin gene deletion in (delta beta (0)) -thalassaemia. Gene (1979) 1.69

The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J (1995) 1.67

A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts. Oncogene (2000) 1.67

Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol Cell Biol (1996) 1.62

Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J (1996) 1.61

Cell cycle regulation by the retinoblastoma family of growth inhibitory proteins. Biochim Biophys Acta (1996) 1.60

A genetic screen for modifiers of E2F in Drosophila melanogaster. Genetics (1999) 1.51

Role of adenovirus types 5 and 12 early region 1b tumor antigens in oncogenic transformation. Virology (1983) 1.50

The structure of the human beta-globin gene in beta-thalassaemia. Nucleic Acids Res (1979) 1.46

Loss-of-function genetic screens as a tool to improve the diagnosis and treatment of cancer. Oncogene (2009) 1.40

Role of the adenovirus early region 1B tumor antigens in transformation and lytic infection. Virology (1986) 1.38

Interaction of c-Myc with the pRb-related protein p107 results in inhibition of c-Myc-mediated transactivation. EMBO J (1994) 1.37

Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat Cell Biol (2001) 1.36

E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3. J Biol Chem (2000) 1.35

Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. EMBO J (1996) 1.33

Requirements for cell cycle arrest by p16INK4a. Mol Cell (2000) 1.31

Suppression of MHC class I gene expression by N-myc through enhancer inactivation. EMBO J (1989) 1.27

Repression of c-Myc responsive genes in cycling cells causes G1 arrest through reduction of cyclin E/CDK2 kinase activity. Oncogene (1997) 1.27

PRAME expression and clinical outcome of breast cancer. Br J Cancer (2008) 1.26

Deletion mutants of region E1a of AD12 E1 plasmids: effect on oncogenic transformation. Virology (1983) 1.26

Structure of the human G gamma-A gamma-delta-beta-globin gene locus. Proc Natl Acad Sci U S A (1979) 1.25

Polyomavirus large T mutants affected in retinoblastoma protein binding are defective in immortalization. J Virol (1991) 1.25

BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation. EMBO J (1995) 1.21

c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the rat ornithine decarboxylase (ODC) gene. Nucleic Acids Res (1997) 1.20

B-myb rescues ras-induced premature senescence, which requires its transactivation domain. Cancer Lett (2001) 1.20

mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect. J Biol Chem (1996) 1.20

The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. Oncogene (2000) 1.16

Expression of cyclins E1 and E2 during mouse development and in neoplasia. Proc Natl Acad Sci U S A (2001) 1.16

A role for Ebi in neuronal cell cycle control. EMBO J (2000) 1.15

Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein. Oncogene (1999) 1.15

Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties. Proc Natl Acad Sci U S A (1990) 1.09

Functional analysis of Burkitt's lymphoma mutant c-Myc proteins. J Biol Chem (1996) 1.08

Targeting the epigenome for treatment of cancer. Oncogene (2011) 1.06

Cancer of the esophagus and gastric cardia: recent advances. Dis Esophagus (2004) 1.06

Molecular and functional characterisation of E2F-5, a new member of the E2F family. Oncogene (1995) 1.02

Adenovirus: transformation and oncogenicity. Biochim Biophys Acta (1984) 1.01

An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis. Br J Dermatol (2006) 1.00

The large subunit of replication factor C promotes cell survival after DNA damage in an LxCxE motif- and Rb-dependent manner. Mol Cell (2001) 0.99

Different activities of the adenovirus types 5 and 12 E1A regions in transformation with the EJ Ha-ras oncogene. J Virol (1986) 0.99

Transformation and oncogenicity by adenoviruses. Curr Top Microbiol Immunol (1984) 0.98

N-myc down regulates neural cell adhesion molecule expression in rat neuroblastoma. Mol Cell Biol (1990) 0.97

Distinct mechanisms of nuclear accumulation regulate the functional consequence of E2F transcription factors. J Cell Sci (1997) 0.95

Structure and expression of major histocompatibility complex-binding protein 2, a 275-kDa zinc finger protein that binds to an enhancer of major histocompatibility complex class I genes. Proc Natl Acad Sci U S A (1992) 0.95

Rapid dephosphorylation of p107 following UV irradiation. Oncogene (1999) 0.94

A transgenic mouse model for trilateral retinoblastoma. Arch Ophthalmol (1990) 0.94

N-myc suppresses major histocompatibility complex class I gene expression through down-regulation of the p50 subunit of NF-kappa B. EMBO J (1993) 0.93

A dominant-negative mutant of Max that inhibits sequence-specific DNA binding by Myc proteins. Proc Natl Acad Sci U S A (1993) 0.91

Histone deacetylase-dependent transcriptional repression by pRB in yeast occurs independently of interaction through the LXCXE binding cleft. Proc Natl Acad Sci U S A (2001) 0.91

Long-term impact of the 70-gene signature on breast cancer outcome. Breast Cancer Res Treat (2014) 0.90

p27kip1-independent cell cycle regulation by MYC. Oncogene (2000) 0.88

Construction and characterization of an adenovirus type 5/adenovirus type 12 recombinant virus. Virology (1983) 0.88

No effect of loss of E2F1 on liver regeneration or hepatocarcinogenesis in C57BL/6J or C3H/HeJ mice. Mol Carcinog (1999) 0.87

The murine retinoblastoma homolog maps to chromosome 14 near Es-10. Genomics (1989) 0.87

A functionally distinct member of the DP family of E2F subunits. Oncogene (2006) 0.86

Two E2F sites control growth-regulated and cell cycle-regulated transcription of the Htf9-a/RanBP1 gene through functionally distinct mechanisms. J Biol Chem (1999) 0.85

Expression of the retinoblastoma protein in low-grade B-cell lymphoma: relationship to cyclin D1. Blood (1996) 0.85

Oncogenicity by adenovirus is not determined by the transforming region only. J Virol (1984) 0.84

Growth suppression by members of the retinoblastoma protein family. Cold Spring Harb Symp Quant Biol (1994) 0.83

Trilateral retinoblastoma in transgenic mice. Trans Am Ophthalmol Soc (1989) 0.81

Functional identification of cancer-relevant genes through large-scale RNA interference screens in mammalian cells. Cold Spring Harb Symp Quant Biol (2004) 0.81

Communication between the extracellular environment, cytoplasmic signalling cascades and the nuclear cell-cycle machinery. FEBS Lett (1997) 0.81

The c-myc oncoprotein forms a specific complex with the product of the retinoblastoma gene. Cold Spring Harb Symp Quant Biol (1991) 0.78