Published in Mol Biol Cell on September 23, 2009
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
Diverse roles for the paxillin family of proteins in cancer. Genes Cancer (2012) 0.98
Role of FAK in S1P-regulated endothelial permeability. Microvasc Res (2011) 0.97
Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration. J Cell Biol (2014) 0.86
The endosomal adaptor protein APPL1 impairs the turnover of leading edge adhesions to regulate cell migration. Mol Biol Cell (2012) 0.84
The adaptor protein and Arf GTPase-activating protein Cat-1/Git-1 is required for cellular transformation. J Biol Chem (2012) 0.84
Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration. Cell Adh Migr (2010) 0.83
Dose-related gene expression changes in forebrain following acute, low-level chlorpyrifos exposure in neonatal rats. Toxicol Appl Pharmacol (2010) 0.80
CdGAP regulates cell migration and adhesion dynamics in two-and three-dimensional matrix environments. Cytoskeleton (Hoboken) (2012) 0.80
The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. Biochem Biophys Res Commun (2012) 0.78
In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer (2013) 0.78
The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development. Dev Biol (2010) 0.78
FAK and paxillin, two potential targets in pancreatic cancer. Oncotarget (2016) 0.78
Biochemical and functional characterization of the interaction between liprin-α1 and GIT1: implications for the regulation of cell motility. PLoS One (2011) 0.78
Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol Biol Cell (2013) 0.78
Structural and mechanistic insights into the interaction between Pyk2 and paxillin LD motifs. J Mol Biol (2014) 0.76
Integrin-mediated traction force enhances paxillin molecular associations and adhesion dynamics that increase the invasiveness of tumor cells into a three-dimensional extracellular matrix. Mol Biol Cell (2017) 0.76
The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene (2016) 0.75
Paxillin functions as an oncogene in human gliomas by promoting cell migration and invasion. Onco Targets Ther (2016) 0.75
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
Cell migration: integrating signals from front to back. Science (2003) 29.13
Rho GTPases and the actin cytoskeleton. Science (1998) 28.19
Cell migration: a physically integrated molecular process. Cell (1996) 23.49
Rho GTPases in cell biology. Nature (2002) 22.81
Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol (1997) 11.36
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol (2005) 10.44
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol (1999) 8.66
Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev (1999) 8.36
Biology of the p21-activated kinases. Annu Rev Biochem (2003) 7.63
Regulation of cell motility by mitogen-activated protein kinase. J Cell Biol (1997) 7.14
Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell (2001) 7.07
Functional atlas of the integrin adhesome. Nat Cell Biol (2007) 6.89
FAK integrates growth-factor and integrin signals to promote cell migration. Nat Cell Biol (2000) 6.54
Signaling through focal adhesion kinase. Prog Biophys Mol Biol (1999) 5.33
Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J (1999) 5.05
Nuclear movement regulated by Cdc42, MRCK, myosin, and actin flow establishes MTOC polarization in migrating cells. Cell (2005) 4.86
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol Cell Biol (2002) 4.50
Paxillin: adapting to change. Physiol Rev (2004) 4.48
A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol (2005) 4.40
Activation of endogenous Cdc42 visualized in living cells. Science (2004) 3.57
Paxillin comes of age. J Cell Sci (2008) 3.57
An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol (2005) 3.44
Adhesion signaling - crosstalk between integrins, Src and Rho. J Cell Sci (2009) 3.38
The interplay between Src and integrins in normal and tumor biology. Oncogene (2004) 3.37
Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. J Cell Biol (1999) 3.34
Guidance of cell migration by the Drosophila PDGF/VEGF receptor. Cell (2001) 3.16
Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics. J Cell Biol (2006) 3.15
Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Mol Cell Biol (2000) 2.92
Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol (1997) 2.83
GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol (2007) 2.80
Cell migration at a glance. J Cell Sci (2005) 2.80
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J Cell Biol (2007) 2.79
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73
Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members. Annu Rev Pharmacol Toxicol (2002) 2.62
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Leading the way: Directional sensing through phosphatidylinositol 3-kinase and other signaling pathways. J Cell Sci (2003) 2.49
Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-Src. EMBO J (2000) 2.44
Regulation of leading edge microtubule and actin dynamics downstream of Rac1. J Cell Biol (2003) 2.41
Cdc42 controls the polarity of the actin and microtubule cytoskeletons through two distinct signal transduction pathways. J Cell Sci (2005) 2.37
Polarity proteins in migration and invasion. Oncogene (2008) 2.11
The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL). J Cell Biol (2001) 2.10
Cellular and molecular mechanisms of border cell migration analyzed using time-lapse live-cell imaging. Dev Cell (2007) 2.09
beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. Proc Natl Acad Sci U S A (1998) 2.08
A primary role for Golgi positioning in directed secretion, cell polarity, and wound healing. Mol Biol Cell (2009) 2.05
Cool-1 functions as an essential regulatory node for EGF receptor- and Src-mediated cell growth. Nat Cell Biol (2006) 2.04
ERK activation propagates in epithelial cell sheets and regulates their migration during wound healing. Curr Biol (2004) 2.00
Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase. J Cell Biol (2007) 1.93
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Mol Cell (2004) 1.86
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Mol Cell (2003) 1.83
Focal adhesion kinase is required for the spatial organization of the leading edge in migrating cells. J Cell Sci (2005) 1.80
Localized suppression of RhoA activity by Tyr31/118-phosphorylated paxillin in cell adhesion and migration. J Cell Biol (2002) 1.78
ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65. J Cell Biol (2008) 1.73
ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol Cell Biol (1998) 1.73
Distinct mechanisms regulate hemocyte chemotaxis during development and wound healing in Drosophila melanogaster. J Cell Biol (2006) 1.73
Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor. Mol Biol Cell (2003) 1.72
Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell (2002) 1.72
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell (2005) 1.69
Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective. Cell Signal (2007) 1.65
Role of p120 Ras-GAP in directed cell movement. J Cell Biol (2000) 1.59
Microtubule involvement in NIH 3T3 Golgi and MTOC polarity establishment. J Cell Sci (2003) 1.58
A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci (2009) 1.55
The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. J Biol Chem (2000) 1.44
uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol (2008) 1.43
FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX. Mol Biol Cell (2006) 1.42
GIT1 is a scaffold for ERK1/2 activation in focal adhesions. J Biol Chem (2005) 1.33
Guidance of mesoderm cell migration in the Xenopus gastrula requires PDGF signaling. Development (2004) 1.33
Transgenic mouse proteomics identifies new 14-3-3-associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics (2006) 1.32
Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Nat Immunol (2006) 1.21
JNK signaling controls border cell cluster integrity and collective cell migration. Curr Biol (2008) 1.20
GIT2 represses Crk- and Rac1-regulated cell spreading and Cdc42-mediated focal adhesion turnover. EMBO J (2006) 1.18
Focal adhesion kinase facilitates platelet-derived growth factor-BB-stimulated ERK2 activation required for chemotaxis migration of vascular smooth muscle cells. J Biol Chem (2000) 1.15
A RAC/CDC-42-independent GIT/PIX/PAK signaling pathway mediates cell migration in C. elegans. PLoS Genet (2008) 1.09
Protein kinase A-dependent phosphorylation modulates beta1Pix guanine nucleotide exchange factor activity through 14-3-3beta binding. Mol Cell Biol (2007) 1.08
Disruption of PDGFRalpha-initiated PI3K activation and migration of somite derivatives leads to spina bifida. Development (2008) 1.04
v-Src rescues actin-based cytoskeletal architecture and cell motility and induces enhanced anchorage independence during oncogenic transformation of focal adhesion kinase-null fibroblasts. J Biol Chem (2003) 1.04
An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. J Cell Sci (2009) 1.04
CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility. Curr Biol (2006) 1.03
Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblasts. Mol Biol Cell (2005) 1.00
Wnt signalling regulates paxillin ubiquitination essential for mesodermal cell motility. Nat Cell Biol (2007) 1.00
GIT1 paxillin-binding domain is a four-helix bundle, and it binds to both paxillin LD2 and LD4 motifs. J Biol Chem (2008) 0.88
Constitutive diffuse activation of phosphoinositide 3-kinase at the plasma membrane by v-Src suppresses the chemotactic response to PDGF by abrogating the polarity of PDGF receptor signalling. Exp Cell Res (2007) 0.79
FAK-Src signalling through paxillin, ERK and MLCK regulates adhesion disassembly. Nat Cell Biol (2004) 9.31
Paxillin: adapting to change. Physiol Rev (2004) 4.48
Paxillin comes of age. J Cell Sci (2008) 3.57
The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Mol Cell Biol (2002) 2.73
Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83
RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Mol Cell Biol (2003) 1.75
Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. Mol Biol Cell (2002) 1.72
Src and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness. Mol Biol Cell (2005) 1.69
Quantification of integrin receptor agonism by fluorescence lifetime imaging. J Cell Sci (2008) 1.64
Tension development during contractile stimulation of smooth muscle requires recruitment of paxillin and vinculin to the membrane. Am J Physiol Cell Physiol (2003) 1.56
Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis. Mol Biol Cell (2011) 1.54
Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization. J Biol Chem (2001) 1.45
Hic-5 promotes invadopodia formation and invasion during TGF-β-induced epithelial-mesenchymal transition. J Cell Biol (2012) 1.45
Paxillin-dependent stimulation of microtubule catastrophes at focal adhesion sites. J Cell Sci (2008) 1.34
Regulation of paxillin family members during epithelial-mesenchymal transformation: a putative role for paxillin delta. J Cell Sci (2005) 1.31
FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci (2009) 1.29
Hic-5 contributes to epithelial-mesenchymal transformation through a RhoA/ROCK-dependent pathway. J Cell Physiol (2007) 1.22
The paxillin LD motifs. FEBS Lett (2002) 1.17
Hic-5 promotes the hypertrophic scar myofibroblast phenotype by regulating the TGF-beta1 autocrine loop. J Invest Dermatol (2008) 1.16
Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts. Mol Biol Cell (2003) 1.16
Expression of non-phosphorylatable paxillin mutants in canine tracheal smooth muscle inhibits tension development. J Physiol (2003) 1.15
The integrin-linked kinase regulates cell morphology and motility in a rho-associated kinase-dependent manner. J Biol Chem (2004) 1.08
EphB1-mediated cell migration requires the phosphorylation of paxillin at Tyr-31/Tyr-118. J Biol Chem (2004) 1.08
Extracellular signal-regulated kinase mediates phosphorylation of tropomyosin-1 to promote cytoskeleton remodeling in response to oxidative stress: impact on membrane blebbing. Mol Biol Cell (2003) 1.05
Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker. J Cell Sci (2005) 1.05
A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem (2002) 1.03
CdGAP associates with actopaxin to regulate integrin-dependent changes in cell morphology and motility. Curr Biol (2006) 1.03
Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol (2008) 1.01
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One (2012) 1.00
LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration. FASEB J (2012) 1.00
Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. J Biol Chem (2005) 0.98
Diverse roles for the paxillin family of proteins in cancer. Genes Cancer (2012) 0.98
Phosphorylation of actopaxin regulates cell spreading and migration. J Cell Biol (2004) 0.97
Roles for the tubulin- and PTP-PEST-binding paxillin LIM domains in cell adhesion and motility. Int J Biochem Cell Biol (2002) 0.97
TGF-beta1 slows the growth of pathogenic myofibroblasts through a mechanism requiring the focal adhesion protein, Hic-5. J Invest Dermatol (2007) 0.93
Ca2+-dependent localization of integrin-linked kinase to cell junctions in differentiating keratinocytes. J Biol Chem (2003) 0.89
Tyrosine-phosphorylated Hic-5 inhibits epidermal growth factor-induced lamellipodia formation. Exp Cell Res (2005) 0.86
Actopaxin is phosphorylated during mitosis and is a substrate for cyclin B1/cdc2 kinase. Biochem J (2002) 0.84
LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. PLoS One (2013) 0.83
Emerging role of paxillin-PKL in regulation of cell adhesion, polarity and migration. Cell Adh Migr (2010) 0.83
CdGAP regulates cell migration and adhesion dynamics in two-and three-dimensional matrix environments. Cytoskeleton (Hoboken) (2012) 0.80
Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion. J Biol Chem (2012) 0.80
Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration. Mol Biol Cell (2013) 0.78
The cell adhesion-associated protein Git2 regulates morphogenetic movements during zebrafish embryonic development. Dev Biol (2010) 0.78
Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading. Novartis Found Symp (2005) 0.78
Integrin-linked kinase: a possible role in scar contracture. Ann Plast Surg (2004) 0.77
Beta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradation. PLoS One (2012) 0.76
Epidermal growth factor stimulates serine/threonine phosphorylation of the focal adhesion protein paxillin in a MEK-dependent manner in normal rat kidney cells. J Cell Physiol (2002) 0.76