Published in J Biol Chem on August 07, 2008
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions. Cell Death Differ (2010) 1.77
Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. PLoS Genet (2017) 1.40
Differential 14-3-3 affinity capture reveals new downstream targets of phosphatidylinositol 3-kinase signaling. Mol Cell Proteomics (2009) 1.35
Endothelin-1 inhibits the epithelial Na+ channel through betaPix/14-3-3/Nedd4-2. J Am Soc Nephrol (2010) 1.22
Role of the ubiquitin system in regulating ion transport. Pflugers Arch (2010) 1.12
Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors. Exp Cell Res (2012) 1.08
Targeting SGK1 in diabetes. Expert Opin Ther Targets (2009) 1.02
Regulation of epithelial sodium channel trafficking by ubiquitination. Proc Am Thorac Soc (2010) 1.00
AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking. Mol Biol Cell (2010) 0.99
Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes. J Biol Chem (2009) 0.94
Stimulation of Ca2+-channel Orai1/STIM1 by serum- and glucocorticoid-inducible kinase 1 (SGK1). FASEB J (2011) 0.93
Dimerization is essential for 14-3-3zeta stability and function in vivo. J Biol Chem (2009) 0.92
Interactome analysis of the six cotton 14-3-3s that are preferentially expressed in fibres and involved in cell elongation. J Exp Bot (2010) 0.91
Rsk-mediated phosphorylation and 14-3-3ɛ binding of Apaf-1 suppresses cytochrome c-induced apoptosis. EMBO J (2012) 0.90
Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis. Mol Biol Cell (2012) 0.90
The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. PLoS One (2012) 0.89
Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites. J Biol Chem (2011) 0.89
Proteomic analysis of bovine sperm YWHA binding partners identify proteins involved in signaling and metabolism. Biol Reprod (2008) 0.87
Transcription factor NF-κB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. J Biol Chem (2011) 0.87
14-3-3epsilon contributes to tumour suppression in laryngeal carcinoma by affecting apoptosis and invasion. BMC Cancer (2010) 0.87
CLIMP-63 is a gentamicin-binding protein that is involved in drug-induced cytotoxicity. Cell Death Dis (2010) 0.86
L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins. PLoS One (2013) 0.84
Role of βPix in the Kidney. Front Physiol (2012) 0.83
Osmoprotective proteome adjustments in mouse kidney papilla. Biochim Biophys Acta (2011) 0.82
A NudE/14-3-3 pathway coordinates dynein and the kinesin Khc73 to position the mitotic spindle. Dev Cell (2013) 0.82
Regulation of the Water Channel Aquaporin-2 via 14-3-3θ and -ζ. J Biol Chem (2015) 0.79
Inhibition of ENaC by endothelin-1. Vitam Horm (2015) 0.78
Protein modifications regulate the role of 14-3-3γ adaptor protein in cAMP-induced steroidogenesis in MA-10 Leydig cells. J Biol Chem (2014) 0.77
Regulation of tyrosine hydroxylase is preserved across different homo- and heterodimeric 14-3-3 proteins. Amino Acids (2016) 0.75
Molecular mechanisms of human hypertension. Cell (2001) 11.17
The structural basis for 14-3-3:phosphopeptide binding specificity. Cell (1997) 10.87
Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature (1994) 9.76
Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell (1996) 7.81
Epithelial sodium channel related to proteins involved in neurodegeneration. Nature (1993) 6.04
Epithelial sodium channels: function, structure, and regulation. Physiol Rev (1997) 5.90
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome. EMBO J (1996) 5.24
Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest (1999) 4.11
How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett (2002) 4.08
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J (2001) 3.43
14-3-3 proteins: a number of functions for a numbered protein. Sci STKE (2005) 3.09
Crystal structure of the zeta isoform of the 14-3-3 protein. Nature (1995) 2.98
Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. Nature (1995) 2.68
Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3-ligand complexes: a comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Semin Cancer Biol (2006) 2.42
Genetic dissection of human blood pressure variation: common pathways from rare phenotypes. Harvey Lect (2006) 2.32
A structural basis for 14-3-3sigma functional specificity. J Biol Chem (2005) 2.20
A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. FASEB J (2001) 2.13
Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: possible role of SGK. Am J Physiol Renal Physiol (2001) 2.13
Regulation of maturation and processing of ENaC subunits in the rat kidney. Am J Physiol Renal Physiol (2006) 1.98
Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC. J Biol Chem (2007) 1.81
14-3-3 proteins modulate the expression of epithelial Na+ channels by phosphorylation-dependent interaction with Nedd4-2 ubiquitin ligase. J Biol Chem (2005) 1.74
Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool. J Gen Physiol (2005) 1.70
14-3-3 Proteins--a focus on cancer and human disease. J Mol Cell Cardiol (2004) 1.67
Relative contribution of Nedd4 and Nedd4-2 to ENaC regulation in epithelia determined by RNA interference. J Biol Chem (2003) 1.66
SGK integrates insulin and mineralocorticoid regulation of epithelial sodium transport. Am J Physiol Renal Physiol (2001) 1.54
Ca2+ but not H2O2 modulates GRE-element activation by the human mineralocorticoid receptor in HEK cells. Mol Cell Endocrinol (2006) 1.46
Serum- and glucocorticoid-regulated kinase 1 regulates ubiquitin ligase neural precursor cell-expressed, developmentally down-regulated protein 4-2 by inducing interaction with 14-3-3. Mol Endocrinol (2005) 1.46
The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel. J Biol Chem (2007) 1.43
Mammalian and yeast 14-3-3 isoforms form distinct patterns of dimers in vivo. Biochem Biophys Res Commun (2003) 1.42
Specificity of 14-3-3 isoform dimer interactions and phosphorylation. Biochem Soc Trans (2002) 1.40
New ideas about aldosterone signaling in epithelia. Am J Physiol Renal Physiol (2002) 1.34
Early aldosterone-induced gene product regulates the epithelial sodium channel by deubiquitylation. J Am Soc Nephrol (2007) 1.31
The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res (2005) 1.13
14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J Biol Chem (2006) 1.11
C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors. J Biol Chem (2005) 1.07
Intracellular Na+ controls cell surface expression of Na,K-ATPase via a cAMP-independent PKA pathway in mammalian kidney collecting duct cells. Mol Biol Cell (2003) 1.07
Impact of Nedd4 proteins and serum and glucocorticoid-induced kinases on epithelial Na+ transport in the distal nephron. J Am Soc Nephrol (2005) 1.03
Sgk1 gene expression in kidney and its regulation by aldosterone: spatio-temporal heterogeneity and quantitative analysis. J Am Soc Nephrol (2002) 1.02
Inhibitory interaction of the 14-3-3{epsilon} protein with isoform 4 of the plasma membrane Ca(2+)-ATPase pump. J Biol Chem (2005) 0.97
Disturbances of Na/K balance: pseudohypoaldosteronism revisited. J Am Soc Nephrol (2002) 0.91
Regulation of sodium transport in mammalian collecting duct cells by aldosterone-induced kinase, SGK1: structure/function studies. Mol Cell Endocrinol (2004) 0.88
Disorders of the epithelial sodium channel: insights into the regulation of extracellular volume and blood pressure. Kidney Int (1999) 0.83
The renal epithelial sodium channel: genetic heterogeneity and implications for the treatment of high blood pressure. Curr Pharm Des (2006) 0.80
Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A (2009) 5.72
An essential role for LEDGF/p75 in HIV integration. Science (2006) 4.18
Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes. Diabetes (2009) 3.16
Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol (2012) 2.75
Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis. Nat Chem Biol (2009) 2.70
Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol (2012) 2.58
Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis. J Biol Chem (2006) 1.77
Acute ENaC stimulation by cAMP in a kidney cell line is mediated by exocytic insertion from a recycling channel pool. J Gen Physiol (2005) 1.70
Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants. J Biol Chem (2006) 1.69
The role of regulated CFTR trafficking in epithelial secretion. Am J Physiol Cell Physiol (2003) 1.55
Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action. J Clin Invest (2015) 1.53
SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia. J Gen Physiol (2009) 1.44
The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel. J Biol Chem (2007) 1.43
Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells. Mol Biol Cell (2009) 1.41
Regulation of the epithelial sodium channel by membrane trafficking. Am J Physiol Renal Physiol (2008) 1.41
Sex, age, and regional differences in L-type calcium current are important determinants of arrhythmia phenotype in rabbit hearts with drug-induced long QT type 2. Circ Res (2008) 1.30
Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin. J Biol Chem (2006) 1.27
Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation. Mol Biol Cell (2006) 1.24
Testosterone activates mitogen-activated protein kinase and the cAMP response element binding protein transcription factor in Sertoli cells. Proc Natl Acad Sci U S A (2004) 1.22
Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis. Am J Physiol Lung Cell Mol Physiol (2008) 1.21
Acute regulation of the epithelial sodium channel in airway epithelia by proteases and trafficking. Am J Respir Cell Mol Biol (2010) 1.18
Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J (2008) 1.17
Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in sertoli cells. Endocrinology (2007) 1.15
Pharmacological rescue of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) detected by use of a novel fluorescence platform. Mol Med (2012) 1.15
Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells. J Biol Chem (2009) 1.12
Syntaxin 1A regulates ENaC channel activity. J Biol Chem (2003) 1.11
Cysteine string protein interacts with and modulates the maturation of the cystic fibrosis transmembrane conductance regulator. J Biol Chem (2002) 1.11
14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J Biol Chem (2006) 1.11
Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions. Proc Natl Acad Sci U S A (2013) 1.06
The epithelial sodium channel (ENaC) traffics to apical membrane in lipid rafts in mouse cortical collecting duct cells. J Biol Chem (2007) 1.05
Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC). Am J Physiol Renal Physiol (2011) 1.03
Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol (2008) 1.01
AS160 modulates aldosterone-stimulated epithelial sodium channel forward trafficking. Mol Biol Cell (2010) 0.99
Cysteine string protein monitors late steps in cystic fibrosis transmembrane conductance regulator biogenesis. J Biol Chem (2006) 0.97
NF-kappaB and TNF-alpha stimulate androgen receptor expression in Sertoli cells. Mol Cell Endocrinol (2003) 0.97
Regulation of human cystic fibrosis transmembrane conductance regulator (CFTR) by serum- and glucocorticoid-inducible kinase (SGK1). Cell Physiol Biochem (2007) 0.95
Regulation of CFTR trafficking by its R domain. J Biol Chem (2008) 0.95
Finally, mice with CF lung disease. Nat Med (2004) 0.95
CCR7 mediates inflammation-associated tumor progression. Immunol Res (2006) 0.94
Regulation of Sertoli-germ cell adhesion and sperm release by FSH and nonclassical testosterone signaling. Mol Endocrinol (2010) 0.93
Chemokine receptor 7 (CCR7) gene expression is regulated by NF-κB and activator protein 1 (AP1) in metastatic squamous cell carcinoma of head and neck (SCCHN). J Biol Chem (2011) 0.93
Human heat shock protein 105/110 kDa (Hsp105/110) regulates biogenesis and quality control of misfolded cystic fibrosis transmembrane conductance regulator at multiple levels. J Biol Chem (2012) 0.92
Small heat shock proteins target mutant cystic fibrosis transmembrane conductance regulator for degradation via a small ubiquitin-like modifier-dependent pathway. Mol Biol Cell (2012) 0.91
Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis. Mol Biol Cell (2012) 0.90
The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. PLoS One (2012) 0.89
Syntaxin 1A regulates ENaC via domain-specific interactions. J Biol Chem (2003) 0.89
Regulated recycling of mutant CFTR is partially restored by pharmacological treatment. J Cell Sci (2013) 0.88
USF1/2 transcription factor DNA-binding activity is induced during rat Sertoli cell differentiation. Biol Reprod (2008) 0.86
Elevated urinary excretion of immunoglobulins in nonproteinuric patients with type 1 diabetes. Am J Physiol Renal Physiol (2012) 0.86
The Id2 transcriptional repressor is induced by follicle-stimulating hormone and cAMP. J Biol Chem (2004) 0.86
Regulation of cyclic adenosine 3',5'-monophosphate response element binding protein (CREB) expression by Sp1 in the mammalian testis. Biol Reprod (2002) 0.85
Cytokines increase CRE binding but decrease CRE-mediated reporter activity in rat hepatocytes by increasing c-Jun. Hepatology (2004) 0.85
Sympathetic nerve stimulation produces spatial heterogeneities of action potential restitution. Heart Rhythm (2009) 0.84
Identification and membrane localization of electrogenic sodium bicarbonate cotransporters in Calu-3 cells. Biochim Biophys Acta (2006) 0.84
The tyrosine phosphatase SHP2 regulates Sertoli cell junction complexes. Biol Reprod (2013) 0.84
Cystic fibrosis transmembrane conductance regulator degradation: cross-talk between the ubiquitylation and SUMOylation pathways. FEBS J (2013) 0.83
Risk of ESRD and all cause mortality in type 2 diabetes according to circulating levels of FGF-23 and TNFR1. PLoS One (2013) 0.81
Follicle-stimulating hormone (FSH) transiently blocks FSH receptor transcription by increasing inhibitor of deoxyribonucleic acid binding/differentiation-2 and decreasing upstream stimulatory factor expression in rat Sertoli cells. Endocrinology (2009) 0.81
Upstream stimulatory factor induces Nr5a1 and Shbg gene expression during the onset of rat Sertoli cell differentiation. Biol Reprod (2011) 0.80
Insulin-like peptide 6: characterization of secretory status and posttranslational modifications. Endocrinology (2006) 0.80
The transition from stem cell to progenitor spermatogonia and male fertility requires the SHP2 protein tyrosine phosphatase. Stem Cells (2014) 0.80
CFTR Folding Consortium: methods available for studies of CFTR folding and correction. Methods Mol Biol (2011) 0.79
Developmental and stage-specific expression of Smad2 and Smad3 in rat testis. J Androl (2003) 0.79
Informed consent to participate in a research study -- gene therapy for cystic fibrosis using cationic liposome mediated gene transfer: a phase I trial of safety and efficacy in the nasal airway. Hum Gene Ther (1994) 0.78
Scrutiny of the glutamine-fructose-6-phosphate transaminase 1 (GFPT1) locus reveals conserved haplotype block structure not associated with diabetic nephropathy. Diabetes (2004) 0.78
Transepithelial impedance analysis of chloride secretion. Methods Mol Med (2002) 0.78
USP10: the nexus between nexin and vasopressin. Am J Physiol Renal Physiol (2008) 0.75