Published in J Biol Chem on May 14, 2007
Regulation of the epithelial sodium channel by membrane trafficking. Am J Physiol Renal Physiol (2008) 1.41
Beta-subunits promote the expression of Ca(V)2.2 channels by reducing their proteasomal degradation. J Biol Chem (2011) 1.32
Calcium activates Nedd4 E3 ubiquitin ligases by releasing the C2 domain-mediated auto-inhibition. J Biol Chem (2010) 1.25
AF17 competes with AF9 for binding to Dot1a to up-regulate transcription of epithelial Na+ channel alpha. J Biol Chem (2009) 1.22
Epithelial Na+ channel (ENaC), hormones, and hypertension. J Biol Chem (2010) 1.22
Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci U S A (2009) 1.21
Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem (2010) 1.20
RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter. Am J Physiol Renal Physiol (2010) 1.20
Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport. Physiol Rev (2012) 1.18
Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. J Biol Chem (2010) 1.13
Respiratory distress and perinatal lethality in Nedd4-2-deficient mice. Nat Commun (2011) 1.13
HECT E3 ubiquitin ligase Nedd4-1 ubiquitinates ACK and regulates epidermal growth factor (EGF)-induced degradation of EGF receptor and ACK. Mol Cell Biol (2010) 1.13
Role of the ubiquitin system in regulating ion transport. Pflugers Arch (2010) 1.12
An obligatory heterodimer of 14-3-3beta and 14-3-3epsilon is required for aldosterone regulation of the epithelial sodium channel. J Biol Chem (2008) 1.12
The activity of the epithelial sodium channels is regulated by caveolin-1 via a Nedd4-2-dependent mechanism. J Biol Chem (2009) 1.11
Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel. Am J Physiol Renal Physiol (2008) 1.10
Ubiquitin-dependent sorting in endocytosis. Cold Spring Harb Perspect Biol (2014) 1.10
Epithelial Na(+) channel regulation by cytoplasmic and extracellular factors. Exp Cell Res (2012) 1.08
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem (2009) 1.04
Deubiquitylation regulates activation and proteolytic cleavage of ENaC. J Am Soc Nephrol (2008) 1.03
Regulation of sodium transport by ENaC in the kidney. Curr Opin Nephrol Hypertens (2010) 1.00
Regulation of epithelial sodium channel trafficking by ubiquitination. Proc Am Thorac Soc (2010) 1.00
Regulation of the epithelial sodium channel (ENaC) by membrane trafficking. Biochim Biophys Acta (2010) 0.99
The role of monoubiquitination in endocytic degradation of human ether-a-go-go-related gene (hERG) channels under low K+ conditions. J Biol Chem (2010) 0.96
Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1. Neurochem Int (2008) 0.95
ENaC activity is increased in isolated, split-open cortical collecting ducts from protein kinase Cα knockout mice. Am J Physiol Renal Physiol (2013) 0.92
Association of variants in NEDD4L with blood pressure response and adverse cardiovascular outcomes in hypertensive patients treated with thiazide diuretics. J Hypertens (2013) 0.91
The epithelial sodium channel (ENaC) establishes a trafficking vesicle pool responsible for its regulation. PLoS One (2012) 0.89
Lysine 48-linked polyubiquitination of organic anion transporter-1 is essential for its protein kinase C-regulated endocytosis. Mol Pharmacol (2012) 0.89
Regulation of ENaC-mediated alveolar fluid clearance by insulin via PI3K/Akt pathway in LPS-induced acute lung injury. Respir Res (2012) 0.88
An excellent monitoring system for surface ubiquitination-induced internalization in mammals. PLoS One (2008) 0.87
Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9). J Biol Chem (2012) 0.86
Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1. J Biol Chem (2011) 0.86
Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways. J Biol Chem (2010) 0.86
Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel. J Biol Chem (2013) 0.86
Nedd4-2 and the regulation of epithelial sodium transport. Front Physiol (2012) 0.85
Sorting it out in endosomes: an emerging concept in renal epithelial cell transport regulation. Physiology (Bethesda) (2010) 0.85
Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90. PLoS One (2012) 0.85
Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem (2012) 0.85
Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases. J Biol Chem (2009) 0.85
H2O2 regulates lung epithelial sodium channel (ENaC) via ubiquitin-like protein Nedd8. J Biol Chem (2013) 0.85
WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination. Am J Physiol Renal Physiol (2013) 0.84
The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels. J Biol Chem (2008) 0.83
Integrated control of transporter endocytosis and recycling by the arrestin-related protein Rod1 and the ubiquitin ligase Rsp5. Elife (2014) 0.83
Calmodulin and CaMKII modulate ENaC activity by regulating the association of MARCKS and the cytoskeleton with the apical membrane. Am J Physiol Renal Physiol (2015) 0.83
Aldosterone regulates microRNAs in the cortical collecting duct to alter sodium transport. J Am Soc Nephrol (2014) 0.82
Three ubiquitination sites of organic anion transporter-1 synergistically mediate protein kinase C-dependent endocytosis of the transporter. Mol Pharmacol (2013) 0.82
Feedback inhibition of ENaC: acute and chronic mechanisms. Channels (Austin) (2014) 0.82
A human polymorphism affects NEDD4L subcellular targeting by leading to two isoforms that contain or lack a C2 domain. BMC Cell Biol (2009) 0.80
Ion channels in renal disease. Chem Rev (2012) 0.79
ENaC activity and expression is decreased in the lungs of protein kinase C-α knockout mice. Am J Physiol Lung Cell Mol Physiol (2014) 0.79
Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. Biochim Biophys Acta (2015) 0.78
An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3. Mol Pharm (2015) 0.77
Unique regulation of human Na+/H+ exchanger 3 (NHE3) by Nedd4-2 ligase that differs from non-primate NHE3s. J Biol Chem (2014) 0.77
Ubiquitin-specific protease USP2-45 acts as a molecular switch to promote α2δ-1-induced downregulation of Cav1.2 channels. Pflugers Arch (2014) 0.77
Nedd4-2 but not Nedd4-1 is critical for protein kinase C-regulated ubiquitination, expression, and transport activity of human organic anion transporter 1. Am J Physiol Renal Physiol (2016) 0.77
The N-terminal domain allosterically regulates cleavage and activation of the epithelial sodium channel. J Biol Chem (2014) 0.77
Saccharomyces cerivisiae as a model system for kidney disease: what can yeast tell us about renal function? Am J Physiol Renal Physiol (2011) 0.77
Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion. J Am Soc Nephrol (2017) 0.77
TGF-β and lung fluid balance in ARDS. Proc Natl Acad Sci U S A (2014) 0.76
Direct interactions between ENaC gamma subunit and ClCN2 in cystic fibrosis epithelial cells. Physiol Rep (2015) 0.76
Posttranslational Regulation of Organic Anion Transporters by Ubiquitination: Known and Novel. Med Res Rev (2016) 0.75
Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation. J Biol Chem (2015) 0.75
Association Between Polymorphisms of ADRBK1 Gene and Plasma Renin Activity in Hypertensive Patients: A Case-Control Study. Med Sci Monit (2016) 0.75
Cholera toxin enhances Na(+) absorption across MCF10A human mammary epithelia. Am J Physiol Cell Physiol (2013) 0.75
H-Ras mediates the inhibitory effect of epidermal growth factor on the epithelial Na+ channel. PLoS One (2015) 0.75
The role of Nedd4-1 WW domains in binding and regulating human organic anion transporter 1. Am J Physiol Renal Physiol (2016) 0.75
The ubiquitin ligase Nedd4L regulates the Na/K/2Cl co-transporter NKCC1/SLC12A2 in the colon. J Biol Chem (2017) 0.75
SOCS-1 rescues IL-1β-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1. Oncotarget (2016) 0.75
Hypercapnia Impairs ENaC Cell Surface Stability by Promoting Phosphorylation, Polyubiquitination and Endocytosis of β-ENaC in a Human Alveolar Epithelial Cell Line. Front Immunol (2017) 0.75
Deletion of Nedd4-2 results in progressive kidney disease in mice. Cell Death Differ (2017) 0.75
Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A (2002) 3.05
Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. J Biol Chem (2008) 2.00
Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2. Am J Physiol Renal Physiol (2008) 1.60
Liddle's syndrome mutations increase Na+ transport through dual effects on epithelial Na+ channel surface expression and proteolytic cleavage. Proc Natl Acad Sci U S A (2006) 1.60
Nedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channels. J Biol Chem (2008) 1.46
The kidney-specific WNK1 isoform is induced by aldosterone and stimulates epithelial sodium channel-mediated Na+ transport. Proc Natl Acad Sci U S A (2004) 1.43
Extracellular chloride regulates the epithelial sodium channel. J Biol Chem (2009) 1.40
Extracellular protons regulate human ENaC by modulating Na+ self-inhibition. J Biol Chem (2008) 1.31
Oxidant regulated inter-subunit disulfide bond formation between ASIC1a subunits. Proc Natl Acad Sci U S A (2009) 1.29
Ubiquitin-protein ligase WWP2 binds to and downregulates the epithelial Na(+) channel. Am J Physiol Renal Physiol (2002) 1.23
Mutations of KCNJ10 together with mutations of SLC26A4 cause digenic nonsyndromic hearing loss associated with enlarged vestibular aqueduct syndrome. Am J Hum Genet (2009) 1.16
Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation. J Biol Chem (2004) 1.13
Intracellular sodium regulates proteolytic activation of the epithelial sodium channel. J Biol Chem (2008) 1.10
Identification of epithelial Na+ channel (ENaC) intersubunit Cl- inhibitory residues suggests a trimeric alpha gamma beta channel architecture. J Biol Chem (2010) 1.03
Alternate promoters and variable splicing lead to hNedd4-2 isoforms with a C2 domain and varying number of WW domains. Am J Physiol Renal Physiol (2003) 1.03
N-glycosylation of acid-sensing ion channel 1a regulates its trafficking and acidosis-induced spine remodeling. J Neurosci (2012) 0.96
An evolutionarily conserved N-terminal Sgk1 variant with enhanced stability and improved function. Am J Physiol Renal Physiol (2008) 0.92
Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation. PLoS One (2010) 0.87
Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9). J Biol Chem (2012) 0.86
Ubiquitin-specific peptidase 8 (USP8) regulates endosomal trafficking of the epithelial Na+ channel. J Biol Chem (2013) 0.86
Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways. J Biol Chem (2010) 0.86
The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function. PLoS One (2010) 0.85
Regulation of cardiac ATP-sensitive potassium channel surface expression by calcium/calmodulin-dependent protein kinase II. J Biol Chem (2012) 0.82
Identification of extracellular domain residues required for epithelial Na+ channel activation by acidic pH. J Biol Chem (2012) 0.81
A region directly following the second transmembrane domain in gamma ENaC is required for normal channel gating. J Biol Chem (2003) 0.80
Acid-sensing ion channels (ASICs) are differentially modulated by anions dependent on their subunit composition. Am J Physiol Cell Physiol (2012) 0.78
Intoxicated Na(+) channels. Focus on "ethanol stimulates epithelial sodium channels by elevating reactive oxygen species". Am J Physiol Cell Physiol (2012) 0.77
Regulation of the delta and alpha epithelial sodium channel (ENaC) by ubiquitination and Nedd8. J Cell Physiol (2013) 0.75