Published in Cytokine on August 19, 2008
Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe (2009) 3.86
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem (2009) 1.68
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix. J Cell Sci (2009) 1.62
Autophagy and innate immunity: triggering, targeting and tuning. Semin Cell Dev Biol (2010) 1.49
Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes. J Virol (2013) 1.46
Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways. PLoS One (2013) 1.40
Unleashing the therapeutic potential of NOD-like receptors. Nat Rev Drug Discov (2009) 1.39
Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. J Biol Chem (2009) 1.37
Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants. Proc Natl Acad Sci U S A (2014) 1.36
Peptidoglycan-modifying enzyme Pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni. PLoS Pathog (2012) 1.34
Mitochondria in innate immunity. EMBO Rep (2011) 1.31
Expression of Nlrp1b inflammasome components in human fibroblasts confers susceptibility to anthrax lethal toxin. Infect Immun (2009) 1.26
Innate immunity. J Allergy Clin Immunol (2009) 1.23
Sterile inflammatory response in acute pancreatitis. Pancreas (2012) 1.15
Three-dimensional structure of the NLRP7 pyrin domain: insight into pyrin-pyrin-mediated effector domain signaling in innate immunity. J Biol Chem (2010) 1.11
Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector? Antioxid Redox Signal (2015) 1.07
Peptidoglycan LD-carboxypeptidase Pgp2 influences Campylobacter jejuni helical cell shape and pathogenic properties and provides the substrate for the DL-carboxypeptidase Pgp1. J Biol Chem (2014) 1.04
Asbestos-induced cellular and molecular alteration of immunocompetent cells and their relationship with chronic inflammation and carcinogenesis. J Biomed Biotechnol (2012) 1.01
Translation inhibition and metabolic stress pathways in the host response to bacterial pathogens. Nat Rev Microbiol (2013) 0.95
Nod-like receptor protein 3 (NLRP3) inflammasome activation and podocyte injury via thioredoxin-interacting protein (TXNIP) during hyperhomocysteinemia. J Biol Chem (2014) 0.94
Disease severity in patients infected with Leishmania mexicana relates to IL-1β. PLoS Negl Trop Dis (2012) 0.89
Retracted NOD2 signaling contributes to host defense in the lungs against Escherichia coli infection. Infect Immun (2012) 0.87
Insights into the Role of Chemokines, Damage-Associated Molecular Patterns, and Lymphocyte-Derived Mediators from Computational Models of Trauma-Induced Inflammation. Antioxid Redox Signal (2015) 0.87
Caspase-1 activation via Rho GTPases: a common theme in mucosal infections? PLoS Pathog (2010) 0.85
The Legionella pneumophila EnhC protein interferes with immunostimulatory muramyl peptide production to evade innate immunity. Cell Host Microbe (2012) 0.83
Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection. FEMS Immunol Med Microbiol (2012) 0.83
The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia. Nat Commun (2015) 0.82
Stimulation of human dendritic cells by wild-type and M protein mutant vesicular stomatitis viruses engineered to express bacterial flagellin. J Virol (2010) 0.81
Intersection of autophagy with pathways of antigen presentation. Protein Cell (2012) 0.81
Signaling via pattern recognition receptors NOD2 and TLR2 contributes to immunomodulatory control of lethal pneumovirus infection. Antiviral Res (2016) 0.80
Secretion of Flagellar Proteins by the Pseudomonas aeruginosa Type III Secretion-Injectisome System. J Bacteriol (2015) 0.79
Ragweed pollen extract intensifies lipopolysaccharide-induced priming of NLRP3 inflammasome in human macrophages. Immunology (2013) 0.79
NLRC5 Mediates IL-6 and IL-1β Secretion in LX-2 Cells and Modulated by the NF-κB/Smad3 Pathway. Inflammation (2015) 0.79
Natural Compounds as Regulators of NLRP3 Inflammasome-Mediated IL-1β Production. Mediators Inflamm (2016) 0.77
Analyzing cold tolerance mechanism in transgenic zebrafish (Danio rerio). PLoS One (2014) 0.77
Inflammation-Related IL1β/IL1R Signaling Promotes the Development of Asbestos-Induced Malignant Mesothelioma. Cancer Prev Res (Phila) (2016) 0.77
NLRC5 mediates cytokine secretion in RAW264.7 macrophages and modulated by the JAK2/STAT3 pathway. Inflammation (2014) 0.76
Identification of MDP (muramyl dipeptide)-binding key domains in NOD2 (nucleotide-binding and oligomerization domain-2) receptor of Labeo rohita. Fish Physiol Biochem (2012) 0.76
Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin. J Biol Chem (2015) 0.75
The P2X7 Receptor-Interleukin-1 Liaison. Front Pharmacol (2017) 0.75
Identification of the Q969R gain-of-function polymorphism in the gene encoding porcine NLRP3 and its distribution in pigs of Asian and European origin. Immunogenetics (2016) 0.75
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49
Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Nod-like proteins in immunity, inflammation and disease. Nat Immunol (2006) 5.25
The NLR gene family: a standard nomenclature. Immunity (2008) 4.77
Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem (2003) 3.83
Bacterial infection causes stress-induced memory dysfunction in mice. Gut (2010) 3.06
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut (2011) 2.91
NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. EMBO Rep (2008) 2.83
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Cell Host Microbe (2012) 2.70
Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep (2004) 2.64
Nucleotide-binding oligomerization domain-2 modulates specific TLR pathways for the induction of cytokine release. J Immunol (2005) 2.52
Recognition of Staphylococcus aureus by the innate immune system. Clin Microbiol Rev (2005) 2.50
Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat Med (2011) 2.48
A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system. Proc Natl Acad Sci U S A (2007) 2.46
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A (2005) 2.46
Shigella induces mitochondrial dysfunction and cell death in nonmyleoid cells. Cell Host Microbe (2009) 2.21
Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc Natl Acad Sci U S A (2003) 2.16
Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity. Immunity (2007) 2.15
NOD2 and toll-like receptors are nonredundant recognition systems of Mycobacterium tuberculosis. PLoS Pathog (2005) 2.04
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature (2011) 2.04
Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology. EMBO J (2002) 1.94
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol (2005) 1.90
Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells. Cell Microbiol (2009) 1.87
Modulating immunity as a therapy for bacterial infections. Nat Rev Microbiol (2012) 1.86
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol (2003) 1.79
Nod2-dependent Th2 polarization of antigen-specific immunity. J Immunol (2008) 1.78
NLRC5 limits the activation of inflammatory pathways. J Immunol (2010) 1.73
The protein ATG16L1 suppresses inflammatory cytokines induced by the intracellular sensors Nod1 and Nod2 in an autophagy-independent manner. Immunity (2013) 1.71
pH-dependent internalization of muramyl peptides from early endosomes enables Nod1 and Nod2 signaling. J Biol Chem (2009) 1.68
An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix. J Cell Sci (2009) 1.62
The role of Toll-like receptors and Nod proteins in bacterial infection. Mol Immunol (2004) 1.61
Listeria phospholipases subvert host autophagic defenses by stalling pre-autophagosomal structures. EMBO J (2013) 1.61
Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies. Trends Microbiol (2002) 1.59
Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol (2006) 1.55
The role of mitochondria in cellular defense against microbial infection. Semin Immunol (2009) 1.52
NACHT-LRR proteins (NLRs) in bacterial infection and immunity. Trends Microbiol (2005) 1.42
The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction. Cell Microbiol (2007) 1.41
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Rep (2005) 1.41
Unleashing the therapeutic potential of NOD-like receptors. Nat Rev Drug Discov (2009) 1.39
NOD1 activators link innate immunity to insulin resistance. Diabetes (2011) 1.38
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm (Vienna) (2011) 1.35
Triggering receptor expressed on myeloid cells-1 (TREM-1) amplifies the signals induced by the NACHT-LRR (NLR) pattern recognition receptors. J Leukoc Biol (2006) 1.34
Peptidoglycan-modifying enzyme Pgp1 is required for helical cell shape and pathogenicity traits in Campylobacter jejuni. PLoS Pathog (2012) 1.34
Role of AmiA in the morphological transition of Helicobacter pylori and in immune escape. PLoS Pathog (2006) 1.34
Mitochondria in innate immunity. EMBO Rep (2011) 1.31
Enhancement of reactive oxygen species production and chlamydial infection by the mitochondrial Nod-like family member NLRX1. J Biol Chem (2010) 1.31
Aspergillus fumigatus induces innate immune responses in alveolar macrophages through the MAPK pathway independently of TLR2 and TLR4. J Immunol (2006) 1.29
Nod1 participates in the innate immune response to Pseudomonas aeruginosa. J Biol Chem (2005) 1.29
The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem (2005) 1.28
Mitochondrial ROS fuel the inflammasome. Cell Res (2011) 1.26
Innate immune sensing of microbes by Nod proteins. Ann N Y Acad Sci (2006) 1.24
Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis. Proc Natl Acad Sci U S A (2008) 1.24
Nod1 and Nod2 induce CCL5/RANTES through the NF-kappaB pathway. Eur J Immunol (2007) 1.24
Mycobacterium paratuberculosis is recognized by Toll-like receptors and NOD2. J Leukoc Biol (2007) 1.22
The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. Semin Immunopathol (2007) 1.21
Nod1 and Nod2 regulation of inflammation in the Salmonella colitis model. Infect Immun (2010) 1.20
Engagement of NOD2 has a dual effect on proIL-1beta mRNA transcription and secretion of bioactive IL-1beta. Eur J Immunol (2008) 1.20
The intestinal epithelial barrier: how to distinguish between the microbial flora and pathogens. Semin Immunol (2007) 1.20
Contribution of phagocytosis and intracellular sensing for cytokine production by Staphylococcus aureus-activated macrophages. Infect Immun (2006) 1.19
Innate IL-17 and IL-22 responses to enteric bacterial pathogens. Trends Immunol (2012) 1.18
What is new with Nods? Curr Opin Immunol (2010) 1.18
Nod-like receptors: sentinels at host membranes. Curr Opin Immunol (2010) 1.18
Mini-review: the role of peptidoglycan recognition in innate immunity. Eur J Immunol (2004) 1.18
hPepT1 selectively transports muramyl dipeptide but not Nod1-activating muramyl peptides. Can J Physiol Pharmacol (2006) 1.14
Essential role of Rip2 in the modulation of innate and adaptive immunity triggered by Nod1 and Nod2 ligands. Eur J Immunol (2011) 1.14
Muramylpeptide shedding modulates cell sensing of Shigella flexneri. Cell Microbiol (2007) 1.13
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology (2012) 1.12