Published in Nat Genet on September 07, 2008
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet (2010) 17.38
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18
Decanalization and the origin of complex disease. Nat Rev Genet (2009) 3.12
Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol (2010) 2.91
Distribution and medical impact of loss-of-function variants in the Finnish founder population. PLoS Genet (2014) 2.89
Innate lymphoid cells regulate intestinal epithelial cell glycosylation. Science (2014) 2.59
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Hum Mol Genet (2010) 2.51
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet (2009) 1.87
Expression quantitative trait loci analysis identifies associations between genotype and gene expression in human intestine. Gastroenterology (2013) 1.69
Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr (2011) 1.63
Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet (2009) 1.33
Novel locus including FGF21 is associated with dietary macronutrient intake. Hum Mol Genet (2013) 1.27
FUT2 nonsecretor status links type 1 diabetes susceptibility and resistance to infection. Diabetes (2011) 1.22
Genome-wide association study identifies common variants associated with circulating vitamin E levels. Hum Mol Genet (2011) 1.14
Variant ABO blood group alleles, secretor status, and risk of pancreatic cancer: results from the pancreatic cancer cohort consortium. Cancer Epidemiol Biomarkers Prev (2010) 1.11
Monitoring of vitamin B-12 nutritional status in the United States by using plasma methylmalonic acid and serum vitamin B-12. Am J Clin Nutr (2011) 1.08
Mendelian randomization in health research: using appropriate genetic variants and avoiding biased estimates. Econ Hum Biol (2013) 1.08
Genetic architecture of vitamin B12 and folate levels uncovered applying deeply sequenced large datasets. PLoS Genet (2013) 1.04
Autozygome sequencing expands the horizon of human knockout research and provides novel insights into human phenotypic variation. PLoS Genet (2013) 1.02
Geographic differences in allele frequencies of susceptibility SNPs for cardiovascular disease. BMC Med Genet (2011) 0.98
Inherited cobalamin malabsorption. Mutations in three genes reveal functional and ethnic patterns. Orphanet J Rare Dis (2012) 0.98
Genomics and epigenomics of the human glycome. Glycoconj J (2012) 0.90
Weighting sequence variants based on their annotation increases power of whole-genome association studies. Nat Genet (2016) 0.88
Systems Epidemiology: A New Direction in Nutrition and Metabolic Disease Research. Curr Nutr Rep (2013) 0.87
Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children. PLoS One (2012) 0.86
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men. J Nutr (2012) 0.83
The causal roles of vitamin B(12) and transcobalamin in prostate cancer: can Mendelian randomization analysis provide definitive answers? Int J Mol Epidemiol Genet (2011) 0.82
Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial. Front Public Health (2014) 0.79
A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity. Hum Mol Genet (2010) 0.79
Vitamin B-12. Adv Nutr (2012) 0.77
From association to causality: the new frontier for complex traits. Genome Med (2009) 0.77
A Common Polymorphism in HIBCH Influences Methylmalonic Acid Concentrations in Blood Independently of Cobalamin. Am J Hum Genet (2016) 0.77
Genetic determinants of serum vitamin B12 and their relation to body mass index. Eur J Epidemiol (2016) 0.76
Intakes of Folate and Vitamin B12 and Biomarkers of Status in the Very Old: The Newcastle 85+ Study. Nutrients (2016) 0.75
eMERGE Phenome-Wide Association Study (PheWAS) identifies clinical associations and pleiotropy for stop-gain variants. BMC Med Genomics (2016) 0.75
A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts. PLoS One (2017) 0.75
Concept mapping One-Carbon Metabolism to model future ontologies for nutrient-gene-phenotype interactions. Genes Nutr (2014) 0.75
A genetic variant in vitamin B12 metabolic genes that reduces the risk of congenital heart disease in Han Chinese populations. PLoS One (2014) 0.75
Population Structure of UK Biobank and Ancient Eurasians Reveals Adaptation at Genes Influencing Blood Pressure. Am J Hum Genet (2016) 0.75
Genetic variants influencing biomarkers of nutrition are not associated with cognitive capability in middle-aged and older adults. J Nutr (2013) 0.75
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Mechanisms of GII.4 norovirus persistence in human populations. PLoS Med (2008) 4.57
Vitamin B12 sources and bioavailability. Exp Biol Med (Maywood) (2007) 1.44
Genetically heterogeneous selective intestinal malabsorption of vitamin B12: founder effects, consanguinity, and high clinical awareness explain aggregations in Scandinavia and the Middle East. Hum Mutat (2004) 1.38
Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations. Genetics (2001) 1.30
Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotype. J Pathol (2008) 1.26
Relation of Helicobacter pylori infection to plasma vitamin B12, folic acid, and homocysteine levels in patients who underwent diagnostic coronary arteriography. Am J Gastroenterol (2002) 1.11
Atypical cobalamin deficiency. Subtle biochemical evidence of deficiency is commonly demonstrable in patients without megaloblastic anemia and is often associated with protein-bound cobalamin malabsorption. J Lab Clin Med (1987) 1.09
The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. QJM (2007) 1.09
Prospective study of plasma folate, vitamin B12, and cognitive function and decline. Epidemiology (2006) 1.06
Vitamin B12 deficiency and gastric histopathology in older patients. World J Gastroenterol (2005) 1.03
Plasma vitamin B12 concentrations and the risk of colorectal cancer: a nested case-referent study. Int J Cancer (2008) 1.02
Consequences of Helicobacter pylori infection on the absorption of micronutrients. Dig Liver Dis (2002) 0.99
Vitamin B12 status and its association with Helicobacter pylori infection in alcohol dependent patients. J Nutr Sci Vitaminol (Tokyo) (2004) 0.87
Finding the missing heritability of complex diseases. Nature (2009) 67.95
Genome-wide association study identifies novel breast cancer susceptibility loci. Nature (2007) 29.23
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet (2007) 22.96
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet (2008) 22.35
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24. Nat Genet (2007) 21.18
International network of cancer genome projects. Nature (2010) 20.35
Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01
Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet (2008) 17.65
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet (2008) 16.25
Replicating genotype-phenotype associations. Nature (2007) 16.11
Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet (2008) 15.94
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
A human genome diversity cell line panel. Science (2002) 14.11
Statistics in medicine--reporting of subgroup analyses in clinical trials. N Engl J Med (2007) 12.55
The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24
Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22
Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med (2002) 11.20
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet (2012) 11.09
Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem (2003) 10.79
The life history of 21 breast cancers. Cell (2012) 10.59
Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat Genet (2009) 10.34
Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24. Nat Genet (2007) 9.88
Estimation of effect size distribution from genome-wide association studies and implications for future discoveries. Nat Genet (2010) 9.07
Incidental meniscal findings on knee MRI in middle-aged and elderly persons. N Engl J Med (2008) 8.40
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet (2009) 8.39
Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet (2013) 8.24
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Genetic risk prediction--are we there yet? N Engl J Med (2009) 7.30
Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nat Genet (2009) 7.30
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09
Diet quality and major chronic disease risk in men and women: moving toward improved dietary guidance. Am J Clin Nutr (2002) 6.96
Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet (2010) 6.60
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut (2008) 6.26
Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet (2008) 6.22
Sex hormone-binding globulin and risk of type 2 diabetes in women and men. N Engl J Med (2009) 6.16
Breast cancer incidence, 1980-2006: combined roles of menopausal hormone therapy, screening mammography, and estrogen receptor status. J Natl Cancer Inst (2007) 6.08
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet (2009) 5.81
Performance of common genetic variants in breast-cancer risk models. N Engl J Med (2010) 5.79
A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med (2004) 5.68
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. Nat Genet (2013) 5.58
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet (2002) 5.31
Physical activity and survival after colorectal cancer diagnosis. J Clin Oncol (2006) 5.22
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet (2009) 5.14
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet (2010) 4.89