Published in Mol Carcinog on May 01, 2009
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Mouse patched1 controls body size determination and limb patterning. Development (1999) 1.42
High incidence of medulloblastoma following X-ray-irradiation of newborn Ptc1 heterozygous mice. Oncogene (2002) 1.23
Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res (2006) 1.16
Two-hit model for progression of medulloblastoma preneoplasia in Patched heterozygous mice. Oncogene (2006) 0.92
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Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55
Lgr6 marks stem cells in the hair follicle that generate all cell lineages of the skin. Science (2010) 4.45
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Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta (2010) 3.21
A culture system using human foreskin fibroblasts as feeder cells allows production of human embryonic stem cells. Hum Reprod (2003) 2.66
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapy. Cell Cycle (2007) 2.16
Wounding enhances epidermal tumorigenesis by recruiting hair follicle keratinocytes. Proc Natl Acad Sci U S A (2011) 1.89
Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway. J Exp Med (2009) 1.85
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Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site. Gene (2004) 1.82
Role for ELOVL3 and fatty acid chain length in development of hair and skin function. J Biol Chem (2003) 1.72
PTCH mutations: distribution and analyses. Hum Mutat (2006) 1.68
Suppressor of Fused inhibits mammalian Hedgehog signaling in the absence of cilia. Dev Biol (2009) 1.52
DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS. Nat Struct Mol Biol (2010) 1.49
The hair follicle-a stem cell zoo. Exp Cell Res (2010) 1.46
A defined and xeno-free culture method enabling the establishment of clinical-grade human embryonic, induced pluripotent and adipose stem cells. PLoS One (2010) 1.39
The first reported generation of several induced pluripotent stem cell lines from homozygous and heterozygous Huntington's disease patients demonstrates mutation related enhanced lysosomal activity. Neurobiol Dis (2012) 1.35
Hypermetabolism in mice caused by the central action of an unliganded thyroid hormone receptor alpha1. EMBO J (2007) 1.33
3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing. BMC Cancer (2013) 1.31
Development of mammary tumors by conditional expression of GLI1. Cancer Res (2009) 1.30
Monocytes/macrophages and/or neutrophils are the target of IL-10 in the LPS endotoxemia model. Eur J Immunol (2010) 1.27
Epidermal and craniofacial defects in mice overexpressing Klf5 in the basal layer of the epidermis. J Cell Sci (2006) 1.25
Anti-VEGF agents confer survival advantages to tumor-bearing mice by improving cancer-associated systemic syndrome. Proc Natl Acad Sci U S A (2008) 1.24
Novel human glioma-associated oncogene 1 (GLI1) splice variants reveal distinct mechanisms in the terminal transduction of the hedgehog signal. J Biol Chem (2008) 1.23
Increased expression of the dyslexia candidate gene DCDC2 affects length and signaling of primary cilia in neurons. PLoS One (2011) 1.22
Hedgehog signalling in breast cancer. Carcinogenesis (2009) 1.18
Retardation of post-natal development caused by a negatively acting thyroid hormone receptor alpha1. EMBO J (2002) 1.16
Sufu recruits GSK3beta for efficient processing of Gli3. Biochem Biophys Res Commun (2009) 1.15
Alternative first exons of PTCH1 are differentially regulated in vivo and may confer different functions to the PTCH1 protein. Oncogene (2002) 1.15
Progressive loss of mitochondrial DNA in thymidine kinase 2-deficient mice. Hum Mol Genet (2008) 1.13
Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease. J Cell Sci (2008) 1.12
Inactivation of the nuclear receptor coactivator RAP250 in mice results in placental vascular dysfunction. Mol Cell Biol (2003) 1.12
Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappaB inhibition. Proc Natl Acad Sci U S A (2004) 1.11
Distinct roles of PTCH2 splice variants in Hedgehog signalling. Biochem J (2004) 1.08
Reduction of human embryonal rhabdomyosarcoma tumor growth by inhibition of the hedgehog signaling pathway. Genes Cancer (2010) 1.07
Basal cell carcinoma - molecular biology and potential new therapies. J Clin Invest (2012) 1.06
An ancient duplication of exon 5 in the Snap25 gene is required for complex neuronal development/function. PLoS Genet (2008) 1.05
The Hedgehog pathway as a drug target in cancer therapy. Curr Opin Investig Drugs (2007) 1.04
Characterization of the progressive skin disease and inflammatory cell infiltrate in mice with inhibited NF-kappaB signaling. J Invest Dermatol (2004) 1.04
Targeted expression of GLI1 in the mammary gland disrupts pregnancy-induced maturation and causes lactation failure. J Biol Chem (2007) 1.02
Organized development from human embryonic stem cells after injection into immunodeficient mice. Stem Cells Dev (2004) 1.01
Inhibition of Rel/Nuclear Factor-kappaB signaling in skin results in defective DNA damage-induced cell cycle arrest and Ha-ras- and p53-independent tumor development. Oncogene (2002) 1.01
Commensal gut flora reduces susceptibility to experimentally induced colitis via T-cell-derived interleukin-10. Inflamm Bowel Dis (2010) 1.00
Human Krüppel-like factor5/KLF5: synergy with NF-kappaB/Rel factors and expression in human skin and hair follicles. Eur J Cell Biol (2002) 0.98
Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin. J Immunol (2005) 0.97
Aire-deficient mice develop hematopoetic irregularities and marginal zone B-cell lymphoma. Blood (2006) 0.97
The two-faced NF-kappaB in the skin. Int Rev Immunol (2008) 0.96
An effective serum- and xeno-free chemically defined freezing procedure for human embryonic and induced pluripotent stem cells. Hum Reprod (2010) 0.96
Structural basis of SUFU-GLI interaction in human Hedgehog signalling regulation. Acta Crystallogr D Biol Crystallogr (2013) 0.95
Hedgehog signaling and pancreatic tumor development. Adv Cancer Res (2011) 0.94
Multiple phenotypes in adult mice following inactivation of the Coxsackievirus and Adenovirus Receptor (Car) gene. PLoS One (2011) 0.94
Antipsychotic drugs regulate hedgehog signaling by modulation of 7-dehydrocholesterol reductase levels. Mol Pharmacol (2010) 0.94
Attenuation of acute experimental colitis by preventing NPY Y1 receptor signaling. Am J Physiol Gastrointest Liver Physiol (2004) 0.92
Vaccination with recombinant alphavirus or immune-stimulating complex antigen against respiratory syncytial virus. J Immunol (2002) 0.92
Inhibition of GLI1 gene activation by Patched1. Biochem J (2006) 0.91
Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis. Stem Cell Reports (2015) 0.89
The FU gene and its possible protein isoforms. BMC Genomics (2004) 0.89
The PSORS1 locus gene CCHCR1 affects keratinocyte proliferation in transgenic mice. Hum Mol Genet (2008) 0.89
Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype. Genesis (2005) 0.89
Expression of the Hutchinson-Gilford progeria mutation during osteoblast development results in loss of osteocytes, irregular mineralization, and poor biomechanical properties. J Biol Chem (2012) 0.87
Targeted expression of GLI1 in the salivary glands results in an altered differentiation program and hyperplasia. Am J Pathol (2011) 0.84
Differential expression of A-type and B-type lamins during hair cycling. PLoS One (2009) 0.84
Glutathione is essential for early embryogenesis--analysis of a glutathione synthetase knockout mouse. Biochem Biophys Res Commun (2011) 0.83
Timed NF-kappaB inhibition in skin reveals dual independent effects on development of HED/EDA and chronic inflammation. J Invest Dermatol (2009) 0.82
Tumour suppressors in liver carcinogenesis. J Hepatol (2007) 0.81
Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. Arch Dermatol Res (2004) 0.81
Genetic variations regulate alternative splicing in the 5' untranslated regions of the mouse glioma-associated oncogene 1, Gli1. BMC Mol Biol (2010) 0.81
Loss of Trp53 promotes medulloblastoma development but not skin tumorigenesis in Sufu heterozygous mutant mice. Mol Carcinog (2011) 0.81
Hematopoiesis in the thymidine kinase 2 deficient mouse model of mitochondrial DNA depletion syndrome. J Inherit Metab Dis (2010) 0.80
Dynamics of early histopathological changes in GVHD after busulphan/cyclophosphamide conditioning regimen. Int J Clin Exp Pathol (2011) 0.79
Inhibition of NF-kappaB signaling interferes with phorbol ester-induced growth arrest of keratinocytes in a TNFR1-independent manner. J Recept Signal Transduct Res (2009) 0.79
Hedgehog in Wnterland. Nat Genet (2008) 0.79
Hedgehog signalling stimulates precursor cell accumulation and impairs epithelial maturation in the murine oesophagus. Gut (2012) 0.78
Inhibition of the intrinsic but not the extrinsic apoptosis pathway accelerates and drives MYC-driven tumorigenesis towards acute myeloid leukemia. PLoS One (2012) 0.78
Association between hair-induced oronasal inflammation and ulcerative dermatitis in C57BL/6 mice. Comp Med (2011) 0.78
Differential hepatocellular zonation pattern of cholesterol 7alpha-hydroxylase (Cyp7a1) and sterol 12alpha-hydroxylase (Cyp8b1) in the mouse. Histochem Cell Biol (2007) 0.78
Early and persisting response to vismodegib in a patient with bone metastasizing medulloblastoma. Acta Oncol (2012) 0.76
Severe defect in thymic development in an insertional mutant mouse model. J Immunol (2007) 0.76
Human sterol 12a-hydroxylase (CYP8B1) is mainly expressed in hepatocytes in a homogenous pattern. Histochem Cell Biol (2005) 0.76
Smoothing out drug resistance. Cancer Cell (2013) 0.76
Global and 3D spatial assessment of neuroinflammation in rodent models of Multiple Sclerosis. PLoS One (2013) 0.75
Meeting report of the conference on UV-Radiation-Induced Disease--Roles of UVA and UVB. J Invest Dermatol (2008) 0.75
Erratum: Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth. Nat Commun (2016) 0.75