Published in J Biol Chem on September 09, 2008
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor. Mol Syst Biol (2009) 2.10
Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med (2010) 1.80
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Emerging functions of amphiregulin in orchestrating immunity, inflammation, and tissue repair. Immunity (2015) 1.26
RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Res (2009) 1.21
Inhibition of Src kinase blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells and prevents diabetic nephropathy in mice. Diabetes (2013) 1.09
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. J Proteome Res (2009) 1.07
Mitochondrial reactive oxygen species mediate GPCR-induced TACE/ADAM17-dependent transforming growth factor-alpha shedding. Mol Biol Cell (2009) 1.03
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Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context. Mol Biosyst (2010) 0.96
From wavy hair to naked proteins: the role of transforming growth factor alpha in health and disease. Semin Cell Dev Biol (2014) 0.89
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Protein secretion in human mammary epithelial cells following HER1 receptor activation: influence of HER2 and HER3 expression. BMC Cancer (2011) 0.84
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Met receptor acts uniquely for survival and morphogenesis of EGFR-dependent normal mammary epithelial and cancer cells. PLoS One (2012) 0.79
Reactive oxygen species alter autocrine and paracrine signaling. Free Radic Biol Med (2011) 0.78
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Integrating signals from RTKs to ERK/MAPK. Oncogene (2007) 3.28
Effects of HER2 overexpression on cell signaling networks governing proliferation and migration. Mol Syst Biol (2006) 3.01
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TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. EMBO J (2003) 2.55
Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding. Mol Biol Cell (2002) 2.54
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The metalloprotease Kuzbanian (ADAM10) mediates the transactivation of EGF receptor by G protein-coupled receptors. J Cell Biol (2002) 1.99
Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1999) 1.96
SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Cancer Res (2004) 1.88
Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem (2003) 1.88
Multiple G-protein-coupled receptor signals converge on the epidermal growth factor receptor to promote migration and invasion. Oncogene (2004) 1.80
The EGF receptor as central transducer of heterologous signalling systems. Trends Pharmacol Sci (1999) 1.77
Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. J Biol Chem (2000) 1.76
Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding. J Biol Chem (2001) 1.66
TACE/ADAM17 processing of EGFR ligands indicates a role as a physiological convertase. Ann N Y Acad Sci (2003) 1.52
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Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells. J Biol Chem (2004) 1.41
Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. J Biol Chem (2002) 1.37
Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response. Biophys J (2006) 1.36
ADAM17 mediates epidermal growth factor receptor transactivation and vascular smooth muscle cell hypertrophy induced by angiotensin II. Arterioscler Thromb Vasc Biol (2006) 1.33
Improved proteome coverage by using high efficiency cysteinyl peptide enrichment: the human mammary epithelial cell proteome. Proteomics (2005) 1.33
Ligand accumulation in autocrine cell cultures. Biophys J (2005) 1.25
Multidimensional proteome analysis of human mammary epithelial cells. J Proteome Res (2004) 1.24
Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor alpha. J Biol Chem (2004) 1.18
GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways. Biol Chem (2005) 1.17
Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized. Proc Natl Acad Sci U S A (1998) 1.13
Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells. Cancer Res (2000) 1.13
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Affinity regulates spatial range of EGF receptor autocrine ligand binding. Dev Biol (2002) 1.01
Trafficking and proteolytic release of epidermal growth factor receptor ligands are modulated by their membrane-anchoring domains. J Biol Chem (2000) 1.01
Mitogen-activated protein kinase-dependent and -independent routes control shedding of transmembrane growth factors through multiple secretases. Biochem J (2002) 1.01
Ectodomain shedding-dependent transactivation of epidermal growth factor receptors in response to insulin-like growth factor type I. Mol Endocrinol (2004) 1.00
Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells. Int J Cancer (2002) 1.00
Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK1/2 responses to gonadotropin-releasing hormone receptor activation. J Biol Chem (2003) 1.00
A matrix metalloproteinase inhibitor prevents processing of tumor necrosis factor alpha (TNF alpha) and abrogates endotoxin-induced lethality. Shock (1997) 0.99
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The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode. Mol Biol Cell (2005) 0.88
Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery (2005) 0.88
Cross-talk between the calcium-sensing receptor and the epidermal growth factor receptor in Rat-1 fibroblasts. Exp Cell Res (2005) 0.83
Selective formation of ErbB-2/ErbB-3 heterodimers depends on the ErbB-3 affinity of epidermal growth factor-like ligands. J Biol Chem (2003) 0.82
Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol (2006) 5.49
Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology (2003) 4.10
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology (2009) 4.08
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell (2012) 3.91
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Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (2005) 3.57
Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library. Nat Biotechnol (2003) 3.34
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A (2002) 2.65
Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor. Mol Syst Biol (2009) 2.10
Removal of G(ialpha1) constraints on adenylyl cyclase in the hippocampus enhances LTP and impairs memory formation. Neuron (2004) 2.07
Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J Am Soc Nephrol (2008) 2.04
Characterization and improvement of RNA-Seq precision in quantitative transcript expression profiling. Bioinformatics (2011) 2.00
Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels. J Biol Chem (2003) 1.93
Amphiregulin exosomes increase cancer cell invasion. Curr Biol (2011) 1.93
Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology (2007) 1.87
Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometry. Proteomics (2004) 1.82
An integrated model of epidermal growth factor receptor trafficking and signal transduction. Biophys J (2003) 1.80
Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects. Cancer Res (2003) 1.80
Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. Gut (2011) 1.67
Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions. Curr Biol (2012) 1.67
Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Clin Cancer Res (2008) 1.66
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Mol Cell Proteomics (2012) 1.55
The enterocyte microvillus is a vesicle-generating organelle. J Cell Biol (2009) 1.51
Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models. Bioinformatics (2008) 1.51
Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane. Biophys J (2005) 1.47
TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res (2008) 1.44
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A (2004) 1.42
Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha. J Biol Chem (2002) 1.42
Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells. J Biol Chem (2004) 1.41
p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest (2010) 1.41
EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation. J Cell Sci (2007) 1.40
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J Clin Oncol (2005) 1.38
Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response. Biophys J (2006) 1.36
Volume of preclinical xenograft tumors is more accurately assessed by ultrasound imaging than manual caliper measurements. J Ultrasound Med (2010) 1.35
Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest (2010) 1.35
Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol (2006) 1.32
Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc Natl Acad Sci U S A (2004) 1.30
Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology (2003) 1.28
Ligand accumulation in autocrine cell cultures. Biophys J (2005) 1.25
Enabling high-throughput data management for systems biology: the Bioinformatics Resource Manager. Bioinformatics (2007) 1.23
Cell surface receptors for signal transduction and ligand transport: a design principles study. PLoS Comput Biol (2007) 1.21
Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J Biol Chem (2010) 1.18
Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics (2008) 1.18
Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor alpha. J Biol Chem (2004) 1.18
Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium. J Cell Physiol (2007) 1.18
Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol (2005) 1.16
Efficacy of cetuximab in the treatment of Menetrier's disease. Sci Transl Med (2009) 1.14
Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Gastroenterology (2005) 1.14
HER2-mediated effects on EGFR endosomal sorting: analysis of biophysical mechanisms. Biophys J (2003) 1.14
ProMAT: protein microarray analysis tool. Bioinformatics (2006) 1.13
Distinguishing Ménétrier's disease from its mimics. Gut (2010) 1.12
Pathology of rodent models of intestinal cancer: progress report and recommendations. Gastroenterology (2013) 1.12
Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. PLoS One (2013) 1.12
Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation. Mol Cancer Res (2007) 1.11
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Mol Biol Cell (2007) 1.10
Basolateral sorting of transforming growth factor-alpha precursor in polarized epithelial cells: characterization of cytoplasmic domain determinants. Exp Cell Res (2003) 1.10
Differential effects of amphiregulin and TGF-alpha on the morphology of MDCK cells. Exp Cell Res (2005) 1.09
Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin Cancer Res (2002) 1.07
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. J Proteome Res (2009) 1.07
Self-organization of polarized cell signaling via autocrine circuits: computational model analysis. Biophys J (2004) 1.06
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol (2007) 1.05
A unified mixed effects model for gene set analysis of time course microarray experiments. Stat Appl Genet Mol Biol (2009) 1.05
Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin. J Am Soc Nephrol (2009) 1.02
Affinity regulates spatial range of EGF receptor autocrine ligand binding. Dev Biol (2002) 1.01
Proteomic consequences of a single gene mutation in a colorectal cancer model. J Proteome Res (2011) 1.01
Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. Pain Med (2002) 1.01
Lrp6 is required for convergent extension during Xenopus gastrulation. Development (2007) 1.00
HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells. BMC Cell Biol (2009) 1.00
Extracellular vesicles: communication, coercion, and conditioning. Mol Biol Cell (2013) 0.99
Chronic treatment of Ménétrier's disease with Erbitux: clinical efficacy and insight into pathophysiology. Clin Gastroenterol Hepatol (2005) 0.98
Adenoma formation following limited ablation of p120-catenin in the mouse intestine. PLoS One (2011) 0.98
Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J Clin Invest (2014) 0.98
Resistance to EGFR-targeted therapy: a family affair. Cancer Cell (2011) 0.97
Novel association of APC with intermediate filaments identified using a new versatile APC antibody. BMC Cell Biol (2009) 0.97
3'-Deoxy-3'-18F-fluorothymidine PET predicts response to (V600E)BRAF-targeted therapy in preclinical models of colorectal cancer. J Nucl Med (2013) 0.97
Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context. Mol Biosyst (2010) 0.96
Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein. Exp Cell Res (2005) 0.95
A general system for studying protein-protein interactions in Gram-negative bacteria. J Proteome Res (2008) 0.95
Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3. Virology (2004) 0.95
Cellular trafficking of phospholamban and formation of functional sarcoplasmic reticulum during myocyte differentiation. Am J Physiol Cell Physiol (2007) 0.94
Structural studies of human Naked2: a biologically active intrinsically unstructured protein. Biochem Biophys Res Commun (2006) 0.94
Oscillatory dynamics of the extracellular signal-regulated kinase pathway. Curr Opin Genet Dev (2010) 0.94
Trafficking of epidermal growth factor receptor ligands in polarized epithelial cells. Annu Rev Physiol (2013) 0.94
Effects of trastuzumab on epidermal growth factor receptor-dependent and -independent human colon cancer cells. Int J Cancer (2004) 0.94
Stromal production of prostacyclin confers an antiapoptotic effect to colonic epithelial cells. Cancer Res (2003) 0.93
EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation. Proc Natl Acad Sci U S A (2008) 0.93
Receptor downregulation and desensitization enhance the information processing ability of signalling receptors. BMC Syst Biol (2007) 0.92
Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin. PLoS One (2011) 0.92