Published in Development on November 01, 2007
Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell (2009) 18.31
Wnt signal transduction pathways. Organogenesis (2008) 2.14
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol (2011) 1.52
Planar cell polarity: keeping hairs straight is not so simple. Cold Spring Harb Perspect Biol (2010) 1.24
The extracellular domain of Lrp5/6 inhibits noncanonical Wnt signaling in vivo. Mol Biol Cell (2008) 1.23
Wnt5a cooperates with canonical Wnts to generate midbrain dopaminergic neurons in vivo and in stem cells. Proc Natl Acad Sci U S A (2013) 1.12
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression. Biochem Pharmacol (2010) 0.98
ADAM13 induces cranial neural crest by cleaving class B Ephrins and regulating Wnt signaling. Dev Cell (2010) 0.94
β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation. Development (2013) 0.87
DeltaNp63 antagonizes p53 to regulate mesoderm induction in Xenopus laevis. Dev Biol (2009) 0.86
Modulation of the beta-catenin signaling pathway by the dishevelled-associated protein Hipk1. PLoS One (2009) 0.85
LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure. Hum Mol Genet (2013) 0.84
Wnt11b is involved in cilia-mediated symmetry breakage during Xenopus left-right development. PLoS One (2013) 0.84
Activation and function of small GTPases Rho, Rac, and Cdc42 during gastrulation. Methods Mol Biol (2012) 0.78
Novel mutations in Lrp6 orthologs in mouse and human neural tube defects affect a highly dosage-sensitive Wnt non-canonical planar cell polarity pathway. Hum Mol Genet (2013) 0.77
Wnt/beta-catenin signaling in development and disease. Cell (2006) 30.09
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature (1998) 8.02
LDL-receptor-related proteins in Wnt signal transduction. Nature (2000) 6.94
Inversin, the gene product mutated in nephronophthisis type II, functions as a molecular switch between Wnt signaling pathways. Nat Genet (2005) 6.67
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation. Nature (2005) 5.50
arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature (2000) 5.13
Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature (2005) 4.88
A mechanism for Wnt coreceptor activation. Mol Cell (2004) 4.31
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. Cell (2001) 4.22
Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature (2006) 3.80
How we are shaped: the biomechanics of gastrulation. Differentiation (2003) 3.72
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell (2005) 3.43
Casein kinase I transduces Wnt signals. Nature (1999) 3.38
Axin and Frat1 interact with dvl and GSK, bridging Dvl to GSK in Wnt-mediated regulation of LEF-1. EMBO J (1999) 3.18
Planar cell polarization: an emerging model points in the right direction. Annu Rev Cell Dev Biol (2005) 3.10
JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep (2001) 3.08
Analysis of Dishevelled signalling pathways during Xenopus development. Curr Biol (1996) 2.98
Evidence for kinesin-related proteins in the mitotic apparatus using peptide antibodies. J Cell Sci (1992) 2.87
The entire mesodermal mantle behaves as Spemann's organizer in dorsoanterior enhanced Xenopus laevis embryos. Dev Biol (1988) 2.79
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci (2006) 2.73
The dishevelled protein is modified by wingless signaling in Drosophila. Genes Dev (1995) 2.46
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet (2005) 2.36
Cell autonomous regulation of multiple Dishevelled-dependent pathways by mammalian Nkd. Proc Natl Acad Sci U S A (2001) 2.22
Xenopus laevis: Practical uses in cell and molecular biology. Solutions and protocols. Methods Cell Biol (1991) 2.13
The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev (2002) 2.02
The hedgehog signaling network. Am J Med Genet A (2003) 2.02
Cell motility driving mediolateral intercalation in explants of Xenopus laevis. Development (1992) 2.02
Wise, a context-dependent activator and inhibitor of Wnt signalling. Development (2003) 1.97
Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling. Mech Dev (2001) 1.86
The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus. Dev Biol (2002) 1.84
Xenopus Dishevelled signaling regulates both neural and mesodermal convergent extension: parallel forces elongating the body axis. Development (2001) 1.82
XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation. Dev Cell (2006) 1.79
PKC delta is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Genes Dev (2003) 1.79
The planar polarity gene strabismus regulates convergent extension movements in Xenopus. EMBO J (2002) 1.76
The prickle-related gene in vertebrates is essential for gastrulation cell movements. Curr Biol (2003) 1.76
Induction of neuronal differentiation by planar signals in Xenopus embryos. Dev Dyn (1993) 1.75
Regional expression, pattern and timing of convergence and extension during gastrulation of Xenopus laevis. Development (1988) 1.66
Planar cell polarity signaling in vertebrates. Bioessays (2007) 1.62
Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulation. Dev Biol (2003) 1.59
Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog Knypek. Genes Dev (2007) 1.36
Patterns of cell motility in the organizer and dorsal mesoderm of Xenopus laevis. Development (1992) 1.29
Planar cell polarity genes and neural tube closure. Birth Defects Res C Embryo Today (2003) 1.25
Activation of Gbetagamma signaling downstream of Wnt-11/Xfz7 regulates Cdc42 activity during Xenopus gastrulation. Dev Biol (2003) 1.19
Planar cell polarity signaling: a common mechanism for cellular polarization. Mt Sinai J Med (2006) 1.18
A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor. Development (2003) 1.02
Microtubule disruption reveals that Spemann's organizer is subdivided into two domains by the vegetal alignment zone. Development (1997) 1.00
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Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann Neurol (2006) 5.49
The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol (2003) 4.89
Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology (2003) 4.10
Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology (2009) 4.08
The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell (2012) 3.91
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly. Cell (2004) 3.68
EGF receptor ligands. Exp Cell Res (2003) 3.60
Pancreatic epithelial plasticity mediated by acinar cell transdifferentiation and generation of nestin-positive intermediates. Development (2005) 3.57
Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A (2008) 3.34
Anteroposterior patterning in hemichordates and the origins of the chordate nervous system. Cell (2003) 3.00
Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nat Chem Biol (2010) 2.71
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol (2007) 2.70
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis. Proc Natl Acad Sci U S A (2002) 2.65
A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol (2010) 2.47
Detection of S-phase cell cycle progression using 5-ethynyl-2'-deoxyuridine incorporation with click chemistry, an alternative to using 5-bromo-2'-deoxyuridine antibodies. Biotechniques (2008) 2.23
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3's phosphorylation of beta-catenin. Proc Natl Acad Sci U S A (2008) 2.14
Fibrocystin/polyductin modulates renal tubular formation by regulating polycystin-2 expression and function. J Am Soc Nephrol (2008) 2.04
Evidence for an upper limit to mitotic spindle length. Curr Biol (2008) 1.94
Amphiregulin exosomes increase cancer cell invasion. Curr Biol (2011) 1.93
Potentiation of oxyntic atrophy-induced gastric metaplasia in amphiregulin-deficient mice. Gastroenterology (2007) 1.87
Proteome analysis of human colon cancer by two-dimensional difference gel electrophoresis and mass spectrometry. Proteomics (2004) 1.82
The Wnt modulator sFRP2 enhances mesenchymal stem cell engraftment, granulation tissue formation and myocardial repair. Proc Natl Acad Sci U S A (2008) 1.77
Cross-cultural differences in somatic presentation in patients with generalized anxiety disorder. J Nerv Ment Dis (2006) 1.76
Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions. Curr Biol (2012) 1.67
Spasmolytic polypeptide-expressing metaplasia (SPEM) in the gastric oxyntic mucosa does not arise from Lgr5-expressing cells. Gut (2011) 1.67
Molecular imaging of therapeutic response to epidermal growth factor receptor blockade in colorectal cancer. Clin Cancer Res (2008) 1.66
Imaging protein synthesis in cells and tissues with an alkyne analog of puromycin. Proc Natl Acad Sci U S A (2011) 1.65
An index for selective toxicity of miticides to phytophagous mites and their predators based on orchard trials. Pest Manag Sci (2003) 1.56
Metabolic labeling and direct imaging of choline phospholipids in vivo. Proc Natl Acad Sci U S A (2009) 1.56
Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS. Mol Cell Proteomics (2012) 1.55
Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling. Chem Biol (2011) 1.52
The enterocyte microvillus is a vesicle-generating organelle. J Cell Biol (2009) 1.51
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol (2011) 1.48
Bub1 is essential for assembly of the functional inner centromere. J Cell Biol (2007) 1.45
TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer. Clin Cancer Res (2008) 1.44
PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells. Proc Natl Acad Sci U S A (2004) 1.42
Transactivation of the epidermal growth factor receptor in colonic epithelial cells by carbachol requires extracellular release of transforming growth factor-alpha. J Biol Chem (2002) 1.42
p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest (2010) 1.41
A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem (2002) 1.40
Randomized phase II trial of the clinical and biological effects of two dose levels of gefitinib in patients with recurrent colorectal adenocarcinoma. J Clin Oncol (2005) 1.38
The way Wnt works: components and mechanism. Growth Factors (2012) 1.37
Volume of preclinical xenograft tumors is more accurately assessed by ultrasound imaging than manual caliper measurements. J Ultrasound Med (2010) 1.35
Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. J Clin Invest (2010) 1.35
Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. PLoS Pathog (2012) 1.34
Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol (2006) 1.32
Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells. Proc Natl Acad Sci U S A (2004) 1.30
Overexpression of heparin-binding EGF-like growth factor in mouse pancreas results in fibrosis and epithelial metaplasia. Gastroenterology (2003) 1.28
Pyrvinium, a potent small molecule Wnt inhibitor, promotes wound repair and post-MI cardiac remodeling. PLoS One (2010) 1.24
Myristoylated Naked2 antagonizes Wnt-beta-catenin activity by degrading Dishevelled-1 at the plasma membrane. J Biol Chem (2010) 1.18
sFRP2 suppression of bone morphogenic protein (BMP) and Wnt signaling mediates mesenchymal stem cell (MSC) self-renewal promoting engraftment and myocardial repair. J Biol Chem (2010) 1.18
Use of fluorescence-activated vesicle sorting for isolation of Naked2-associated, basolaterally targeted exocytic vesicles for proteomics analysis. Mol Cell Proteomics (2008) 1.18
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol (2013) 1.18
Oncogenic KRAS provides a uniquely powerful and variable oncogenic contribution among RAS family members in the colonic epithelium. J Cell Physiol (2007) 1.18
alpha-Endosulfine is a conserved protein required for oocyte meiotic maturation in Drosophila. Development (2008) 1.17
Mtgr1 is a transcriptional corepressor that is required for maintenance of the secretory cell lineage in the small intestine. Mol Cell Biol (2005) 1.16
Efficacy of cetuximab in the treatment of Menetrier's disease. Sci Transl Med (2009) 1.14
Evidence for repatterning of the gastric fundic epithelium associated with Ménétrier's disease and TGFalpha overexpression. Gastroenterology (2005) 1.14
Distinguishing Ménétrier's disease from its mimics. Gut (2010) 1.12
Limits of [18F]-FLT PET as a biomarker of proliferation in oncology. PLoS One (2013) 1.12
Pathology of rodent models of intestinal cancer: progress report and recommendations. Gastroenterology (2013) 1.12
Targeted imaging of colonic tumors in smad3-/- mice discriminates cancer and inflammation. Mol Cancer Res (2007) 1.11
Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep (2012) 1.11
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells. Mol Biol Cell (2007) 1.10
Context-dependent activation or inhibition of Wnt-beta-catenin signaling by Kremen. Sci Signal (2008) 1.10
Basolateral sorting of transforming growth factor-alpha precursor in polarized epithelial cells: characterization of cytoplasmic domain determinants. Exp Cell Res (2003) 1.10
Differential effects of amphiregulin and TGF-alpha on the morphology of MDCK cells. Exp Cell Res (2005) 1.09
Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo. Clin Cancer Res (2002) 1.07
Effects of dispersal, predators (Acari: Phytoseiidae), weather, and ground cover treatments on populations of Tetranychus urticae (Acari: Tetranychidae) in apple orchards. J Econ Entomol (2005) 1.07
Myeloid translocation gene family members associate with T-cell factors (TCFs) and influence TCF-dependent transcription. Mol Cell Biol (2007) 1.06
Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells. J Biol Chem (2008) 1.06
A unified mixed effects model for gene set analysis of time course microarray experiments. Stat Appl Genet Mol Biol (2009) 1.05
Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Dev Biol (2007) 1.05
Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity. Cancer Res (2011) 1.05
The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci (2007) 1.04
Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc Natl Acad Sci U S A (2013) 1.02
Conditional mutation of Pkd2 causes cystogenesis and upregulates beta-catenin. J Am Soc Nephrol (2009) 1.02
Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Sci Signal (2010) 1.01
Proteomic consequences of a single gene mutation in a colorectal cancer model. J Proteome Res (2011) 1.01
Inflammatory masses associated with intrathecal drug infusion: a review of preclinical evidence and human data. Pain Med (2002) 1.01