Published in Biol Chem on November 01, 2008
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M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage. Cell (2004) 2.46
The N terminus of the MUC2 mucin forms trimers that are held together within a trypsin-resistant core fragment. J Biol Chem (2002) 2.44
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Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci U S A (2013) 2.32
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Pathogenic mechanisms in lupus nephritis: Nucleosomes bind aberrant laminin β1 with high affinity and colocalize in the electron-dense deposits. Arthritis Rheumatol (2014) 2.13
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Immunological mechanisms underlying the genetic predisposition to severe Staphylococcus aureus infection in the mouse model. Am J Pathol (2008) 1.77
β₂-glycoprotein I: a novel component of innate immunity. Blood (2011) 1.75
COMP acts as a catalyst in collagen fibrillogenesis. J Biol Chem (2007) 1.74
Complexes of matrilin-1 and biglycan or decorin connect collagen VI microfibrils to both collagen II and aggrecan. J Biol Chem (2003) 1.72
The recombinant C-terminus of the human MUC2 mucin forms dimers in Chinese-hamster ovary cells and heterodimers with full-length MUC2 in LS 174T cells. Biochem J (2003) 1.67
The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J Biol Chem (2005) 1.61
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Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc Natl Acad Sci U S A (2011) 1.52
Dominant collagen VI mutations are a common cause of Ullrich congenital muscular dystrophy. Hum Mol Genet (2004) 1.51
Activation of the complement system generates antibacterial peptides. Proc Natl Acad Sci U S A (2004) 1.51
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The contact system--a novel branch of innate immunity generating antibacterial peptides. EMBO J (2006) 1.36
Streptococcal M protein: a multipotent and powerful inducer of inflammation. J Immunol (2006) 1.36
Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures. J Biol Chem (2002) 1.35
TGF-beta1 induced epithelial to mesenchymal transition (EMT) in human bronchial epithelial cells is enhanced by IL-1beta but not abrogated by corticosteroids. Respir Res (2009) 1.32
Streptococcus pyogenes expressing M and M-like surface proteins are phagocytosed but survive inside human neutrophils. Cell Microbiol (2003) 1.29
Clinical relevance of intra-abdominal hypertension in patients with severe acute pancreatitis. Pancreas (2008) 1.28
The anti-inflammatory effect of glucocorticoids is mediated by glucocorticoid-induced leucine zipper in epithelial cells. J Allergy Clin Immunol (2006) 1.27
Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages. J Clin Invest (2008) 1.25
Galectin-7 (PIG1) exhibits pro-apoptotic function through JNK activation and mitochondrial cytochrome c release. J Biol Chem (2001) 1.25
Galectin-3 functions as an adhesion molecule to support eosinophil rolling and adhesion under conditions of flow. J Immunol (2007) 1.23
Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum (2010) 1.23
Distribution of PG-M/versican variants in human tissues and de novo expression of isoform V3 upon endothelial cell activation, migration, and neoangiogenesis in vitro. J Biol Chem (2002) 1.22
Suppression of sulfonylurea- and glucose-induced insulin secretion in vitro and in vivo in mice lacking the chloride transport protein ClC-3. Cell Metab (2009) 1.22
Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation. Mol Immunol (2008) 1.21
Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma. Proc Natl Acad Sci U S A (2007) 1.20
Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury. Am J Respir Crit Care Med (2012) 1.18
Secretion of heparin-binding protein from human neutrophils is determined by its localization in azurophilic granules and secretory vesicles. Blood (2002) 1.18
The association of obesity and asthma severity and control in children. J Allergy Clin Immunol (2011) 1.17
Molecular consequences of dominant Bethlem myopathy collagen VI mutations. Ann Neurol (2007) 1.15
Collagen VI glycine mutations: perturbed assembly and a spectrum of clinical severity. Ann Neurol (2008) 1.14
Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins. Structure (2004) 1.14
A novel localization of the G-protein-coupled CysLT1 receptor in the nucleus of colorectal adenocarcinoma cells. Cancer Res (2005) 1.13
Proteolysis of human thrombin generates novel host defense peptides. PLoS Pathog (2010) 1.12
Antimicrobial activity of histidine-rich peptides is dependent on acidic conditions. Biochim Biophys Acta (2007) 1.12
Domain 5 of high molecular weight kininogen is antibacterial. J Biol Chem (2005) 1.11
Podocytes express ADAMTS13 in normal renal cortex and in patients with thrombotic thrombocytopenic purpura. Br J Haematol (2007) 1.11
B cell activation by outer membrane vesicles--a novel virulence mechanism. PLoS Pathog (2010) 1.09
Identification of two protein-binding and functional regions of curli, a surface organelle and virulence determinant of Escherichia coli. J Biol Chem (2002) 1.09
Antimicrobial peptides derived from growth factors. Growth Factors (2007) 1.09
Simvastatin reduces endotoxin-induced acute lung injury by decreasing neutrophil recruitment and radical formation. PLoS One (2012) 1.08
The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement membrane anchor. J Biol Chem (2002) 1.08
Streptococcus pyogenes bacteria modulate membrane traffic in human neutrophils and selectively inhibit azurophilic granule fusion with phagosomes. Cell Microbiol (2006) 1.06
Contact system activation in severe infectious diseases. J Mol Med (Berl) (2010) 1.06
Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias. J Biol Chem (2006) 1.06
Kinked collagen VI tetramers and reduced microfibril formation as a result of Bethlem myopathy and introduced triple helical glycine mutations. J Biol Chem (2001) 1.06
The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins. J Immunol (2008) 1.05
Characterization of recombinant amino-terminal NC4 domain of human collagen IX: interaction with glycosaminoglycans and cartilage oligomeric matrix protein. J Biol Chem (2004) 1.05
Streptococcal M proteins and their role as virulence determinants. Clin Chim Acta (2010) 1.05
Presence of activated mobile fibroblasts in bronchoalveolar lavage from patients with mild asthma. Am J Respir Crit Care Med (2004) 1.05
The dual role of the contact system in bacterial infectious disease. Thromb Haemost (2007) 1.05
Moraxella catarrhalis outer membrane vesicles carry β-lactamase and promote survival of Streptococcus pneumoniae and Haemophilus influenzae by inactivating amoxicillin. Antimicrob Agents Chemother (2011) 1.05
The fibrillogenic L178H variant of apolipoprotein A-I forms helical fibrils. J Lipid Res (2011) 1.05
Collagen VI is a subepithelial adhesive target for human respiratory tract pathogens. J Innate Immun (2009) 1.04
Boosting antimicrobial peptides by hydrophobic oligopeptide end tags. J Biol Chem (2009) 1.03
Elevated plasma levels of antimicrobial polypeptides in patients with severe sepsis. J Innate Immun (2010) 1.03
All four members of the Ten-m/Odz family of transmembrane proteins form dimers. J Biol Chem (2002) 1.03
Complement inhibitor C4b-binding protein interacts directly with small glycoproteins of the extracellular matrix. J Immunol (2009) 1.03
C-terminal peptides of tissue factor pathway inhibitor are novel host defense molecules. J Biol Chem (2010) 1.02
Coagulation systems of invertebrates and vertebrates and their roles in innate immunity: the same side of two coins? J Innate Immun (2010) 1.01
The human CXC chemokine granulocyte chemotactic protein 2 (GCP-2)/CXCL6 possesses membrane-disrupting properties and is antibacterial. Antimicrob Agents Chemother (2008) 1.01
Cigarette smoke decreases innate responses of epithelial cells to rhinovirus infection. Am J Respir Cell Mol Biol (2010) 1.01
Multicomponent Moraxella catarrhalis outer membrane vesicles induce an inflammatory response and are internalized by human epithelial cells. Cell Microbiol (2010) 1.01
ScFv antibody-induced translocation of cell-surface heparan sulfate proteoglycan to endocytic vesicles: evidence for heparan sulfate epitope specificity and role of both syndecan and glypican. J Biol Chem (2009) 1.01
Increased plasma levels of heparin-binding protein in patients with shock: a prospective, cohort study. Inflamm Res (2011) 1.00
Localization of human neutrophil interleukin-8 (CXCL-8) to organelle(s) distinct from the classical granules and secretory vesicles. J Leukoc Biol (2005) 1.00
Lipopolysaccharide-driven Th2 cytokine production in macrophages is regulated by both MyD88 and TRAM. J Biol Chem (2009) 0.99
M1 protein-dependent intracellular trafficking promotes persistence and replication of Streptococcus pyogenes in macrophages. J Innate Immun (2010) 0.99
Identification of proteins released by mammalian cells that mediate DNA internalization through proteoglycan-dependent macropinocytosis. J Biol Chem (2007) 0.99
Severe streptococcal infection is associated with M protein-induced platelet activation and thrombus formation. Mol Microbiol (2007) 0.99
Thrombin-activatable fibrinolysis inhibitor binds to Streptococcus pyogenes by interacting with collagen-like proteins A and B. J Biol Chem (2007) 0.99