Published in J Biol Chem on September 12, 2008
Toll-6 and Toll-7 function as neurotrophin receptors in the Drosophila melanogaster CNS. Nat Neurosci (2013) 1.10
Proteolytic activation and function of the cytokine Spätzle in the innate immune response of a lepidopteran insect, Manduca sexta. FEBS J (2009) 1.09
Extracellular matrix and its receptors in Drosophila neural development. Dev Neurobiol (2011) 0.98
Molecular mechanism that induces activation of Spätzle, the ligand for the Drosophila Toll receptor. J Biol Chem (2010) 0.95
Neuron-type specific functions of DNT1, DNT2 and Spz at the Drosophila neuromuscular junction. PLoS One (2013) 0.87
Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila. J Cell Biol (2017) 0.81
Crystallization of Spätzle, a cystine-knot protein involved in embryonic development and innate immunity in Drosophila melanogaster. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.80
Functional insights from the crystal structure of the N-terminal domain of the prototypical toll receptor. Structure (2012) 0.80
Cytokine Spatzle binds to the Drosophila immunoreceptor Toll with a neurotrophin-like specificity and couples receptor activation. Proc Natl Acad Sci U S A (2013) 0.79
Structure of the Toll-Spatzle complex, a molecular hub in Drosophila development and innate immunity. Proc Natl Acad Sci U S A (2014) 0.77
The pro-domains of neurotrophins, including BDNF, are linked to Alzheimer's disease through a toxic synergy with Aβ. Hum Mol Genet (2015) 0.77
Relish2 mediates bursicon homodimer-induced prophylactic immunity in the mosquito Aedes aegypti. Sci Rep (2017) 0.75
Reconstitution of Torso signaling in cultured cells suggests a role for both Trunk and Torsolike in receptor activation. Development (2017) 0.75
The Toll Signaling Pathway in the Chinese Oak Silkworm, Antheraea pernyi: Innate Immune Responses to Different Microorganisms. PLoS One (2016) 0.75
Kek-6: A truncated-Trk-like receptor for Drosophila neurotrophin 2 regulates structural synaptic plasticity. PLoS Genet (2017) 0.75
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing. EMBO J (2002) 5.70
The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster. Genetics (2004) 3.71
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics (2007) 3.08
Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila. Genes Dev (2004) 3.08
Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell (2007) 2.66
Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc Natl Acad Sci U S A (2002) 2.51
The ribosomal protein genes and Minute loci of Drosophila melanogaster. Genome Biol (2007) 2.40
Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila. Semin Cell Dev Biol (2003) 2.37
Histone modification and the control of heterochromatic gene silencing in Drosophila. Chromosome Res (2006) 2.28
Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor. Proc Natl Acad Sci U S A (2007) 2.13
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1. Nat Struct Mol Biol (2010) 2.12
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTP. Science (2009) 2.08
Pivotal role of AtSUVH2 in heterochromatic histone methylation and gene silencing in Arabidopsis. EMBO J (2005) 2.04
Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med (2008) 2.01
Passing the baton in class B GPCRs: peptide hormone activation via helix induction? Trends Biochem Sci (2009) 1.89
Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2. Nat Genet (2009) 1.78
Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila. Cold Spring Harb Perspect Biol (2013) 1.76
Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. RNA (2008) 1.76
Deciphering the cryptic genome: genome-wide analyses of the rice pathogen Fusarium fujikuroi reveal complex regulation of secondary metabolism and novel metabolites. PLoS Pathog (2013) 1.72
Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs. RNA (2008) 1.63
Crystal structure of the nucleotide-binding domain of the ABC-transporter haemolysin B: identification of a variable region within ABC helical domains. J Mol Biol (2003) 1.63
Cellular mechanism for targeting heterochromatin formation in Drosophila. Int Rev Cell Mol Biol (2009) 1.51
Crystal structure of DltA. Implications for the reaction mechanism of non-ribosomal peptide synthetase adenylation domains. J Biol Chem (2008) 1.50
Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification. Mol Microbiol (2003) 1.50
Structural basis for the cyclization of the lipopeptide antibiotic surfactin by the thioesterase domain SrfTE. Structure (2002) 1.49
Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications. Prostaglandins Other Lipid Mediat (2002) 1.47
SU(VAR)3-9 is a conserved key function in heterochromatic gene silencing. Genetica (2003) 1.45
Prolyl isomerization as a molecular timer in phage infection. Nat Struct Mol Biol (2005) 1.41
Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation. J Med Chem (2002) 1.38
Molecular enzymology of lipoxygenases. Arch Biochem Biophys (2010) 1.37
Molecular dioxygen enters the active site of 12/15-lipoxygenase via dynamic oxygen access channels. Proc Natl Acad Sci U S A (2007) 1.32
Protein folding and stability of human CDK inhibitor p19(INK4d). J Mol Biol (2002) 1.25
Recombinogenic effects of suppressors of position-effect variegation in Drosophila. Genetics (2002) 1.24
Mammalian Su(var) genes in chromatin control. Annu Rev Cell Dev Biol (2010) 1.22
Epigenetic programming via histone methylation at WRKY53 controls leaf senescence in Arabidopsis thaliana. Plant J (2009) 1.21
Structural biology of mammalian lipoxygenases: enzymatic consequences of targeted alterations of the protein structure. Biochem Biophys Res Commun (2005) 1.19
YcdB from Escherichia coli reveals a novel class of Tat-dependently translocated hemoproteins. J Biol Chem (2006) 1.15
Heterochromatin proteins and the control of heterochromatic gene silencing in Arabidopsis. J Plant Physiol (2005) 1.15
Asymmetric arginine dimethylation of heterogeneous nuclear ribonucleoprotein K by protein-arginine methyltransferase 1 inhibits its interaction with c-Src. J Biol Chem (2006) 1.13
IGF2BP1 enhances HCV IRES-mediated translation initiation via the 3'UTR. RNA (2009) 1.10
DnaK plays a pivotal role in Tat targeting of CueO and functions beside SlyD as a general Tat signal binding chaperone. J Biol Chem (2007) 1.10
Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers. Biophys J (2008) 1.10
T-rich DNA single strands bind to a preformed site on the bacterial cold shock protein Bs-CspB. J Mol Biol (2006) 1.08
Trans-splicing of the mod(mdg4) complex locus is conserved between the distantly related species Drosophila melanogaster and D. virilis. Genetics (2004) 1.06
SlyD proteins from different species exhibit high prolyl isomerase and chaperone activities. Biochemistry (2006) 1.05
Crystal structure of 1-deoxy-D-xylulose-5-phosphate reductoisomerase, a crucial enzyme in the non-mevalonate pathway of isoprenoid biosynthesis. J Biol Chem (2001) 1.05
Structural basis of the sulphate starvation response in E. coli: crystal structure and mutational analysis of the cofactor-binding domain of the Cbl transcriptional regulator. J Mol Biol (2006) 1.05
The Drosophila melanogaster Gene cg4930 Encodes a High Affinity Inhibitor for Endonuclease G. J Biol Chem (2009) 1.05
Human platelet 12-lipoxygenase, new findings about its activity, membrane binding and low-resolution structure. J Mol Biol (2007) 1.04
Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J Biol Chem (2008) 1.02
Conserved introns reveal novel transcripts in Drosophila melanogaster. Genome Res (2009) 1.01
The Arabidopsis SUVR4 protein is a nucleolar histone methyltransferase with preference for monomethylated H3K9. Nucleic Acids Res (2006) 0.99
The expression of heat shock protein 60 in myocardium of patients with chronic atrial fibrillation. Basic Res Cardiol (2002) 0.99
Biochemical and structural analysis of substrate promiscuity in plant Mg2+-dependent O-methyltransferases. J Mol Biol (2008) 0.99
NMR solution structure of SlyD from Escherichia coli: spatial separation of prolyl isomerase and chaperone function. J Mol Biol (2009) 0.98
Structural basis for cooperativity of CRM1 export complex formation. Proc Natl Acad Sci U S A (2012) 0.98
Folding mechanism of an ankyrin repeat protein: scaffold and active site formation of human CDK inhibitor p19(INK4d). J Mol Biol (2007) 0.97
Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex. J Cell Biol (2011) 0.97
High-level expression of rabbit 15-lipoxygenase induces collapse of the mitochondrial pH gradient in cell culture. Biochemistry (2004) 0.96
Recognition of T-rich single-stranded DNA by the cold shock protein Bs-CspB in solution. Nucleic Acids Res (2006) 0.96
Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14. J Mol Biol (2003) 0.95
DNA methylation in Drosophila--a critical evaluation. Prog Mol Biol Transl Sci (2011) 0.95
Single-stranded DNA binding of the cold-shock protein CspB from Bacillus subtilis: NMR mapping and mutational characterization. Protein Sci (2003) 0.95
The SUVR4 histone lysine methyltransferase binds ubiquitin and converts H3K9me1 to H3K9me3 on transposon chromatin in Arabidopsis. PLoS Genet (2011) 0.95
Structural basis for the broad substrate range of the UDP-sugar pyrophosphorylase from Leishmania major. J Mol Biol (2010) 0.94
NMR spectroscopic characterization of millisecond protein folding by transverse relaxation dispersion measurements. J Am Chem Soc (2005) 0.94
The carbohydrate-binding site in galectin-3 is preorganized to recognize a sugarlike framework of oxygens: ultra-high-resolution structures and water dynamics. Biochemistry (2011) 0.94
Conformational switch upon phosphorylation: human CDK inhibitor p19INK4d between the native and partially folded state. ACS Chem Biol (2009) 0.94
RNA single strands bind to a conserved surface of the major cold shock protein in crystals and solution. RNA (2011) 0.94
Amyloid fibril recognition with the conformational B10 antibody fragment depends on electrostatic interactions. J Mol Biol (2010) 0.94
The O-carbamoyltransferase TobZ catalyzes an ancient enzymatic reaction. Angew Chem Int Ed Engl (2012) 0.93
Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis. J Med Chem (2003) 0.93
Improving hydrogen/deuterium exchange mass spectrometry by reduction of the back-exchange effect. J Mass Spectrom (2003) 0.93
Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis. J Biol Chem (2005) 0.93
Protein folding studied by real-time NMR spectroscopy. Methods (2004) 0.92
Arachidonic Acid metabolites in the cardiovascular system: the role of lipoxygenase isoforms in atherogenesis with particular emphasis on vascular remodeling. J Cardiovasc Pharmacol (2007) 0.91
Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties. Proc Natl Acad Sci U S A (2009) 0.91
Molecular basis of β-amyloid oligomer recognition with a conformational antibody fragment. Proc Natl Acad Sci U S A (2012) 0.91
Applicability of the triad concept for the positional specificity of mammalian lipoxygenases. J Biol Chem (2009) 0.91
Structural and dynamical characterization of fibrils from a disease-associated alanine expansion domain using proteolysis and solid-state NMR spectroscopy. J Am Chem Soc (2008) 0.91
Cadmium induces a novel metallothionein and phytochelatin 2 in an aquatic fungus. Biochem Biophys Res Commun (2005) 0.90
Combined NMR-observation of cold denaturation in supercooled water and heat denaturation enables accurate measurement of deltaC(p) of protein unfolding. Eur Biophys J (2005) 0.90
High yield production of recombinant native and modified peptides exemplified by ligands for G-protein coupled receptors. Protein Expr Purif (2008) 0.90
Aurora1 phosphorylation activity on histone H3 and its cross-talk with other post-translational histone modifications in Arabidopsis. Plant J (2009) 0.90
Structural basis for membrane binding and catalytic activation of the peripheral membrane enzyme pyruvate oxidase from Escherichia coli. Proc Natl Acad Sci U S A (2008) 0.90
Electron microscopy of biotinylated protein complexes bound to streptavidin monolayer crystals. J Struct Biol (2012) 0.89
Structural insights into an equilibrium folding intermediate of an archaeal ankyrin repeat protein. Proc Natl Acad Sci U S A (2008) 0.89
Double duty for a conserved glutamate in pyruvate decarboxylase: evidence of the participation in stereoelectronically controlled decarboxylation and in protonation of the nascent carbanion/enamine intermediate . Biochemistry (2010) 0.89