Published in Infect Immun on September 01, 1991
Cryptococcosis in the era of AIDS--100 years after the discovery of Cryptococcus neoformans. Clin Microbiol Rev (1995) 8.81
Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot Cell (2003) 4.71
Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Eukaryot Cell (2005) 4.36
Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Nat Genet (2010) 3.65
Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies. Infect Immun (1996) 3.08
Ectopic expression of URA3 can influence the virulence phenotypes and proteome of Candida albicans but can be overcome by targeted reintegration of URA3 at the RPS10 locus. Eukaryot Cell (2004) 2.63
Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans. J Bacteriol (1999) 2.53
Altered expression of selectable marker URA3 in gene-disrupted Candida albicans strains complicates interpretation of virulence studies. Infect Immun (1998) 2.51
Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A (2006) 2.39
A triple deletion of the secreted aspartyl proteinase genes SAP4, SAP5, and SAP6 of Candida albicans causes attenuated virulence. Infect Immun (1997) 2.35
The pH of the host niche controls gene expression in and virulence of Candida albicans. Infect Immun (1998) 2.24
Disruption of each of the secreted aspartyl proteinase genes SAP1, SAP2, and SAP3 of Candida albicans attenuates virulence. Infect Immun (1997) 2.24
An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Cell Host Microbe (2011) 2.23
A hyphal-specific chitin synthase gene (CHS2) is not essential for growth, dimorphism, or virulence of Candida albicans. Proc Natl Acad Sci U S A (1994) 1.99
The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid. Infect Immun (1993) 1.96
Nucleotide biosynthesis is critical for growth of bacteria in human blood. PLoS Pathog (2008) 1.83
Cloning and sequencing of a Candida albicans catalase gene and effects of disruption of this gene. Infect Immun (1998) 1.76
Attenuated virulence of chitin-deficient mutants of Candida albicans. Proc Natl Acad Sci U S A (1995) 1.73
Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus. Infect Immun (2002) 1.65
Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Mol Biol Cell (2005) 1.63
Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus. Infect Immun (1996) 1.60
Reduced virulence of Candida albicans PHR1 mutants. Infect Immun (1995) 1.53
Calcineurin is essential for virulence in Candida albicans. Infect Immun (2003) 1.46
Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. Cell Host Microbe (2013) 1.45
Evaluation of the roles of four Candida albicans genes in virulence by using gene disruption strains that express URA3 from the native locus. Infect Immun (2003) 1.45
Reduced virulence of Candida albicans mutants affected in multidrug resistance. Infect Immun (1995) 1.29
The high affinity iron permease is a key virulence factor required for Rhizopus oryzae pathogenesis. Mol Microbiol (2010) 1.27
Cdc24, the GDP-GTP exchange factor for Cdc42, is required for invasive hyphal growth of Candida albicans. Eukaryot Cell (2003) 1.21
Genes contributing to Staphylococcus aureus fitness in abscess- and infection-related ecologies. MBio (2014) 1.15
Development of a gene knockout system in Candida parapsilosis reveals a conserved role for BCR1 in biofilm formation. Eukaryot Cell (2007) 1.14
Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis. Infect Immun (2003) 1.12
Candida glabrata persistence in mice does not depend on host immunosuppression and is unaffected by fungal amino acid auxotrophy. Infect Immun (2009) 1.10
Single-copy IMH3 allele is sufficient to confer resistance to mycophenolic acid in Candida albicans and to mediate transformation of clinical Candida species. Infect Immun (2001) 1.09
Fungal virulence genes as targets for antifungal chemotherapy. Antimicrob Agents Chemother (1996) 1.07
Fungal virulence studies come of age. Genome Biol (2001) 1.07
Virulence of a phosphoribosylaminoimidazole carboxylase-deficient Candida albicans strain in an immunosuppressed murine model of systemic candidiasis. Infect Immun (2001) 1.06
Virulence studies of Aspergillus nidulans mutants requiring lysine or p-aminobenzoic acid in invasive pulmonary aspergillosis. Infect Immun (1994) 1.00
Modulation of phagosomal pH by Candida albicans promotes hyphal morphogenesis and requires Stp2p, a regulator of amino acid transport. PLoS Pathog (2014) 0.99
Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli. Biochemistry (2008) 0.99
The URA5 gene is necessary for histoplasma capsulatum growth during infection of mouse and human cells. Infect Immun (1999) 0.98
Migration of the fungal pathogen Candida albicans across endothelial monolayers. Infect Immun (1996) 0.97
Candida albicans uses multiple mechanisms to acquire the essential metabolite inositol during infection. Infect Immun (2008) 0.96
Gastrointestinal colonization by Candida albicans mutant strains in antibiotic-treated mice. Clin Diagn Lab Immunol (2001) 0.96
Candida albicans Cas5, a regulator of cell wall integrity, is required for virulence in murine and toll mutant fly models. J Infect Dis (2009) 0.96
Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin. Microbiology (2009) 0.95
Avirulence of Candida albicans FAS2 mutants in a mouse model of systemic candidiasis. Infect Immun (1997) 0.95
Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening. Bioorg Med Chem (2009) 0.94
De novo GTP biosynthesis is critical for virulence of the fungal pathogen Cryptococcus neoformans. PLoS Pathog (2012) 0.94
Ferrochelatase is a conserved downstream target of the blue light-sensing White collar complex in fungi. Microbiology (2010) 0.93
GLN3 encodes a global regulator of nitrogen metabolism and virulence of C. albicans. Fungal Genet Biol (2007) 0.91
The Candida albicans ATO Gene Family Promotes Neutralization of the Macrophage Phagolysosome. Infect Immun (2015) 0.82
Strategies for the identification of virulence determinants in human pathogenic fungi. Curr Genet (2003) 0.81
A genomic safe haven for mutant complementation in Cryptococcus neoformans. PLoS One (2015) 0.79
Proteome analysis of the two-component SalK/SalR system in Epidemic Streptococcus suis serotype 2. Curr Microbiol (2013) 0.79
Structural and biochemical characterization of N5-carboxyaminoimidazole ribonucleotide synthetase and N5-carboxyaminoimidazole ribonucleotide mutase from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr (2011) 0.77
Dissection of the Candida albicans Cdc4 protein reveals the involvement of domains in morphogenesis and cell flocculation. J Biomed Sci (2013) 0.76
Candida albicans ISW2 Regulates Chlamydospore Suspensor Cell Formation and Virulence In Vivo in a Mouse Model of Disseminated Candidiasis. PLoS One (2016) 0.75
Grf10 and Bas1 Regulate Transcription of Adenylate and One-Carbon Biosynthesis Genes and Affect Virulence in the Human Fungal Pathogen Candida albicans. mSphere (2017) 0.75
Isolation of the Candida albicans gene for orotidine-5'-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations. Mol Gen Genet (1984) 11.51
Heterozygosity and segregation in Candida albicans. Mol Gen Genet (1980) 4.56
Integrative transformation of Candida albicans, using a cloned Candida ADE2 gene. Mol Cell Biol (1986) 4.30
Critical role of germ tube formation in the pathogenesis of candidal vaginitis. Infect Immun (1984) 3.07
Directed mutagenesis in Candida albicans: one-step gene disruption to isolate ura3 mutants. Mol Cell Biol (1987) 2.71
Development of autonomously replicating plasmids for Candida albicans. Mol Cell Biol (1987) 2.58
Studies on the pink, adenine-deficient strains of Candida albicans. I. Cultural and morphological characteristics. Sabouraudia (1970) 2.29
Isolation of hem3 mutants from Candida albicans by sequential gene disruption. Mol Gen Genet (1989) 2.26
Genetic analysis of red, adenine-requiring mutants of Candida albicans. J Bacteriol (1983) 2.16
An examination of the production of hydrolytic enzymes and toxins by pathogenic strains of Candida albicans. J Gen Microbiol (1971) 2.10
Pathogenicity of morphological and auxotrophic mutants of Candida albicans in experimental infections. Infect Immun (1985) 1.68
PROMOTION OF RETARDATION OF THE GROWTH OF ADENINE AUXOTROPHS OF CANDIDA ALBICANS BY PURINES, PYRIMIDINES AND NUCLEOSIDES. Antonie Van Leeuwenhoek (1964) 1.55
Yeast adhesion in the pathogenesis of endocarditis due to Candida albicans: studies with adherence-negative mutants. J Infect Dis (1985) 1.48
Biological and chemical characterization of toxic substances from Candida albicans. Infect Immun (1972) 1.41
Candida albicans proteinase as a virulence factor in the pathogenesis of Candida infections. Zentralbl Bakteriol Mikrobiol Hyg A (1985) 1.40
Comparative pathogenicity of auxotrophic mutants of Candida albicans. Can J Microbiol (1984) 1.39
Porphyrine mutants of Saccharomyces cerevisiae: correlated lesions in sterol and fatty acid biosynthesis. Biochem Biophys Res Commun (1974) 1.26
The molecular genetics of Candida albicans. Microbiol Sci (1988) 1.23
Candida proteinases and candidosis. Crit Rev Biotechnol (1988) 1.18
Correlative relationship between adherence of Candida albicans to human vaginal epithelial cells in vitro and candidal vaginitis. Sabouraudia (1984) 1.09
Protoplast fusion hybrids of Candida albicans sterol mutants differing in nystatin resistance. J Gen Microbiol (1982) 1.09
Phospholipase activity in Candida albicans. Sabouraudia (1977) 1.03
One-step gene disruption by cotransformation to isolate double auxotrophs in Candida albicans. Mol Gen Genet (1988) 1.01
The cytochemical localization of phospholipase a and lysophospholipase in Candida albicans. Sabouraudia (1975) 0.92
Toxins produced by Candida albicans. Contrib Microbiol Immunol (1977) 0.88
Amphotericin B lipid complex therapy of experimental fungal infections in mice. Antimicrob Agents Chemother (1991) 1.88
In-vivo properties of SQ 26,776. J Antimicrob Chemother (1981) 1.64
Characterization and quantitation of experimental surgical-wound infections used to evaluate topical antibacterial agents. Antimicrob Agents Chemother (1976) 1.38
In vivo evaluation of tigemonam, a novel oral monobactam. Antimicrob Agents Chemother (1987) 1.19
Lysobactin, a novel antibacterial agent produced by Lysobacter sp. II. Biological properties. J Antibiot (Tokyo) (1988) 1.18
Evaluation of vaginal antifungal formulations in vivo. Postgrad Med J (1979) 1.06
Responsiveness of experimental surgical-wound infections to topical chemotherapy. Antimicrob Agents Chemother (1976) 0.83
Evaluation of chemotherapeutic agents in experimental Haemophilus influenzae bacteremia and meningitis in infant rats. Chemotherapy (1980) 0.75