Published in Circulation on October 28, 2008
Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32
Genetic variation in SCN10A influences cardiac conduction. Nat Genet (2010) 2.30
Etiology of sudden death in the community: results of anatomical, metabolic, and genetic evaluation. Am Heart J (2010) 1.70
Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study. Circ Cardiovasc Genet (2011) 1.67
Clinical and genetic determinants of torsade de pointes risk. Circulation (2012) 1.67
Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters. Heart Rhythm (2010) 1.58
Sudden cardiac death: epidemiology and risk factors. Nat Rev Cardiol (2010) 1.53
Genome-wide association study identifies a susceptibility locus at 21q21 for ventricular fibrillation in acute myocardial infarction. Nat Genet (2010) 1.47
Clinical correlates and heritability of QT interval duration in blacks: the Jackson Heart Study. Circ Arrhythm Electrophysiol (2009) 1.08
Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure. Circ Res (2013) 0.98
The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias. Front Physiol (2012) 0.95
Impact of ancestry and common genetic variants on QT interval in African Americans. Circ Cardiovasc Genet (2012) 0.94
Systems biology and cardiac arrhythmias. Lancet (2012) 0.92
Absence of the inhibitory G-protein Galphai2 predisposes to ventricular cardiac arrhythmia. Circ Arrhythm Electrophysiol (2010) 0.90
Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias. PLoS One (2012) 0.79
CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol (2016) 0.77
High speed sCMOS-based oblique plane microscopy applied to the study of calcium dynamics in cardiac myocytes. J Biophotonics (2015) 0.77
Genetic predisposition for sudden cardiac death in myocardial ischaemia: the Arrhythmia Genetics in the NEtherlandS study. Neth Heart J (2011) 0.76
A pilot study of angiotensin converting enzyme (ACE) genotype and return of spontaneous circulation following out-of-hospital cardiac arrest. Open Heart (2014) 0.75
Inherited Arrhythmias: Of Channels, Currents, and Swimming. Biophys J (2016) 0.75
Genetic Basis of Ventricular Arrhythmias. Curr Cardiovasc Risk Rep (2010) 0.75
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science (2007) 51.70
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Nat Genet (2008) 20.73
Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med (2006) 15.60
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10
Polymorphisms associated with cholesterol and risk of cardiovascular events. N Engl J Med (2008) 9.83
Development of a risk score for atrial fibrillation (Framingham Heart Study): a community-based cohort study. Lancet (2009) 7.27
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet (2006) 6.39
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits. PLoS Genet (2012) 6.15
Novel and conventional biomarkers for prediction of incident cardiovascular events in the community. JAMA (2009) 5.52
Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. JAMA (2009) 5.22
The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet (2007) 5.02
Conserved noncoding sequences are selectively constrained and not mutation cold spots. Nat Genet (2005) 4.79
Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet (2010) 3.97
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88
Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet (2009) 3.80
Genome-wide association study of PR interval. Nat Genet (2010) 3.73
Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet (2010) 3.55
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation (2006) 3.15
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet (2007) 3.04
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. BMC Med Genet (2007) 2.93
Candidate gene association resource (CARe): design, methods, and proof of concept. Circ Cardiovasc Genet (2010) 2.91
Common NOS1AP variants are associated with a prolonged QTc interval in the Rotterdam Study. Circulation (2007) 2.82
Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet (2010) 2.24
Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension (2008) 2.14
Large scale replication and meta-analysis of variants on chromosome 4q25 associated with atrial fibrillation. Eur Heart J (2009) 2.06
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet (2009) 2.02
Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation. Am J Cardiol (2010) 1.97
The early repolarization pattern in the general population: clinical correlates and heritability. J Am Coll Cardiol (2011) 1.95
Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat Genet (2013) 1.91
Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. Heart Rhythm (2009) 1.91
Burden of rare sarcomere gene variants in the Framingham and Jackson Heart Study cohorts. Am J Hum Genet (2012) 1.90
Increased burden of cardiovascular disease in carriers of APOL1 genetic variants. Circ Res (2013) 1.82
Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function. Circulation (2006) 1.78
Assessment of conventional cardiovascular risk factors and multiple biomarkers for the prediction of incident heart failure and atrial fibrillation. J Am Coll Cardiol (2010) 1.77
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet (2013) 1.72
Genome-wide association analysis identifies multiple loci related to resting heart rate. Hum Mol Genet (2010) 1.67
Common genetic variants, QT interval, and sudden cardiac death in a Finnish population-based study. Circ Cardiovasc Genet (2011) 1.67
Clinical and genetic determinants of torsade de pointes risk. Circulation (2012) 1.67
Relation of visceral adiposity to circulating natriuretic peptides in ambulatory individuals. Am J Cardiol (2011) 1.65
Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC Med Genet (2007) 1.65
Influence of sex and hormone status on circulating natriuretic peptides. J Am Coll Cardiol (2011) 1.61
A blood pressure genetic risk score is a significant predictor of incident cardiovascular events in 32,669 individuals. Hypertension (2013) 1.60
Association of hypertension drug target genes with blood pressure and hypertension in 86,588 individuals. Hypertension (2011) 1.60
Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery. Circ Cardiovasc Genet (2009) 1.59
Relationship of common candidate gene variants to electrocardiographic T-wave peak to T-wave end interval and T-wave morphology parameters. Heart Rhythm (2010) 1.58
Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study. Eur Heart J (2007) 1.55
Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium. Hum Mol Genet (2011) 1.54
Association of NOS1AP genetic variants with QT interval duration in families from the Diabetes Heart Study. Diabetes (2008) 1.53
Genome-wide association studies of the PR interval in African Americans. PLoS Genet (2011) 1.53
Genetic basis of blood pressure and hypertension. Trends Genet (2012) 1.51
Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies. J Clin Endocrinol Metab (2011) 1.50
A common missense variant in the neuregulin 1 gene is associated with both schizophrenia and sudden cardiac death. Heart Rhythm (2013) 1.47
Blood pressure loci identified with a gene-centric array. Am J Hum Genet (2011) 1.44
Plasma copeptin and the risk of diabetes mellitus. Circulation (2010) 1.44
Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study. Eur J Heart Fail (2012) 1.43
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. PLoS Genet (2011) 1.38
Multiple biomarkers and the risk of incident hypertension. Hypertension (2007) 1.34
Low plasma level of atrial natriuretic peptide predicts development of diabetes: the prospective Malmo Diet and Cancer study. J Clin Endocrinol Metab (2011) 1.31
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies. PLoS One (2009) 1.28
Loci influencing blood pressure identified using a cardiovascular gene-centric array. Hum Mol Genet (2013) 1.27
Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study. Hum Mol Genet (2009) 1.23
Common variants in cardiac ion channel genes are associated with sudden cardiac death. Circ Arrhythm Electrophysiol (2010) 1.22
Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest (2013) 1.17
Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes. J Mol Cell Cardiol (2011) 1.17
Clinical correlates and heritability of QT interval duration in blacks: the Jackson Heart Study. Circ Arrhythm Electrophysiol (2009) 1.08
High prevalence of four long QT syndrome founder mutations in the Finnish population. Ann Med (2009) 1.08
Large-scale candidate gene analysis in whites and African Americans identifies IL6R polymorphism in relation to atrial fibrillation: the National Heart, Lung, and Blood Institute's Candidate Gene Association Resource (CARe) project. Circ Cardiovasc Genet (2011) 1.06
Psychotropic drugs associated with corrected QT interval prolongation. J Clin Psychopharmacol (2009) 1.05
Effect of weight loss after weight loss surgery on plasma N-terminal pro-B-type natriuretic peptide levels. Am J Cardiol (2010) 1.05
QT interval and long-term mortality risk in the Framingham Heart Study. Ann Noninvasive Electrocardiol (2012) 1.04
Common genetic variants associated with sudden cardiac death: the FinSCDgen study. PLoS One (2012) 1.04
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. J Clin Invest (2013) 1.04
Cardiac transplantation followed by dose-intensive melphalan and autologous stem-cell transplantation for light chain amyloidosis and heart failure. Transplantation (2010) 1.04
Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study. Circulation (2013) 1.03
Early repolarization pattern in competitive athletes: clinical correlates and the effects of exercise training. Circ Arrhythm Electrophysiol (2011) 1.01
Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population. Hum Mol Genet (2010) 0.98
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts. Circ Cardiovasc Genet (2012) 0.97
Heritability, linkage, and genetic associations of exercise treadmill test responses. Circulation (2007) 0.95
Genetic predisposition to higher blood pressure increases coronary artery disease risk. Hypertension (2013) 0.95
Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study. Hypertension (2007) 0.94
Impact of ancestry and common genetic variants on QT interval in African Americans. Circ Cardiovasc Genet (2012) 0.94
Genetic polymorphisms for estimating risk of atrial fibrillation in the general population: a prospective study. Arch Intern Med (2012) 0.92
Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium. Eur Heart J (2012) 0.92
A common NOS1AP genetic polymorphism is associated with increased cardiovascular mortality in users of dihydropyridine calcium channel blockers. Br J Clin Pharmacol (2008) 0.91
Genetic variants and blood pressure in a population-based cohort: the Cardiovascular Risk in Young Finns study. Hypertension (2011) 0.91
A common variant in the β2-adrenergic receptor and risk of sudden cardiac death. Heart Rhythm (2011) 0.90
Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation. Pharmacogenet Genomics (2009) 0.90
Common variation in the NOS1AP gene is associated with reduced glucose-lowering effect and with increased mortality in users of sulfonylurea. Pharmacogenet Genomics (2008) 0.90
Electrocardiographic assessment for therapeutic proteins--scientific discussion. Am Heart J (2010) 0.89
Development and application of a longitudinal electrocardiogram repository: the Framingham Heart Study. J Electrocardiol (2012) 0.88
Genome-wide association study in humans. Methods Mol Biol (2009) 0.88
On the interpretation of genetic association studies. Eur Heart J (2004) 0.87
Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease. PLoS One (2013) 0.87
Predictive value of electrocardiographic T-wave morphology parameters and T-wave peak to T-wave end interval for sudden cardiac death in the general population. Circ Arrhythm Electrophysiol (2013) 0.86
Intracranial aneurysm risk locus 5q23.2 is associated with elevated systolic blood pressure. PLoS Genet (2012) 0.85
Blood pressure and human genetic variation in the general population. Curr Opin Cardiol (2010) 0.85
Prevalence of arrhythmia-associated gene mutations and risk of sudden cardiac death in the Finnish population. Ann Med (2013) 0.85
Therapeutic hypothermia for cardiac arrest: real-world utilization trends and hospital mortality. J Hosp Med (2012) 0.85