Cardiac myocyte Z-line calmodulin is mainly RyR2-bound, and reduction is arrhythmogenic and occurs in heart failure.

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Published in Circ Res on November 01, 2013

Authors

Yi Yang1, Tao Guo, Tetsuro Oda, Asima Chakraborty, Le Chen, Hitoshi Uchinoumi, Anne A Knowlton, Bradley R Fruen, Razvan L Cornea, Gerhard Meissner, Donald M Bers

Author Affiliations

1: From the Department of Pharmacology (Y.Y., T.G., T.O., H.U., A.A.K., D.M.B.), and Molecular and Cellular Cardiology Division, Department of Medicine (L.C., A.A.K.), University of California, Davis, CA; Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC (A.C., G.M.); and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN (B.R.F., R.L.C.).

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