Published in Cell on October 17, 2008
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87
Crosstalk among Histone Modifications. Cell (2008) 2.70
CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem Sci (2009) 2.59
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Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis. Proc Natl Acad Sci U S A (2011) 1.69
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Jarid1b targets genes regulating development and is involved in neural differentiation. EMBO J (2011) 1.50
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Epigenetic regulation of the neural transcriptome: the meaning of the marks. Nat Neurosci (2010) 1.44
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Male germline transmits fetal alcohol adverse effect on hypothalamic proopiomelanocortin gene across generations. Biol Psychiatry (2012) 1.24
Structural insight into histone recognition by the ING PHD fingers. Curr Drug Targets (2009) 1.11
Histone variant H2A.Z regulates centromere silencing and chromosome segregation in fission yeast. J Biol Chem (2009) 1.11
The Schizosaccharomyces pombe JmjC-protein, Msc1, prevents H2A.Z localization in centromeric and subtelomeric chromatin domains. PLoS Genet (2009) 1.10
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Drosophila p53 is required to increase the levels of the dKDM4B demethylase after UV-induced DNA damage to demethylate histone H3 lysine 9. J Biol Chem (2010) 0.97
Carcinoma in situ testis displays permissive chromatin modifications similar to immature foetal germ cells. Br J Cancer (2010) 0.94
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Structural basis for human PHF2 Jumonji domain interaction with metal ions. J Mol Biol (2010) 0.87
A companion cell-dominant and developmentally regulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression. PLoS Genet (2012) 0.87
Overexpression of a histone H3K4 demethylase, JMJ15, accelerates flowering time in Arabidopsis. Plant Cell Rep (2012) 0.86
KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis. Nucleic Acids Res (2014) 0.85
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Cell cycle-dependent deposition of CENP-A requires the Dos1/2-Cdc20 complex. Proc Natl Acad Sci U S A (2012) 0.84
The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells. Blood Cancer J (2015) 0.83
IBM1, a JmjC domain-containing histone demethylase, is involved in the regulation of RNA-directed DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis. Nucleic Acids Res (2012) 0.82
Drosophila Kdm4 demethylases in histone H3 lysine 9 demethylation and ecdysteroid signaling. Sci Rep (2013) 0.82
Ectopic centromere nucleation by CENP--a in fission yeast. Genetics (2014) 0.81
Exposure to coplanar PCBs induces endothelial cell inflammation through epigenetic regulation of NF-κB subunit p65. Toxicol Appl Pharmacol (2015) 0.80
Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells. J Immunol (2014) 0.80
Lsd1 and lsd2 control programmed replication fork pauses and imprinting in fission yeast. Cell Rep (2012) 0.80
DNA replication, RNAi and epigenetic inheritance. Epigenetics (2012) 0.80
Mediator regulates non-coding RNA transcription at fission yeast centromeres. Epigenetics Chromatin (2012) 0.79
Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer. J Clin Invest (2015) 0.79
Adipogenic histone mark regulation by matrix metalloproteinase 14 in collagen-rich microenvironments. Mol Endocrinol (2011) 0.79
Histone acetylation in heterochromatin assembly. Genes Dev (2010) 0.79
The enzymatic activity of Arabidopsis protein arginine methyltransferase 10 is essential for flowering time regulation. Protein Cell (2012) 0.78
CRL4-like Clr4 complex in Schizosaccharomyces pombe depends on an exposed surface of Dos1 for heterochromatin silencing. Proc Natl Acad Sci U S A (2014) 0.78
Condensin Promotes Position Effects within Tandem DNA Repeats via the RITS Complex. Cell Rep (2016) 0.77
A PHF8 homolog in C. elegans promotes DNA repair via homologous recombination. PLoS One (2015) 0.77
Transcriptional Gene Silencing (TGS) via the RNAi Machinery in HIV-1 Infections. Biology (Basel) (2012) 0.77
DNA replication components as regulators of epigenetic inheritance--lesson from fission yeast centromere. Protein Cell (2014) 0.77
Are all repeats created equal? Understanding DNA repeats at an individual level. Curr Genet (2016) 0.76
Nucleation and spreading of a heterochromatic domain in fission yeast. Nat Commun (2016) 0.76
C-terminal domains of a histone demethylase interact with a pair of transcription factors and mediate specific chromatin association. Cell Discov (2015) 0.76
The relationship between lysine 4 on histone H3 methylation levels of alcohol tolerance genes and changes of ethanol tolerance in Saccharomyces cerevisiae. Microb Biotechnol (2014) 0.75
Epigenetic Control of Phenotypic Plasticity in the Filamentous Fungus Neurospora crassa. G3 (Bethesda) (2016) 0.75
Germline-specific labeling of the somatic chromosomes by protein phosphatase 2A and histone H3S28 phosphorylation in Acricotopus lucidus. Protoplasma (2017) 0.75
Molecular genetic analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol (1991) 33.90
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi. Science (2002) 17.04
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Science (2001) 13.55
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol (2007) 10.98
RNAi-mediated targeting of heterochromatin by the RITS complex. Science (2004) 8.73
Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69
Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol (2007) 6.13
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04
Noncoding RNAs and gene silencing. Cell (2007) 5.99
Dynamic regulation of histone lysine methylation by demethylases. Mol Cell (2007) 5.14
The role of RNA interference in heterochromatic silencing. Nature (2004) 4.56
Two RNAi complexes, RITS and RDRC, physically interact and localize to noncoding centromeric RNAs. Cell (2004) 4.34
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell (2007) 4.34
The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell (2007) 3.79
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell (2007) 3.68
RNAi-independent heterochromatin nucleation by the stress-activated ATF/CREB family proteins. Science (2004) 2.80
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. Mol Cell (2007) 2.72
Argonaute slicing is required for heterochromatic silencing and spreading. Science (2006) 2.48
Binding of pRB to the PHD protein RBP2 promotes cellular differentiation. Mol Cell (2005) 2.35
cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site. Curr Biol (2002) 2.27
Ubiquitin ligase component Cul4 associates with Clr4 histone methyltransferase to assemble heterochromatin. Nat Cell Biol (2005) 2.21
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol (2007) 2.05
The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat Struct Mol Biol (2007) 1.99
A cullin E3 ubiquitin ligase complex associates with Rik1 and the Clr4 histone H3-K9 methyltransferase and is required for RNAi-mediated heterochromatin formation. RNA Biol (2005) 1.98
Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18. EMBO J (2000) 1.91
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast. Proc Natl Acad Sci U S A (2002) 1.87
A Rik1-associated, cullin-dependent E3 ubiquitin ligase is essential for heterochromatin formation. Genes Dev (2005) 1.87
Kinetochore and heterochromatin domains of the fission yeast centromere. Chromosome Res (2004) 1.85
S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol Cell (2007) 1.84
Two novel proteins, dos1 and dos2, interact with rik1 to regulate heterochromatic RNA interference and histone modification. Curr Biol (2005) 1.60
The Clr7 and Clr8 directionality factors and the Pcu4 cullin mediate heterochromatin formation in the fission yeast Schizosaccharomyces pombe. Genetics (2005) 1.44
High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts. J Biol Chem (2002) 1.43
Trilogies of histone lysine methylation as epigenetic landmarks of the eukaryotic genome. Cold Spring Harb Symp Quant Biol (2004) 1.38
Identifying novel proteins recognizing histone modifications using peptide pull-down assay. Methods (2006) 1.38
Retinoblastoma-binding protein 2-homolog 1: a retinoblastoma-binding protein downregulated in malignant melanomas. Mod Pathol (2005) 1.16
The fission yeast Jmj2 reverses histone H3 Lysine 4 trimethylation. J Biol Chem (2007) 1.01
Mutations in deoxyribonucleotide biosynthesis pathway cause spreading of silencing across heterochromatic barriers at the mating-type region of the fission yeast. Yeast (2008) 0.93
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature (2009) 35.48
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci U S A (2009) 20.66
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
The B73 maize genome: complexity, diversity, and dynamics. Science (2009) 18.73
Long noncoding RNA as modular scaffold of histone modification complexes. Science (2010) 15.23
Role of transposable elements in heterochromatin and epigenetic control. Nature (2004) 10.51
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature (2006) 9.30
A DNA vector-based RNAi technology to suppress gene expression in mammalian cells. Proc Natl Acad Sci U S A (2002) 8.57
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08
Three-dimensional resolution doubling in wide-field fluorescence microscopy by structured illumination. Biophys J (2008) 6.86
A histone H3 lysine 27 demethylase regulates animal posterior development. Nature (2007) 6.57
Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature (2003) 6.48
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04
Comparative functional genomics of the fission yeasts. Science (2011) 6.00
Structural basis for double-stranded RNA processing by Dicer. Science (2006) 5.86
Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell (2005) 5.74
Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science (2007) 5.69
Histone methylation: a dynamic mark in health, disease and inheritance. Nat Rev Genet (2012) 5.42
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell (2011) 4.89
The role of RNA interference in heterochromatic silencing. Nature (2004) 4.56
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature (2007) 4.49
Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. Nature (2011) 4.41
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature (2007) 4.35
LincRNA-p21 suppresses target mRNA translation. Mol Cell (2012) 3.87
Distinct mechanisms determine transposon inheritance and methylation via small interfering RNA and histone modification. PLoS Biol (2003) 3.71
Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylases. Annu Rev Biochem (2010) 3.50
Structural insights into histone demethylation by JMJD2 family members. Cell (2006) 3.37
Profiling histone modification patterns in plants using genomic tiling microarrays. Nat Methods (2005) 3.28
Yin Yang 1 is a negative regulator of p53. Cell (2004) 3.24
Yin Yang 1 is a critical regulator of B-cell development. Genes Dev (2007) 3.06
The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol (2011) 3.01
The genome of Naegleria gruberi illuminates early eukaryotic versatility. Cell (2010) 2.93
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87
SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature (2008) 2.84
Mechanisms involved in the regulation of histone lysine demethylases. Curr Opin Cell Biol (2008) 2.81
RNA interference guides histone modification during the S phase of chromosomal replication. Curr Biol (2008) 2.72
Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell (2007) 2.69
Prolyl 4-hydroxylation regulates Argonaute 2 stability. Nature (2008) 2.51
Essential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression. Mol Cell Biol (2006) 2.48
Argonaute slicing is required for heterochromatic silencing and spreading. Science (2006) 2.48
The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation. Neuron (2007) 2.38
CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. Genes Dev (2002) 2.36
Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome. Am J Hum Genet (2008) 2.33
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature (2010) 2.20
ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome. Nat Struct Mol Biol (2011) 2.18
Coordination of meiotic recombination, pairing, and synapsis by PHS1. Science (2004) 2.15
Patrol detection for replica attacks on wireless sensor networks. Sensors (Basel) (2011) 2.14
Profiling DNA methylation patterns using genomic tiling microarrays. Nat Methods (2005) 2.10
Hypoxia-induced acute lung injury in murine models of sickle cell disease. Am J Physiol Lung Cell Mol Physiol (2003) 2.08
ramosa2 encodes a LATERAL ORGAN BOUNDARY domain protein that determines the fate of stem cells in branch meristems of maize. Plant Cell (2006) 2.07
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol (2010) 1.96
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. Mol Cell (2008) 1.94
Developmental roles of the histone lysine demethylases. Development (2009) 1.92
Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein. Science (2006) 1.88
Selective silencing by RNAi of a dominant allele that causes amyotrophic lateral sclerosis. Aging Cell (2003) 1.88
S. pombe LSD1 homologs regulate heterochromatin propagation and euchromatic gene transcription. Mol Cell (2007) 1.84
Chromosome mobility during meiotic prophase in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 1.84
Epigenetic and genetic influences on DNA methylation variation in maize populations. Plant Cell (2013) 1.83
A unified phylogeny-based nomenclature for histone variants. Epigenetics Chromatin (2012) 1.82
Distinct passenger strand and mRNA cleavage activities of human Argonaute proteins. Nat Struct Mol Biol (2009) 1.81
A bouquet of chromosomes. J Cell Sci (2004) 1.80
RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II. Nature (2011) 1.79
YY1 functions with INO80 to activate transcription. Nat Struct Mol Biol (2007) 1.79
Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A (2007) 1.74
Phosphorylation by the beta-catenin/MAPK complex promotes 14-3-3-mediated nuclear export of TCF/POP-1 in signal-responsive cells in C. elegans. Cell (2004) 1.73
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation. Mol Cell (2010) 1.73
Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway. J Biol Chem (2003) 1.73
Epigenomic consequences of immortalized plant cell suspension culture. PLoS Biol (2008) 1.68
A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol (2007) 1.68
Alleles of afd1 dissect REC8 functions during meiotic prophase I. J Cell Sci (2006) 1.67
Relation of low vitamin D to nonvalvular persistent atrial fibrillation in Chinese patients. Ann Noninvasive Electrocardiol (2013) 1.66
Emerging roles for chromatin as a signal integration and storage platform. Nat Rev Mol Cell Biol (2013) 1.65
Translocations disrupting PHF21A in the Potocki-Shaffer-syndrome region are associated with intellectual disability and craniofacial anomalies. Am J Hum Genet (2012) 1.64
The histone demethylase UTX enables RB-dependent cell fate control. Genes Dev (2010) 1.62
Two novel proteins, dos1 and dos2, interact with rik1 to regulate heterochromatic RNA interference and histone modification. Curr Biol (2005) 1.60
NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression. Proc Natl Acad Sci U S A (2006) 1.59
Par-4 links dopamine signaling and depression. Cell (2005) 1.58
Determination of oleanolic acid and ursolic acid contents in Ziziphora clinopodioides Lam. by HPLC method. Pharmacogn Mag (2010) 1.57
Characterization of human cardiac mitochondrial ATP-sensitive potassium channel and its regulation by phorbol ester in vitro. Am J Physiol Heart Circ Physiol (2005) 1.57
Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity (2013) 1.56
Heritable epigenetic variation among maize inbreds. PLoS Genet (2011) 1.54
MicroRNA-targeted and small interfering RNA-mediated mRNA degradation is regulated by argonaute, dicer, and RNA-dependent RNA polymerase in Arabidopsis. Plant Cell (2006) 1.54
Adenovirus virus-associated RNA is processed to functional interfering RNAs involved in virus production. J Virol (2006) 1.53
Parent-of-origin effects on gene expression and DNA methylation in the maize endosperm. Plant Cell (2011) 1.53
Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. Cardiovasc Res (2007) 1.52
Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. J Neurosci (2006) 1.51