Published in Proc Natl Acad Sci U S A on October 28, 2008
Malaria biology and disease pathogenesis: insights for new treatments. Nat Med (2013) 2.38
Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia. Emerg Infect Dis (2011) 2.11
Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study*. Crit Care Med (2012) 1.97
Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children. PLoS One (2009) 1.93
Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. J Infect Dis (2009) 1.86
Diagnosing severe falciparum malaria in parasitaemic African children: a prospective evaluation of plasma PfHRP2 measurement. PLoS Med (2012) 1.82
Assessment of endothelial function using digital pulse amplitude tonometry. Trends Cardiovasc Med (2009) 1.69
The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children. Crit Care (2010) 1.62
Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria. Malar J (2009) 1.59
Combinations of host biomarkers predict mortality among Ugandan children with severe malaria: a retrospective case-control study. PLoS One (2011) 1.55
Defining falciparum-malaria-attributable severe febrile illness in moderate-to-high transmission settings on the basis of plasma PfHRP2 concentration. J Infect Dis (2012) 1.49
Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria. PLoS Pathog (2009) 1.46
Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study. PLoS One (2010) 1.43
Biomarkers of endothelial activation/dysfunction in infectious diseases. Virulence (2013) 1.42
A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria. Blood (2015) 1.40
Angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratio as indicators of potential severity of Plasmodium vivax malaria in patients with thrombocytopenia. PLoS One (2014) 1.39
The role of previously unmeasured organic acids in the pathogenesis of severe malaria. Crit Care (2015) 1.39
Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathog (2010) 1.37
Plasma Plasmodium falciparum histidine-rich protein-2 concentrations are associated with malaria severity and mortality in Tanzanian children. PLoS One (2012) 1.35
Increased pulmonary pressures and myocardial wall stress in children with severe malaria. J Infect Dis (2010) 1.33
Dysregulation of coagulation in cerebral malaria. Mol Biochem Parasitol (2009) 1.29
VEGF promotes malaria-associated acute lung injury in mice. PLoS Pathog (2010) 1.28
Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care (2010) 1.23
Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis. PLoS Pathog (2013) 1.22
Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis. PLoS One (2011) 1.15
Greater endothelial activation, Weibel-Palade body release and host inflammatory response to Plasmodium vivax, compared with Plasmodium falciparum: a prospective study in Papua, Indonesia. J Infect Dis (2010) 1.11
Sepsis-associated microvascular dysfunction measured by peripheral arterial tonometry: an observational study. Crit Care (2009) 1.10
Angiopoietin-2-driven vascular remodeling in airway inflammation. Am J Pathol (2010) 1.07
Inhaled nitric oxide for the adjunctive therapy of severe malaria: protocol for a randomized controlled trial. Trials (2011) 1.06
Pathogenesis of cerebral malaria--inflammation and cytoadherence. Front Cell Infect Microbiol (2014) 1.06
Cerebral malaria: we have come a long way. Am J Pathol (2012) 1.04
Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria. PLoS One (2011) 1.03
Coma in fatal adult human malaria is not caused by cerebral oedema. Malar J (2011) 1.02
A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics. PLoS One (2013) 1.02
S1P is associated with protection in human and experimental cerebral malaria. Mol Med (2011) 1.02
Thrombocytopenia in Plasmodium vivax malaria is related to platelets phagocytosis. PLoS One (2013) 1.01
Plasma levels of angiopoietin-1 and -2 predict cerebral malaria outcome in Central India. Malar J (2011) 0.99
Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax. Proc Natl Acad Sci U S A (2012) 0.99
Microvascular obstruction and endothelial activation are independently associated with the clinical manifestations of severe falciparum malaria in adults: an observational study. BMC Med (2015) 0.98
Parasite biomass-related inflammation, endothelial activation, microvascular dysfunction and disease severity in vivax malaria. PLoS Pathog (2015) 0.98
CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin. Am J Pathol (2011) 0.97
Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria. Malar J (2012) 0.97
Host immune response in returning travellers infected with malaria. Malar J (2012) 0.96
Contrasting pediatric and adult cerebral malaria: the role of the endothelial barrier. Virulence (2013) 0.96
Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence (2013) 0.95
Dysregulation of angiopoietins is associated with placental malaria and low birth weight. PLoS One (2010) 0.94
Induction of the vascular endothelial growth factor pathway in the brain of adults with fatal falciparum malaria is a non-specific response to severe disease. Histopathology (2010) 0.93
Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria. Infect Immun (2013) 0.93
New inflammation-related biomarkers during malaria infection. PLoS One (2011) 0.91
Persistent endothelial activation and inflammation after Plasmodium falciparum Infection in Malawian children. J Infect Dis (2013) 0.91
Inhaled nitric oxide as adjunctive therapy for severe malaria: a randomized controlled trial. Malar J (2015) 0.91
Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale. Med Hypotheses (2011) 0.89
A clinicopathological correlation of the expression of the angiopoietin-Tie-2 receptor pathway in the brain of adults with Plasmodium falciparum malaria. Malar J (2013) 0.87
Erythropoietin and its receptors in the brainstem of adults with fatal falciparum malaria. Malar J (2009) 0.87
Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria. J Infect Dis (2014) 0.86
Platelet activation determines angiopoietin-1 and VEGF levels in malaria: implications for their use as biomarkers. PLoS One (2013) 0.86
Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes. Hum Genet (2009) 0.86
Potential serological biomarkers of cerebral malaria. Dis Markers (2011) 0.85
Plasmodium falciparum antigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria. BMC Infect Dis (2014) 0.84
A prospective study of endothelial activation biomarkers, including plasma angiopoietin-1 and angiopoietin-2, in Kenyan women initiating antiretroviral therapy. BMC Infect Dis (2013) 0.84
Endothelial activation biomarkers increase after HIV-1 acquisition: plasma vascular cell adhesion molecule-1 predicts disease progression. AIDS (2013) 0.84
Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria. Malar J (2014) 0.83
Immunomodulation in Plasmodium falciparum malaria: experiments in nature and their conflicting implications for potential therapeutic agents. Expert Rev Anti Infect Ther (2012) 0.83
The fluid management of adults with severe malaria. Crit Care (2014) 0.82
Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans. J Infect Dis (2010) 0.82
Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity. PLoS Pathog (2015) 0.82
Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomass. Proc Natl Acad Sci U S A (2016) 0.82
PPARγ agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria. PLoS Pathog (2014) 0.82
Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections. MBio (2016) 0.81
Marked elevation in plasma osteoprotegerin constitutes an early and consistent feature of cerebral malaria. Thromb Haemost (2016) 0.81
Use of a rapid test to assess plasma Plasmodium falciparum HRP2 and guide management of severe febrile illness. Malar J (2015) 0.81
Protective or pathogenic effects of vascular endothelial growth factor (VEGF) as potential biomarker in cerebral malaria. Pathog Glob Health (2014) 0.81
A potential role for plasma uric acid in the endothelial pathology of Plasmodium falciparum malaria. PLoS One (2013) 0.80
The clinical implications of thrombocytopenia in adults with severe falciparum malaria: a retrospective analysis. BMC Med (2015) 0.80
Angiotensin receptors and β-catenin regulate brain endothelial integrity in malaria. J Clin Invest (2016) 0.80
Angiopoietin-1 is associated with cerebral vasospasm and delayed cerebral ischemia in subarachnoid hemorrhage. BMC Neurol (2011) 0.80
Vascular dysfunction as a target for adjuvant therapy in cerebral malaria. Mem Inst Oswaldo Cruz (2014) 0.79
The Malaria-High Blood Pressure Hypothesis. Circ Res (2016) 0.79
The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria. PPAR Res (2011) 0.78
Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case-control study of Ugandan children. Malar J (2015) 0.78
EPCR and Malaria Severity: The Center of a Perfect Storm. Trends Parasitol (2016) 0.77
Inhaled Nitric Oxide as an Adjunctive Treatment for Cerebral Malaria in Children: A Phase II Randomized Open-Label Clinical Trial. Open Forum Infect Dis (2015) 0.77
Making the most of clinical data: reviewing the role of pharmacokinetic-pharmacodynamic models of anti-malarial drugs. AAPS J (2014) 0.77
Tying malaria and microRNAs: from the biology to future diagnostic perspectives. Malar J (2016) 0.76
Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial. Malar J (2016) 0.76
miR-155 Modifies Inflammation, Endothelial Activation and Blood-Brain Barrier Dysfunction in Cerebral Malaria. Mol Med (2017) 0.76
Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria. PLoS One (2017) 0.75
B-type natriuretic peptide and plasma hemoglobin levels following transfusion of shorter-storage versus longer-storage red blood cells: Results from the TOTAL randomized trial. Am Heart J (2016) 0.75
Host Biomarkers Are Associated With Response to Therapy and Long-Term Mortality in Pediatric Severe Malaria. Open Forum Infect Dis (2016) 0.75
Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1. Sci Rep (2016) 0.75
Sequestration and Red Cell Deformability as Determinants of Hyperlactatemia in Falciparum Malaria. J Infect Dis (2015) 0.75
Systematic review of the role of angiopoietin-1 and angiopoietin-2 in Plasmodium species infections: biomarkers or therapeutic targets? Malar J (2016) 0.75
Asymmetric Dimethylarginine in Adult Falciparum Malaria: Relationships With Disease Severity, Antimalarial Treatment, Hemolysis, and Inflammation. Open Forum Infect Dis (2016) 0.75
Dynamic interactions of Plasmodium spp. with vascular endothelium. Tissue Barriers (2016) 0.75
A better biomarker for cerebral malaria: in the eye of the beheld?*. Crit Care Med (2012) 0.75
Exploring health practitioners' acceptability of a prospective semi-quantitative pfHRP2 device to define severe malaria in the Democratic Republic of Congo. Malar J (2015) 0.75
VEGF: inflammatory paradoxes. Pathog Glob Health (2015) 0.75
Pathogenic CD8(+) T Cells Cause Increased Levels of VEGF-A in Experimental Malaria-Associated Acute Respiratory Distress Syndrome, but Therapeutic VEGFR Inhibition Is Not Effective. Front Cell Infect Microbiol (2017) 0.75
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Malarial retinopathy: a newly established diagnostic sign in severe malaria. Am J Trop Med Hyg (2006) 5.14
Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison. Lancet (2007) 4.85
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Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India. Malar J (2008) 2.00
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Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. J Exp Med (2007) 3.13
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The relationship between age and the manifestations of and mortality associated with severe malaria. Clin Infect Dis (2008) 3.05
Lung injury in vivax malaria: pathophysiological evidence for pulmonary vascular sequestration and posttreatment alveolar-capillary inflammation. J Infect Dis (2007) 3.02
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Strikingly different angiogenic properties of endothelial progenitor cell subpopulations: insights from a novel human angiogenesis assay. J Am Coll Cardiol (2008) 2.98
A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. Lancet (2002) 2.69
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Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms. PLoS One (2007) 2.66
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A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria. Malar J (2009) 2.64
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Tryptophan metabolism to kynurenine is a potential novel contributor to hypotension in human sepsis. Crit Care Med (2011) 2.27
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Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med (2010) 2.12
Severe Plasmodium knowlesi malaria in a tertiary care hospital, Sabah, Malaysia. Emerg Infect Dis (2011) 2.11
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Plasmodium vivax: clinical spectrum, risk factors and pathogenesis. Adv Parasitol (2012) 1.95
Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. J Infect Dis (2009) 1.86
Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet (2003) 1.86
Consumption of saturated fat impairs the anti-inflammatory properties of high-density lipoproteins and endothelial function. J Am Coll Cardiol (2006) 1.84
Chinese herbs Danshen and Gegen modulate key early atherogenic events in vitro. Int J Cardiol (2005) 1.83
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A sex-specific role for androgens in angiogenesis. J Exp Med (2010) 1.78
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Angular (Gothic) aortic arch leads to enhanced systolic wave reflection, central aortic stiffness, and increased left ventricular mass late after aortic coarctation repair: evaluation with magnetic resonance flow mapping. J Thorac Cardiovasc Surg (2008) 1.75
Simplified antimalarial therapeutic monitoring: using the day-7 drug level? Trends Parasitol (2008) 1.70
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A dosing regimen for immediate N-acetylcysteine treatment for acute paracetamol overdose. Clin Toxicol (Phila) (2011) 1.66
Limitations of microscopy to differentiate Plasmodium species in a region co-endemic for Plasmodium falciparum, Plasmodium vivax and Plasmodium knowlesi. Malar J (2013) 1.66
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Repetitive hypoxia increases lipid loading in human macrophages-a potentially atherogenic effect. Atherosclerosis (2005) 1.63
Primaquine radical cure of Plasmodium vivax: a critical review of the literature. Malar J (2012) 1.61
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Activated charcoal decreases the risk of QT prolongation after citalopram overdose. Ann Emerg Med (2007) 1.58
A systematic review and meta-analysis of pharmacist-led fee-for-services medication review. Br J Clin Pharmacol (2014) 1.57