Angiopoietin-2-driven vascular remodeling in airway inflammation.

PubWeight™: 1.07‹?› | Rank: Top 10%

🔗 View Article (PMC 2993300)

Published in Am J Pathol on October 15, 2010

Authors

Sebastien P Tabruyn1, Katharine Colton, Tohru Morisada, Jonas Fuxe, Stanley J Wiegand, Gavin Thurston, Anthony J Coyle, Jane Connor, Donald M McDonald

Author Affiliations

1: Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143-0425, USA.

Articles citing this

Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev (2011) 5.64

Vascular endothelial hyperpermeability induces the clinical symptoms of Clarkson disease (the systemic capillary leak syndrome). Blood (2012) 1.58

Drug Repurposing Screen Identifies Foxo1-Dependent Angiopoietin-2 Regulation in Sepsis. Crit Care Med (2015) 1.45

Lymphangiogenic factors, mechanisms, and applications. J Clin Invest (2014) 1.27

Effects of a synthetic PEG-ylated Tie-2 agonist peptide on endotoxemic lung injury and mortality. Am J Physiol Lung Cell Mol Physiol (2011) 1.25

The immunomodulatory properties of mesenchymal stem cells. Semin Immunopathol (2011) 1.16

Endothelial destabilization by angiopoietin-2 via integrin β1 activation. Nat Commun (2015) 1.09

Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol (2011) 1.08

The complex role of angiopoietin-2 in the angiopoietin-tie signaling pathway. Cold Spring Harb Perspect Med (2012) 1.06

Receptor tyrosine kinase-mediated angiogenesis. Cold Spring Harb Perspect Biol (2013) 1.01

Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS. Virulence (2013) 0.95

Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation. Proc Am Thorac Soc (2011) 0.87

Ratio of angiopoietin-2 to angiopoietin-1 predicts mortality in acute lung injury induced by paraquat. Med Sci Monit (2013) 0.86

Endothelial cell-derived angiopoietin-2 is a therapeutic target in treatment-naive and bevacizumab-resistant glioblastoma. EMBO Mol Med (2015) 0.84

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest (2016) 0.82

Pro-angiogenic hematopoietic progenitor cells and endothelial colony-forming cells in pathological angiogenesis of bronchial and pulmonary circulation. Angiogenesis (2011) 0.82

Prostate angiogenesis in development and inflammation. Prostate (2013) 0.81

Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest (2016) 0.81

Directed evolution of an angiopoietin-2 ligand trap by somatic hypermutation and cell surface display. J Biol Chem (2013) 0.78

Synergistic Actions of Blocking Angiopoietin-2 and Tumor Necrosis Factor-α in Suppressing Remodeling of Blood Vessels and Lymphatics in Airway Inflammation. Am J Pathol (2015) 0.77

Angiopoietin-2 concentration in serum is associated with severe asthma phenotype. Allergy Asthma Clin Immunol (2016) 0.77

Neutrophil dependence of vascular remodeling after Mycoplasma infection of mouse airways. Am J Pathol (2014) 0.77

Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems. Clin Sci (Lond) (2017) 0.75

Articles cited by this

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science (1997) 15.48

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell (1996) 13.95

Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. Cell (1996) 9.10

Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1. Science (1999) 6.96

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell (2002) 6.41

Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med (2000) 5.58

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med (2006) 5.49

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest (2005) 4.09

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood (2004) 3.50

The mechanics of airway narrowing in asthma. Am Rev Respir Dis (1989) 3.21

Angiopoietins: a link between angiogenesis and inflammation. Trends Immunol (2006) 3.21

Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria. Proc Natl Acad Sci U S A (2008) 2.80

Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death. Nat Med (2006) 2.63

Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. Circ Res (1997) 2.58

Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules. Am J Physiol Heart Circ Physiol (2005) 2.34

The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules. J Leukoc Biol (1999) 2.33

Angiogenesis and remodeling of airway vasculature in chronic inflammation. Am J Respir Crit Care Med (2001) 2.18

Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol (2009) 2.09

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A (2006) 2.03

Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression. Circ Res (2001) 1.99

Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling. Exp Cell Res (2005) 1.92

TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest (2009) 1.76

Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. Blood (2004) 1.71

Angiogenesis in mice with chronic airway inflammation: strain-dependent differences. Am J Pathol (1998) 1.69

Time course of endothelial cell proliferation and microvascular remodeling in chronic inflammation. Am J Pathol (2001) 1.67

Differences in virulence for mice among strains of Mycoplasma pulmonis. Infect Immun (1988) 1.54

Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock (2009) 1.47

Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels. Circ Res (2004) 1.45

A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models. Mol Cancer Ther (2010) 1.45

Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis. Crit Care (2009) 1.41

Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways. Am J Pathol (2004) 1.39

Expression of the neutrophil elastase gene during human bone marrow cell differentiation. J Exp Med (1989) 1.39

Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period. Development (2005) 1.38

Tumor necrosis factor-alpha upregulates angiopoietin-2 in human umbilical vein endothelial cells. Biochem Biophys Res Commun (2000) 1.21

Intracage ammonia promotes growth of Mycoplasma pulmonis in the respiratory tract of rats. Infect Immun (1982) 1.20

Expression of angiopoietin-2 in endothelial cells is controlled by positive and negative regulatory promoter elements. Arterioscler Thromb Vasc Biol (2004) 1.20

Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production. Br J Pharmacol (2003) 1.20

Lymphotoxin-alpha contributes to lymphangiogenesis. Blood (2010) 1.19

In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin. Arterioscler Thromb Vasc Biol (2006) 1.15

Endogenous endothelial cell signaling systems maintain vascular stability. Angiogenesis (2009) 1.12

Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways. Am J Pathol (2010) 1.06

Angiopoietin-1 protects against airway inflammation and hyperreactivity in asthma. Am J Respir Crit Care Med (2008) 1.01

The Tie2 receptor antagonist angiopoietin 2 facilitates vascular inflammation in systemic lupus erythematosus. Ann Rheum Dis (2008) 0.99

The importance of the airway microvasculature in asthma. Curr Opin Allergy Clin Immunol (2006) 0.97

Expression and release of angiopoietin-1 from human neutrophils: intracellular mechanisms. Growth Factors (2009) 0.97

Angiopoietin 2 concentrations in infants developing bronchopulmonary dysplasia: attenuation by dexamethasone. J Perinatol (2007) 0.95

Microvascular remodelling in chronic airway inflammation in mice. Clin Exp Pharmacol Physiol (2000) 0.94

Roles of angiopoietin-1 and angiopoietin-2 on airway microvascular permeability in asthmatic patients. Chest (2007) 0.93

Angiopoietin affects neutrophil migration. Microcirculation (2005) 0.91

Role of vascular endothelial growth factor in the pathogenesis of chronic obstructive pulmonary disease. Med Sci Monit (2007) 0.91

Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P. Am J Physiol Lung Cell Mol Physiol (2001) 0.90

Angiopoietin-mediated endothelial P-selectin translocation: cell signaling mechanisms. J Leukoc Biol (2007) 0.90

Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation. Am J Pathol (2010) 0.88

Potential role of soluble angiopoietin-2 and Tie-2 in patients with inflammatory bowel disease. Eur J Clin Invest (2006) 0.87

Increased expression of angiopoietins and Tie2 in the lungs of chronic asthmatic mice. Am J Respir Cell Mol Biol (2010) 0.86

Angiopoietins-1 and -2 are both capable of mediating endothelial PAF synthesis: intracellular signalling pathways. Cell Signal (2006) 0.83

Blockade of airway inflammation and hyper-responsiveness by an angiopoietin-1 variant, COMP-Ang1. Exp Mol Med (2007) 0.82

Increased levels of angiopoietin-2 in induced sputum from smoking asthmatic patients. Clin Exp Allergy (2009) 0.81

Molecular mechanisms in chronic obstructive pulmonary disease: potential targets for therapy. Cell Biochem Biophys (2007) 0.79

Promotion of Mycoplasma pulmonis growth in rat tracheal organ cultures by ammonium chloride. Lab Anim Sci (1988) 0.77

Articles by these authors

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67

Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity (2006) 10.58

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. Nat Immunol (2007) 8.33

VEGF-Trap: a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci U S A (2002) 8.10

Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science (2003) 7.49

Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol (2004) 7.22

Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis. Nature (2006) 7.01

Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature (2002) 6.58

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1. Dev Cell (2002) 6.41

Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest (2006) 6.12

A chitinase-like protein in the lung and circulation of patients with severe asthma. N Engl J Med (2007) 6.02

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest (2008) 5.96

HMGB1 and RAGE in inflammation and cancer. Annu Rev Immunol (2010) 5.65

VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest (2004) 5.59

VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol (2005) 5.56

Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol (2009) 5.55

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation. Nat Med (2006) 5.49

Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature (2006) 5.49

Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol (2003) 5.07

Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol (2002) 5.04

Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol (2003) 4.66

Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol (2004) 4.47

Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis (2012) 4.42

Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med (2007) 4.10

Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest (2005) 4.09

Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A (2004) 4.06

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med (2006) 3.76

Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med (2004) 3.64

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting. Nat Cell Biol (2010) 3.61

Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest (2004) 3.53

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood (2004) 3.50

Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev (2005) 3.38

Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol (2005) 3.28

Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med (2005) 3.18

A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol (2009) 3.12

Vascular endothelial growth factor gene therapy increases survival, promotes lung angiogenesis, and prevents alveolar damage in hyperoxia-induced lung injury: evidence that angiogenesis participates in alveolarization. Circulation (2005) 3.00

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev (2008) 2.91

IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med (2009) 2.78

Agouti-related protein-deficient mice display an age-related lean phenotype. Cell Metab (2005) 2.75

Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov (2012) 2.57

Role of YKL-40 in bronchial smooth muscle remodeling in asthma. Am J Respir Crit Care Med (2012) 2.53

Continuous exposure to house dust mite elicits chronic airway inflammation and structural remodeling. Am J Respir Crit Care Med (2003) 2.44

Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am J Pathol (2003) 2.37

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways. Am J Respir Crit Care Med (2010) 2.36

Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules. Am J Physiol Heart Circ Physiol (2005) 2.34

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med (2009) 2.34

Inhibition of hemangiogenesis and lymphangiogenesis after normal-risk corneal transplantation by neutralizing VEGF promotes graft survival. Invest Ophthalmol Vis Sci (2004) 2.27

Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells. J Clin Invest (2002) 2.26

Genetic deletion of ghrelin does not decrease food intake but influences metabolic fuel preference. Proc Natl Acad Sci U S A (2004) 2.23

Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res (2007) 2.22

Mature T cells depend on signaling through the IKK complex. Immunity (2003) 2.21

Retinal vascular endothelial growth factor induces intercellular adhesion molecule-1 and endothelial nitric oxide synthase expression and initiates early diabetic retinal leukocyte adhesion in vivo. Am J Pathol (2002) 2.20

VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci U S A (2007) 2.19

Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell (2009) 2.17

Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow. Circ Res (2005) 2.14

Neutralization of interferon-alpha/beta-inducible genes and downstream effect in a phase I trial of an anti-interferon-alpha monoclonal antibody in systemic lupus erythematosus. Arthritis Rheum (2009) 2.14

Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-kappaB activation. Proc Natl Acad Sci U S A (2004) 2.09

Intranasal exposure of mice to house dust mite elicits allergic airway inflammation via a GM-CSF-mediated mechanism. J Immunol (2004) 2.06

Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A (2006) 2.03

Acute intensive insulin therapy exacerbates diabetic blood-retinal barrier breakdown via hypoxia-inducible factor-1alpha and VEGF. J Clin Invest (2002) 1.95

VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res (2011) 1.92

NLRP3/cryopyrin is necessary for interleukin-1beta (IL-1beta) release in response to hyaluronan, an endogenous trigger of inflammation in response to injury. J Biol Chem (2009) 1.91

Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res (2010) 1.90

Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol (2009) 1.87

Safety profile, pharmacokinetics, and biologic activity of MEDI-563, an anti-IL-5 receptor alpha antibody, in a phase I study of subjects with mild asthma. J Allergy Clin Immunol (2010) 1.86

Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res (2007) 1.83

Controlling escape from angiogenesis inhibitors. Nat Rev Cancer (2012) 1.81

In situ force mapping of mammary gland transformation. Integr Biol (Camb) (2011) 1.78

YKL-40 is elevated in patients with chronic obstructive pulmonary disease and activates alveolar macrophages. J Immunol (2008) 1.78

Activated STAT3 is a mediator and biomarker of VEGF endothelial activation. Cancer Biol Ther (2008) 1.77

TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest (2009) 1.76

Angiopoietin-1 promotes lymphatic sprouting and hyperplasia. Blood (2005) 1.71

VEGF-TRAP(R1R2) suppresses choroidal neovascularization and VEGF-induced breakdown of the blood-retinal barrier. J Cell Physiol (2003) 1.71

Iron administration before stem cell harvest enables MR imaging tracking after transplantation. Radiology (2013) 1.70

Suppression of diabetic retinopathy with angiopoietin-1. Am J Pathol (2002) 1.68

Programmed death-1 targeting can promote allograft survival. J Immunol (2002) 1.68

MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. J Leukoc Biol (2007) 1.67

The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGFR2. Dev Cell (2012) 1.66

ICOS controls the pool size of effector-memory and regulatory T cells. J Immunol (2008) 1.62

Markers for microscopic imaging of lymphangiogenesis and angiogenesis. Ann N Y Acad Sci (2008) 1.62

Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat Med (2005) 1.61

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization. J Allergy Clin Immunol (2012) 1.59

Host-derived angiopoietin-2 affects early stages of tumor development and vessel maturation but is dispensable for later stages of tumor growth. Cancer Res (2009) 1.58

Psoriasiform dermatitis is driven by IL-36-mediated DC-keratinocyte crosstalk. J Clin Invest (2012) 1.58

The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep (2008) 1.57

Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res (2011) 1.51

Transgenic overexpression of interleukin-1β induces persistent lymphangiogenesis but not angiogenesis in mouse airways. Am J Pathol (2013) 1.50

Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res (2012) 1.50

Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 1.49

VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. FASEB J (2008) 1.48