Published in J Pharmacol Exp Ther on November 12, 2008
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med (2014) 2.51
Inhaled corticosteroids as combination therapy with beta-adrenergic agonists in airways disease: present and future. Eur J Clin Pharmacol (2009) 1.40
Glucocorticoid sensitivity of lipopolysaccharide-stimulated chronic obstructive pulmonary disease alveolar macrophages. Clin Exp Immunol (2009) 1.13
Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin. Cancer Biol Ther (2012) 0.98
Anti-inflammatory effect of a selective IkappaB kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke. Pulm Pharmacol Ther (2010) 0.98
Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages. Clin Exp Immunol (2014) 0.93
p38 MAPK inhibitors, IKK2 inhibitors, and TNFα inhibitors in COPD. Curr Opin Pharmacol (2012) 0.88
Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide. Br J Pharmacol (2012) 0.87
Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate. PLoS One (2013) 0.86
Lung inflammation changes and oxidative stress induced by cigarette smoke exposure in guinea pigs affected by Zataria multiflora and its constituent, carvacrol. BMC Complement Altern Med (2015) 0.84
Comparison of the anti-inflammatory effects of Cilomilast, Budesonide and a p38 Mitogen activated protein kinase inhibitor in COPD lung tissue macrophages. BMC Pharmacol Toxicol (2012) 0.83
Effect of the Zataria multiflora on systemic inflammation of experimental animals model of COPD. Biomed Res Int (2014) 0.83
Corticosteroid insensitive alveolar macrophages from asthma patients; synergistic interaction with a p38 mitogen-activated protein kinase (MAPK) inhibitor. Br J Clin Pharmacol (2015) 0.80
Identifying early inflammatory changes in monocyte-derived macrophages from a population with IQ-discrepant episodic memory. PLoS One (2013) 0.77
Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies. J Immunol (2016) 0.77
Characterization of TLR-induced inflammatory responses in COPD and control lung tissue explants. Int J Chron Obstruct Pulmon Dis (2016) 0.75
FJU-C4, a new 2-pyridone compound, attenuates lipopolysaccharide-induced systemic inflammation via p38MAPK and NF-κB in mice. PLoS One (2013) 0.75
Characterisation of lung macrophage subpopulations in COPD patients and controls. Sci Rep (2017) 0.75
Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med (1996) 5.53
Activation and signaling of the p38 MAP kinase pathway. Cell Res (2005) 5.48
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO J (1999) 5.47
Rosetta error model for gene expression analysis. Bioinformatics (2006) 4.67
p38-Dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol (2001) 4.38
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell (2005) 4.30
Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol (2006) 3.20
Severity of airflow limitation is associated with severity of airway inflammation in smokers. Am J Respir Crit Care Med (1998) 2.62
Accumulation of dendritic cells and increased CCL20 levels in the airways of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 2.26
Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Mol Cell Biol (2006) 2.21
Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med (2004) 2.19
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol Cell Biol (2002) 2.10
Airway bacterial load and FEV1 decline in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2003) 1.85
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. J Allergy Clin Immunol (2002) 1.84
Impaired inhibition by dexamethasone of cytokine release by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2002) 1.82
Determination of dual effects of parathyroid hormone on skeletal gene expression in vivo by microarray and network analysis. J Biol Chem (2007) 1.79
A pooled analysis of FEV1 decline in COPD patients randomized to inhaled corticosteroids or placebo. Chest (2007) 1.79
New concepts in chronic obstructive pulmonary disease. Annu Rev Med (2001) 1.75
Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias. J Clin Oncol (2007) 1.64
Increased levels of the chemokines GROalpha and MCP-1 in sputum samples from patients with COPD. Thorax (2002) 1.51
Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase. Inflamm Res (1999) 1.40
Increased activation of p38 MAPK in COPD. Eur Respir J (2007) 1.33
Free, soluble interleukin-17 protein during severe inflammation in human airways. Eur Respir J (2002) 1.27
Inhibition of glucocorticoid receptor-mediated transcriptional activation by p38 mitogen-activated protein (MAP) kinase. J Biol Chem (2004) 1.24
CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Chest (2007) 1.22
Interleukin-18 production and pulmonary function in COPD. Eur Respir J (2007) 1.19
Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br J Pharmacol (2006) 1.13
"Dirty little secrets"--endotoxin contamination of recombinant proteins. Immunol Lett (2006) 1.06
Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage. J Pharmacol Exp Ther (2007) 1.02
Gene network and canonical pathway analysis in prostate cancer: a microarray study. Exp Mol Med (2008) 1.01
Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung. Pulm Pharmacol Ther (2006) 1.00
Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages. Cytokine (2008) 0.95
Novel signal transduction modulators for the treatment of airway diseases. Pharmacol Ther (2005) 0.92
Inhibition of LPL expression in human monocyte-derived macrophages is dependent on LDL oxidation state: a key role for lysophosphatidylcholine. Arterioscler Thromb Vasc Biol (1998) 0.89
Inhibitors of p38 mitogen-activated protein kinase: potential as anti-inflammatory agents in asthma? BioDrugs (2003) 0.87
Second-generation inhibitors demonstrate the involvement of p38 mitogen-activated protein kinase in post-transcriptional modulation of inflammatory mediator production in human and rodent airways. J Pharmacol Exp Ther (2005) 0.86
A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism. Sci Transl Med (2014) 2.51
The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines. Proc Natl Acad Sci U S A (2011) 2.38
Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter. Cancer Res (2003) 1.88
Predictors of objective cough frequency in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 1.64
Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory disease. Am J Physiol Lung Cell Mol Physiol (2007) 1.58
Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Nat Genet (2003) 1.58
Once-daily NVA237 improves exercise tolerance from the first dose in patients with COPD: the GLOW3 trial. Int J Chron Obstruct Pulmon Dis (2012) 1.52
Efficacy and safety of tiotropium Respimat SMI in COPD in two 1-year randomized studies. Int J Chron Obstruct Pulmon Dis (2010) 1.51
Increased airway T regulatory cells in asthmatic subjects. Chest (2010) 1.50
Efficacy and safety of twice-daily aclidinium bromide in COPD patients: the ATTAIN study. Eur Respir J (2012) 1.50
A comparison of lung function methods for assessing dose-response effects of salbutamol. Br J Clin Pharmacol (2004) 1.45
Immediate and delayed impact of oral glucocorticoid therapy on risk of serious infection in older patients with rheumatoid arthritis: a nested case-control analysis. Ann Rheum Dis (2012) 1.43
Identification of multiple, oxygen-stable HIF1 alpha isoforms, and augmented expression of adrenomedullin in rheumatoid arthritis. Clin Exp Rheumatol (2013) 1.40
A new strategy for the identification of novel molecules with targeted proresolution of inflammation properties. J Immunol (2009) 1.34
Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature (2013) 1.30
Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype. J Clin Endocrinol Metab (2004) 1.29
MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 1.27
CD4-regulatory cells in COPD patients. Chest (2007) 1.27
alpha,beta-Unsaturated aldehydes contained in cigarette smoke elicit IL-8 release in pulmonary cells through mitogen-activated protein kinases. Am J Physiol Lung Cell Mol Physiol (2009) 1.24
Impulse oscillometry in COPD: identification of measurements related to airway obstruction, airway conductance and lung volumes. Respir Med (2008) 1.19
Safety of indacaterol in the treatment of patients with COPD. Int J Chron Obstruct Pulmon Dis (2011) 1.19
Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol (2009) 1.14
VEGF polymorphisms are associated with severity of diabetic retinopathy. Invest Ophthalmol Vis Sci (2008) 1.14
The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial. Am J Respir Crit Care Med (2014) 1.11
Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One (2011) 1.11
Drug insight: selective agonists and antagonists of the glucocorticoid receptor. Nat Clin Pract Endocrinol Metab (2008) 1.07
Depression and its relationship with poor exercise capacity, BODE index and muscle wasting in COPD. Respir Med (2009) 1.06
The use of plethysmography and oscillometry to compare long-acting bronchodilators in patients with COPD. Br J Clin Pharmacol (2008) 1.06
Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor. J Endocrinol (2008) 1.05
Steroid biomarkers and genetic studies reveal inactivating mutations in hexose-6-phosphate dehydrogenase in patients with cortisone reductase deficiency. J Clin Endocrinol Metab (2008) 1.04
Impact factor and its role in academic promotion. Int J Chron Obstruct Pulmon Dis (2009) 1.04
The effect of peroxisome proliferator-activated receptor-γ ligands on in vitro and in vivo models of COPD. Eur Respir J (2013) 1.04
Current concepts in glucocorticoid resistance. Steroids (2012) 1.03
CD44 is a phagocytic receptor. Blood (2006) 1.03
Inhibition of nuclear factor-kappaB activation un-masks the ability of TNF-alpha to induce human eosinophil apoptosis. Eur J Immunol (2002) 1.02
Increased phosphorylated p38 mitogen-activated protein kinase in COPD lungs. Eur Respir J (2012) 1.02
NF-kappaB signalling is inhibited by glucocorticoid receptor and STAT6 via distinct mechanisms. J Cell Sci (2003) 1.02
Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One (2011) 1.00
Cigarette smoke and its component acrolein augment IL-8/CXCL8 mRNA stability via p38 MAPK/MK2 signaling in human pulmonary cells. Am J Physiol Lung Cell Mol Physiol (2012) 0.98
The repeatability of interleukin-6, tumor necrosis factor-alpha, and C-reactive protein in COPD patients over one year. Int J Chron Obstruct Pulmon Dis (2009) 0.98
Regulation of cortisol bioavailability--effects on hormone measurement and action. Nat Rev Endocrinol (2012) 0.98
Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses. J Biol Chem (2007) 0.97
T lymphocyte insensitivity to corticosteroids in chronic obstructive pulmonary disease. Respir Res (2012) 0.97
CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages. Blood (2007) 0.97
COPD phenotype description using principal components analysis. Respir Res (2009) 0.97
Non-invasive phenotyping using exhaled volatile organic compounds in asthma. Thorax (2011) 0.97
Macrophage migration inhibitory factor gene polymorphism is associated with psoriasis. J Invest Dermatol (2004) 0.96
Protein kinase C modulates tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by targeting the apical events of death receptor signaling. J Biol Chem (2003) 0.96
Cigarette smoke extract induced cytokine and chemokine gene expression changes in COPD macrophages. Cytokine (2008) 0.95
Induced sputum genes associated with spirometric and radiological disease severity in COPD ex-smokers. Thorax (2011) 0.95
The role of the circadian clock in rheumatoid arthritis. Arthritis Res Ther (2013) 0.95
Biomarkers of systemic inflammation and depression and fatigue in moderate clinically stable COPD. Respir Res (2011) 0.95
Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2010) 0.94
Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis. Arthritis Res Ther (2004) 0.94
Liver X receptor agonists increase airway reactivity in a model of asthma via increasing airway smooth muscle growth. J Immunol (2008) 0.94
MNAR functionally interacts with both NH2- and COOH-terminal GR domains to modulate transactivation. Am J Physiol Endocrinol Metab (2008) 0.93
Non-invasive metabolomic analysis of breath using differential mobility spectrometry in patients with chronic obstructive pulmonary disease and healthy smokers. Analyst (2010) 0.93
Neutrophil chemotaxis caused by chronic obstructive pulmonary disease alveolar macrophages: the role of CXCL8 and the receptors CXCR1/CXCR2. J Pharmacol Exp Ther (2013) 0.93
A comparison of exhaled nitric oxide measurements performed using three different analysers. Respir Med (2006) 0.92
LPS challenge in healthy subjects: an investigation of neutrophil chemotaxis mechanisms involving CXCR1 and CXCR2. Int Immunopharmacol (2012) 0.91
Loss of glucocorticoid receptor expression by DNA methylation prevents glucocorticoid induced apoptosis in human small cell lung cancer cells. PLoS One (2011) 0.89
Abnormalities in the pulmonary innate immune system in cystic fibrosis. Am J Respir Cell Mol Biol (2005) 0.89
Inhaled LPS challenges in smokers: a study of pulmonary and systemic effects. Br J Clin Pharmacol (2012) 0.88
Treatment with a peroxisomal proliferator activated receptor gamma agonist has a modest effect in the allergen challenge model in asthma: a randomised controlled trial. Respir Med (2009) 0.88
Glucocorticoid receptor over-expression promotes human small cell lung cancer apoptosis in vivo and thereby slows tumor growth. Endocr Relat Cancer (2010) 0.88
The effects of dexamethasone on cigarette smoke induced gene expression changes in COPD macrophages. Int Immunopharmacol (2009) 0.87
Reduced glucocorticoid receptor expression and function in airway neutrophils. Int Immunopharmacol (2011) 0.87
The relationship between intranuclear mobility of the NF-kappaB subunit p65 and its DNA binding affinity. J Biol Chem (2006) 0.87
MR Quantitative Equilibrium Signal Mapping: A Reliable Alternative to CT in the Assessment of Emphysema in Patients with Chronic Obstructive Pulmonary Disease. Radiology (2015) 0.86
Evaluation of glucocorticoid receptor function in COPD lung macrophages using beclomethasone-17-monopropionate. PLoS One (2013) 0.86
Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution. J Immunol (2014) 0.85
Inhibition of NF-kappa B by a cell permeable form of I kappa B alpha induces apoptosis in eosinophils. Biochem Biophys Res Commun (2005) 0.85
A pragmatic randomized controlled trial of thiopurine methyltransferase genotyping prior to azathioprine treatment: the TARGET study. Pharmacogenomics (2011) 0.84
Down regulation of T cell receptor expression in COPD pulmonary CD8 cells. PLoS One (2013) 0.84
Hypoxia and glucocorticoid signaling converge to regulate macrophage migration inhibitory factor gene expression. Arthritis Rheum (2009) 0.84
Non-invasive biomarkers and pulmonary function in smokers. Int J Chron Obstruct Pulmon Dis (2008) 0.84
Regulation of Wnt4 in chronic obstructive pulmonary disease. FASEB J (2013) 0.84
Increased levels of soluble interleukin-6 receptor and CCL3 in COPD sputum. Respir Res (2014) 0.83
The role of the liver X receptor in chronic obstructive pulmonary disease. Respir Res (2013) 0.83
Novel anti-inflammatory agents in COPD: targeting lung and systemic inflammation. Curr Drug Targets (2013) 0.83
The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer. J Biol Chem (2014) 0.83
The circadian clock and asthma. Thorax (2013) 0.83
A pharmacological approach to enhancing the therapeutic index of corticosteroids in airway inflammatory disease. Curr Opin Pharmacol (2005) 0.82