Mark H Ginsberg

Author PubWeight™ 216.74‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cell migration: integrating signals from front to back. Science 2003 29.13
2 Talin binding to integrin beta tails: a final common step in integrin activation. Science 2003 7.56
3 Structural basis of integrin activation by talin. Cell 2007 5.37
4 The final steps of integrin activation: the end game. Nat Rev Mol Cell Biol 2010 4.72
5 Networks and crosstalk: integrin signalling spreads. Nat Cell Biol 2002 4.66
6 Structural determinants of integrin recognition by talin. Mol Cell 2003 4.20
7 Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A 2003 4.03
8 Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3. Curr Biol 2006 3.81
9 Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability. Nat Med 2008 3.67
10 An alpha4 integrin-paxillin-Arf-GAP complex restricts Rac activation to the leading edge of migrating cells. Nat Cell Biol 2005 3.44
11 The phosphotyrosine binding-like domain of talin activates integrins. J Biol Chem 2002 2.97
12 KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions. J Cell Biol 2007 2.92
13 Integrin beta cytoplasmic domain interactions with phosphotyrosine-binding domains: a structural prototype for diversity in integrin signaling. Proc Natl Acad Sci U S A 2003 2.89
14 Talin is required for integrin-mediated platelet function in hemostasis and thrombosis. J Exp Med 2007 2.85
15 The structure of an integrin/talin complex reveals the basis of inside-out signal transduction. EMBO J 2009 2.76
16 Receptor tyrosine kinases and TLR/IL1Rs unexpectedly activate myeloid cell PI3kγ, a single convergent point promoting tumor inflammation and progression. Cancer Cell 2011 2.70
17 Recreation of the terminal events in physiological integrin activation. J Cell Biol 2010 2.48
18 The structure of the integrin alphaIIbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J 2009 2.45
19 Regulation of integrin activation. Annu Rev Cell Dev Biol 2011 2.32
20 RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences. J Biol Chem 2008 2.29
21 Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol 2007 2.27
22 Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity. J Exp Med 2010 2.23
23 Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathway. Nat Med 2009 2.12
24 Integrin modulation and signaling in leukocyte adhesion and migration. Immunol Rev 2007 2.10
25 Talin phosphorylation by Cdk5 regulates Smurf1-mediated talin head ubiquitylation and cell migration. Nat Cell Biol 2009 1.99
26 The Kindler syndrome protein is regulated by transforming growth factor-beta and involved in integrin-mediated adhesion. J Biol Chem 2003 1.97
27 The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation. J Clin Invest 2007 1.95
28 Mechanisms and consequences of agonist-induced talin recruitment to platelet integrin alphaIIbbeta3. J Cell Biol 2008 1.93
29 Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. Stroke 2011 1.91
30 CD98hc (SLC3A2) mediates integrin signaling. Proc Natl Acad Sci U S A 2004 1.88
31 Transmembrane domain helix packing stabilizes integrin alphaIIbbeta3 in the low affinity state. J Biol Chem 2004 1.84
32 Ras GTPases: integrins' friends or foes? Nat Rev Mol Cell Biol 2003 1.81
33 Structure of the integrin beta3 transmembrane segment in phospholipid bicelles and detergent micelles. Biochemistry 2008 1.80
34 Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity. Nat Cell Biol 2009 1.73
35 Antithrombotic effects of targeting alphaIIbbeta3 signaling in platelets. Blood 2008 1.73
36 Talin1 and Rap1 are critical for osteoclast function. Mol Cell Biol 2012 1.68
37 Matrix-specific suppression of integrin activation in shear stress signaling. Mol Biol Cell 2006 1.67
38 Specification of the direction of adhesive signaling by the integrin beta cytoplasmic domain. J Biol Chem 2005 1.65
39 Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation. Blood 2012 1.64
40 Spatial restriction of alpha4 integrin phosphorylation regulates lamellipodial stability and alpha4beta1-dependent cell migration. J Cell Biol 2003 1.58
41 Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol 2011 1.51
42 UV-C irradiation disrupts platelet surface disulfide bonds and activates the platelet integrin alphaIIbbeta3. Blood 2008 1.51
43 Competition for talin results in trans-dominant inhibition of integrin activation. J Biol Chem 2004 1.46
44 The N-terminal SH2 domains of Syk and ZAP-70 mediate phosphotyrosine-independent binding to integrin beta cytoplasmic domains. J Biol Chem 2002 1.46
45 Alpha4 integrins and the immune response. Immunol Rev 2002 1.45
46 Talin forges the links between integrins and actin. Nat Cell Biol 2003 1.45
47 Interactions of platelet integrin alphaIIb and beta3 transmembrane domains in mammalian cell membranes and their role in integrin activation. Blood 2009 1.41
48 Beta integrin tyrosine phosphorylation is a conserved mechanism for regulating talin-induced integrin activation. J Biol Chem 2009 1.40
49 Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J 2002 1.40
50 A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. Hum Mol Genet 2010 1.39
51 Small-molecule synergist of the Wnt/beta-catenin signaling pathway. Proc Natl Acad Sci U S A 2007 1.39
52 RLIP76 (RalBP1) is an R-Ras effector that mediates adhesion-dependent Rac activation and cell migration. J Cell Biol 2006 1.38
53 Integrin activation. Biochem Soc Trans 2008 1.36
54 Structural determinants of integrin binding to the talin rod. J Biol Chem 2009 1.35
55 Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation. Mol Biol Cell 2005 1.33
56 Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell 2008 1.32
57 Structural basis for phosphatidylinositol phosphate kinase type Igamma binding to talin at focal adhesions. J Biol Chem 2004 1.32
58 Microfluidic devices for studies of shear-dependent platelet adhesion. Lab Chip 2008 1.32
59 Alpha4 integrins are type I cAMP-dependent protein kinase-anchoring proteins. Nat Cell Biol 2007 1.31
60 Rap1 and its effector KRIT1/CCM1 regulate beta-catenin signaling. Dis Model Mech 2009 1.31
61 Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src. Mol Cell Biol 2005 1.30
62 PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation. J Biol Chem 2003 1.30
63 Basic amino-acid side chains regulate transmembrane integrin signalling. Nature 2011 1.30
64 CD98 at the crossroads of adaptive immunity and cancer. J Cell Sci 2012 1.24
65 The mechanism of kindlin-mediated activation of integrin αIIbβ3. Curr Biol 2013 1.22
66 The talin-tail interaction places integrin activation on FERM ground. Trends Biochem Sci 2004 1.22
67 CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling. J Cell Biol 2007 1.21
68 Domain-specific interactions of talin with the membrane-proximal region of the integrin beta3 subunit. Biochemistry 2003 1.21
69 Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. J Clin Invest 2006 1.20
70 Talin phosphorylation sites mapped by mass spectrometry. J Cell Sci 2005 1.19
71 An easy to assemble microfluidic perfusion device with a magnetic clamp. Lab Chip 2009 1.18
72 Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2. J Immunol 2003 1.18
73 Integrin-associated proteins as potential therapeutic targets. Immunol Rev 2008 1.17
74 Alpha4beta1-dependent adhesion strengthening under mechanical strain is regulated by paxillin association with the alpha4-cytoplasmic domain. J Cell Biol 2005 1.17
75 CD98hc (SLC3A2) interaction with the integrin beta subunit cytoplasmic domain mediates adhesive signaling. J Biol Chem 2007 1.12
76 Two modes of integrin activation form a binary molecular switch in adhesion maturation. Mol Biol Cell 2013 1.10
77 Integrin alpha 4 beta 1-dependent T cell migration requires both phosphorylation and dephosphorylation of the alpha 4 cytoplasmic domain to regulate the reversible binding of paxillin. J Biol Chem 2003 1.10
78 Talin activates integrins by altering the topology of the β transmembrane domain. J Cell Biol 2012 1.09
79 A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Mol Biol Cell 2011 1.09
80 Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. PLoS One 2012 1.08
81 Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. J Cell Biol 2012 1.07
82 Suppression of integrin activation by activated Ras or Raf does not correlate with bulk activation of ERK MAP kinase. Mol Biol Cell 2002 1.06
83 Subcellular localization of talin is regulated by inter-domain interactions. J Biol Chem 2012 1.05
84 New approaches to blockade of alpha4-integrins, proven therapeutic targets in chronic inflammation. Biochem Pharmacol 2006 1.05
85 Reconstruction of integrin activation. Blood 2011 1.04
86 PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2. Cancer Res 2007 1.04
87 Inhibitors of cell migration that inhibit intracellular paxillin/alpha4 binding: a well-documented use of positional scanning libraries. Chem Biol 2002 1.04
88 A fragment of paxillin binds the alpha 4 integrin cytoplasmic domain (tail) and selectively inhibits alpha 4-mediated cell migration. J Biol Chem 2002 1.03
89 Dependence of proliferative vascular smooth muscle cells on CD98hc (4F2hc, SLC3A2). J Exp Med 2009 1.01
90 Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol 2012 1.01
91 CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nat Immunol 2009 1.00
92 Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity. Diabetes 2008 0.99
93 Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J Immunol 2011 0.98
94 Talin and kindlin: the one-two punch in integrin activation. Front Med 2014 0.97
95 High refractive index silicone gels for simultaneous total internal reflection fluorescence and traction force microscopy of adherent cells. PLoS One 2011 0.97
96 Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7. Genetics 2002 0.97
97 Neurobiology: New connections between integrins and axon guidance. Curr Biol 2004 0.95
98 Localized alpha4 integrin phosphorylation directs shear stress-induced endothelial cell alignment. Circ Res 2008 0.95
99 Endothelial cell talin1 is essential for embryonic angiogenesis. Dev Biol 2010 0.94
100 Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. Proc Natl Acad Sci U S A 2010 0.94
101 C-terminal sequences in R-Ras are involved in integrin regulation and in plasma membrane microdomain distribution. Biochem Biophys Res Commun 2003 0.91
102 The structure of the ternary complex of Krev interaction trapped 1 (KRIT1) bound to both the Rap1 GTPase and the heart of glass (HEG1) cytoplasmic tail. J Biol Chem 2013 0.90
103 Differences in regulation of Drosophila and vertebrate integrin affinity by talin. Mol Biol Cell 2008 0.90
104 Phosphorylation sites in the cerebral cavernous malformations complex. J Cell Sci 2011 0.89
105 An experimentally derived database of candidate Ras-interacting proteins. J Proteome Res 2007 0.86
106 Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. J Clin Invest 2015 0.86
107 Neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with alpha4beta1 integrins. BMC Neurosci 2007 0.84
108 Physical mapping of genes in somatic cell radiation hybrids by comparative genomic hybridization to cDNA microarrays. Genome Biol 2002 0.84
109 A small molecule that inhibits the interaction of paxillin and alpha 4 integrin inhibits accumulation of mononuclear leukocytes at a site of inflammation. J Biol Chem 2010 0.82
110 R-Ras C-terminal sequences are sufficient to confer R-Ras specificity to H-Ras. Oncogene 2002 0.82
111 Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha. Mol Biol Cell 2009 0.81
112 The nucleus of endothelial cell as a sensor of blood flow direction. Biol Open 2013 0.81
113 Live cell imaging of paxillin in rolling neutrophils by dual-color quantitative dynamic footprinting. Microcirculation 2011 0.78
114 Phospholipase C epsilon suppresses integrin activation. J Biol Chem 2006 0.77
115 Blockade of platelet GPIIB-IIIA (Integrin alphaII(b)beta(3)) in flowing human blood leads to passivation of prothrombotic surfaces. Thromb Haemost 2002 0.77
116 Cell-to-cell contact and extracellular matrix. Curr Opin Cell Biol 2008 0.76
117 A small molecule inhibitor of alpha4 integrin-dependent cell migration. Bioorg Med Chem 2008 0.76
118 Reconstructing integrin activation in vitro. Methods Mol Biol 2013 0.75