Published in Science on December 11, 2003
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
The polycomb group protein Suz12 is required for embryonic stem cell differentiation. Mol Cell Biol (2007) 8.57
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J (2004) 7.32
Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev (2008) 5.25
Capturing pluripotency. Cell (2008) 5.08
Suppression of Erk signalling promotes ground state pluripotency in the mouse embryo. Development (2009) 4.25
Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome. Genes Dev (2009) 4.20
Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing. EMBO J (2006) 4.16
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3. EMBO J (2004) 3.51
A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes Dev (2006) 3.41
Characterization of DNA methyltransferase specificities using single-molecule, real-time DNA sequencing. Nucleic Acids Res (2011) 3.18
Long noncoding RNAs: past, present, and future. Genetics (2013) 3.16
A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome. Cell (2008) 3.10
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo. Mol Cell Biol (2008) 2.93
Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase. Proc Natl Acad Sci U S A (2005) 2.81
X-inactivation in female human embryonic stem cells is in a nonrandom pattern and prone to epigenetic alterations. Proc Natl Acad Sci U S A (2008) 2.53
The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences. Proc Natl Acad Sci U S A (2006) 2.44
Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome. Mol Cell Biol (2004) 2.43
Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation. Nat Rev Genet (2011) 2.39
Distinct regulation of histone H3 methylation at lysines 27 and 9 by CpG methylation in Arabidopsis. EMBO J (2005) 2.37
Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications. Nucleic Acids Res (2004) 2.28
Genomic imprinting mechanisms in mammals. Mutat Res (2008) 2.28
RNAi-dependent H3K27 methylation is required for heterochromatin formation and DNA elimination in Tetrahymena. Genes Dev (2007) 2.26
Silencing of unpaired chromatin and histone H2A ubiquitination in mammalian meiosis. Mol Cell Biol (2005) 2.22
Mutually exclusive expression of virulence genes by malaria parasites is regulated independently of antigen production. PLoS Pathog (2006) 2.18
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse. Hum Mol Genet (2005) 2.12
The Polycomb group protein EED is dispensable for the initiation of random X-chromosome inactivation. PLoS Genet (2006) 2.08
Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes. PLoS Biol (2007) 2.06
X-linked clonality testing: interpretation and limitations. Blood (2007) 2.04
High-resolution analysis of epigenetic changes associated with X inactivation. Genome Res (2009) 2.02
Noncoding RNA and Polycomb recruitment. RNA (2013) 2.00
The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol (2006) 1.97
Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation. Genes Dev (2005) 1.92
Molecular coupling of Tsix regulation and pluripotency. Nature (2010) 1.69
The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing. Development (2009) 1.69
Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control. Nat Rev Mol Cell Biol (2011) 1.66
Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature (2010) 1.64
X chromosome reactivation initiates in nascent primordial germ cells in mice. PLoS Genet (2007) 1.63
Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites. EMBO Rep (2007) 1.62
Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos. Cell (2016) 1.61
X chromosome sites autonomously recruit the dosage compensation complex in Drosophila males. PLoS Biol (2004) 1.59
X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected. J Cell Physiol (2008) 1.59
A novel RNA transcript with antiapoptotic function is silenced in fragile X syndrome. PLoS One (2008) 1.57
Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice. Proc Natl Acad Sci U S A (2009) 1.56
RNF12 activates Xist and is essential for X chromosome inactivation. PLoS Genet (2011) 1.56
Xist and the order of silencing. EMBO Rep (2007) 1.55
Mapping global histone methylation patterns in the coding regions of human genes. Mol Cell Biol (2005) 1.55
Meiotic silencing and the epigenetics of sex. Chromosome Res (2007) 1.52
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev (2011) 1.52
Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature (2009) 1.49
Partitioning of the maize epigenome by the number of methyl groups on histone H3 lysines 9 and 27. Genetics (2006) 1.47
Two-step imprinted X inactivation: repeat versus genic silencing in the mouse. Mol Cell Biol (2010) 1.46
Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line. Proc Natl Acad Sci U S A (2015) 1.44
GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes. EMBO J (2004) 1.43
Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis. Proc Natl Acad Sci U S A (2004) 1.41
CAF-1 is essential for heterochromatin organization in pluripotent embryonic cells. PLoS Genet (2006) 1.41
X chromosome activity in mouse XX primordial germ cells. PLoS Genet (2008) 1.38
A new model for random X chromosome inactivation. Development (2008) 1.35
The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation. Development (2010) 1.35
Hematopoietic precursor cells transiently reestablish permissiveness for X inactivation. Mol Cell Biol (2006) 1.34
Recent advancements in cloning by somatic cell nuclear transfer. Philos Trans R Soc Lond B Biol Sci (2013) 1.33
X chromosome inactivation is initiated in human preimplantation embryos. Am J Hum Genet (2009) 1.31
No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. J Clin Invest (2008) 1.30
Dicer regulates Xist promoter methylation in ES cells indirectly through transcriptional control of Dnmt3a. Epigenetics Chromatin (2008) 1.30
Xist regulation and function explored. Hum Genet (2011) 1.28
An essential role for the DXPas34 tandem repeat and Tsix transcription in the counting process of X chromosome inactivation. Proc Natl Acad Sci U S A (2006) 1.28
Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26
Imprinted noncoding RNAs. Mamm Genome (2008) 1.24
New and Xisting regulatory mechanisms of X chromosome inactivation. Curr Opin Genet Dev (2012) 1.23
Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice. Mol Cell Biol (2006) 1.20
The liberation of embryonic stem cells. PLoS Genet (2011) 1.20
Sexual differentiation of the rodent brain: dogma and beyond. Front Neurosci (2012) 1.20
Evolutionary diversity and developmental regulation of X-chromosome inactivation. Hum Genet (2011) 1.20
XACT, a long noncoding transcript coating the active X chromosome in human pluripotent cells. Nat Genet (2013) 1.20
The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals. BMC Evol Biol (2007) 1.19
Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells. Mol Cell Biol (2005) 1.19
Epigenetic inheritance: uncontested? Cell Res (2011) 1.19
Epigenetic factors in aging and longevity. Pflugers Arch (2009) 1.15
Targeting Polycomb systems to regulate gene expression: modifications to a complex story. Nat Rev Mol Cell Biol (2015) 1.15
X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet (2011) 1.14
Accessing naïve human pluripotency. Curr Opin Genet Dev (2012) 1.13
Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci. Epigenetics Chromatin (2014) 1.12
Random X inactivation and extensive mosaicism in human placenta revealed by analysis of allele-specific gene expression along the X chromosome. PLoS One (2010) 1.11
Genetic and parent-of-origin influences on X chromosome choice in Xce heterozygous mice. Mamm Genome (2005) 1.10
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic development. Proc Natl Acad Sci U S A (2009) 1.09
The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever. PLoS Genet (2011) 1.08
Polycomblike 2 facilitates the recruitment of PRC2 Polycomb group complexes to the inactive X chromosome and to target loci in embryonic stem cells. Development (2011) 1.08
Early loss of Xist RNA expression and inactive X chromosome associated chromatin modification in developing primordial germ cells. PLoS One (2007) 1.08
Dosage compensation in mammals. Cold Spring Harb Perspect Biol (2015) 1.07
The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Res (2007) 1.06
Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte. EMBO Rep (2005) 1.05
The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells. Hum Genet (2011) 1.04
Lessons from comparative analysis of X-chromosome inactivation in mammals. Chromosome Res (2009) 1.03
Caenorhabditis elegans dosage compensation regulates histone H4 chromatin state on X chromosomes. Mol Cell Biol (2012) 1.02
Evolution from XIST-independent to XIST-controlled X-chromosome inactivation: epigenetic modifications in distantly related mammals. PLoS One (2011) 1.01
Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol Cell (2013) 1.01
ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells. Chromosoma (2008) 1.01
Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy. Proc Natl Acad Sci U S A (2014) 1.01
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (2002) 18.30
EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell (2003) 11.40
DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA. Nature (2007) 11.14
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73
Role of histone H3 lysine 27 methylation in X inactivation. Science (2003) 9.85
Spatial partitioning of the regulatory landscape of the X-inactivation centre. Nature (2012) 9.75
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark. Mol Cell (2007) 9.73
Functional dissection of protein complexes involved in yeast chromosome biology using a genetic interaction map. Nature (2007) 9.25
Elongation by RNA polymerase II: the short and long of it. Genes Dev (2004) 9.17
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development. Cell (2005) 8.86
Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell (2010) 8.79
Histone and chromatin cross-talk. Curr Opin Cell Biol (2003) 8.69
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin. Genes Dev (2004) 8.66
Epigenetics: a landscape takes shape. Cell (2007) 8.29
MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell (2002) 8.17
Multivalent engagement of chromatin modifications by linked binding modules. Nat Rev Mol Cell Biol (2007) 8.14
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev (2003) 7.91
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature (2006) 7.70
A unified theory of gene expression. Cell (2002) 7.61
Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature (2002) 7.54
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science (2007) 7.41
Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev Cell (2003) 7.11
Suz12 binds to silenced regions of the genome in a cell-type-specific manner. Genome Res (2006) 6.75
Role of the polycomb protein EED in the propagation of repressive histone marks. Nature (2009) 6.62
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell (2003) 6.44
Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature (2005) 6.40
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science (2013) 6.29
Covalent histone modifications--miswritten, misinterpreted and mis-erased in human cancers. Nat Rev Cancer (2010) 6.27
Extraction, purification and analysis of histones. Nat Protoc (2007) 6.25
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev (2004) 6.19
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12
Regulation of MLL1 H3K4 methyltransferase activity by its core components. Nat Struct Mol Biol (2006) 6.03
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin. Mol Cell Biol (2006) 5.99
Histones: annotating chromatin. Annu Rev Genet (2009) 5.93
FACT facilitates transcription-dependent nucleosome alteration. Science (2003) 5.83
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Mol Cell (2007) 5.78
Regulation of p53 activity through lysine methylation. Nature (2004) 5.78
Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X inactivation. Dev Cell (2004) 5.72
RNA meets chromatin. Genes Dev (2005) 5.66
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin. Mol Cell (2002) 5.59
Histone lysine methylation: a signature for chromatin function. Trends Genet (2003) 5.55
Human PAD4 regulates histone arginine methylation levels via demethylimination. Science (2004) 5.46
Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation. Genes Dev (2002) 5.43
Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Mol Cell Biol (2002) 5.42
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell (2004) 5.37
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol (2009) 5.27
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. Cell (2006) 5.14
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
The key to development: interpreting the histone code? Curr Opin Genet Dev (2005) 4.96
Molecular signals of epigenetic states. Science (2010) 4.81
Binary switches and modification cassettes in histone biology and beyond. Nature (2003) 4.75
Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres. Proc Natl Acad Sci U S A (2010) 4.73
Jarid2 and PRC2, partners in regulating gene expression. Genes Dev (2010) 4.65
Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A (2005) 4.57
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nat Genet (2003) 4.56
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol (2005) 4.52
Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol (2002) 4.50
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell (2008) 4.44
EZH2 expression is associated with high proliferation rate and aggressive tumor subgroups in cutaneous melanoma and cancers of the endometrium, prostate, and breast. J Clin Oncol (2005) 4.24
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains. J Biol Chem (2005) 4.20
Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell (2003) 4.13
Monoubiquitination of human histone H2B: the factors involved and their roles in HOX gene regulation. Mol Cell (2005) 4.04
Chromatin structure and the inheritance of epigenetic information. Nat Rev Genet (2010) 4.03
Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell (2006) 3.87
Organismal differences in post-translational modifications in histones H3 and H4. J Biol Chem (2006) 3.84
Tails of intrigue: phosphorylation of RNA polymerase II mediates histone methylation. Cell (2003) 3.82
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science (2005) 3.80
Gene silencing: trans-histone regulatory pathway in chromatin. Nature (2002) 3.77
Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer. J Natl Cancer Inst (2003) 3.73
L3MBTL1, a histone-methylation-dependent chromatin lock. Cell (2007) 3.70
LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation. Cell (2010) 3.70
Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation. Nat Cell Biol (2006) 3.66
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes. Nat Genet (2001) 3.63
Reactivation of the paternal X chromosome in early mouse embryos. Science (2004) 3.59
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA. Genes Dev (2010) 3.49
A novel role for Xist RNA in the formation of a repressive nuclear compartment into which genes are recruited when silenced. Genes Dev (2006) 3.41
Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes. Genes Dev (2002) 3.37
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
Decoding the epigenetic language of neuronal plasticity. Neuron (2008) 3.23
Tracking FACT and the RNA polymerase II elongation complex through chromatin in vivo. Science (2003) 3.22
Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena. Cell (2002) 3.16
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature (2009) 3.13
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation. Cell (2008) 3.09
Polycomb group protein ezh2 controls actin polymerization and cell signaling. Cell (2005) 3.01
Expression patterns and post-translational modifications associated with mammalian histone H3 variants. J Biol Chem (2005) 3.00
Polycomb group proteins Ezh2 and Rnf2 direct genomic contraction and imprinted repression in early mouse embryos. Dev Cell (2008) 2.96
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. PLoS Genet (2012) 2.94