Published in Matrix Biol on October 29, 2008
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Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer (2006) 5.58
Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol (2004) 4.16
Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol (2004) 4.16
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A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells. Proc Natl Acad Sci U S A (1990) 1.39
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Functional imaging of tumor proteolysis. Annu Rev Pharmacol Toxicol (2006) 1.26
Imaging specific cell-surface proteolytic activity in single living cells. Nat Methods (2006) 1.20
Visualization of polarized membrane type 1 matrix metalloproteinase activity in live cells by fluorescence resonance energy transfer imaging. J Biol Chem (2008) 1.18
Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensor. Biochim Biophys Acta (2006) 1.03
Intracellular protease activation in apoptosis and cell-mediated cytotoxicity characterized by cell-permeable fluorogenic protease substrates. Cell Res (2008) 0.91
Tumor cell invasion of model 3-dimensional matrices: demonstration of migratory pathways, collagen disruption, and intercellular cooperation. FASEB J (2001) 0.88
The relationship between force and focal complex development. J Cell Biol (2002) 6.26
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Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control. Immunity (2008) 5.86
Fibronectin at a glance. J Cell Sci (2002) 5.51
One-dimensional topography underlies three-dimensional fibrillar cell migration. J Cell Biol (2009) 5.07
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A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol (2005) 4.40
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Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk. Nat Cell Biol (2007) 4.26
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Cell migration in 3D matrix. Curr Opin Cell Biol (2005) 3.63
Fibronectin requirement in branching morphogenesis. Nature (2003) 3.41
Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J Biol Chem (2004) 3.31
Polymerizing actin fibers position integrins primed to probe for adhesion sites. Science (2007) 3.15
Molecular architecture and function of matrix adhesions. Cold Spring Harb Perspect Biol (2011) 2.82
Nonpolarized signaling reveals two distinct modes of 3D cell migration. J Cell Biol (2012) 2.76
The matrix reorganized: extracellular matrix remodeling and integrin signaling. Curr Opin Cell Biol (2006) 2.58
Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung. Dev Biol (2005) 2.23
Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates. Nat Med (2002) 2.20
High-throughput quantitative analysis of HIV-1 and SIV-specific ADCC-mediating antibody responses. Cytometry A (2011) 2.14
Cell and fibronectin dynamics during branching morphogenesis. J Cell Sci (2006) 2.10
Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp Cell Res (2006) 1.96
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci U S A (2007) 1.87
Integrin regulation of growth factor receptors. Nat Cell Biol (2002) 1.80
Direct comparisons of the morphology, migration, cell adhesions, and actin cytoskeleton of fibroblasts in four different three-dimensional extracellular matrices. Tissue Eng Part A (2010) 1.77
Btbd7 regulates epithelial cell dynamics and branching morphogenesis. Science (2010) 1.75
At the leading edge of three-dimensional cell migration. J Cell Sci (2013) 1.66
uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol (2003) 1.60
ECM degradation assays for analyzing local cell invasion. Methods Mol Biol (2009) 1.57
Differentiation of human bone marrow-derived cells into buccal epithelial cells in vivo: a molecular analytical study. Lancet (2003) 1.56
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Self-organization and branching morphogenesis of primary salivary epithelial cells. Tissue Eng (2007) 1.52
ECM-modulated cellular dynamics as a driving force for tissue morphogenesis. Curr Opin Genet Dev (2013) 1.49
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
New dimensions in cell migration. Nat Rev Mol Cell Biol (2012) 1.46
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. J Cell Sci (2004) 1.42
Dimensions in cell migration. Curr Opin Cell Biol (2013) 1.36
High-throughput investigation of osteoblast response to polymer crystallinity: influence of nanometer-scale roughness on proliferation. Biomaterials (2003) 1.31
Matrix control of stem cell fate. Cell (2006) 1.28
Three-dimensional microenvironments modulate fibroblast signaling responses. Adv Drug Deliv Rev (2007) 1.27
The role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation. Mol Biol Cell (2009) 1.27
Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. J Biol Chem (2003) 1.27
Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics. J Cell Sci (2012) 1.26
Role of PI 3-kinase and PIP3 in submandibular gland branching morphogenesis. Dev Biol (2003) 1.24
Granzyme B activity in target cells detects attack by cytotoxic lymphocytes. J Immunol (2007) 1.24
Multiparametric analysis of apoptosis by flow and image cytometry. Methods Mol Biol (2004) 1.19
Phosphatases in cell-matrix adhesion and migration. Nat Rev Mol Cell Biol (2003) 1.19
Laminin-10/11 and fibronectin differentially prevent apoptosis induced by serum removal via phosphatidylinositol 3-kinase/Akt- and MEK1/ERK-dependent pathways. J Biol Chem (2002) 1.16
Targeting membrane-localized focal adhesion kinase to focal adhesions: roles of tyrosine phosphorylation and SRC family kinases. J Biol Chem (2003) 1.14
Dual function of focal adhesion kinase in regulating integrin-induced MMP-2 and MMP-9 release by human T lymphoid cells. FASEB J (2005) 1.11
JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration. J Biol Chem (2005) 1.10
Functional live-cell imaging demonstrates that beta1-integrin promotes type IV collagen degradation by breast and prostate cancer cells. Mol Imaging (2009) 1.05
CrkI adapter protein modulates cell migration and invasion in glioblastoma. Cancer Res (2003) 1.04
The Krüppel-like factor epiprofin is expressed by epithelium of developing teeth, hair follicles, and limb buds and promotes cell proliferation. J Biol Chem (2003) 1.03
Regulation of cell adhesion and migration by cell-derived matrices. Exp Cell Res (2013) 1.00
beta1 integrin cytoplasmic domain residues selectively modulate fibronectin matrix assembly and cell spreading through talin and Akt-1. J Biol Chem (2009) 0.99
Direct transmembrane clustering and cytoplasmic dimerization of focal adhesion kinase initiates its tyrosine phosphorylation. Biochim Biophys Acta (2002) 0.99
Dynamic membrane remodeling at invadopodia differentiates invadopodia from podosomes. Eur J Cell Biol (2010) 0.98
DPSS yellow-green 561-nm lasers for improved fluorochrome detection by flow cytometry. Cytometry A (2005) 0.98
Integrin clustering induces kinectin accumulation. J Cell Sci (2002) 0.97
Tensin 2 modulates cell contractility in 3D collagen gels through the RhoGAP DLC1. J Cell Biochem (2010) 0.96
Detection of localized caspase activity in early apoptotic cells by laser scanning cytometry. Cytometry (2002) 0.96
Mechanisms for macrophage-mediated HIV-1 induction. J Immunol (2004) 0.96
Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions of human keratinocytes. Exp Cell Res (2004) 0.95
Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration. J Cell Sci (2003) 0.94
The structure of the rat ameloblastin gene and its expression in amelogenesis. Mol Cells (2003) 0.93
Heme oxygenase-1 induction alters chemokine regulation and ameliorates human immunodeficiency virus-type-1 infection in lipopolysaccharide-stimulated macrophages. Biochem Biophys Res Commun (2013) 0.93
Extracellular matrix protein anosmin promotes neural crest formation and regulates FGF, BMP, and WNT activities. Dev Cell (2012) 0.92
Salivary gland branching morphogenesis--recent progress and future opportunities. Int J Oral Sci (2010) 0.91
Intracellular protease activation in apoptosis and cell-mediated cytotoxicity characterized by cell-permeable fluorogenic protease substrates. Cell Res (2008) 0.91
Cell biology: survival in three dimensions. Nature (2002) 0.90
Systems analysis of salivary gland development and disease. Wiley Interdiscip Rev Syst Biol Med (2010) 0.90
Of mice and men: Relevance of cellular and molecular characterizations of myosin IIA to MYH9-related human disease. Cell Adh Migr (2007) 0.90
Region-specific epithelial cell dynamics during branching morphogenesis. Dev Dyn (2013) 0.90
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Cell biology: tumour jailbreak. Nature (2003) 0.88
Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance. Biochem Biophys Res Commun (2011) 0.87
Inhibition of rho GTPases by RNA interference. Methods Enzymol (2006) 0.85
Synergistic activity of fibronectin and fibroblast growth factor receptors on neuronal adhesion and neurite extension through extracellular signal-regulated kinase pathway. Biochem Biophys Res Commun (2002) 0.83
Cell biology: Sensing tension. Nature (2010) 0.82
A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated. Oncogene (2002) 0.82
Caspase activity is not sufficient to execute cell death. Exp Cell Res (2003) 0.82
Cell-matrix adhesions on poly(vinyl alcohol) hydrogels. Tissue Eng (2003) 0.81
Cell-cell adhesion and RhoA-mediated actin polymerization are independent phenomena in microtubule disrupted keratinocytes. J Invest Dermatol (2002) 0.81
Multiparametric analysis of apoptosis by flow cytometry. Methods Mol Biol (2011) 0.80
Assessment of lymphocyte-mediated cytotoxicity using flow cytometry. Methods Mol Biol (2004) 0.79
Involvement of integrin alphavbeta3 in the pathogenesis of human immunodeficiency virus type 1 infection in monocytes. Virology (2002) 0.79
The effector phase of physiological cell death relies exclusively on the posttranslational activation of resident components. Exp Cell Res (2002) 0.78
A method in enzymology for measuring hydrolytic activities in live cell environments. Methods Enzymol (2008) 0.78
Microanalysis of gene expression in tissues using T7-SAGE: serial analysis of gene expression after high-fidelity T7-based RNA amplification. Curr Protoc Cell Biol (2002) 0.78
Rho GEFs and GAPs: emerging integrators of extracellular matrix signaling. Small GTPases (2015) 0.78
Antibodies against a multiple-peptide conjugate comprising chemically modified human immunodeficiency virus type-1 functional Tat peptides inhibit infection. Peptides (2006) 0.77
Non-radioactive quantification of fibronectin matrix assembly. Curr Protoc Cell Biol (2004) 0.76
Cloning and characterization of chicken α5 integrin: endogenous and experimental expression in early chicken embryos. Matrix Biol (2013) 0.75
Selective side-chain modification of cysteine and arginine residues blocks pathogenic activity of HIV-1-Tat functional peptides. Peptides (2005) 0.75