Physical limits of cell migration: control by ECM space and nuclear deformation and tuning by proteolysis and traction force.

PubWeight™: 3.77‹?› | Rank: Top 1%

🔗 View Article (PMC 3691458)

Published in J Cell Biol on June 24, 2013

Authors

Katarina Wolf1, Mariska Te Lindert, Marina Krause, Stephanie Alexander, Joost Te Riet, Amanda L Willis, Robert M Hoffman, Carl G Figdor, Stephen J Weiss, Peter Friedl

Author Affiliations

1: Department of Cell Biology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands. k.wolf@ncmls.ru.nl

Articles citing this

(truncated to the top 100)

Generation of compartmentalized pressure by a nuclear piston governs cell motility in a 3D matrix. Science (2014) 2.98

Nuclear envelope rupture and repair during cancer cell migration. Science (2016) 2.60

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. J Cell Biol (2014) 2.01

Heterogeneous tumor subpopulations cooperate to drive invasion. Cell Rep (2014) 1.88

Nuclear mechanics and mechanotransduction in health and disease. Curr Biol (2013) 1.51

Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks. Am J Physiol Cell Physiol (2014) 1.50

Fascin Regulates Nuclear Movement and Deformation in Migrating Cells. Dev Cell (2016) 1.45

Full-Length Fibronectin Drives Fibroblast Accumulation at the Surface of Collagen Microtissues during Cell-Induced Tissue Morphogenesis. PLoS One (2016) 1.40

Dimensions in cell migration. Curr Opin Cell Biol (2013) 1.36

Three-dimensional cell migration does not follow a random walk. Proc Natl Acad Sci U S A (2014) 1.30

Innate control of actin nucleation determines two distinct migration behaviours in dendritic cells. Nat Cell Biol (2015) 1.27

Broken nuclei--lamins, nuclear mechanics, and disease. Trends Cell Biol (2013) 1.25

Nuclear deformability constitutes a rate-limiting step during cell migration in 3-D environments. Cell Mol Bioeng (2014) 1.24

3D collagen alignment limits protrusions to enhance breast cancer cell persistence. Biophys J (2014) 1.19

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments. Nat Commun (2016) 1.13

The multiple faces of leukocyte interstitial migration. Semin Immunopathol (2014) 1.12

Traversing the basement membrane in vivo: a diversity of strategies. J Cell Biol (2014) 1.11

Sizing and shaping the nucleus: mechanisms and significance. Curr Opin Cell Biol (2014) 1.09

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat Commun (2014) 1.08

Discoidin domain receptor 1 controls linear invadosome formation via a Cdc42-Tuba pathway. J Cell Biol (2014) 1.06

Bleb-driven chemotaxis of Dictyostelium cells. J Cell Biol (2014) 1.06

The nuclear lamina is mechano-responsive to ECM elasticity in mature tissue. J Cell Sci (2014) 1.04

Non-muscle myosin IIB is critical for nuclear translocation during 3D invasion. J Cell Biol (2015) 1.04

Microfluidic platform for the quantitative analysis of leukocyte migration signatures. Nat Commun (2014) 1.01

Biomechanical and biochemical remodeling of stromal extracellular matrix in cancer. Trends Biotechnol (2015) 0.99

Cellular mechanosensing: getting to the nucleus of it all. Prog Biophys Mol Biol (2014) 0.99

Local 3D matrix microenvironment regulates cell migration through spatiotemporal dynamics of contractility-dependent adhesions. Nat Commun (2015) 0.99

The nano-scale mechanical properties of the extracellular matrix regulate dermal fibroblast function. J Invest Dermatol (2014) 0.98

3D traction stresses activate protease-dependent invasion of cancer cells. Biophys J (2014) 0.97

Reproducibility and cell biology. J Cell Biol (2015) 0.93

Squish and squeeze-the nucleus as a physical barrier during migration in confined environments. Curr Opin Cell Biol (2016) 0.92

Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions. Sci Rep (2015) 0.91

Illuminating breast cancer invasion: diverse roles for cell-cell interactions. Curr Opin Cell Biol (2014) 0.91

Estimating the 3D pore size distribution of biopolymer networks from directionally biased data. Biophys J (2013) 0.91

Collective and individual migration following the epithelial-mesenchymal transition. Nat Mater (2014) 0.90

Application of GFP imaging in cancer. Lab Invest (2015) 0.90

Microvessel manifold for perfusion and media exchange in three-dimensional cell cultures. Biomicrofluidics (2016) 0.89

Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments. Integr Biol (Camb) (2015) 0.88

Podosomes in space: macrophage migration and matrix degradation in 2D and 3D settings. Cell Adh Migr (2014) 0.88

LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP. Sci Rep (2016) 0.88

Nuclear mechanics in cancer. Adv Exp Med Biol (2014) 0.88

Measuring dynamic cell-material interactions and remodeling during 3D human mesenchymal stem cell migration in hydrogels. Proc Natl Acad Sci U S A (2015) 0.87

Changes in cell and tissue organization in cancer of the breast and colon. Curr Opin Cell Biol (2013) 0.86

Biphasic response of cell invasion to matrix stiffness in three-dimensional biopolymer networks. Acta Biomater (2014) 0.85

Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography. Am J Physiol Cell Physiol (2013) 0.85

Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics. J Biomech Eng (2016) 0.85

Repair of dense connective tissues via biomaterial-mediated matrix reprogramming of the wound interface. Biomaterials (2014) 0.85

Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks. Nat Commun (2016) 0.84

The cellular mastermind(?)-mechanotransduction and the nucleus. Prog Mol Biol Transl Sci (2014) 0.84

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus. Mol Biol Cell (2017) 0.84

The nuclear lamina in health and disease. Nucleus (2016) 0.84

In silico synchronization reveals regulators of nuclear ruptures in lamin A/C deficient model cells. Sci Rep (2016) 0.84

Vinculin is required for cell polarization, migration, and extracellular matrix remodeling in 3D collagen. FASEB J (2015) 0.84

Migration in Confined 3D Environments Is Determined by a Combination of Adhesiveness, Nuclear Volume, Contractility, and Cell Stiffness. Biophys J (2015) 0.84

Protrusive waves guide 3D cell migration along nanofibers. J Cell Biol (2015) 0.84

Regulated delivery of molecular cargo to invasive tumour-derived microvesicles. Nat Commun (2015) 0.84

Synergistic regulation of cerebellar Purkinje neuron development by laminin epitopes and collagen on an artificial hybrid matrix construct. Biomater Sci (2014) 0.83

Force Matters: Biomechanical Regulation of Cell Invasion and Migration in Disease. Trends Cell Biol (2016) 0.83

Causes and consequences of nuclear envelope alterations in tumour progression. Eur J Cell Biol (2016) 0.83

Podosomes of dendritic cells facilitate antigen sampling. J Cell Sci (2014) 0.82

Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices. Sci Rep (2016) 0.82

Fast and precise targeting of single tumor cells in vivo by multimodal correlative microscopy. J Cell Sci (2015) 0.82

Collective cancer cell invasion induced by coordinated contractile stresses. Oncotarget (2015) 0.82

Immunohistochemical expression of MMP-14 and MMP-2, and MMP-2 activity during human ovarian follicular development. Reprod Biol Endocrinol (2014) 0.82

Radiofrequency treatment alters cancer cell phenotype. Sci Rep (2015) 0.82

Impact of dimensionality and network disruption on microrheology of cancer cells in 3D environments. PLoS Comput Biol (2014) 0.82

Mechanical decision trees for investigating and modulating single-cell cancer invasion dynamics. Lab Chip (2014) 0.81

Stem cell-paved biobridge facilitates neural repair in traumatic brain injury. Front Syst Neurosci (2014) 0.81

Mechanical plasticity of cells. Nat Mater (2016) 0.81

A three-dimensional computational model of collagen network mechanics. PLoS One (2014) 0.81

Extracellular Matrix Properties Regulate the Migratory Response of Glioblastoma Stem Cells in Three-Dimensional Culture. Tissue Eng Part A (2015) 0.81

Cancer cell migration in 3D tissue: Negotiating space by proteolysis and nuclear deformability. Cell Adh Migr (2015) 0.80

Fibroblasts Lead the Way: A Unified View of 3D Cell Motility. Trends Cell Biol (2015) 0.80

Preservation of tissue microstructure and functionality during freezing by modulation of cytoskeletal structure. J Mech Behav Biomed Mater (2015) 0.80

Cells as active particles in asymmetric potentials: motility under external gradients. Biophys J (2014) 0.80

From repair to regeneration: biomaterials to reprogram the meniscus wound microenvironment. Ann Biomed Eng (2015) 0.80

A 3D tension bioreactor platform to study the interplay between ECM stiffness and tumor phenotype. J Biotechnol (2014) 0.79

Cancer Cell Invasion in Three-dimensional Collagen Is Regulated Differentially by Gα13 Protein and Discoidin Domain Receptor 1-Par3 Protein Signaling. J Biol Chem (2015) 0.79

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes. Nat Cell Biol (2016) 0.79

Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics. J Leukoc Biol (2016) 0.78

Rho GEFs and GAPs: emerging integrators of extracellular matrix signaling. Small GTPases (2015) 0.78

Capturing relevant extracellular matrices for investigating cell migration. F1000Res (2015) 0.78

Probing the biophysical properties of primary breast tumor-derived fibroblasts. Cell Mol Bioeng (2015) 0.78

Engineering strategies to mimic the glioblastoma microenvironment. Adv Drug Deliv Rev (2014) 0.78

The Regulation of Cellular Responses to Mechanical Cues by Rho GTPases. Cells (2016) 0.78

An open access microfluidic device for the study of the physical limits of cancer cell deformation during migration in confined environments. Microelectron Eng (2015) 0.78

Concentric gel system to study the biophysical role of matrix microenvironment on 3D cell migration. J Vis Exp (2015) 0.78

Stem cell-paved biobridges facilitate stem transplant and host brain cell interactions for stroke therapy. Brain Res (2015) 0.78

Proteolytic and non-proteolytic regulation of collective cell invasion: tuning by ECM density and organization. Sci Rep (2016) 0.78

Quantifying Modes of 3D Cell Migration. Trends Cell Biol (2015) 0.78

How Tissue Mechanical Properties Affect Enteric Neural Crest Cell Migration. Sci Rep (2016) 0.78

Dynamic myosin activation promotes collective morphology and migration by locally balancing oppositional forces from surrounding tissue. Mol Biol Cell (2016) 0.78

Cell migration on planar and three-dimensional matrices: a hydrogel-based perspective. Tissue Eng Part B Rev (2014) 0.77

Guidance of mesenchymal stem cells on fibronectin structured hydrogel films. PLoS One (2014) 0.77

Microfluidic mazes to characterize T-cell exploration patterns following activation in vitro. Integr Biol (Camb) (2015) 0.77

Continual cell deformation induced via attachment to oriented fibers enhances fibroblast cell migration. PLoS One (2015) 0.77

Fibroblast Migration in 3D is Controlled by Haptotaxis in a Non-muscle Myosin II-Dependent Manner. Ann Biomed Eng (2015) 0.77

Interplay of the physical microenvironment, contact guidance, and intracellular signaling in cell decision making. FASEB J (2016) 0.77

Multiscale mechanobiology: computational models for integrating molecules to multicellular systems. Integr Biol (Camb) (2015) 0.77

Physical view on migration modes. Cell Adh Migr (2015) 0.77

Articles cited by this

Cell migration: integrating signals from front to back. Science (2003) 29.13

Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell (2009) 14.40

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89

A tense situation: forcing tumour progression. Nat Rev Cancer (2009) 7.80

Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis. Proc Natl Acad Sci U S A (2006) 7.48

Rapid leukocyte migration by integrin-independent flowing and squeezing. Nature (2008) 7.28

Collagen reorganization at the tumor-stromal interface facilitates local invasion. BMC Med (2006) 6.44

Cancer invasion and the microenvironment: plasticity and reciprocity. Cell (2011) 6.36

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol (2007) 6.15

Rac activation and inactivation control plasticity of tumor cell movement. Cell (2008) 6.01

Plasticity of cell migration: a multiscale tuning model. J Cell Biol (2009) 5.82

Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell (2003) 4.56

Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol (2004) 4.16

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04

Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3. J Cell Biol (2000) 3.53

Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res (2006) 3.42

Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol (2009) 2.84

Adhesion in cell migration. Curr Opin Cell Biol (1995) 2.73

Noninvasive assessment of collagen gel microstructure and mechanics using multiphoton microscopy. Biophys J (2006) 2.71

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia. J Cell Biol (2010) 2.62

Neutrophils emigrate from venules by a transendothelial cell pathway in response to FMLP. J Exp Med (1998) 2.61

The nuclear envelope lamina network has elasticity and a compressibility limit suggestive of a molecular shock absorber. J Cell Sci (2004) 2.47

Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. Blood (2003) 2.40

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol (2008) 2.39

Nuclear mechanics during cell migration. Curr Opin Cell Biol (2010) 2.32

The mechanical integrin cycle. J Cell Sci (2009) 2.28

Migration of highly aggressive MV3 melanoma cells in 3-dimensional collagen lattices results in local matrix reorganization and shedding of alpha2 and beta1 integrins and CD44. Cancer Res (1997) 2.26

The role of myosin II in glioma invasion of the brain. Mol Biol Cell (2008) 2.20

Segregation and activation of myosin IIB creates a rear in migrating cells. J Cell Biol (2008) 2.15

Cell motility and mechanics in three-dimensional collagen matrices. Annu Rev Cell Dev Biol (2010) 2.06

Navigating ECM barriers at the invasive front: the cancer cell-stroma interface. Annu Rev Cell Dev Biol (2009) 2.00

Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res (2004) 1.90

Proteolytic interstitial cell migration: a five-step process. Cancer Metastasis Rev (2009) 1.85

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration. Trends Cell Biol (2011) 1.82

Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions. Nat Immunol (2010) 1.82

Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells. Cancer Res (2010) 1.75

Physical confinement alters tumor cell adhesion and migration phenotypes. FASEB J (2012) 1.74

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in? J Cell Sci (2010) 1.73

The nuclear envelope environment and its cancer connections. Nat Rev Cancer (2012) 1.68

Robust strategies for automated AFM force curve analysis--I. Non-adhesive indentation of soft, inhomogeneous materials. J Biomech Eng (2007) 1.63

Elucidating the role of matrix stiffness in 3D cell migration and remodeling. Biophys J (2011) 1.58

The differential regulation of cell motile activity through matrix stiffness and porosity in three dimensional collagen matrices. Biomaterials (2010) 1.54

Pore size variable type I collagen gels and their interaction with glioma cells. Biomaterials (2010) 1.47

The tumor suppressor functions of p27(kip1) include control of the mesenchymal/amoeboid transition. Mol Cell Biol (2009) 1.43

A close-up view of migrating Langerhans cells in the skin. J Invest Dermatol (2002) 1.43

Impact of tumor cell cytoskeleton organization on invasiveness and migration: a microchannel-based approach. PLoS One (2010) 1.43

Direct visualization of protease activity on cells migrating in three-dimensions. Matrix Biol (2008) 1.42

An algorithm for extracting the network geometry of three-dimensional collagen gels. J Microsc (2008) 1.40

Real-time in vivo dual-color imaging of intracapillary cancer cell and nucleus deformation and migration. Cancer Res (2005) 1.35

MT1-MMP- and Cdc42-dependent signaling co-regulate cell invasion and tunnel formation in 3D collagen matrices. J Cell Sci (2009) 1.33

Filaments made from A- and B-type lamins differ in structure and organization. J Cell Sci (2008) 1.32

Two-photon laser-generated microtracks in 3D collagen lattices: principles of MMP-dependent and -independent collective cancer cell invasion. Phys Biol (2011) 1.30

Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. J Clin Invest (2012) 1.27

Collagen self-assembly in vitro. Differentiating specific telopeptide-dependent interactions using selective enzyme modification and the addition of free amino telopeptide. J Biol Chem (1981) 1.27

The regulatory role of cell mechanics for migration of differentiating myeloid cells. Proc Natl Acad Sci U S A (2009) 1.26

Rheology and confocal reflectance microscopy as probes of mechanical properties and structure during collagen and collagen/hyaluronan self-assembly. Biophys J (2009) 1.25

Enhancing mechanical properties of tissue-engineered constructs via lysyl oxidase crosslinking activity. J Biomed Mater Res A (2003) 1.23

Chemotaxis of cell populations through confined spaces at single-cell resolution. PLoS One (2012) 1.22

Tumor cell invasion through matrigel is regulated by activated matrix metalloproteinase-2. Anticancer Res (1998) 1.21

Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood (2001) 1.18

Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration. BMC Cancer (2008) 1.17

MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells. Br J Cancer (2007) 1.14

Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo. Arterioscler Thromb Vasc Biol (2009) 1.14

A blind spot in confocal reflection microscopy: the dependence of fiber brightness on fiber orientation in imaging biopolymer networks. Biophys J (2010) 1.13

Modulation of the membrane type 1 matrix metalloproteinase cytoplasmic tail enhances tumor cell invasion and proliferation in three-dimensional collagen matrices. J Biol Chem (2009) 1.08

Interlaboratory round robin on cantilever calibration for AFM force spectroscopy. Ultramicroscopy (2011) 1.08

Cell migration through small gaps. Eur Biophys J (2006) 1.05

Disruption of Rho signal transduction upon cell detachment. J Cell Sci (2004) 1.00

Reconstructing leukocyte migration in 3D extracellular matrix by time-lapse videomicroscopy and computer-assisted tracking. Methods Mol Biol (2004) 0.96

Electron microscopy of collagen fibril structure in vitro and in vivo including three-dimensional reconstruction. Methods Cell Biol (2008) 0.92

The role of chromatin structure in cell migration. Trends Cell Biol (2010) 0.87

Long-term histological comparison between near-infrared irradiated skin and scar tissues. Clin Cosmet Investig Dermatol (2010) 0.83

Articles by these authors

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68

Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol (2003) 7.89

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell (2002) 6.76

Cancer invasion and the microenvironment: plasticity and reciprocity. Cell (2011) 6.36

Dissecting p53 tumor suppressor functions in vivo. Cancer Cell (2002) 6.24

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion. Nat Cell Biol (2007) 6.15

Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy. Nat Biotechnol (2005) 5.80

Gene expression profiling predicts clinical outcome of prostate cancer. J Clin Invest (2004) 4.59

Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature (2011) 4.57

Membrane type I matrix metalloproteinase usurps tumor growth control imposed by the three-dimensional extracellular matrix. Cell (2003) 4.56

A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol (2006) 4.55

Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP. J Cell Biol (2004) 4.16

Protease-dependent versus -independent cancer cell invasion programs: three-dimensional amoeboid movement revisited. J Cell Biol (2009) 4.04

A pericellular collagenase directs the 3-dimensional development of white adipose tissue. Cell (2006) 3.90

Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest (2010) 3.74

The dendritic cell-specific adhesion receptor DC-SIGN internalizes antigen for presentation to T cells. J Immunol (2002) 3.48

Transdifferentiation of glioblastoma cells into vascular endothelial cells. Proc Natl Acad Sci U S A (2011) 3.45

Development of real-time subcellular dynamic multicolor imaging of cancer-cell trafficking in live mice with a variable-magnification whole-mouse imaging system. Cancer Res (2006) 3.42

Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting. Nat Rev Immunol (2007) 3.42

Biomimetic amplification of nanoparticle homing to tumors. Proc Natl Acad Sci U S A (2007) 3.26

Breaching the basement membrane: who, when and how? Trends Cell Biol (2008) 3.14

Identification of liver cancer progenitors whose malignant progression depends on autocrine IL-6 signaling. Cell (2013) 3.08

Nestin expression in hair follicle sheath progenitor cells. Proc Natl Acad Sci U S A (2003) 3.07

Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem (2005) 3.03

Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol (2009) 2.84

Glioma tumor stem-like cells promote tumor angiogenesis and vasculogenesis via vascular endothelial growth factor and stromal-derived factor 1. Cancer Res (2009) 2.80

A cancer cell metalloprotease triad regulates the basement membrane transmigration program. Genes Dev (2006) 2.78

Multipotent nestin-positive, keratin-negative hair-follicle bulge stem cells can form neurons. Proc Natl Acad Sci U S A (2005) 2.78

Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. Proc Natl Acad Sci U S A (2005) 2.76

Collective cell movement in primary melanoma explants: plasticity of cell-cell interaction, beta1-integrin function, and migration strategies. Cancer Res (2002) 2.55

Different faces of the heme-heme oxygenase system in inflammation. Pharmacol Rev (2003) 2.52

Targeted therapy with a Salmonella typhimurium leucine-arginine auxotroph cures orthotopic human breast tumors in nude mice. Cancer Res (2006) 2.51

In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation. Proc Natl Acad Sci U S A (2009) 2.46

Monotherapy with a tumor-targeting mutant of Salmonella typhimurium cures orthotopic metastatic mouse models of human prostate cancer. Proc Natl Acad Sci U S A (2007) 2.46

MT1-MMP-dependent neovessel formation within the confines of the three-dimensional extracellular matrix. J Cell Biol (2004) 2.45

Fluorophore-conjugated anti-CEA antibody for the intraoperative imaging of pancreatic and colorectal cancer. J Gastrointest Surg (2008) 2.41

Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases. Blood (2003) 2.40

Dynamic imaging of cancer growth and invasion: a modified skin-fold chamber model. Histochem Cell Biol (2008) 2.39

Multipotent hair follicle stem cells promote repair of spinal cord injury and recovery of walking function. Cell Cycle (2008) 2.39

Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells. Angew Chem Int Ed Engl (2010) 2.36

Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs. J Med Chem (2008) 2.35

Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. Cancer Res (2003) 2.32

The C-type lectin DC-SIGN (CD209) is an antigen-uptake receptor for Candida albicans on dendritic cells. Eur J Immunol (2003) 2.30

Systemic targeting of primary bone tumor and lung metastasis of high-grade osteosarcoma in nude mice with a tumor-selective strain of Salmonella typhimurium. Cell Cycle (2009) 2.28

Imaging of primary and metastatic pancreatic cancer using a fluorophore-conjugated anti-CA19-9 antibody for surgical navigation. World J Surg (2008) 2.27

Fluorescence-guided surgery allows for more complete resection of pancreatic cancer, resulting in longer disease-free survival compared with standard surgery in orthotopic mouse models. J Am Coll Surg (2012) 2.24

Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci U S A (2005) 2.22

TRPM7, a novel regulator of actomyosin contractility and cell adhesion. EMBO J (2006) 2.20

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol (2011) 2.19

Mechanisms of collective cell migration at a glance. J Cell Sci (2009) 2.15

Real-time optical imaging of primary tumor growth and multiple metastatic events in a pancreatic cancer orthotopic model. Cancer Res (2002) 2.11

Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination. Cancer Res (2012) 2.08

In situ tumor ablation creates an antigen source for the generation of antitumor immunity. Cancer Res (2004) 2.06

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition. Circ Res (2007) 2.05

A woman who gained weight and became schizophrenic. Lancet (2002) 2.04

Nascent blood vessels in the skin arise from nestin-expressing hair-follicle cells. Proc Natl Acad Sci U S A (2004) 2.00

Navigating ECM barriers at the invasive front: the cancer cell-stroma interface. Annu Rev Cell Dev Biol (2009) 2.00

Mesenchymal cells reactivate Snail1 expression to drive three-dimensional invasion programs. J Cell Biol (2009) 1.99

Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells. Proc Natl Acad Sci U S A (2003) 1.98

MT1-MMP-dependent control of skeletal stem cell commitment via a β1-integrin/YAP/TAZ signaling axis. Dev Cell (2013) 1.95

Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice. J Clin Invest (2011) 1.91

Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression. Cancer Res (2004) 1.90

Infrared multiphoton microscopy: subcellular-resolved deep tissue imaging. Curr Opin Biotechnol (2009) 1.86

Myosin II and mechanotransduction: a balancing act. Trends Cell Biol (2007) 1.85

Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. Proc Natl Acad Sci U S A (2009) 1.84

Mapping proteolytic cancer cell-extracellular matrix interfaces. Clin Exp Metastasis (2008) 1.83

Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity. Blood (2011) 1.83

Extracellular matrix determinants of proteolytic and non-proteolytic cell migration. Trends Cell Biol (2011) 1.82

Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells. Proc Natl Acad Sci U S A (2004) 1.82

A novel red fluorescent protein orthotopic pancreatic cancer model for the preclinical evaluation of chemotherapeutics. J Surg Res (2003) 1.82

Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processes. J Exp Med (2002) 1.81

Efficacy of a genetically-modified Salmonella typhimurium in an orthotopic human pancreatic cancer in nude mice. Anticancer Res (2009) 1.81

Fibronectin fibrillogenesis regulates three-dimensional neovessel formation. Genes Dev (2008) 1.81

p53 and microRNA-34 are suppressors of canonical Wnt signaling. Sci Signal (2011) 1.80

Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production. Blood (2008) 1.79

In vivo identification of regulators of cell invasion across basement membranes. Sci Signal (2010) 1.77

How C-type lectins detect pathogens. Cell Microbiol (2005) 1.77

Monotherapy with a tumor-targeting mutant of S. typhimurium inhibits liver metastasis in a mouse model of pancreatic cancer. J Surg Res (2009) 1.76

Tumor-selective, adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection. Cell Cycle (2011) 1.76

In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases. Cancer Res (2006) 1.76

Glowing tumors make for better detection and resection. Sci Transl Med (2011) 1.74

The bulge area is the origin of nestin-expressing pluripotent stem cells of the hair follicle. J Cell Biochem (2011) 1.74

Cancer metastasis directly eradicated by targeted therapy with a modified Salmonella typhimurium. J Cell Biochem (2009) 1.73

Facile whole-body imaging of internal fluorescent tumors in mice with an LED flashlight. Biotechniques (2005) 1.72

Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1. J Biol Chem (2002) 1.71

Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer. Cell Cycle (2006) 1.69

Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds. Proc Natl Acad Sci U S A (2006) 1.68

Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A (2010) 1.67

The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med (2005) 1.66

Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells. Cancer Res (2005) 1.66

Nestin-linked green fluorescent protein transgenic nude mouse for imaging human tumor angiogenesis. Cancer Res (2005) 1.64

Stathmin activity influences sarcoma cell shape, motility, and metastatic potential. Mol Biol Cell (2008) 1.62

Whole-body subcellular multicolor imaging of tumor-host interaction and drug response in real time. Cancer Res (2007) 1.61

The bulge area is the major hair follicle source of nestin-expressing pluripotent stem cells which can repair the spinal cord compared to the dermal papilla. Cell Cycle (2011) 1.61

Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses. Mol Cancer Ther (2009) 1.61

Toll-like receptor expression and function in human dendritic cell subsets: implications for dendritic cell-based anti-cancer immunotherapy. Cancer Immunol Immunother (2010) 1.60

Consolidative dendritic cell-based immunotherapy elicits cytotoxicity against malignant mesothelioma. Am J Respir Crit Care Med (2010) 1.60