Anoctamin/TMEM16 family members are Ca2+-activated Cl- channels.

ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proc Natl Acad Sci U S A (2009) 2.61

A Ca(2+)-activated Cl(-) conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity. J Physiol (2009) 2.59

TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflugers Arch (2009) 2.20

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis. Nat Genet (2011) 2.05

X-ray structure of a calcium-activated TMEM16 lipid scramblase. Nature (2014) 2.04

TMEM16A induces MAPK and contributes directly to tumorigenesis and cancer progression. Cancer Res (2012) 1.98

Chloride channels: often enigmatic, rarely predictable. Annu Rev Physiol (2010) 1.94

Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells. J Biol Chem (2010) 1.93

Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies. Am J Hum Genet (2010) 1.81

TMEM16A/anoctamin 1 protein mediates calcium-activated chloride currents in pulmonary arterial smooth muscle cells. J Physiol (2010) 1.74

Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members. J Biol Chem (2013) 1.74

Inhibition of Ca2+-activated Cl- channels by gallotannins as a possible molecular basis for health benefits of red wine and green tea. FASEB J (2010) 1.71

The TMEM16 protein family: a new class of chloride channels? Biophys J (2009) 1.68

Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels? Acta Pharmacol Sin (2011) 1.64

Functional roles of bestrophins in ocular epithelia. Prog Retin Eye Res (2009) 1.52

Expression profile and protein translation of TMEM16A in murine smooth muscle. Am J Physiol Cell Physiol (2010) 1.44

ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins. Am J Physiol Cell Physiol (2011) 1.43

Bestrophins and retinopathies. Pflugers Arch (2010) 1.41

Targeted next-generation sequencing of a 12.5 Mb homozygous region reveals ANO10 mutations in patients with autosomal-recessive cerebellar ataxia. Am J Hum Genet (2010) 1.40

Molecular components of signal amplification in olfactory sensory cilia. Proc Natl Acad Sci U S A (2010) 1.39

Ano1 as a regulator of proliferation. Am J Physiol Gastrointest Liver Physiol (2011) 1.32

Calmodulin-dependent activation and inactivation of anoctamin calcium-gated chloride channels. J Gen Physiol (2013) 1.30

Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. J Clin Invest (2010) 1.29

Calcium concentration jumps reveal dynamic ion selectivity of calcium-activated chloride currents in mouse olfactory sensory neurons and TMEM16b-transfected HEK 293T cells. J Physiol (2010) 1.24

A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. Elife (2014) 1.23

Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes. Physiology (Bethesda) (2010) 1.22

Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network. Proc Natl Acad Sci U S A (2012) 1.17

Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension. Am J Physiol Cell Physiol (2012) 1.15

Evolution and functional divergence of the anoctamin family of membrane proteins. BMC Evol Biol (2010) 1.12

Identification of a lipid scrambling domain in ANO6/TMEM16F. Elife (2015) 1.12

Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases. Pflugers Arch (2010) 1.08

TMEM16F (Anoctamin 6), an anion channel of delayed Ca(2+) activation. J Gen Physiol (2013) 1.08

Epac1 mediates protein kinase A-independent mechanism of forskolin-activated intestinal chloride secretion. J Gen Physiol (2010) 1.06

The Ca(2+) -activated Cl(-) channel, ANO1 (TMEM16A), is a double-edged sword in cell proliferation and tumorigenesis. Cancer Med (2014) 1.05

Anoctamins and gastrointestinal smooth muscle excitability. Exp Physiol (2011) 1.05

A new distal myopathy with mutation in anoctamin 5. Neuromuscul Disord (2010) 1.03

Bradykinin-induced chemotaxis of human gliomas requires the activation of KCa3.1 and ClC-3. J Neurosci (2013) 1.03

Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse. J Neurophysiol (2010) 1.02

Bradykinin enhances invasion of malignant glioma into the brain parenchyma by inducing cells to undergo amoeboid migration. J Physiol (2014) 1.02

The significance of interstitial cells in neurogastroenterology. J Neurogastroenterol Motil (2014) 1.01

Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2. J Physiol (2009) 0.99

Overexpression of miR-30b in the developing mouse mammary gland causes a lactation defect and delays involution. PLoS One (2012) 0.99

The role of TMEM16A (ANO1) and TMEM16F (ANO6) in cell migration. Pflugers Arch (2013) 0.98

Frequency and characterisation of anoctamin 5 mutations in a cohort of Italian limb-girdle muscular dystrophy patients. Neuromuscul Disord (2012) 0.96

Expression of genes encoding multi-transmembrane proteins in specific primate taste cell populations. PLoS One (2009) 0.96

Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells. Pulm Circ (2011) 0.94

A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid. Pflugers Arch (2016) 0.92

Immunoreactivity for Ano1 detects depletion of Kit-positive interstitial cells of Cajal in patients with slow transit constipation. Neurogastroenterol Motil (2011) 0.92

Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing. BMC Mol Biol (2011) 0.92

The voltage dependence of the TMEM16B/anoctamin2 calcium-activated chloride channel is modified by mutations in the first putative intracellular loop. J Gen Physiol (2012) 0.92

Functional expression of the TMEM16 family of calcium-activated chloride channels in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol (2013) 0.91

Yeast Ist2 recruits the endoplasmic reticulum to the plasma membrane and creates a ribosome-free membrane microcompartment. PLoS One (2012) 0.90

Interactions between permeation and gating in the TMEM16B/anoctamin2 calcium-activated chloride channel. J Gen Physiol (2014) 0.89

Dysregulation of human bestrophin-1 by ceramide-induced dephosphorylation. J Physiol (2009) 0.89

CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype. Am J Physiol Lung Cell Mol Physiol (2010) 0.88

Data mining of high density genomic variant data for prediction of Alzheimer's disease risk. BMC Med Genet (2012) 0.87

17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Cl(-) current in rabbit articular chondrocytes. Br J Pharmacol (2012) 0.86

Exposure of phosphatidylserine on the cell surface. Cell Death Differ (2016) 0.86

Conditional knockout of TMEM16A/anoctamin1 abolishes the calcium-activated chloride current in mouse vomeronasal sensory neurons. J Gen Physiol (2015) 0.85

TMEM16A alternative splicing coordination in breast cancer. Mol Cancer (2013) 0.85

Presynaptic Localization and Possible Function of Calcium-Activated Chloride Channel Anoctamin 1 in the Mammalian Retina. PLoS One (2013) 0.84

Acidic amino acids in the first intracellular loop contribute to voltage- and calcium- dependent gating of anoctamin1/TMEM16A. PLoS One (2014) 0.83

The Ca2+-activated Cl- channel ANO1/TMEM16A regulates primary ciliogenesis. Mol Biol Cell (2014) 0.83

Activation of the basolateral membrane Cl- conductance essential for electrogenic K+ secretion suppresses electrogenic Cl- secretion. Exp Physiol (2010) 0.83

Immunogenetic study in Chinese population with ankylosing spondylitis: are there specific genes recently disclosed? Clin Dev Immunol (2013) 0.82

Functional swapping between transmembrane proteins TMEM16A and TMEM16F. J Biol Chem (2014) 0.81

Anoctamin 6 regulates C2C12 myoblast proliferation. PLoS One (2014) 0.81

Ano1/TMEM16A Overexpression Is Associated with Good Prognosis in PR-Positive or HER2-Negative Breast Cancer Patients following Tamoxifen Treatment. PLoS One (2015) 0.80

Effects of elevated seawater pCO(2) on gene expression patterns in the gills of the green crab, Carcinus maenas. BMC Genomics (2011) 0.80

Influence of intracellular Ca2+ and alternative splicing on the pharmacological profile of ANO1 channels. Am J Physiol Cell Physiol (2016) 0.80

Defective membrane fusion and repair in Anoctamin5-deficient muscular dystrophy. Hum Mol Genet (2016) 0.79

Murine vasa recta pericyte chloride conductance is controlled by calcium, depolarization, and kinase activity. Am J Physiol Regul Integr Comp Physiol (2010) 0.79

Anoctamin and transmembrane channel-like proteins are evolutionarily related. Int J Mol Med (2009) 0.78

Calcium signaling in membrane repair. Semin Cell Dev Biol (2015) 0.78

High extracellular Ca2+ stimulates Ca2+-activated Cl- currents in frog parathyroid cells through the mediation of arachidonic acid cascade. PLoS One (2011) 0.78

A comprehensive strategy to identify stoichiometric membrane protein interactomes. Cell Logist (2012) 0.78

Hypoxia augments the calcium-activated chloride current carried by anoctamin-1 in cardiac vascular endothelial cells of neonatal mice. Br J Pharmacol (2014) 0.78

Canonical transient receptor potential channel 2 (TRPC2): old name-new games. Importance in regulating of rat thyroid cell physiology. Pflugers Arch (2014) 0.77

Characterization of Cardiac Anoctamin1 Ca²⁺-Activated Chloride Channels and Functional Role in Ischemia-Induced Arrhythmias. J Cell Physiol (2015) 0.77

Identifying olfaction's 'other channels'. J Physiol (2009) 0.77

A PI3 kinase inhibitor found to activate bestrophin 3. J Cardiovasc Pharmacol (2010) 0.77

Downregulation of LRRC8A protects human ovarian and alveolar carcinoma cells against Cisplatin-induced expression of p53, MDM2, p21Waf1/Cip1, and Caspase-9/-3 activation. Am J Physiol Cell Physiol (2016) 0.76

Bestrophin-encoded Ca²⁺-activated Cl⁻ channels underlie a current with properties similar to the native current in the moth Spodoptera littoralis olfactory receptor neurons. PLoS One (2012) 0.76

Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle. Pulm Circ (2015) 0.76

A novel exon in the human Ca2+-activated Cl- channel Ano1 imparts greater sensitivity to intracellular Ca2. Am J Physiol Gastrointest Liver Physiol (2015) 0.76

Expression of calcium-activated chloride channels Ano1 and Ano2 in mouse taste cells. Pflugers Arch (2015) 0.76

A Postural Tremor Highly Responsive to Transcranial Cerebello-Cerebral DCS in ARCA3. Front Neurol (2017) 0.75

Anoctamin 6 Contributes to Cl- Secretion in Accessory Cholera Enterotoxin (Ace) Stimulated Diarrhea: An Essential Role for PIP2 Signaling in Cholera. J Biol Chem (2016) 0.75

Regulatory Roles of Anoctamin-6 in Human Trabecular Meshwork Cells. Invest Ophthalmol Vis Sci (2017) 0.75

Macular dystrophy presenting in one of two siblings with limb-girdle muscular dystrophy type 2L due to mutation of ANO5. Eye (Lond) (2013) 0.75

Transcriptomic features of Pecten maximus oocyte quality and maturation. PLoS One (2017) 0.75

Unravelling the complexity of Cl- channels: how long is a piece of string? J Physiol (2009) 0.75

Molecular simulation assisted identification of Ca(2+) binding residues in TMEM16A. J Comput Aided Mol Des (2015) 0.75

EAVK "segment c" sequence confers Ca(2+)-dependent changes to the kinetics of full length human Ano1. Am J Physiol Gastrointest Liver Physiol (2017) 0.75

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Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Natl Acad Sci U S A (2002) 20.48

TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity. Science (2008) 8.74

TMEM16A confers receptor-activated calcium-dependent chloride conductance. Nature (2008) 8.40

Expression cloning of TMEM16A as a calcium-activated chloride channel subunit. Cell (2008) 7.79

Molecular structure and physiological function of chloride channels. Physiol Rev (2002) 6.09

A transient calcium-dependent chloride current in the immature Xenopus oocyte. J Physiol (1983) 5.64

A calcium-dependent transient outward current in Xenopus laevis oocytes. Proc R Soc Lond B Biol Sci (1982) 5.60

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Calcium-activated chloride channels. Annu Rev Physiol (2005) 4.67

The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status. Am J Pathol (2004) 3.84

The vitelliform macular dystrophy protein defines a new family of chloride channels. Proc Natl Acad Sci U S A (2002) 3.73

Voltage-activated and calcium-activated currents studied in solitary rod inner segments from the salamander retina. J Physiol (1982) 3.52

Altered regulation of airway epithelial cell chloride channels in cystic fibrosis. Science (1986) 3.40

Theoretical foundation of the balanced minimum evolution method of phylogenetic inference and its relationship to weighted least-squares tree fitting. Mol Biol Evol (2003) 3.26

Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies. Physiol Rev (2008) 2.73

A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors. Am J Surg Pathol (2008) 2.68

The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol (2008) 2.61

Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels. Proc Natl Acad Sci U S A (1987) 2.41

Properties of volume-regulated anion channels in mammalian cells. Prog Biophys Mol Biol (1997) 2.39

Structure-function analysis of the bestrophin family of anion channels. J Biol Chem (2003) 2.30

Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet (1999) 2.26

The light peak of the electroretinogram is dependent on voltage-gated calcium channels and antagonized by bestrophin (best-1). J Gen Physiol (2006) 2.18

Estimation of the number of amino acid substitutions per site when the substitution rate varies among sites. J Mol Evol (1995) 2.14

Bimodal control of a Ca(2+)-activated Cl(-) channel by different Ca(2+) signals. J Gen Physiol (2000) 2.11

An unexpected role for ion channels in brain tumor metastasis. Exp Biol Med (Maywood) (2008) 2.00

Calcium, the two-faced messenger of olfactory transduction and adaptation. Curr Opin Neurobiol (2003) 1.88

The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD). Am J Hum Genet (2004) 1.86

Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel. Mol Pharmacol (2007) 1.85

Calcium-activated chloride channels: (un)known, (un)loved? Proc Am Thorac Soc (2004) 1.82

Activation of calcium-dependent chloride channels in rat parotid acinar cells. J Gen Physiol (1996) 1.82

Mouse bestrophin-2 is a bona fide Cl(-) channel: identification of a residue important in anion binding and conduction. J Gen Physiol (2004) 1.79

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Two bestrophins cloned from Xenopus laevis oocytes express Ca(2+)-activated Cl(-) currents. J Biol Chem (2003) 1.76

Bestrophin-3 (vitelliform macular dystrophy 2-like 3 protein) is essential for the cGMP-dependent calcium-activated chloride conductance in vascular smooth muscle cells. Circ Res (2008) 1.70

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