Published in Oncogene on November 17, 2008
Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev Biol (2011) 1.45
A Network Biology Approach Identifies Molecular Cross-Talk between Normal Prostate Epithelial and Prostate Carcinoma Cells. PLoS Comput Biol (2016) 1.42
Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation. Biochim Biophys Acta (2012) 1.16
Analytic and clinical validation of a prostate cancer-enhanced messenger RNA detection assay in whole blood as a prognostic biomarker for survival. Eur Urol (2013) 1.12
The transcription factors Grainyhead-like 2 and NK2-homeobox 1 form a regulatory loop that coordinates lung epithelial cell morphogenesis and differentiation. J Biol Chem (2012) 1.10
Dual roles of the transcription factor grainyhead-like 2 (GRHL2) in breast cancer. J Biol Chem (2013) 1.07
Grainyhead-like 2 enhances the human telomerase reverse transcriptase gene expression by inhibiting DNA methylation at the 5'-CpG island in normal human keratinocytes. J Biol Chem (2010) 1.04
A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis. Proc Natl Acad Sci U S A (2011) 0.99
Inferring regulatory element landscapes and transcription factor networks from cancer methylomes. Genome Biol (2015) 0.98
Downregulation of GRHL2 inhibits the proliferation of colorectal cancer cells by targeting ZEB1. Cancer Biol Ther (2014) 0.96
Gene expression profile and response to trastuzumab-docetaxel-based treatment in breast carcinoma. Br J Cancer (2009) 0.94
Identification and functional characterization of nuclear mortalin in human carcinogenesis. J Biol Chem (2014) 0.94
Grainyhead-like 2 (GRHL2) inhibits keratinocyte differentiation through epigenetic mechanism. Cell Death Dis (2012) 0.94
Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome. Am J Hum Genet (2014) 0.90
A Grainyhead-Like 2/Ovo-Like 2 Pathway Regulates Renal Epithelial Barrier Function and Lumen Expansion. J Am Soc Nephrol (2015) 0.90
Recent discoveries concerning the involvement of transcription factors from the Grainyhead-like family in cancer. Exp Biol Med (Maywood) (2015) 0.88
GRHL2-miR-200-ZEB1 maintains the epithelial status of ovarian cancer through transcriptional regulation and histone modification. Sci Rep (2016) 0.88
AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders. Thyroid Res (2011) 0.85
Grainyhead-like 2 Promotes Tumor Growth and is Associated with Poor Prognosis in Colorectal Cancer. J Cancer (2015) 0.84
Marked overlap of four genetic syndromes with dyskeratosis congenita confounds clinical diagnosis. Haematologica (2016) 0.81
Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2013) 0.81
Chromatin redistribution of the DEK oncoprotein represses hTERT transcription in leukemias. Neoplasia (2014) 0.80
Grhl2 reduces invasion and migration through inhibition of TGFβ-induced EMT in gastric cancer. Oncogenesis (2017) 0.80
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene. Genes (Basel) (2016) 0.79
Expression of transcription factor grainyhead-like 2 is diminished in cervical cancer. Int J Clin Exp Pathol (2014) 0.78
Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea. Sci Rep (2016) 0.78
Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia. Biomed Res Int (2015) 0.76
Role of Telomerase in the Cardiovascular System. Genes (Basel) (2016) 0.76
Antitumor effects of a dual cancer-specific oncolytic adenovirus on colorectal cancer in vitro and in vivo. Exp Ther Med (2014) 0.76
The p63 Gene Is Regulated by Grainyhead-like 2 (GRHL2) through Reciprocal Feedback and Determines the Epithelial Phenotype in Human Keratinocytes. J Biol Chem (2015) 0.76
Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells. Cell Cycle (2017) 0.75
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer. Am J Transl Res (2017) 0.75
Changes in telomerase activity due to alternative splicing of human telomerase reverse transcriptase in colorectal cancer. Oncol Lett (2017) 0.75
Telomerase and drug resistance in cancer. Cell Mol Life Sci (2017) 0.75
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell (2005) 3.18
Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res (2000) 2.54
The human telomerase catalytic subunit hTERT: organization of the gene and characterization of the promoter. Hum Mol Genet (1999) 2.52
Structure and genomic organization of the human AUF1 gene: alternative pre-mRNA splicing generates four protein isoforms. Genomics (1998) 2.17
Defects in mismatch repair promote telomerase-independent proliferation. Nature (2001) 2.13
Species-specific interaction of the glutamine-rich activation domains of Sp1 with the TATA box-binding protein. Mol Cell Biol (1994) 2.07
Activity, function, and gene regulation of the catalytic subunit of telomerase (hTERT). Gene (2001) 1.86
Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. Mol Cell Biol (1997) 1.83
Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival. Br J Cancer (2006) 1.71
Immortalization of normal human oral keratinocytes with type 16 human papillomavirus. Carcinogenesis (1991) 1.68
A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Mech Dev (2002) 1.64
hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation. Mol Cell Biol (2005) 1.50
Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells. J Biol Chem (2002) 1.47
Control of mRNA translation and stability in haematopoietic cells: the function of hnRNPs K and E1/E2. Biol Cell (2004) 1.41
Targeting telomerase for cancer therapeutics. Br J Cancer (2008) 1.35
Telomerase redefined: integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity. Biochimie (2007) 1.26
Replicative senescence of normal human oral keratinocytes is associated with the loss of telomerase activity without shortening of telomeres. Cell Growth Differ (1998) 1.11
Bmi-1 cooperates with human papillomavirus type 16 E6 to immortalize normal human oral keratinocytes. Exp Cell Res (2006) 1.11
14-3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decay. EMBO J (2006) 1.11
Cell biology: master regulators of sealing and healing. Curr Biol (2005) 1.07
TAK1 represses transcription of the human telomerase reverse transcriptase gene. Oncogene (2007) 1.06
Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells. J Biol Chem (2007) 1.06
Functional interaction of the DNA-binding transcription factor Sp1 through its DNA-binding domain with the histone chaperone TAF-I. J Biol Chem (2003) 1.02
Msh2 deficiency leads to chromosomal abnormalities, centrosome amplification, and telomere capping defect. Oncogene (2006) 0.99
Senescence occurs with hTERT repression and limited telomere shortening in human oral keratinocytes cultured with feeder cells. J Cell Physiol (2004) 0.97
Evidence for heterogeneous nuclear ribonucleoprotein K overexpression in oral squamous cell carcinoma. Br J Cancer (2007) 0.95
Direct visualization of the binding of c-Myc/Max heterodimeric b-HLH-LZ to E-box sequences on the hTERT promoter. Biochemistry (2007) 0.92
Heterogeneous nuclear ribonucleoprotein K enhances insulin-induced expression of mitochondrial UCP2 protein. J Biol Chem (2004) 0.90
Lysine-specific demethylase 1 (LSD1) Is required for the transcriptional repression of the telomerase reverse transcriptase (hTERT) gene. PLoS One (2008) 0.89
Expression of telomerase genes correlates with telomerase activity in human colorectal carcinogenesis. J Pathol (2001) 0.89
The opposing effect of hypoxia-inducible factor-2alpha on expression of telomerase reverse transcriptase. Mol Cancer Res (2007) 0.86
hTERT transcription is repressed by Cbfa1 in human mesenchymal stem cell populations. J Bone Miner Res (2007) 0.84
Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature (1995) 34.97
Differential regulation and properties of MAPKs. Oncogene (2007) 6.36
Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome. JAMA (2001) 5.13
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell (2000) 4.45
Anesthesiologist direction and patient outcomes. Anesthesiology (2000) 4.31
GPCRDB: an information system for G protein-coupled receptors. Nucleic Acids Res (1998) 3.94
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature (1994) 3.70
A large-scale insertional mutagenesis screen in zebrafish. Genes Dev (1999) 3.57
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia (2008) 3.41
Distinguishing between mechanisms of eukaryotic transcriptional activation with bacteriophage T7 RNA polymerase. Cell (1987) 3.26
Yeast mRNA initiation sites are determined primarily by specific sequences, not by the distance from the TATA element. EMBO J (1985) 2.87
Intranasal lidocaine for treatment of migraine: a randomized, double-blind, controlled trial. JAMA (1996) 2.83
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry (2006) 2.80
Critical care transport: outcome evaluation after interfacility transfer and hospitalization. Ann Emerg Med (1999) 2.71
Human homologue of the Drosophila melanogaster lats tumour suppressor modulates CDC2 activity. Nat Genet (1999) 2.60
Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet (1999) 2.46
Microstrip RF surface coil design for extremely high-field MRI and spectroscopy. Magn Reson Med (2001) 2.43
CDKN2 gene silencing in lung cancer by DNA hypermethylation and kinetics of p16INK4 protein induction by 5-aza 2'deoxycytidine. Oncogene (1995) 2.23
Transcriptome analysis and molecular signature of human retinal pigment epithelium. Hum Mol Genet (2010) 2.20
Multivariate matching and bias reduction in the surgical outcomes study. Med Care (2001) 2.19
Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial. Eur J Neurol (2012) 2.18
A microplate assay for the detection of oxidative products using 2',7'-dichlorofluorescin-diacetate. J Immunol Methods (1992) 2.17
Pleiotrophin signals increased tyrosine phosphorylation of beta beta-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase beta/zeta. Proc Natl Acad Sci U S A (2000) 2.15
The number and location of glycans on influenza hemagglutinin determine folding and association with calnexin and calreticulin. J Cell Biol (1997) 2.14
Frequent somatic hypermutation of the 5' noncoding region of the BCL6 gene in B-cell lymphoma. Proc Natl Acad Sci U S A (1995) 2.13
Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med (1998) 2.12
Bone sialoprotein. Crit Rev Oral Biol Med (1999) 2.12
The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/Akt signaling pathway through a transcription factor complex containing CREB. Mol Cell Biol (1999) 2.12
Essential role of growth hormone in ischemia-induced retinal neovascularization. Science (1997) 2.11
Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res (1994) 2.10
Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons. Lancet (1997) 2.09
Falling cholecystectomy thresholds since the introduction of laparoscopic cholecystectomy. JAMA (1995) 2.08
Production of tumor necrosis factor/cachectin by human B cell lines and tonsillar B cells. J Exp Med (1988) 2.07
Completely diverted tube ileostomy compared with loop ileostomy for protection of low colorectal anastomosis: a pilot study. Colorectal Dis (2014) 2.06
Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2. Nat Genet (1994) 2.06
Refinement of the alpha aminooleic acid bioprosthetic valve anticalcification technique. Ann Thorac Surg (1997) 2.05
Biodegradation of organophosphorus pesticides by surface-expressed organophosphorus hydrolase. Nat Biotechnol (1997) 2.04
The multidrug resistance gene PDR1 from Saccharomyces cerevisiae. J Biol Chem (1987) 2.02
Reduced serum amino acid concentrations in infants with necrotizing enterocolitis. J Pediatr (2000) 1.97
Is obesity a high-risk factor for laparoscopic colorectal surgery? Surg Endosc (2002) 1.95
An epidemiological study of lung cancer in Xuan Wei County, China: current progress. Case-control study on lung cancer and cooking fuel. Environ Health Perspect (1991) 1.95
The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation. Recent Prog Horm Res (1996) 1.94
MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1. Oncogene (2011) 1.94
Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes. J Biol Chem (1997) 1.92
Cappuccino, a Drosophila maternal effect gene required for polarity of the egg and embryo, is related to the vertebrate limb deformity locus. Genes Dev (1995) 1.87
Infected cell protein (ICP)47 enhances herpes simplex virus neurovirulence by blocking the CD8+ T cell response. J Exp Med (1998) 1.85
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet (2010) 1.83
Caloric restriction reverses hepatic insulin resistance in aging rats by decreasing visceral fat. J Clin Invest (1998) 1.82
Synectin, syndecan-4 cytoplasmic domain binding PDZ protein, inhibits cell migration. J Cell Physiol (2000) 1.82
Adrenoleukodystrophy: increased plasma content of saturated very long chain fatty acids. Neurology (1981) 1.81
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes (2001) 1.80
Identification of a methylation imprint mark within the mouse Gnas locus. Mol Cell Biol (2000) 1.78
Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene (2010) 1.78
An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds. Proc Natl Acad Sci U S A (2000) 1.75
MUC1 oncoprotein is targeted to mitochondria by heregulin-induced activation of c-Src and the molecular chaperone HSP90. Oncogene (2006) 1.75
Co-translational folding of an alphavirus capsid protein in the cytosol of living cells. Nat Cell Biol (1999) 1.74
Relation of isovolumic relaxation to left ventricular wall movement in man. Br Heart J (1979) 1.71
Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res (2000) 1.71
Elevated Bmi-1 expression is associated with dysplastic cell transformation during oral carcinogenesis and is required for cancer cell replication and survival. Br J Cancer (2006) 1.71
Melanocortin-1 receptor genotype is a risk factor for basal and squamous cell carcinoma. J Invest Dermatol (2001) 1.69
Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol (1999) 1.69
MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. Am J Hum Genet (2001) 1.67
Primary structure, neural-specific expression, and dendritic location of human BC200 RNA. J Neurosci (1993) 1.67
Novel mutations in spastin gene and absence of correlation with age at onset of symptoms. Neurology (2000) 1.67
The contribution of childhood obesity to adult carotid intima-media thickness: the Bogalusa Heart Study. Int J Obes (Lond) (2008) 1.66
Interactions between distinct types of DNA binding proteins enhance binding to ocs element promoter sequences. Plant Cell (1995) 1.65
Quantitation of hepatic glucose fluxes and pathways of hepatic glycogen synthesis in conscious mice. Am J Physiol (1995) 1.64
beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem (2001) 1.63
Elevated expression of hTERT is associated with dysplastic cell transformation during human oral carcinogenesis in situ. Clin Cancer Res (2001) 1.62
Expression of multiple functional chemokine receptors and monocyte chemoattractant protein-1 in human neurons. Neuroscience (2000) 1.61
Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem (1997) 1.61
Expression of minute virus of mice major nonstructural protein in insect cells: purification and identification of ATPase and helicase activities. Virology (1991) 1.59
Immunity to oncogenic proteins. Immunol Rev (1995) 1.58
The vaccinia virus B1R gene product is a serine/threonine protein kinase. J Virol (1992) 1.57
Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by protein kinase A and its anchoring protein AKAP79. J Biol Chem (2001) 1.55
Structure and expression of a membrane component of the inhibin receptor system. Endocrinology (2000) 1.53
Endothelial mechanotransduction, nitric oxide and vascular inflammation. J Intern Med (2006) 1.53
Crystal structure of p38 mitogen-activated protein kinase. J Biol Chem (1996) 1.52
In vivo glucosamine infusion induces insulin resistance in normoglycemic but not in hyperglycemic conscious rats. J Clin Invest (1995) 1.52
Constitutive and coordinately regulated transcription of yeast genes: promoter elements, positive and negative regulatory sites, and DNA binding proteins. Cold Spring Harb Symp Quant Biol (1985) 1.52
The conserved box 1 motif of cytokine receptors is required for association with JAK kinases. J Biol Chem (1995) 1.51
Active immunity to Pneumocystis carinii reinfection in T-cell-depleted mice. Infect Immun (1995) 1.50
Outcomes of maintenance therapy with tacrolimus versus azathioprine for active lupus nephritis: a multicenter randomized clinical trial. Lupus (2012) 1.50
Role of the glucosamine pathway in fat-induced insulin resistance. J Clin Invest (1997) 1.49
Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export. J Cell Biol (2001) 1.47
Endovascular stent-graft treatment for Stanford type A aortic dissection. Eur J Vasc Endovasc Surg (2011) 1.47
Functional mapping in the human brain using high magnetic fields. Philos Trans R Soc Lond B Biol Sci (1999) 1.47
Gene delivery from a DNA controlled-release stent in porcine coronary arteries. Nat Biotechnol (2000) 1.46
Multivariable modelling for meta-epidemiological assessment of the association between trial quality and treatment effects estimated in randomized clinical trials. Stat Med (2007) 1.45
Episodic evolution mediates interspecies transfer of a murine coronavirus. J Virol (1997) 1.44
17O relaxation time and NMR sensitivity of cerebral water and their field dependence. Magn Reson Med (2001) 1.44
Comparative immunochemical analyses of the developmental expression and distribution of ameloblastin and amelogenin in rat incisors. J Histochem Cytochem (1998) 1.44
Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux. J Biol Chem (2001) 1.44
Persistent infection promotes cross-species transmissibility of mouse hepatitis virus. J Virol (1999) 1.44
Novel structurally altered P(2X1) receptor is preferentially activated by adenosine diphosphate in platelets and megakaryocytic cells. Blood (2001) 1.43
Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants. Heart Rhythm (2012) 1.43
Impact of low copy repeats on the generation of balanced and unbalanced chromosomal aberrations in mental retardation. Cytogenet Genome Res (2006) 1.42
Imaging near metal with a MAVRIC-SEMAC hybrid. Magn Reson Med (2011) 1.42
The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities. J Biol Chem (2000) 1.40