Convergent functional genomics of genome-wide association data for bipolar disorder: comprehensive identification of candidate genes, pathways and mechanisms.

PubWeight™: 1.92‹?› | Rank: Top 3%

🔗 View Article (PMID 19025758)

Published in Am J Med Genet B Neuropsychiatr Genet on March 05, 2009

Authors

H Le-Niculescu1, S D Patel, M Bhat, R Kuczenski, S V Faraone, M T Tsuang, F J McMahon, N J Schork, J I Nurnberger, A B Niculescu

Author Affiliations

1: Department of Psychiatry, Indiana University School of Medicine, Indianapolis, USA.

Associated clinical trials:

Imaging GABAergic/Glutamatergic Drugs in Bipolar Alcoholics Alcoholics | NCT03220776

Articles citing this

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization. Nucleic Acids Res (2009) 7.34

Pathway analysis of genomic data: concepts, methods, and prospects for future development. Trends Genet (2012) 1.86

Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry (2013) 1.69

Genome-wide association scan of trait depression. Biol Psychiatry (2010) 1.65

The genetics of bipolar disorder. Neuroscience (2009) 1.57

A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus. Mol Psychiatry (2012) 1.55

RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Hum Mol Genet (2012) 1.51

Identification of pathways for bipolar disorder: a meta-analysis. JAMA Psychiatry (2014) 1.26

Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees. Biol Psychiatry (2011) 1.25

CRY2 is associated with depression. PLoS One (2010) 1.23

SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder. Depress Anxiety (2011) 1.18

Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci. Mol Psychiatry (2013) 1.16

Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. Mol Psychiatry (2014) 1.12

Transcription factor SP4 is a susceptibility gene for bipolar disorder. PLoS One (2009) 1.10

Genetic analysis of cortical thickness and fractional anisotropy of water diffusion in the brain. Front Neurosci (2011) 1.09

Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. Transl Psychiatry (2011) 1.06

708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits. Mol Psychiatry (2013) 1.05

CRY2 is associated with rapid cycling in bipolar disorder patients. PLoS One (2010) 1.05

The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administration. Pharmacol Biochem Behav (2010) 1.02

Homeodomain protein otp and activity-dependent splicing modulate neuronal adaptation to stress. Neuron (2012) 1.02

DISC1 genetics, biology and psychiatric illness. Front Biol (Beijing) (2013) 1.00

Genetic risk prediction and neurobiological understanding of alcoholism. Transl Psychiatry (2014) 0.97

The urban environment and mental disorders: Epigenetic links. Epigenetics (2011) 0.95

Genome-wide association study of personality traits in bipolar patients. Psychiatr Genet (2011) 0.94

Peripheral brain-derived neurotrophic factor (BDNF) as a biomarker in bipolar disorder: a meta-analysis of 52 studies. BMC Med (2015) 0.93

Integrated neurobiology of bipolar disorder. Front Psychiatry (2014) 0.93

Clock gene variants in mood and anxiety disorders. J Neural Transm (Vienna) (2012) 0.93

Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitive abilities. PLoS One (2009) 0.92

Melatonin in aging and disease -multiple consequences of reduced secretion, options and limits of treatment. Aging Dis (2011) 0.92

Orchestration of neurodevelopmental programs by RBFOX1: implications for autism spectrum disorder. Int Rev Neurobiol (2013) 0.91

Genetic approaches to understanding post-traumatic stress disorder. Int J Neuropsychopharmacol (2013) 0.90

Developmental expression mapping of a gene implicated in multiple neurodevelopmental disorders, A2bp1 (Fox1). Dev Neurosci (2011) 0.90

SNPranker 2.0: a gene-centric data mining tool for diseases associated SNP prioritization in GWAS. BMC Bioinformatics (2013) 0.90

Convergent Functional Genomics: what we have learned and can learn about genes, pathways, and mechanisms. Neuropsychopharmacology (2010) 0.90

Common variants on Xq28 conferring risk of schizophrenia in Han Chinese. Schizophr Bull (2013) 0.90

Systems biology, bioinformatics, and biomarkers in neuropsychiatry. Front Neurosci (2012) 0.89

Gene-based analysis of regionally enriched cortical genes in GWAS data sets of cognitive traits and psychiatric disorders. PLoS One (2012) 0.88

Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene. Mol Psychiatry (2013) 0.87

A review of potassium channels in bipolar disorder. Front Genet (2013) 0.87

Support for association of RORA variant and post traumatic stress symptoms in a population-based study of hurricane exposed adults. Mol Psychiatry (2013) 0.87

The retinoid-related orphan receptor alpha (RORA) gene and fear-related psychopathology. J Affect Disord (2013) 0.86

Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors α- and γ-mediated transactivation. Nucleic Acids Res (2013) 0.86

RORA and posttraumatic stress trajectories: main effects and interactions with childhood physical abuse history. Brain Behav (2015) 0.85

New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia? Front Behav Neurosci (2010) 0.83

Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome. Neuropsychobiology (2011) 0.83

Autism risk assessment in siblings of affected children using sex-specific genetic scores. Mol Autism (2011) 0.82

The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease. Front Synaptic Neurosci (2014) 0.81

Prospero-related homeobox 1 (Prox1) at the crossroads of diverse pathways during adult neural fate specification. Front Cell Neurosci (2015) 0.81

RDoC and translational perspectives on the genetics of trauma-related psychiatric disorders. Am J Med Genet B Neuropsychiatr Genet (2015) 0.80

Database of genetic studies of bipolar disorder. Psychiatr Genet (2011) 0.80

Gene expression alterations in bipolar disorder postmortem brains. Bipolar Disord (2013) 0.80

Interferon stimulated exonuclease gene 20 kDa links psychiatric events to distinct hepatitis C virus responses in human immunodeficiency virus positive patients. J Med Virol (2014) 0.79

A composite peripheral blood gene expression measure as a potential diagnostic biomarker in bipolar disorder. Transl Psychiatry (2015) 0.78

Candidate gene networks and blood biomarkers of methamphetamine-associated psychosis: an integrative RNA-sequencing report. Transl Psychiatry (2016) 0.78

Associations of PER3 and RORA Circadian Gene Polymorphisms and Depressive Symptoms in Older Adults. Am J Geriatr Psychiatry (2015) 0.78

Investigation of associations between NR1D1, RORA and RORB genes and bipolar disorder. PLoS One (2015) 0.77

Sex-specific hippocampal 5-hydroxymethylcytosine is disrupted in response to acute stress. Neurobiol Dis (2016) 0.77

A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder. Front Behav Neurosci (2015) 0.76

Circadian clock gene aryl hydrocarbon receptor nuclear translocator-like polymorphisms are associated with seasonal affective disorder: An Indian family study. Indian J Psychiatry (2016) 0.76

Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study. Psychiatr Genet (2012) 0.76

Prediction of treatment outcomes in psychiatry--where do we stand ? Dialogues Clin Neurosci (2014) 0.76

Highly polygenic architecture of antidepressant treatment response: Comparative analysis of SSRI and NRI treatment in an animal model of depression. Am J Med Genet B Neuropsychiatr Genet (2016) 0.75

Microarrays-Enabled Hypothesis Generation: The Suspect Role of FNBP-1 in Neuropsychiatric Pathogenesis Associated with HIV and/or HCV Infection. J AIDS Clin Res (2016) 0.75

Variants in Ion Channel Genes Link Phenotypic Features of Bipolar Illness to Specific Neurobiological Process Domains. Mol Neuropsychiatry (2015) 0.75

Convergent functional genomics of stem cell-derived cells. Transl Psychiatry (2013) 0.75

Association between obesity and the brain-derived neurotrophic factor gene polymorphism Val66Met in individuals with bipolar disorder in Mexican population. Neuropsychiatr Dis Treat (2016) 0.75

Unique prefrontal GABA and glutamate disturbances in co-occurring bipolar disorder and alcohol dependence. Transl Psychiatry (2017) 0.75

Articles by these authors

Genetic dissection of complex traits. Science (1994) 29.54

A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol (1994) 12.91

Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data. Am J Hum Genet (2000) 11.47

Whole-genome association study of bipolar disorder. Mol Psychiatry (2008) 6.80

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder. Mol Psychiatry (2007) 6.72

A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res (1991) 6.26

Genome-wide search for genes affecting the risk for alcohol dependence. Am J Med Genet (1998) 6.04

Genetic analysis of case/control data using estimated haplotype frequencies: application to APOE locus variation and Alzheimer's disease. Genome Res (2001) 5.78

Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet (1999) 4.54

Age-dependent decline of symptoms of attention deficit hyperactivity disorder: impact of remission definition and symptom type. Am J Psychiatry (2000) 4.34

Who's afraid of epistasis? Nat Genet (1996) 4.24

Normal sexual dimorphism of the adult human brain assessed by in vivo magnetic resonance imaging. Cereb Cortex (2001) 4.03

Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry (1995) 3.98

Sexual orientation and suicidality: a co-twin control study in adult men. Arch Gen Psychiatry (1999) 3.97

Genome-wide association study of bipolar disorder in European American and African American individuals. Mol Psychiatry (2009) 3.64

Comparison of direct interview and family history diagnoses of alcohol dependence. Alcohol Clin Exp Res (1995) 3.61

Genetic influences on DSM-III-R drug abuse and dependence: a study of 3,372 twin pairs. Am J Med Genet (1996) 3.48

Alcoholism susceptibility loci: confirmation studies in a replicate sample and further mapping. Alcohol Clin Exp Res (2000) 3.42

Telomere length inversely correlates with pulse pressure and is highly familial. Hypertension (2000) 3.32

Familial transmission of substance dependence: alcohol, marijuana, cocaine, and habitual smoking: a report from the Collaborative Study on the Genetics of Alcoholism. Arch Gen Psychiatry (1998) 3.32

Patterns of psychiatric comorbidity, cognition, and psychosocial functioning in adults with attention deficit hyperactivity disorder. Am J Psychiatry (1993) 3.27

A 3-year follow-up of children with and without behavioral inhibition. J Am Acad Child Adolesc Psychiatry (1993) 2.98

The Polycomb-group gene eed is required for normal morphogenetic movements during gastrulation in the mouse embryo. Development (1998) 2.90

Further evidence of association between behavioral inhibition and social anxiety in children. Am J Psychiatry (2001) 2.88

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes. Mol Psychiatry (2006) 2.80

A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Arch Gen Psychiatry (1982) 2.75

Further evidence for family-genetic risk factors in attention deficit hyperactivity disorder. Patterns of comorbidity in probands and relatives psychiatrically and pediatrically referred samples. Arch Gen Psychiatry (1992) 2.60

Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. Br J Psychiatry (1980) 2.60

Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions. Am J Hum Genet (2000) 2.59

Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? Am J Psychiatry (1996) 2.54

Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proc Natl Acad Sci U S A (1994) 2.54

Multiple phenotype modeling in gene-mapping studies of quantitative traits: power advantages. Am J Hum Genet (1998) 2.50

Anticipation in bipolar affective disorder. Am J Hum Genet (1993) 2.44

Maternal infections and subsequent psychosis among offspring. Arch Gen Psychiatry (2001) 2.33

Stable behavioral inhibition and its association with anxiety disorder. J Am Acad Child Adolesc Psychiatry (1992) 2.31

T1rho-relaxation in articular cartilage: effects of enzymatic degradation. Magn Reson Med (1997) 2.30

Psychoactive substance use disorders in adults with attention deficit hyperactivity disorder (ADHD): effects of ADHD and psychiatric comorbidity. Am J Psychiatry (1995) 2.22

Can we subtype alcoholism? A latent class analysis of data from relatives of alcoholics in a multicenter family study of alcoholism. Alcohol Clin Exp Res (1996) 2.16

Analysis of coronary angioplasty practice in the United States with an insurance-claims data base. Circulation (1993) 2.16

A genomic-systems biology map for cardiovascular function. Science (2001) 2.09

NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. Am J Med Genet (1998) 2.09

ADHD is associated with early initiation of cigarette smoking in children and adolescents. J Am Acad Child Adolesc Psychiatry (1997) 2.09

Evidence for linkage of bipolar disorder to chromosome 18 with a parent-of-origin effect. Am J Hum Genet (1995) 2.09

Are there sex differences in neuropsychological functions among patients with schizophrenia? Am J Psychiatry (1998) 2.08

Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry (2008) 2.07

Clinical correlates of ADHD in females: findings from a large group of girls ascertained from pediatric and psychiatric referral sources. J Am Acad Child Adolesc Psychiatry (1999) 2.07

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Mol Psychiatry (2012) 2.07

Pruritus associated with nocturnal wakenings: organic or psychogenic? J Am Acad Dermatol (1989) 2.06

Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr Scand (2004) 2.05

Cortical abnormalities in schizophrenia identified by structural magnetic resonance imaging. Arch Gen Psychiatry (1999) 2.04

Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure. J Virol (2000) 1.98

Family-environment risk factors for attention-deficit hyperactivity disorder. A test of Rutter's indicators of adversity. Arch Gen Psychiatry (1995) 1.97

Is ADHD a risk factor for psychoactive substance use disorders? Findings from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry (1997) 1.96

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2. Proc Natl Acad Sci U S A (1999) 1.96

Two variants in Ankyrin 3 (ANK3) are independent genetic risk factors for bipolar disorder. Mol Psychiatry (2008) 1.92

Pharmacotherapy of attention-deficit/hyperactivity disorder reduces risk for substance use disorder. Pediatrics (1999) 1.88

The heritability of alcoholism symptoms: "indicators of genetic and environmental influence in alcohol-dependent individuals" revisited. Alcohol Clin Exp Res (1999) 1.88

Differential heritability of adult and juvenile antisocial traits. Arch Gen Psychiatry (1995) 1.88

Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. Am J Hum Genet (2000) 1.86

Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants. Mol Psychiatry (2012) 1.84

Outcome in Mania. A 4-year prospective follow-up of 75 patients utilizing survival analysis. Arch Gen Psychiatry (1990) 1.82

Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry (2008) 1.78

Pediatric mania: a developmental subtype of bipolar disorder? Biol Psychiatry (2000) 1.78

Toward a new psychometric definition of social disability in children with attention-deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry (1996) 1.77

Candidate genes, pathways and mechanisms for bipolar (manic-depressive) and related disorders: an expanded convergent functional genomics approach. Mol Psychiatry (2004) 1.76

Maternal cytokine levels during pregnancy and adult psychosis. Brain Behav Immun (2001) 1.74

Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenone. FEBS Lett (1987) 1.74

Dental caries and microbial acid production in twins. Caries Res (2005) 1.73

Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement. Mol Psychiatry (2008) 1.72

Genetic dissection of complex traits. Nat Genet (1996) 1.72

Interrelationship of genetic and environmental influences on conduct disorder and alcohol and marijuana dependence symptoms. Am J Med Genet (1999) 1.72

Genome scan of European-American schizophrenia pedigrees: results of the NIMH Genetics Initiative and Millennium Consortium. Am J Med Genet (1998) 1.72

Identifying a series of candidate genes for mania and psychosis: a convergent functional genomics approach. Physiol Genomics (2000) 1.71

Discovery and validation of blood biomarkers for suicidality. Mol Psychiatry (2013) 1.69

Mania in children with pervasive developmental disorder revisited. J Am Acad Child Adolesc Psychiatry (1997) 1.68

Identification of blood biomarkers for psychosis using convergent functional genomics. Mol Psychiatry (2009) 1.68

Adoptive and biological families of children and adolescents with ADHD. J Am Acad Child Adolesc Psychiatry (2000) 1.67