A biologically realistic network model of acquisition and extinction of conditioned fear associations in lateral amygdala neurons.

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Published in J Neurophysiol on November 26, 2008

Authors

Guoshi Li1, Satish S Nair, Gregory J Quirk

Author Affiliations

1: Department of Electrical and Computer Engineering, University of Missouri, Columbia, Missouri, USA.

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Response properties of single units in areas of rat auditory thalamus that project to the amygdala. II. Cells receiving convergent auditory and somatosensory inputs and cells antidromically activated by amygdala stimulation. Exp Brain Res (1994) 1.22

Localization of GABA-like immunoreactivity in the monkey amygdala. Neuroscience (1993) 1.21

Long-term potentiation as a candidate mnemonic device. Brain Res (1984) 1.20

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Heterosynaptic long-term potentiation of inhibitory interneurons in the lateral amygdala. J Neurosci (2004) 1.14

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Reconstruction of hippocampal CA1 pyramidal cell electrophysiology by computer simulation. J Neurophysiol (1994) 1.10

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Hyperpolarization-activated currents in neurons of the rat basolateral amygdala. J Neurophysiol (1993) 0.99

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An anatomically constrained neural network model of fear conditioning. Behav Neurosci (1995) 0.91

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