Both protein kinase A and mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation.

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Published in J Neurosci on September 01, 2000

Authors

Y Y Huang1, K C Martin, E R Kandel

Author Affiliations

1: Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, and Howard Hughes Medical Institute, New York, New York 10032, USA.

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Serotonin-mediated endocytosis of apCAM: an early step of learning-related synaptic growth in Aplysia. Science (1992) 1.62

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