Published in J Biol Chem on December 02, 2008
Sustained activation of EGFR triggers renal fibrogenesis after acute kidney injury. Am J Pathol (2013) 1.01
Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. Am J Physiol Renal Physiol (2009) 0.87
l-Citrulline Protects from Kidney Damage in Type 1 Diabetic Mice. Front Immunol (2013) 0.84
E-cadherin and transglutaminase-1 epithelial barrier restoration precedes type IV collagen basement membrane reconstruction following vocal fold mucosal injury. Cells Tissues Organs (2010) 0.83
Class I histone deacetylase activity is required for proliferation of renal epithelial cells. Am J Physiol Renal Physiol (2013) 0.80
Expression of Transglutaminase in Foreskin of Children with Balanitis Xerotica Obliterans. Int J Mol Sci (2016) 0.75
HIF-1-Dependent TGM1 Expression is Associated with Maintenance of Airway Epithelial Junction Proteins. Lung (2016) 0.75
Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33
Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol (2003) 6.05
JAK-STAT signaling: from interferons to cytokines. J Biol Chem (2007) 5.28
The JAK-STAT signaling pathway: input and output integration. J Immunol (2007) 4.92
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature (1996) 4.04
STAT proteins: novel molecular targets for cancer drug discovery. Oncogene (2000) 3.75
Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest (2004) 3.70
Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol (2003) 3.47
Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends Biochem Sci (2002) 2.74
Keratinocyte-specific transglutaminase of cultured human epidermal cells: relation to cross-linked envelope formation and terminal differentiation. Cell (1985) 2.04
Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol (2002) 1.92
STAT3 activation abrogates growth factor dependence and contributes to head and neck squamous cell carcinoma tumor growth in vivo. Cell Growth Differ (2002) 1.69
Assessment and prognostic significance of mitotic index using the mitosis marker phospho-histone H3 in low and intermediate-grade infiltrating astrocytomas. Am J Surg Pathol (2006) 1.50
c-Src kinase activity is required for hepatocyte growth factor-induced motility and anchorage-independent growth of mammary carcinoma cells. J Biol Chem (1998) 1.38
A novel function for transglutaminase 1: attachment of long-chain omega-hydroxyceramides to involucrin by ester bond formation. Proc Natl Acad Sci U S A (1999) 1.38
Tissue transglutaminase in normal and abnormal wound healing: review article. Amino Acids (2004) 1.38
Opposing actions of STAT-1 and STAT-3. Growth Factors (2005) 1.33
The role of signal transducers and activators of transcription in colon cancer. Front Biosci (2008) 1.32
Targeting cyclins and cyclin-dependent kinases in cancer: lessons from mice, hopes for therapeutic applications in human. Cell Cycle (2006) 1.28
Tissue transglutaminase has intrinsic kinase activity: identification of transglutaminase 2 as an insulin-like growth factor-binding protein-3 kinase. J Biol Chem (2004) 1.27
Expression and function of P-glycoprotein in a mouse kidney cell line. Am J Physiol (1995) 1.23
Mechanisms of renal cell repair and regeneration after acute renal failure. J Pharmacol Exp Ther (2003) 1.23
Tissue transglutaminase and the stress response. Amino Acids (2007) 1.21
Requirement of the epidermal growth factor receptor in renal epithelial cell proliferation and migration. Am J Physiol Renal Physiol (2004) 1.17
Cell type-specific activation of intracellular transglutaminase 2 by oxidative stress or ultraviolet irradiation: implications of transglutaminase 2 in age-related cataractogenesis. J Biol Chem (2004) 1.16
Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells. Clin Cancer Res (2008) 1.15
Highly active soluble processed forms of the transglutaminase 1 enzyme in epidermal keratinocytes. J Biol Chem (1995) 1.12
Signal transduction of MEK/ERK and PI3K/Akt activation by hypoxia/reoxygenation in renal epithelial cells. Eur J Cell Biol (2006) 1.12
STAT3 attenuates EGFR-mediated ERK activation and cell survival during oxidant stress in mouse proximal tubular cells. Kidney Int (2006) 1.08
Transglutaminase type 1 and its cross-linking activity are concentrated at adherens junctions in simple epithelial cells. J Biol Chem (1999) 1.02
Inhibition of transglutaminase activity reduces extracellular matrix accumulation induced by high glucose levels in proximal tubular epithelial cells. J Biol Chem (2004) 1.02
The Ste20-like kinase SLK is required for cell cycle progression through G2. J Biol Chem (2005) 1.01
Phosphorylation of histones by tissue transglutaminase. J Biol Chem (2006) 1.01
In vivo transglutaminase type 1 expression in normal lung, preinvasive bronchial lesions, and lung cancer. Am J Respir Cell Mol Biol (2003) 0.99
Role of transglutaminase II in retinoic acid-induced activation of RhoA-associated kinase-2. EMBO J (2001) 0.97
Transglutaminase 2 kinase activity facilitates protein kinase A-induced phosphorylation of retinoblastoma protein. J Biol Chem (2007) 0.96
Full oncogenic activities of v-Src are mediated by multiple signaling pathways. Ras as an essential mediator for cell survival. J Biol Chem (2000) 0.95
The p53 oncoprotein is a substrate for tissue transglutaminase kinase activity. Biochem Biophys Res Commun (2005) 0.93
Urokinase induces activation of STAT3 in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2006) 0.91
Facilitated wound healing by activation of the Transglutaminase 1 gene. Am J Pathol (2000) 0.91
Transglutaminase C in cerebellar granule neurons: regulation and localization of substrate cross-linking. Neuroscience (1995) 0.84
Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature (2007) 14.28
Creation of a bacterial cell controlled by a chemically synthesized genome. Science (2010) 13.45
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity (2007) 13.29
Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest (2008) 10.74
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity (2008) 9.61
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity (2009) 6.87
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. Nat Genet (2009) 6.42
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4. Nat Genet (2006) 5.36
Stat3 dimerization regulated by reversible acetylation of a single lysine residue. Science (2005) 5.31
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med (2004) 5.01
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease. Nat Genet (2009) 4.00
CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol (2008) 3.51
Expression and regulation of IL-22 in the IL-17-producing CD4+ T lymphocytes. Cell Res (2006) 3.41
Photoacoustic imaging and temperature measurement for photothermal cancer therapy. J Biomed Opt (2008) 2.93
Toll-like receptor 2 signaling in CD4(+) T lymphocytes promotes T helper 17 responses and regulates the pathogenesis of autoimmune disease. Immunity (2010) 2.90
Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. Nat Med (2013) 2.85
Creating bacterial strains from genomes that have been cloned and engineered in yeast. Science (2009) 2.74
Complexity of the microRNA repertoire revealed by next-generation sequencing. RNA (2010) 2.38
TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease. J Exp Med (2008) 2.33
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int (2010) 2.32
Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain. Cell Signal (2007) 2.30
LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med (2012) 2.24
Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet (2012) 2.23
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med (2007) 2.12
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
Internalization of NK cells into tumor cells requires ezrin and leads to programmed cell-in-cell death. Cell Res (2009) 2.07
Replication of CLU, CR1, and PICALM associations with alzheimer disease. Arch Neurol (2010) 2.02
Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response. Mol Cell Biol (2009) 1.80
Genome-wide ORFeome cloning and analysis of Arabidopsis transcription factor genes. Plant Physiol (2004) 1.79
Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies. Cancer Res (2004) 1.77
Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration. J Exp Med (2008) 1.76
Acetylation-dependent signal transduction for type I interferon receptor. Cell (2007) 1.68
Au-Fe3O4 dumbbell nanoparticles as dual-functional probes. Angew Chem Int Ed Engl (2008) 1.64
Candesartan suppresses chronic renal inflammation by a novel antioxidant action independent of AT1R blockade. Kidney Int (2008) 1.62
Detection of SNP epistasis effects of quantitative traits using an extended Kempthorne model. Physiol Genomics (2006) 1.62
Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1. Mol Cell Biol (2009) 1.58
P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk. Am J Physiol Renal Physiol (2010) 1.57
Predicting the impact of antiretrovirals in resource-poor settings: preventing HIV infections whilst controlling drug resistance. Curr Drug Targets Infect Disord (2003) 1.55
Polynitroxylated pegylated hemoglobin: a novel neuroprotective hemoglobin for acute volume-limited fluid resuscitation after combined traumatic brain injury and hemorrhagic hypotension in mice. Crit Care Med (2011) 1.54
Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy. Am J Physiol Renal Physiol (2009) 1.53
Genome-wide association analysis of thirty one production, health, reproduction and body conformation traits in contemporary U.S. Holstein cows. BMC Genomics (2011) 1.52
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation. Genes Dev (2003) 1.51
Histone deacetylase: a potential therapeutic target for fibrotic disorders. J Pharmacol Exp Ther (2010) 1.51
Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells. Nucleic Acids Res (2013) 1.48
Cutting edge: Negative regulation of dendritic cells through acetylation of the nonhistone protein STAT-3. J Immunol (2009) 1.45
SHP-2 is a dual-specificity phosphatase involved in Stat1 dephosphorylation at both tyrosine and serine residues in nuclei. J Biol Chem (2002) 1.44
Long-term outcomes after D2 gastrectomy for early gastric cancer: survival analysis of a single-center experience in China. Asian Pac J Cancer Prev (2014) 1.42
Computational models of a nano probe tip for static behaviors. Scanning (2008) 1.42
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther (2008) 1.41
PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans. J Nucl Med (2009) 1.39
Effects of low concentrations of benzene exposure on levels of platelet-associated antibodies and platelet parameters. J Occup Environ Med (2014) 1.38
Retracted Analysis of the TCR alpha and beta chain CDR3 spectratypes in the peripheral blood of patients with Systemic Lupus Erythematosus. J Autoimmune Dis (2008) 1.38
MicroRNA control of epithelial-mesenchymal transition and metastasis. Cancer Metastasis Rev (2012) 1.34
Cyclooxygenase-2-derived lipoxin A4 increases gastric resistance to aspirin-induced damage. Gastroenterology (2002) 1.33
A CD133-related gene expression signature identifies an aggressive glioblastoma subtype with excessive mutations. Proc Natl Acad Sci U S A (2011) 1.30
ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance. Cell Cycle (2015) 1.30
Diversity of rotavirus strains among children with acute diarrhea in China: 1998-2000 surveillance study. J Clin Microbiol (2002) 1.29
Delayed administration of a single dose of lithium promotes recovery from AKI. J Am Soc Nephrol (2014) 1.28
Genome-wide association study of body weight in chicken F2 resource population. PLoS One (2011) 1.28
Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation. J Biol Chem (2002) 1.28
Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze. Neuropsychopharmacology (2003) 1.27
In vitro assessment of metabolic drug-drug interaction potential of apixaban through cytochrome P450 phenotyping, inhibition, and induction studies. Drug Metab Dispos (2009) 1.26
Blocking the class I histone deacetylase ameliorates renal fibrosis and inhibits renal fibroblast activation via modulating TGF-beta and EGFR signaling. PLoS One (2013) 1.26
Neutral genomic regions refine models of recent rapid human population growth. Proc Natl Acad Sci U S A (2013) 1.25
FFA-induced adipocyte inflammation and insulin resistance: involvement of ER stress and IKKβ pathways. Obesity (Silver Spring) (2010) 1.24
Isolation and identification of mesenchymal stem cells from human fetal pancreas. J Lab Clin Med (2003) 1.24
Slit-Robo signaling induces malignant transformation through Hakai-mediated E-cadherin degradation during colorectal epithelial cell carcinogenesis. Cell Res (2011) 1.24
Long non-coding RNA HOTAIR in carcinogenesis and metastasis. Acta Biochim Biophys Sin (Shanghai) (2013) 1.23
MiR-21 regulates biological behavior through the PTEN/PI-3 K/Akt signaling pathway in human colorectal cancer cells. Int J Oncol (2012) 1.23
Standard uptake value and metabolic tumor volume of ¹⁸F-FDG PET/CT predict short-term outcome early in the course of chemoradiotherapy in advanced non-small cell lung cancer. Eur J Nucl Med Mol Imaging (2011) 1.20
Central role of the threonine residue within the p+1 loop of receptor tyrosine kinase in STAT3 constitutive phosphorylation in metastatic cancer cells. Mol Cell Biol (2004) 1.19
Genetic or pharmacologic blockade of EGFR inhibits renal fibrosis. J Am Soc Nephrol (2012) 1.19
Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev (2012) 1.19
Using DSP, a reversible cross-linker, to fix tissue sections for immunostaining, microdissection and expression profiling. Nucleic Acids Res (2004) 1.19
A new strategy to amplify degraded RNA from small tissue samples for microarray studies. Nucleic Acids Res (2003) 1.18
Contrast extravasation on computed tomography angiography predicts clinical outcome in primary intracerebral hemorrhage: a prospective study of 139 cases. Stroke (2011) 1.18
TRP genes: candidates for nonselective cation channels and store-operated channels in insulin-secreting cells. Diabetes (2002) 1.18
Optimization of ceramic strength using elastic gradients. Acta Mater (2009) 1.17
Long-term, high-dosage candesartan suppresses inflammation and injury in chronic kidney disease: nonhemodynamic renal protection. J Am Soc Nephrol (2007) 1.17
Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study. BMC Cancer (2011) 1.16
Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity. J Biol Chem (2010) 1.16
Histone deacetylases as targets for treatment of multiple diseases. Clin Sci (Lond) (2013) 1.16
Detection and characterization of metabolites in biological matrices using mass defect filtering of liquid chromatography/high resolution mass spectrometry data. Drug Metab Dispos (2006) 1.15
Role of epidermal growth factor receptor in acute and chronic kidney injury. Kidney Int (2013) 1.14
A core metabolic enzyme mediates resistance to phosphine gas. Science (2012) 1.14
Robotic versus laparoscopic gastrectomy for gastric cancer: a meta-analysis of short outcomes. Surg Oncol (2012) 1.12
Advanced glycation end products and its receptor (RAGE) are increased in patients with COPD. Respir Med (2010) 1.12
Inhibition of histone deacetylases preserves myocardial performance and prevents cardiac remodeling through stimulation of endogenous angiomyogenesis. J Pharmacol Exp Ther (2012) 1.12
Ligusticum chuanxiong Hort: a review of chemistry and pharmacology. Pharm Biol (2011) 1.12