Published in Diabetes on December 09, 2008
Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation. J Biol Chem (2009) 1.52
(n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: mechanistic insights. Adv Nutr (2011) 1.39
Mitochondrial lipid oxidation is impaired in cultured myotubes from obese humans. Int J Obes (Lond) (2011) 1.20
Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis. J Biol Chem (2010) 1.03
Metabolic switching of human myotubes is improved by n-3 fatty acids. J Lipid Res (2010) 0.88
Omega-3 Fatty Acids and Skeletal Muscle Health. Mar Drugs (2015) 0.86
Insulin resistance is not conserved in myotubes established from women with PCOS. PLoS One (2010) 0.77
Myotubes from severely obese type 2 diabetic subjects accumulate less lipids and show higher lipolytic rate than myotubes from severely obese non-diabetic subjects. PLoS One (2015) 0.76
Reduced TCA Flux in Diabetic Myotubes: Determined by Single Defects? Biochem Res Int (2012) 0.75
Effect of serial cell passaging in the retention of fiber type and mitochondrial content in primary human myotubes. Obesity (Silver Spring) (2015) 0.75
Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism. PLoS One (2017) 0.75
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process? Biogerontology (2017) 0.75
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell (1999) 19.48
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A (2003) 17.10
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science (2003) 11.39
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem (2002) 9.76
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74
Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell (2008) 7.37
Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc Natl Acad Sci U S A (2003) 6.46
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem (2005) 4.30
Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes (1997) 4.17
Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes (1991) 3.14
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance. J Clin Invest (2007) 2.85
Mitochondrial respiration is decreased in skeletal muscle of patients with type 2 diabetes. Diabetes (2007) 2.75
Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol (1985) (1997) 2.57
Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes (2001) 2.56
Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science (1987) 2.26
Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures. Diabetes (1995) 2.01
Oleate reverses palmitate-induced insulin resistance and inflammation in skeletal muscle cells. J Biol Chem (2008) 1.95
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: role of intramuscular accumulation of lipid metabolites. J Appl Physiol (1985) (2005) 1.88
Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells. Biochem J (2006) 1.75
Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc Natl Acad Sci U S A (2001) 1.67
Free fatty acids and skeletal muscle insulin resistance. Curr Opin Lipidol (2008) 1.64
A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. J Biol Chem (2004) 1.58
Interaction between free fatty acids and glucose metabolism. Curr Opin Clin Nutr Metab Care (2002) 1.54
Long-chain acyl-CoA esters as indicators of lipid metabolism and insulin sensitivity in rat and human muscle. Am J Physiol Endocrinol Metab (2000) 1.48
Colocalization of SCD1 and DGAT2: implying preference for endogenous monounsaturated fatty acids in triglyceride synthesis. J Lipid Res (2006) 1.33
Palmitate-mediated downregulation of peroxisome proliferator-activated receptor-gamma coactivator 1alpha in skeletal muscle cells involves MEK1/2 and nuclear factor-kappaB activation. Diabetes (2006) 1.32
Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes. Diabetes (2004) 1.27
PPAR dual agonists: are they opening Pandora's Box? Pharmacol Res (2007) 1.26
Insulin induces the translocation of the fatty acid transporter FAT/CD36 to the plasma membrane. Am J Physiol Endocrinol Metab (2002) 1.17
The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity. Diabetes (2002) 1.17
Carnitine revisited: potential use as adjunctive treatment in diabetes. Diabetologia (2007) 1.17
A cellular model system of differentiated human myotubes. APMIS (2001) 1.15
The metabolic syndrome and the hepatic fatty acid drainage hypothesis. Biochimie (2005) 1.00
Rosiglitazone increases fatty acid oxidation and fatty acid translocase (FAT/CD36) but not carnitine palmitoyltransferase I in rat muscle mitochondria. J Physiol (2008) 0.97
Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells. J Lipid Res (2005) 0.96
Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway. Diabetes (2005) 0.96
Insulin resistance and the mitochondrial link. Lessons from cultured human myotubes. Biochim Biophys Acta (2007) 0.95
Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. Diabetologia (2005) 0.94
Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids. Biol Cell (2000) 0.90
Cell-based multiwell assays for the detection of substrate accumulation and oxidation. J Lipid Res (2007) 0.87
Long-chain Acyl-CoA is not primarily increased in myotubes established from type 2 diabetic subjects. Biochim Biophys Acta (2006) 0.86
Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR-alpha/delta activation and increased mitochondrial fatty acid oxidation. Diabetes Obes Metab (2009) 0.85
Triacylglycerol accumulation is not primarily affected in myotubes established from type 2 diabetic subjects. Biochim Biophys Acta (2006) 0.84
Stimulation of fatty acid oxidation by a 3-thia fatty acid reduces triacylglycerol secretion in cultured rat hepatocytes. J Lipid Res (1994) 0.82
Tetradecylthioacetic acid prevents high fat diet induced adiposity and insulin resistance. J Lipid Res (2002) 0.80
Ethyl icosapentate (omega-3 fatty acid) causes accumulation of lipids in skeletal muscle but suppresses insulin resistance in OLETF rats. Otsuka Long-Evans Tokushima Fatty. Metabolism (2003) 0.80
Folic acid supplements and risk of facial clefts: national population based case-control study. BMJ (2007) 3.67
Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy and lactation augments children's IQ at 4 years of age. Pediatrics (2003) 2.86
Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes (2004) 2.70
Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell Metab (2013) 2.17
Adiponectin and its receptors are expressed in bone-forming cells. Bone (2004) 1.86
Evidence against a beneficial effect of irisin in humans. PLoS One (2013) 1.68
Hedgehog partial agonism drives Warburg-like metabolism in muscle and brown fat. Cell (2012) 1.65
Serum vitamin D concentration does not predict insulin action or secretion in European subjects with the metabolic syndrome. Diabetes Care (2010) 1.59
The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. FEBS J (2013) 1.58
Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study. Am J Clin Nutr (2007) 1.55
Adipocyte differentiation of 3T3-L1 preadipocytes is dependent on lipoxygenase activity during the initial stages of the differentiation process. Biochem J (2003) 1.52
Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling. J Cell Biochem (2002) 1.49
Intake of flavonoid-rich wine, tea, and chocolate by elderly men and women is associated with better cognitive test performance. J Nutr (2008) 1.47
A critical assessment of the h-index. Bioessays (2012) 1.45
Altered skeletal muscle lipase expression and activity contribute to insulin resistance in humans. Diabetes (2011) 1.45
Cognitive performance among the elderly and dietary fish intake: the Hordaland Health Study. Am J Clin Nutr (2007) 1.38
Different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents. J Obes (2011) 1.34
Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads. Am J Epidemiol (2003) 1.31
Reduced lipid oxidation in skeletal muscle from type 2 diabetic subjects may be of genetic origin: evidence from cultured myotubes. Diabetes (2004) 1.27
Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Endocrinology (2007) 1.24
Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age. Pediatrics (2008) 1.23
Proteomic identification of secreted proteins from human skeletal muscle cells and expression in response to strength training. Am J Physiol Endocrinol Metab (2011) 1.21
Association of 1-y changes in diet pattern with cardiovascular disease risk factors and adipokines: results from the 1-y randomized Oslo Diet and Exercise Study. Am J Clin Nutr (2008) 1.20
Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies. Genes Nutr (2010) 1.18
Molecular nutrition research: the modern way of performing nutritional science. Nutrients (2012) 1.18
IL-7 is expressed and secreted by human skeletal muscle cells. Am J Physiol Cell Physiol (2010) 1.17
Differential utilization of saturated palmitate and unsaturated oleate: evidence from cultured myotubes. Diabetes (2005) 1.17
Design and baseline characteristics of the Food4Me study: a web-based randomised controlled trial of personalised nutrition in seven European countries. Genes Nutr (2014) 1.17
Reduced insulin-mediated citrate synthase activity in cultured skeletal muscle cells from patients with type 2 diabetes: evidence for an intrinsic oxidative enzyme defect. Biochim Biophys Acta (2005) 1.14
Oral ferrous fumarate or intravenous iron sucrose for patients with inflammatory bowel disease. Scand J Gastroenterol (2005) 1.14
Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 status. Clin Chem (2009) 1.14
Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine Study. Am J Clin Nutr (2009) 1.13
Adiponectin is reduced in gestational diabetes mellitus in normal weight women. Acta Obstet Gynecol Scand (2004) 1.13
First-trimester maternal alcohol consumption and the risk of infant oral clefts in Norway: a population-based case-control study. Am J Epidemiol (2008) 1.12
Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturase. J Lipid Res (2010) 1.12
Circulating antioxidants and lipid peroxidation products in untreated tuberculosis patients in Ethiopia. Am J Clin Nutr (2003) 1.11
Plasma total homocysteine level and bone mineral density: the Hordaland Homocysteine Study. Arch Intern Med (2006) 1.09
A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences. PLoS One (2010) 1.09
Remodeling lipid metabolism and improving insulin responsiveness in human primary myotubes. PLoS One (2011) 1.08
Secreted proteins from adipose tissue and skeletal muscle - adipokines, myokines and adipose/muscle cross-talk. Arch Physiol Biochem (2010) 1.08
The Role of PPARα Activation in Liver and Muscle. PPAR Res (2010) 1.07
Increased plasma levels of adipokines in preeclampsia: relationship to placenta and adipose tissue gene expression. Am J Physiol Endocrinol Metab (2005) 1.07
Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. Genet Epidemiol (2009) 1.06
Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts. Am J Med Genet A (2008) 1.05
Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr (2009) 1.02
Electrical pulse stimulation of cultured human skeletal muscle cells as an in vitro model of exercise. PLoS One (2012) 1.00
Dietary patterns, food groups, and nutrients as predictors of plasma choline and betaine in middle-aged and elderly men and women. Am J Clin Nutr (2008) 1.00
Effects of long-term exercise and diet intervention on plasma adipokine concentrations. Am J Clin Nutr (2007) 0.99
Gene-nutrient interactions with dietary fat modulate the association between genetic variation of the ACSL1 gene and metabolic syndrome. J Lipid Res (2010) 0.99
Diet-induced obesity increases NF-kappaB signaling in reporter mice. Genes Nutr (2009) 0.98
Association of polycystic ovary syndrome susceptibility single nucleotide polymorphism rs2479106 and PCOS in Caucasian patients with PCOS or hirsutism as referral diagnosis. Eur J Obstet Gynecol Reprod Biol (2012) 0.97
Eicosapentaenoic acid (20:5 n-3) increases fatty acid and glucose uptake in cultured human skeletal muscle cells. J Lipid Res (2005) 0.96
Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway. Diabetes (2005) 0.96
Cigarette smoking may reduce plasma leptin concentration via catecholamines. Prostaglandins Leukot Essent Fatty Acids (2005) 0.96
Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes. Biochim Biophys Acta (2010) 0.96
The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Organisation. Genes Nutr (2008) 0.96
Relative validity of fruit and vegetable intake estimated from an FFQ, using carotenoid and flavonoid biomarkers and the method of triads. Br J Nutr (2011) 0.96
Enhanced feeding in very-low-birth-weight infants may cause electrolyte disturbances and septicemia--a randomized, controlled trial. Clin Nutr (2012) 0.96
Obesity and body fat classification in the metabolic syndrome: impact on cardiometabolic risk metabotype. Obesity (Silver Spring) (2013) 0.96
Evaluation of energy and dietary intake estimates from a food frequency questionnaire using independent energy expenditure measurement and weighed food records. Nutr J (2010) 0.96
Growth and nutrient intake among very-low-birth-weight infants fed fortified human milk during hospitalisation. Br J Nutr (2009) 0.96
Tissue-specific regulation of leptin expression and secretion by all-trans retinoic acid. J Cell Biochem (2004) 0.95
Correspondence analysis of microarray time-course data in case-control design. J Biomed Inform (2004) 0.95
Attention among very low birth weight infants following early supplementation with docosahexaenoic and arachidonic acid. Acta Paediatr (2011) 0.95
Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats. Scand J Gastroenterol (2011) 0.95
NOS3 gene polymorphisms are associated with risk markers of cardiovascular disease, and interact with omega-3 polyunsaturated fatty acids. Atherosclerosis (2010) 0.94
Low-dose oral ferrous fumarate aggravated intestinal inflammation in rats with DSS-induced colitis. Inflamm Bowel Dis (2005) 0.94
Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids. Am J Physiol Endocrinol Metab (2010) 0.94
Disturbed glutathione metabolism and decreased antioxidant levels in human immunodeficiency virus-infected patients during highly active antiretroviral therapy--potential immunomodulatory effects of antioxidants. J Infect Dis (2003) 0.94
Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet. Br J Nutr (2009) 0.94
LIPGENE food-exchange model for alteration of dietary fat quantity and quality in free-living participants from eight European countries. Br J Nutr (2008) 0.93
Supplementation of n-3 fatty acids during pregnancy and lactation reduces maternal plasma lipid levels and provides DHA to the infants. J Matern Fetal Neonatal Med (2006) 0.93
Dietary predictors of plasma total homocysteine in the Hordaland Homocysteine Study. Br J Nutr (2007) 0.93
Arachidonic acid-dependent inhibition of adipocyte differentiation requires PKA activity and is associated with sustained expression of cyclooxygenases. J Lipid Res (2003) 0.93
Transcriptomic coordination in the human metabolic network reveals links between n-3 fat intake, adipose tissue gene expression and metabolic health. PLoS Comput Biol (2011) 0.93
Expression profiling of insulin action in human myotubes: induction of inflammatory and pro-angiogenic pathways in relationship with glycogen synthesis and type 2 diabetes. Biochem Biophys Res Commun (2004) 0.93
Cardiac peroxisome proliferator-activated receptor-alpha activation causes increased fatty acid oxidation, reducing efficiency and post-ischaemic functional loss. Cardiovasc Res (2009) 0.93
Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects--experiences from relatives and twin studies. Best Pract Res Clin Endocrinol Metab (2003) 0.92
The challenges for molecular nutrition research 2: quantification of the nutritional phenotype. Genes Nutr (2008) 0.92
Differential effects of krill oil and fish oil on the hepatic transcriptome in mice. Front Genet (2011) 0.92
Smooth muscle cells in human atherosclerosis: proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease. J Mol Cell Cardiol (2012) 0.92
Pancreatic contamination of mesenteric adipose tissue samples can be avoided by adjusted dissection procedures. J Lipid Res (2008) 0.90
Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice. J Mol Cell Cardiol (2007) 0.90
Are cultured human myotubes far from home? Cell Tissue Res (2013) 0.90
Cognitive performance among the elderly in relation to the intake of plant foods. The Hordaland Health Study. Br J Nutr (2010) 0.90
Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58. J Lipid Res (2012) 0.89
ATP synthesis is impaired in isolated mitochondria from myotubes established from type 2 diabetic subjects. Biochem Biophys Res Commun (2010) 0.89
Disturbed carnitine regulation in chronic heart failure--increased plasma levels of palmitoyl-carnitine are associated with poor prognosis. Int J Cardiol (2012) 0.89
Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology (Berl) (2008) 0.89
Acute effects of orexigenic antipsychotic drugs on lipid and carbohydrate metabolism in rat. Psychopharmacology (Berl) (2011) 0.89
First year growth among very low birth weight infants. Acta Paediatr (2010) 0.88
Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life. Genes Nutr (2013) 0.88
The interplay between nutrients and the adipose tissue. Proc Nutr Soc (2007) 0.88