Biochemistry of soluble guanylate cyclase.

cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev (2010) 3.27

Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology. Antioxid Redox Signal (2010) 1.63

What part of NO don't you understand? Some answers to the cardinal questions in nitric oxide biology. J Biol Chem (2010) 1.43

Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. Mol Cell (2012) 1.25

A structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformation. Proc Natl Acad Sci U S A (2009) 1.22

Structure and reactivity of hexacoordinate hemoglobins. Biophys Chem (2010) 1.18

H-NOX regulation of c-di-GMP metabolism and biofilm formation in Legionella pneumophila. Mol Microbiol (2010) 1.13

Unusual heme-binding PAS domain from YybT family proteins. J Bacteriol (2011) 1.12

Nitric oxide/cGMP signalling induces Escherichia coli K1 receptor expression and modulates the permeability in human brain endothelial cell monolayers during invasion. Cell Microbiol (2009) 1.06

DiGeorge critical region 8 (DGCR8) is a double-cysteine-ligated heme protein. J Biol Chem (2011) 1.06

Mechanism of binding of NO to soluble guanylyl cyclase: implication for the second NO binding to the heme proximal site. Biochemistry (2012) 1.01

Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization. J Biol Chem (2011) 1.01

A "sliding scale rule" for selectivity among NO, CO, and O₂ by heme protein sensors. Biochemistry (2011) 0.95

Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain. J Pharmacol Exp Ther (2011) 0.94

Is Nostoc H-NOX a NO sensor or redox switch? Biochemistry (2010) 0.92

Determinants of ligand affinity and heme reactivity in H-NOX domains. Angew Chem Int Ed Engl (2010) 0.92

Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. Biochemistry (2010) 0.91

Gas what: NO is not the only answer to sexual function. Br J Pharmacol (2014) 0.89

Structural insights into the molecular mechanism of H-NOX activation. Protein Sci (2010) 0.88

Soluble guanylyl cyclase requires heat shock protein 90 for heme insertion during maturation of the NO-active enzyme. Proc Natl Acad Sci U S A (2012) 0.88

Differential inhibition of various adenylyl cyclase isoforms and soluble guanylyl cyclase by 2',3'-O-(2,4,6-trinitrophenyl)-substituted nucleoside 5'-triphosphates. J Pharmacol Exp Ther (2009) 0.87

Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity. PLoS One (2011) 0.87

Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior. Trends Biochem Sci (2013) 0.86

cGMP becomes a drug target. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.85

The amino-terminus of nitric oxide sensitive guanylyl cyclase α₁ does not affect dimerization but influences subcellular localization. PLoS One (2011) 0.85

Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. Biochemistry (2012) 0.83

Probing domain interactions in soluble guanylate cyclase. Biochemistry (2011) 0.82

The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase. Biochem J (2012) 0.82

Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. Biochemistry (2010) 0.81

Controlling conformational flexibility of an O₂-binding H-NOX domain. Biochemistry (2011) 0.78

Surface plasmon resonance using the catalytic domain of soluble guanylate cyclase allows the detection of enzyme activators. Bioorg Med Chem Lett (2014) 0.78

Sub-Nanomolar Sensitivity of Nitric Oxide Mediated Regulation of cGMP and Vasomotor Reactivity in Vascular Smooth Muscle. Front Pharmacol (2012) 0.78

Protective effects of YC-1 against glutamate induced PC12 cell apoptosis. Cell Mol Neurobiol (2010) 0.78

Contemporary Approaches to Modulating the Nitric Oxide-cGMP Pathway in Cardiovascular Disease. Circ Res (2017) 0.76

A new small molecule inhibitor of soluble guanylate cyclase. Bioorg Med Chem (2015) 0.76

Oxygen mediates vascular smooth muscle relaxation in hypoxia. PLoS One (2013) 0.76

Nitric Oxide Regulation of H-NOX Signaling Pathways in Bacteria. Biochemistry (2016) 0.75

Testing candidate genes for attention-deficit/hyperactivity disorder in fruit flies using a high throughput assay for complex behavior. Fly (Austin) (2016) 0.75

Regulation of sGC via hsp90, Cellular Heme, sGC Agonists, and NO: New Pathways and Clinical Perspectives. Antioxid Redox Signal (2016) 0.75

Genome-Wide Association Study between Single Nucleotide Polymorphisms and Flight Speed in Nellore Cattle. PLoS One (2016) 0.75

Gaseous ligand selectivity of the H-NOX sensor protein from Shewanella oneidensis and comparison to those of other bacterial H-NOXs and soluble guanylyl cyclase. Biochimie (2017) 0.75

Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue. Nature (2004) 5.09

A distributed chemosensory circuit for oxygen preference in C. elegans. PLoS Biol (2006) 2.95

Cellobiose dehydrogenase and a copper-dependent polysaccharide monooxygenase potentiate cellulose degradation by Neurospora crassa. ACS Chem Biol (2011) 2.76

Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine. Nat Chem Biol (2005) 2.60

Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases. Structure (2012) 2.51

Oxidative cleavage of cellulose by fungal copper-dependent polysaccharide monooxygenases. J Am Chem Soc (2011) 2.45

Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases. Proc Natl Acad Sci U S A (2004) 2.41

A molecular basis for NO selectivity in soluble guanylate cyclase. Nat Chem Biol (2005) 2.34

Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa. Proc Natl Acad Sci U S A (2009) 2.17

Neurons detect increases and decreases in oxygen levels using distinct guanylate cyclases. Neuron (2009) 2.14

Assembly of the covalent linkage between lipoic acid and its cognate enzymes. Chem Biol (2003) 2.11

N-terminal processing of proteins exported by malaria parasites. Mol Biochem Parasitol (2008) 1.81

Spectroscopic characterization of the soluble guanylate cyclase-like heme domains from Vibrio cholerae and Thermoanaerobacter tengcongensis. Biochemistry (2004) 1.80

Nitric oxide signaling: no longer simply on or off. Trends Biochem Sci (2006) 1.79

Toward 'omic scale metabolite profiling: a dual separation-mass spectrometry approach for coverage of lipid and central carbon metabolism. Anal Chem (2013) 1.76

Structure and regulation of soluble guanylate cyclase. Annu Rev Biochem (2012) 1.72

Design and characterization of an active site selective caspase-3 transnitrosating agent. ACS Chem Biol (2006) 1.67

Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells. Proc Natl Acad Sci U S A (2007) 1.52

Expression and characterization of the catalytic domains of soluble guanylate cyclase: interaction with the heme domain. Biochemistry (2005) 1.48

Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy. Chem Biol (2002) 1.42

Probing the function of heme distortion in the H-NOX family. ACS Chem Biol (2008) 1.42

Ligand specificity of H-NOX domains: from sGC to bacterial NO sensors. J Inorg Biochem (2005) 1.32

Mycobacteria inhibit nitric oxide synthase recruitment to phagosomes during macrophage infection. Infect Immun (2004) 1.31

Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins. Curr Opin Chem Biol (2005) 1.28

Metal binding characteristics and role of iron oxidation in the ferric uptake regulator from Escherichia coli. Biochemistry (2005) 1.28

The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. BMC Struct Biol (2008) 1.26

Nitric oxide modulates bacterial biofilm formation through a multicomponent cyclic-di-GMP signaling network. Mol Cell (2012) 1.25

Quantitative proteomic approach for cellulose degradation by Neurospora crassa. J Proteome Res (2011) 1.25

Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP. Proc Natl Acad Sci U S A (2005) 1.24

Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases. J Am Chem Soc (2013) 1.23

A structural basis for H-NOX signaling in Shewanella oneidensis by trapping a histidine kinase inhibitory conformation. Proc Natl Acad Sci U S A (2009) 1.22

Characterization of functional heme domains from soluble guanylate cyclase. Biochemistry (2005) 1.21

Mechanisms of S-nitrosothiol formation and selectivity in nitric oxide signaling. Curr Opin Chem Biol (2012) 1.19

Shewanella oneidensis MR-1 H-NOX regulation of a histidine kinase by nitric oxide. Biochemistry (2007) 1.18

Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase. J Biol Chem (2005) 1.16

Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. J Biol Chem (2006) 1.16

An Escherichia coli expression-based method for heme substitution. Nat Methods (2006) 1.15

A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase. Proc Natl Acad Sci U S A (2009) 1.14

Nitric oxide binding to prokaryotic homologs of the soluble guanylate cyclase beta1 H-NOX domain. J Biol Chem (2006) 1.13

Cellulose degradation by polysaccharide monooxygenases. Annu Rev Biochem (2015) 1.11

Sre1, an iron-modulated GATA DNA-binding protein of iron-uptake genes in the fungal pathogen Histoplasma capsulatum. Biochemistry (2008) 1.08

H-NOX-mediated nitric oxide sensing modulates symbiotic colonization by Vibrio fischeri. Proc Natl Acad Sci U S A (2010) 1.06

Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase. Proc Natl Acad Sci U S A (2013) 1.05

Heme binding to the histidine-rich protein II from Plasmodium falciparum. Biochemistry (2005) 1.05

Reactions catalyzed by the heme domain of inducible nitric oxide synthase: evidence for the involvement of tetrahydrobiopterin in electron transfer. Biochemistry (2002) 1.04

The second step of the nitric oxide synthase reaction: evidence for ferric-peroxo as the active oxidant. J Am Chem Soc (2009) 1.03

S-Nitrosation and regulation of inducible nitric oxide synthase. Biochemistry (2005) 1.02

Characterization of two different five-coordinate soluble guanylate cyclase ferrous-nitrosyl complexes. Biochemistry (2008) 1.01

Modulating heme redox potential through protein-induced porphyrin distortion. J Am Chem Soc (2010) 1.01

Site-specific and redox-controlled S-nitrosation of thioredoxin. Proc Natl Acad Sci U S A (2011) 1.01

Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation. Proc Natl Acad Sci U S A (2013) 1.00

Ability of tetrahydrobiopterin analogues to support catalysis by inducible nitric oxide synthase: formation of a pterin radical is required for enzyme activity. Biochemistry (2003) 0.99

Ru-porphyrin protein scaffolds for sensing O2. J Am Chem Soc (2010) 0.99

Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc Natl Acad Sci U S A (2011) 0.95

Resonance Raman spectra of an O2-binding H-NOX domain reveal heme relaxation upon mutation. Biochemistry (2009) 0.95

Nucleotide regulation of soluble guanylate cyclase substrate specificity. Biochemistry (2009) 0.95

Ligand binding and inhibition of an oxygen-sensitive soluble guanylate cyclase, Gyc-88E, from Drosophila. Biochemistry (2007) 0.94

Pterin-centered radical as a mechanistic probe of the second step of nitric oxide synthase. J Am Chem Soc (2010) 0.93

Butyl isocyanide as a probe of the activation mechanism of soluble guanylate cyclase. Investigating the role of non-heme nitric oxide. J Biol Chem (2007) 0.93

Revisiting the kinetics of nitric oxide (NO) binding to soluble guanylate cyclase: the simple NO-binding model is incorrect. Proc Natl Acad Sci U S A (2002) 0.93

Determinants of ligand affinity and heme reactivity in H-NOX domains. Angew Chem Int Ed Engl (2010) 0.92

NO formation by a catalytically self-sufficient bacterial nitric oxide synthase from Sorangium cellulosum. Proc Natl Acad Sci U S A (2009) 0.92

Nitric oxide synthase stabilizes the tetrahydrobiopterin cofactor radical by controlling its protonation state. J Am Chem Soc (2010) 0.92

Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. Biochemistry (2010) 0.91

Metal stoichiometry and functional studies of the diphtheria toxin repressor. Proc Natl Acad Sci U S A (2003) 0.91

Effects of nitroglycerin on soluble guanylate cyclase: implications for nitrate tolerance. J Biol Chem (2002) 0.90

Synthesis of nitric oxide by the NOS-like protein from deinococcus radiodurans: a direct role for tetrahydrofolate. Biochemistry (2009) 0.90

Structure and properties of a bis-histidyl ligated globin from Caenorhabditis elegans. Biochemistry (2010) 0.89

Design and synthesis of C5 methylated L-arginine analogues as active site probes for nitric oxide synthase. J Am Chem Soc (2007) 0.89

Extracellular aldonolactonase from Myceliophthora thermophila. Appl Environ Microbiol (2010) 0.89

Structural insights into the molecular mechanism of H-NOX activation. Protein Sci (2010) 0.88

Use of a semisynthetic epitope to probe histidine kinase activity and regulation. Anal Biochem (2009) 0.88

Characterization of nitrosoalkane binding and activation of soluble guanylate cyclase. Biochemistry (2005) 0.87

Incorporation of tyrosine and glutamine residues into the soluble guanylate cyclase heme distal pocket alters NO and O2 binding. J Biol Chem (2010) 0.87

Nitric oxide-sensing H-NOX proteins govern bacterial communal behavior. Trends Biochem Sci (2013) 0.86

Expression and characterization of the Neurospora crassa endoglucanase GH5-1. Protein Expr Purif (2010) 0.86

Sensitive and selective detection of nitric oxide using an H-NOX domain. J Am Chem Soc (2006) 0.86

Single-particle EM reveals the higher-order domain architecture of soluble guanylate cyclase. Proc Natl Acad Sci U S A (2014) 0.85

Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide. J Biol Chem (2012) 0.84

Mechanism and kinetics of inducible nitric oxide synthase auto-S-nitrosation and inactivation. Biochemistry (2012) 0.83

Redox couples of inducible nitric oxide synthase. J Am Chem Soc (2005) 0.82

Calcium-binding sites of calmodulin and electron transfer by inducible nitric oxide synthase. Biochemistry (2005) 0.82

Probing domain interactions in soluble guanylate cyclase. Biochemistry (2011) 0.82

Inhibiting Plasmodium falciparum growth and heme detoxification pathway using heme-binding DNA aptamers. Proc Natl Acad Sci U S A (2009) 0.81

Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat. Chembiochem (2012) 0.81

Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. Biochemistry (2010) 0.81

L-arginine analogs as alternate substrates for nitric oxide synthase. Bioorg Med Chem Lett (2005) 0.80

Determinants of the heme-CO vibrational modes in the H-NOX family. Biochemistry (2011) 0.80

NG-hydroxyguanidines from primary amines. Org Lett (2006) 0.79

Amino acid substitution and modification resulting from Escherichia coli expression of recombinant Plasmodium falciparum histidine-rich protein II. Biochemistry (2005) 0.79

4,4-Difluorinated analogues of l-arginine and N(G)-hydroxy-l-arginine as mechanistic probes for nitric oxide synthase. Bioorg Med Chem Lett (2009) 0.79

Phosphorylation-dependent derepression by the response regulator HnoC in the Shewanella oneidensis nitric oxide signaling network. Proc Natl Acad Sci U S A (2013) 0.79

The design and synthesis of YC-1 analogues as probes for soluble guanylate cyclase. Bioorg Med Chem Lett (2005) 0.79

Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). Biochemistry (2012) 0.79

Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1. Bioorg Med Chem Lett (2007) 0.78

Spectroscopic and kinetic studies of Nor1, a cytochrome P450 nitric oxide reductase from the fungal pathogen Histoplasma capsulatum. Arch Biochem Biophys (2008) 0.78

Utilizing RNA aptamers to probe a physiologically important heme-regulated cellular network. ACS Chem Biol (2006) 0.78

Controlling conformational flexibility of an O₂-binding H-NOX domain. Biochemistry (2011) 0.78

Porphyrin-substituted H-NOX proteins as high-relaxivity MRI contrast agents. Inorg Chem (2013) 0.77

Direct meso-alkynylation of metalloporphyrins through gold catalysis for hemoprotein engineering. Angew Chem Int Ed Engl (2014) 0.76