PubRank

Gerald W Hart

Author PubWeight™ 128.67‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Dynamic O-GlcNAc modification of nucleocytoplasmic proteins in response to stress. A survival response of mammalian cells. J Biol Chem 2004 3.35
2 Cell signaling, the essential role of O-GlcNAc! Biochim Biophys Acta 2006 3.09
3 Elevated nucleocytoplasmic glycosylation by O-GlcNAc results in insulin resistance associated with defects in Akt activation in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A 2002 3.08
4 Mapping sites of O-GlcNAc modification using affinity tags for serine and threonine post-translational modifications. Mol Cell Proteomics 2002 2.88
5 Extensive crosstalk between O-GlcNAcylation and phosphorylation regulates cytokinesis. Sci Signal 2010 2.79
6 Perturbations in O-linked beta-N-acetylglucosamine protein modification cause severe defects in mitotic progression and cytokinesis. J Biol Chem 2005 2.74
7 O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci U S A 2004 2.67
8 O-linked beta-N-acetylglucosamine (O-GlcNAc): Extensive crosstalk with phosphorylation to regulate signaling and transcription in response to nutrients and stress. Biochim Biophys Acta 2009 2.64
9 O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress. Biochim Biophys Acta 2004 2.62
10 Ogt-dependent X-chromosome-linked protein glycosylation is a requisite modification in somatic cell function and embryo viability. Mol Cell Biol 2004 2.56
11 Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code. Proc Natl Acad Sci U S A 2010 2.47
12 Cross-talk between GlcNAcylation and phosphorylation: site-specific phosphorylation dynamics in response to globally elevated O-GlcNAc. Proc Natl Acad Sci U S A 2008 2.45
13 Cross-talk between GlcNAcylation and phosphorylation: roles in insulin resistance and glucose toxicity. Am J Physiol Endocrinol Metab 2008 2.40
14 O-GlcNAc regulates FoxO activation in response to glucose. J Biol Chem 2008 2.27
15 The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways. J Cell Sci 2010 2.22
16 Cardioprotection by N-acetylglucosamine linkage to cellular proteins. Circulation 2008 2.11
17 Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature 2013 2.08
18 The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol 2010 1.96
19 Roles of the tetratricopeptide repeat domain in O-GlcNAc transferase targeting and protein substrate specificity. J Biol Chem 2003 1.96
20 Dynamic interplay between O-linked N-acetylglucosaminylation and glycogen synthase kinase-3-dependent phosphorylation. Mol Cell Proteomics 2007 1.92
21 Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase. J Biol Chem 2002 1.88
22 O-GlcNAc signalling: implications for cancer cell biology. Nat Rev Cancer 2011 1.87
23 O-GlcNAc modification in diabetes and Alzheimer's disease. Mol Biosyst 2007 1.86
24 AMP-activated protein kinase and p38 MAPK activate O-GlcNAcylation of neuronal proteins during glucose deprivation. J Biol Chem 2008 1.86
25 O-GlcNAc cycling: how a single sugar post-translational modification is changing the way we think about signaling networks. J Cell Biochem 2006 1.79
26 O-GlcNAc transferase is in a functional complex with protein phosphatase 1 catalytic subunits. J Biol Chem 2004 1.77
27 A PGC-1alpha-O-GlcNAc transferase complex regulates FoxO transcription factor activity in response to glucose. J Biol Chem 2008 1.76
28 Tandem mass spectrometry identifies many mouse brain O-GlcNAcylated proteins including EGF domain-specific O-GlcNAc transferase targets. Proc Natl Acad Sci U S A 2012 1.75
29 Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometry. Mol Cell Proteomics 2009 1.72
30 Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: alternative glycosylation/phosphorylation of THR-58, a known mutational hot spot of c-Myc in lymphomas, is regulated by mitogens. J Biol Chem 2002 1.68
31 The emerging significance of O-GlcNAc in cellular regulation. Chem Rev 2002 1.65
32 A mitotic GlcNAcylation/phosphorylation signaling complex alters the posttranslational state of the cytoskeletal protein vimentin. Mol Biol Cell 2008 1.64
33 O-GlcNAc turns twenty: functional implications for post-translational modification of nuclear and cytosolic proteins with a sugar. FEBS Lett 2003 1.64
34 O-linked beta-N-acetylglucosaminyltransferase substrate specificity is regulated by myosin phosphatase targeting and other interacting proteins. J Biol Chem 2008 1.64
35 Identification and cloning of a novel family of coiled-coil domain proteins that interact with O-GlcNAc transferase. J Biol Chem 2002 1.60
36 Site-specific interplay between O-GlcNAcylation and phosphorylation in cellular regulation. FEBS Lett 2010 1.59
37 Symbol nomenclature for glycan representation. Proteomics 2009 1.56
38 Dynamic interplay between O-GlcNAc and O-phosphate: the sweet side of protein regulation. Curr Opin Struct Biol 2003 1.46
39 Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. J Biol Chem 2009 1.45
40 Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling. J Biol Chem 2008 1.45
41 Site-specific GlcNAcylation of human erythrocyte proteins: potential biomarker(s) for diabetes. Diabetes 2008 1.39
42 dbOGAP - an integrated bioinformatics resource for protein O-GlcNAcylation. BMC Bioinformatics 2011 1.36
43 O-GlcNAc: a regulatory post-translational modification. Biochem Biophys Res Commun 2003 1.35
44 O-GlcNAc transferase regulates mitotic chromatin dynamics. J Biol Chem 2010 1.33
45 O-GlcNAc modification: a nutritional sensor that modulates proteasome function. Trends Cell Biol 2004 1.33
46 The transcription factor PDX-1 is post-translationally modified by O-linked N-acetylglucosamine and this modification is correlated with its DNA binding activity and insulin secretion in min6 beta-cells. Arch Biochem Biophys 2003 1.33
47 O-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function. Circ Res 2008 1.32
48 Posttranslational, reversible O-glycosylation is stimulated by high glucose and mediates plasminogen activator inhibitor-1 gene expression and Sp1 transcriptional activity in glomerular mesangial cells. Endocrinology 2006 1.32
49 Quantitative analysis of both protein expression and serine / threonine post-translational modifications through stable isotope labeling with dithiothreitol. Proteomics 2005 1.30
50 Regulation of insulin receptor substrate 1 (IRS-1)/AKT kinase-mediated insulin signaling by O-Linked beta-N-acetylglucosamine in 3T3-L1 adipocytes. J Biol Chem 2009 1.28
51 Proteomic approaches to analyze the dynamic relationships between nucleocytoplasmic protein glycosylation and phosphorylation. Circ Res 2003 1.26
52 Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol 2012 1.24
53 Dynamic interplay between O-glycosylation and O-phosphorylation of nucleocytoplasmic proteins: a new paradigm for metabolic control of signal transduction and transcription. Prog Nucleic Acid Res Mol Biol 2003 1.21
54 Elevation of the post-translational modification of proteins by O-linked N-acetylglucosamine leads to deterioration of the glucose-stimulated insulin secretion in the pancreas of diabetic Goto-Kakizaki rats. Glycobiology 2006 1.20
55 Diverse regulation of protein function by O-GlcNAc: a nuclear and cytoplasmic carbohydrate post-translational modification. Curr Opin Chem Biol 2002 1.19
56 Evidence of the involvement of O-GlcNAc-modified human RNA polymerase II CTD in transcription in vitro and in vivo. J Biol Chem 2012 1.18
57 Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis. J Biol Chem 2008 1.17
58 Glycomics: building upon proteomics to advance glycosciences. Mol Cell Proteomics 2013 1.12
59 Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics 2013 1.12
60 Cross-talk between two essential nutrient-sensitive enzymes: O-GlcNAc transferase (OGT) and AMP-activated protein kinase (AMPK). J Biol Chem 2014 1.09
61 O-GlcNAc cycling enzymes associate with the translational machinery and modify core ribosomal proteins. Mol Biol Cell 2010 1.05
62 O-linked N-acetylglucosamine modification on CCAAT enhancer-binding protein beta: role during adipocyte differentiation. J Biol Chem 2009 1.04
63 Localization of the O-GlcNAc transferase and O-GlcNAc-modified proteins in rat cerebellar cortex. Brain Res 2003 1.02
64 Identification of O-GlcNAc sites on proteins. Methods Enzymol 2006 1.02
65 Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes. Diabetes 2010 1.01
66 Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription. Proc Natl Acad Sci U S A 2012 0.98
67 The dynamic stress-induced "O-GlcNAc-ome" highlights functions for O-GlcNAc in regulating DNA damage/repair and other cellular pathways. Amino Acids 2010 0.98
68 Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1. J Biol Chem 2011 0.97
69 O-GlcNAc modification of nucleocytoplasmic proteins and diabetes. Med Mol Morphol 2005 0.96
70 Dynamic nuclear and cytoplasmic glycosylation: enzymes of O-GlcNAc cycling. Biochemistry 2003 0.95
71 Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Mol Biol 2011 0.94
72 Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Protein Sci 2011 0.93
73 O-GlcNAcylation of kinases. Biochem Biophys Res Commun 2012 0.89
74 The role of O-GlcNAc signaling in the pathogenesis of diabetic retinopathy. Proteomics Clin Appl 2014 0.88
75 Two-dimensional gel-based approaches for the assessment of N-Linked and O-GlcNAc glycosylation in human and simian immunodeficiency viruses. Proteomics 2008 0.85
76 Chemical approaches to study O-GlcNAcylation. Chem Soc Rev 2012 0.84
77 Working group report: the roles of glycans in hemostasis, inflammation and vascular biology. Glycobiology 2008 0.84
78 The E2F-1 associated retinoblastoma-susceptibility gene product is modified by O-GlcNAc. Amino Acids 2010 0.84
79 Reciprocal keratin 18 Ser48 O-GlcNAcylation and Ser52 phosphorylation using peptide analysis. Biochem Biophys Res Commun 2006 0.81
80 Detection and analysis of proteins modified by O-linked N-acetylglucosamine. Curr Protoc Mol Biol 2002 0.81
81 Stressing the role of O-GlcNAc: linking cell survival to keratin modification. Nat Cell Biol 2010 0.79
82 Murine platelets are not regulated by O-linked beta-N-acetylglucosamine. Arch Biochem Biophys 2008 0.78
83 Morphological changes in diabetic kidney are associated with increased O-GlcNAcylation of cytoskeletal proteins including α-actinin 4. Clin Proteomics 2011 0.78
84 Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res 2016 0.76
85 O-GlcNAcylation of Neuronal Proteins: Roles in Neuronal Functions and in Neurodegeneration. Adv Neurobiol 2014 0.76
86 A Quarter Century of Glycobiology. Glycobiology 2015 0.75
87 Sweet insights into learning and memory. Nat Chem Biol 2006 0.75
88 N-propanoylmannosamine interferes with O-GlcNAc modification of the tyrosine 3-monooxygenase and stimulates dopamine secretion. J Neurosci Res 2008 0.75